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Protein

Long-chain-fatty-acid--CoA ligase 5

Gene

Acsl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL (By similarity). May have a role in the survival of glioma cells (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity).By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.2.1.3 3474
ReactomeiR-MMU-75876 Synthesis of very long-chain fatty acyl-CoAs

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 5 (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase 5
Short name:
LACS 5
Gene namesi
Name:Acsl5
Synonyms:Facl5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1919129 Acsl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 32Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 683CytoplasmicSequence analysisAdd BLAST651

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931131 – 683Long-chain-fatty-acid--CoA ligase 5Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei361N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8JZR0
MaxQBiQ8JZR0
PaxDbiQ8JZR0
PRIDEiQ8JZR0

PTM databases

iPTMnetiQ8JZR0
PhosphoSitePlusiQ8JZR0
SwissPalmiQ8JZR0

Expressioni

Gene expression databases

BgeeiENSMUSG00000024981
CleanExiMM_ACSL5
ExpressionAtlasiQ8JZR0 baseline and differential
GenevisibleiQ8JZR0 MM

Interactioni

Protein-protein interaction databases

BioGridi241124, 1 interactor
IntActiQ8JZR0, 2 interactors
MINTiQ8JZR0
STRINGi10090.ENSMUSP00000046585

Structurei

3D structure databases

ProteinModelPortaliQ8JZR0
SMRiQ8JZR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
GeneTreeiENSGT00690000101725
HOGENOMiHOG000159459
HOVERGENiHBG050452
InParanoidiQ8JZR0
KOiK01897
OMAiLGCQIFE
OrthoDBiEOG091G03G9
PhylomeDBiQ8JZR0
TreeFamiTF313877

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q8JZR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFIFNFLFS PLPTPALICL LTFGTAIFLW LINRPQPVLP LIDLDNQSVG
60 70 80 90 100
IEGGARRGAF QKNNDLILYY FSDAKTLYEN FQRGLAVSDN GPCLGYRKPN
110 120 130 140 150
QPYKWISYKQ VSDRAEYLGS CLLHKGYKSS QDQFVGIFAQ NRPEWVISEL
160 170 180 190 200
ACYTYSMVAV PLYDTLGTEA IIFVINRADI PVVICDTPQK ATMLVENVEK
210 220 230 240 250
GLTPGLKTII LMDPFDDDLM KRGEKCGVEM LSLHDAENIG KENFKKPVPP
260 270 280 290 300
KPEDLSVICF TSGTTGDPKG AMLTHENVVS NMAAFLKFLE PIFQPTSDDV
310 320 330 340 350
TISYLPLAHM FERLVQGILF SCGGKIGFFQ GDIRLLPDDM KALKPTVFPT
360 370 380 390 400
VPRLLNRVYD KVQNEAKTPL KKFLLNLAII SKFNEVKNGI IRRDSLWDKL
410 420 430 440 450
VFSKIQGSLG GKVRLMITGA APISTPVLTF FRAAMGCWVF EAYGQTECTG
460 470 480 490 500
GCSITSPGDW TAGHVGTPVA CNFVKLEDVA DMNYFSVNNE GEICIKGNNV
510 520 530 540 550
FKGYLKDPEK TQEVLDKDGW LHTGDIGRWL PNGTLKIVDR KKNIFKLAQG
560 570 580 590 600
EYIAPEKIEN VYSRSRPVLQ VFVHGESLRS FLIGVVVPDP DSLPSFAAKI
610 620 630 640 650
GVKGSFEELC KNQCVKEAIL EDLQKIGKEG GLKSFEQVKS IFVHPEPFTI
660 670 680
ENGLLTPTLK AKRVELAKFF QTQIKSLYES IEE
Length:683
Mass (Da):76,206
Last modified:October 1, 2002 - v1
Checksum:i734A1A5878741D70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031544 mRNA Translation: AAH31544.1
CCDSiCCDS29908.1
PIRiS49487
RefSeqiNP_082252.1, NM_027976.2
XP_006527241.1, XM_006527178.2
UniGeneiMm.292056

Genome annotation databases

EnsembliENSMUST00000043150; ENSMUSP00000046585; ENSMUSG00000024981
GeneIDi433256
KEGGimmu:433256
UCSCiuc008hxp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiACSL5_MOUSE
AccessioniPrimary (citable) accession number: Q8JZR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2002
Last modified: July 18, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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