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Protein

POC1 centriolar protein homolog A

Gene

Poc1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
POC1 centriolar protein homolog A
Alternative name(s):
WD repeat-containing protein 51A
Gene namesi
Name:Poc1a
Synonyms:Wdr51a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1917485 Poc1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002315231 – 405POC1 centriolar protein homolog AAdd BLAST405

Proteomic databases

PaxDbiQ8JZX3
PeptideAtlasiQ8JZX3
PRIDEiQ8JZX3

PTM databases

PhosphoSitePlusiQ8JZX3

Expressioni

Tissue specificityi

Widely expressed in embryonic and adult tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000023345 Expressed in 133 organ(s), highest expression level in embryo
CleanExiMM_WDR51A
ExpressionAtlasiQ8JZX3 baseline and differential
GenevisibleiQ8JZX3 MM

Interactioni

Subunit structurei

Interacts with POC1B.By similarity

Protein-protein interaction databases

BioGridi213931, 6 interactors
IntActiQ8JZX3, 6 interactors
STRINGi10090.ENSMUSP00000072064

Structurei

3D structure databases

ProteinModelPortaliQ8JZX3
SMRiQ8JZX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 56WD 1Add BLAST40
Repeati59 – 98WD 2Add BLAST40
Repeati101 – 140WD 3Add BLAST40
Repeati143 – 182WD 4Add BLAST40
Repeati185 – 224WD 5Add BLAST40
Repeati227 – 266WD 6Add BLAST40
Repeati269 – 308WD 7Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili367 – 395Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the WD repeat POC1 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IF90 Eukaryota
ENOG410XR4H LUCA
GeneTreeiENSGT00810000125363
HOGENOMiHOG000036743
HOVERGENiHBG057502
InParanoidiQ8JZX3
KOiK16482
OMAiCLENQQL
OrthoDBiEOG091G07ES
PhylomeDBiQ8JZX3
TreeFamiTF324210

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8JZX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPSQEDPS LERHFKGHRD AVTCVDFSLN TKHLASGSMD STLMIWHMKP
60 70 80 90 100
QSRAYRFTGH KDAVTCVNFS PSGHLLASGS RDKTVRIWVP NVKGESTVFR
110 120 130 140 150
AHTATVRSVH FCSDGQSLVT ASDDKTVKVW STHRQRFLFS LTQHINWVRC
160 170 180 190 200
AKFSPDGRLI VSASDDKTVK LWDKTSRECI HSYCEHGGFV TYVDFHPSGT
210 220 230 240 250
CIAAAGMDNT VKVWDARTHR LLQHYQLHSA AVNALSFHPS GNYLITASSD
260 270 280 290 300
STLKILDLME GRLLYTLHGH QGPATTVAFS RTGEYFASGG SDEQVMVWKS
310 320 330 340 350
NFDIVDYGDM KARRPPPLTS SSGTLPKMDL PVPPGRDRSL ESVQGEPQES
360 370 380 390 400
ISMPQTLTST LEHIVGQLDI LTQTVSILEQ RLTLTEDRLK QCLENQQLIM

QRTPP
Length:405
Mass (Da):45,125
Last modified:April 4, 2006 - v2
Checksum:i1392C56D894D5659
GO
Isoform 2 (identifier: Q8JZX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-373: Missing.

Note: No experimental confirmation available.
Show »
Length:357
Mass (Da):39,873
Checksum:i3A43C3E4684837AE
GO
Isoform 3 (identifier: Q8JZX3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-7: Missing.
     326-373: Missing.

Note: No experimental confirmation available.
Show »
Length:356
Mass (Da):39,744
Checksum:i90782F3FE04B5269
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQ32A0A1L1SQ32_MOUSE
POC1 centriolar protein homolog A
Poc1a
394Annotation score:
A0A1L1SUQ2A0A1L1SUQ2_MOUSE
POC1 centriolar protein homolog A
Poc1a
367Annotation score:
A0A1L1SR15A0A1L1SR15_MOUSE
POC1 centriolar protein homolog A
Poc1a
299Annotation score:
A0A1L1SRG3A0A1L1SRG3_MOUSE
POC1 centriolar protein homolog A
Poc1a
428Annotation score:
A0A1L1SR04A0A1L1SR04_MOUSE
POC1 centriolar protein homolog A
Poc1a
331Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24C → R in BAB27371 (PubMed:16141072).Curated1
Sequence conflicti50P → S in BAE32416 (PubMed:16141072).Curated1
Sequence conflicti50P → S in AAH34901 (PubMed:15489334).Curated1
Sequence conflicti61K → N in BAB27371 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0178407Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_017841326 – 373Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154163 mRNA Translation: BAE32416.1
AK011064 mRNA Translation: BAB27371.1
BC034901 mRNA Translation: AAH34901.1
CCDSiCCDS23474.1 [Q8JZX3-1]
RefSeqiNP_081630.2, NM_027354.2 [Q8JZX3-1]
UniGeneiMm.23054

Genome annotation databases

EnsembliENSMUST00000072206; ENSMUSP00000072064; ENSMUSG00000023345 [Q8JZX3-1]
ENSMUST00000191434; ENSMUSP00000140374; ENSMUSG00000023345 [Q8JZX3-3]
GeneIDi70235
KEGGimmu:70235
UCSCiuc009rjk.2 mouse [Q8JZX3-1]
uc009rjl.2 mouse [Q8JZX3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154163 mRNA Translation: BAE32416.1
AK011064 mRNA Translation: BAB27371.1
BC034901 mRNA Translation: AAH34901.1
CCDSiCCDS23474.1 [Q8JZX3-1]
RefSeqiNP_081630.2, NM_027354.2 [Q8JZX3-1]
UniGeneiMm.23054

3D structure databases

ProteinModelPortaliQ8JZX3
SMRiQ8JZX3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213931, 6 interactors
IntActiQ8JZX3, 6 interactors
STRINGi10090.ENSMUSP00000072064

PTM databases

PhosphoSitePlusiQ8JZX3

Proteomic databases

PaxDbiQ8JZX3
PeptideAtlasiQ8JZX3
PRIDEiQ8JZX3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072206; ENSMUSP00000072064; ENSMUSG00000023345 [Q8JZX3-1]
ENSMUST00000191434; ENSMUSP00000140374; ENSMUSG00000023345 [Q8JZX3-3]
GeneIDi70235
KEGGimmu:70235
UCSCiuc009rjk.2 mouse [Q8JZX3-1]
uc009rjl.2 mouse [Q8JZX3-3]

Organism-specific databases

CTDi25886
MGIiMGI:1917485 Poc1a

Phylogenomic databases

eggNOGiENOG410IF90 Eukaryota
ENOG410XR4H LUCA
GeneTreeiENSGT00810000125363
HOGENOMiHOG000036743
HOVERGENiHBG057502
InParanoidiQ8JZX3
KOiK16482
OMAiCLENQQL
OrthoDBiEOG091G07ES
PhylomeDBiQ8JZX3
TreeFamiTF324210

Miscellaneous databases

PROiPR:Q8JZX3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023345 Expressed in 133 organ(s), highest expression level in embryo
CleanExiMM_WDR51A
ExpressionAtlasiQ8JZX3 baseline and differential
GenevisibleiQ8JZX3 MM

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOC1A_MOUSE
AccessioniPrimary (citable) accession number: Q8JZX3
Secondary accession number(s): Q9CY09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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