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Protein

Tricarboxylate transport protein, mitochondrial

Gene

Slc25a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in citrate-H+/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD+ for the glycolytic pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-70263 Gluconeogenesis
R-MMU-75105 Fatty acyl-CoA biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tricarboxylate transport protein, mitochondrialBy similarity
Alternative name(s):
Citrate transport proteinBy similarity
Short name:
CTPBy similarity
Solute carrier family 25 member 1Imported
Tricarboxylate carrier proteinBy similarity
Gene namesi
Name:Slc25a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1345283 Slc25a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 46Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei86 – 105Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei129 – 143Helical; Name=3Sequence analysisAdd BLAST15
Transmembranei183 – 202Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei224 – 241Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei278 – 297Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 13MitochondrionBy similarityAdd BLAST13
ChainiPRO_000043057114 – 311Tricarboxylate transport protein, mitochondrialAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei156PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8JZU2
PaxDbiQ8JZU2
PeptideAtlasiQ8JZU2
PRIDEiQ8JZU2

PTM databases

iPTMnetiQ8JZU2
PhosphoSitePlusiQ8JZU2
SwissPalmiQ8JZU2

Expressioni

Tissue specificityi

Expressed minimally but ubiquitously throughout the adult brain. Detected at higher levels in the olfactory bulb, neocortex and cerebellum. Also expressed in a subset of large cells in the globus pallidus.1 Publication

Developmental stagei

Expression reaches a maximum between E16 and P0 and then declines in adulthood.1 Publication

Gene expression databases

BgeeiENSMUSG00000003528
ExpressionAtlasiQ8JZU2 baseline and differential
GenevisibleiQ8JZU2 MM

Interactioni

Protein-protein interaction databases

BioGridi199216, 2 interactors
IntActiQ8JZU2, 3 interactors
MINTiQ8JZU2
STRINGi10090.ENSMUSP00000003622

Structurei

3D structure databases

ProteinModelPortaliQ8JZU2
SMRiQ8JZU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 111Solcar 1PROSITE-ProRule annotationAdd BLAST89
Repeati122 – 208Solcar 2PROSITE-ProRule annotationAdd BLAST87
Repeati218 – 303Solcar 3PROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0756 Eukaryota
ENOG410YAYP LUCA
GeneTreeiENSGT00550000074856
HOGENOMiHOG000168307
HOVERGENiHBG103009
InParanoidiQ8JZU2
KOiK15100
OMAiLTFWSGA
OrthoDBiEOG091G0KE7
PhylomeDBiQ8JZU2
TreeFamiTF105786

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRGPRAL SAAAPGSGKP KLTHPGKAIL AGGLAGGIEI CITFPTEYVK
60 70 80 90 100
TQLQLDERAN PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV
110 120 130 140 150
RFGMFEFLSN HMRDAQGRLD SRRGLLCGLG AGVAEAVVVV CPMETIKVKF
160 170 180 190 200
IHDQTSSNPK YRGFFHGVRE IIREQGLKGT YQGLTATVLK QGSNQAIRFF
210 220 230 240 250
VMTSLRNWYQ GDNHNKPMNP LITGVFGATA GAASVFGNTP LDVIKTRMQG
260 270 280 290 300
LEAHKYRNTL DCGLKILKNE GPKAFYKGTV PRLGRVCLDV AIVFIIYDEV
310
VKLLNKVWKT D
Length:311
Mass (Da):33,931
Last modified:October 1, 2002 - v1
Checksum:iE7910B52F006991D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78H → Y in BAE41625 (PubMed:16141072).Curated1
Sequence conflicti115A → D in BAE41625 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK159289 mRNA Translation: BAE34965.1
AK170191 mRNA Translation: BAE41625.1
AC078895 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK97495.1
BC037087 mRNA Translation: AAH37087.1
CCDSiCCDS28014.1
RefSeqiNP_694790.1, NM_153150.2
UniGeneiMm.229291

Genome annotation databases

EnsembliENSMUST00000003622; ENSMUSP00000003622; ENSMUSG00000003528
GeneIDi13358
KEGGimmu:13358
UCSCiuc007ymp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTXTP_MOUSE
AccessioniPrimary (citable) accession number: Q8JZU2
Secondary accession number(s): Q3TDH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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