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Protein

Splicing factor 45

Gene

Rbm17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor 45
Alternative name(s):
45 kDa-splicing factor
RNA-binding motif protein 17
Gene namesi
Name:Rbm17
Synonyms:Spf45
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924188 Rbm17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000819042 – 405Splicing factor 45Add BLAST404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei21N6-acetyllysineBy similarity1
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei41N6-acetyllysine; alternateCombined sources1
Cross-linki41Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei71PhosphothreonineBy similarity1
Modified residuei155PhosphoserineCombined sources1
Modified residuei169PhosphoserineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei237PhosphothreonineBy similarity1
Cross-linki256Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei266PhosphoserineBy similarity1
Cross-linki276Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei295PhosphoserineBy similarity1
Modified residuei297PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8JZX4
MaxQBiQ8JZX4
PaxDbiQ8JZX4
PeptideAtlasiQ8JZX4
PRIDEiQ8JZX4

PTM databases

iPTMnetiQ8JZX4
PhosphoSitePlusiQ8JZX4

Expressioni

Gene expression databases

BgeeiENSMUSG00000037197
CleanExiMM_RBM17
ExpressionAtlasiQ8JZX4 baseline and differential
GenevisibleiQ8JZX4 MM

Interactioni

Subunit structurei

Binds SXL. Associates with the spliceosome. Interacts with SF3B1, SF1 and U2AF2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi218413, 1 interactor
DIPiDIP-60651N
IntActiQ8JZX4, 2 interactors
MINTiQ8JZX4
STRINGi10090.ENSMUSP00000041831

Structurei

3D structure databases

ProteinModelPortaliQ8JZX4
SMRiQ8JZX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 283G-patchPROSITE-ProRule annotationAdd BLAST49
Domaini310 – 389RRMAdd BLAST80

Phylogenomic databases

eggNOGiKOG1996 Eukaryota
ENOG410XWJ5 LUCA
GeneTreeiENSGT00790000123099
HOGENOMiHOG000231726
HOVERGENiHBG059363
InParanoidiQ8JZX4
KOiK12840
OMAiAIPPPMY
OrthoDBiEOG091G0I8J
PhylomeDBiQ8JZX4
TreeFamiTF313987

Family and domain databases

CDDicd12647 RRM_UHM_SPF45, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR034653 SPF45_RRM
IPR016967 Splicing_factor_SPF45
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF00076 RRM_1, 1 hit
PIRSFiPIRSF031066 Splicing_factor_SPF45, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00361 RRM_1, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLYDDLGVE TSDSKTEGWS KNFKLLQSQL QVKKAALTQA KSQRTKQSTV
60 70 80 90 100
LAPVIDLKRG GSSDDRQIAD TPPHVAAGLK DPVPSGFSAG EVLIPLADEY
110 120 130 140 150
DPMFPNDYEK VVKRQREERQ RQRELERQKE IEEREKRRKD RHEASGFSRR
160 170 180 190 200
PDPDSDEDED YERERRKRSM GGAAIAPPTS LVEKDKELPR DFPYEEDSRP
210 220 230 240 250
RSQSSKAAIP PPVYEEPDRP RSPTGPSNSF LANMGGTVAH KIMQKYGFRE
260 270 280 290 300
GQGLGKHEQG LSTALSVEKT SKRGGKIIVG DATEKGEAQD ASKKSDSNPL
310 320 330 340 350
TEILKCPTKV VLLRNMVGAG EVDEDLEVET KEECEKYGKV GKCVIFEIPG
360 370 380 390 400
APDDEAVRIF LEFERVESAI KAVVDLNGRY FGGRVVKACF YNLDKFRVLD

LAEQV
Length:405
Mass (Da):45,304
Last modified:October 1, 2002 - v1
Checksum:i2BCAE02BFA7AB8CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083384 mRNA Translation: AAC64085.1
AL831794 Genomic DNA No translation available.
BC034896 mRNA Translation: AAH34896.1
CCDSiCCDS15684.1
RefSeqiNP_690037.1, NM_152824.1
UniGeneiMm.182769

Genome annotation databases

EnsembliENSMUST00000040314; ENSMUSP00000041831; ENSMUSG00000037197
GeneIDi76938
KEGGimmu:76938
UCSCiuc008iio.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSPF45_MOUSE
AccessioniPrimary (citable) accession number: Q8JZX4
Secondary accession number(s): A2AP41, O75939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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