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Protein

Synapsin-3

Gene

Syn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity).By similarity

Miscellaneous

Regulated by calcium. Calcium inhibits ATP binding to the C-domain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • neurotransmitter secretion Source: GO_Central
  • synaptic vesicle clustering Source: SynGO
  • synaptic vesicle cycle Source: SynGO

Keywordsi

LigandATP-binding, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-3
Alternative name(s):
Synapsin III
Gene namesi
Name:Syn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1351334 Syn3

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830251 – 579Synapsin-3Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei480PhosphoserineBy similarity1
Modified residuei483PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8JZP2
PaxDbiQ8JZP2
PRIDEiQ8JZP2

PTM databases

iPTMnetiQ8JZP2
PhosphoSitePlusiQ8JZP2

Expressioni

Gene expression databases

BgeeiENSMUSG00000059602 Expressed in 53 organ(s), highest expression level in cerebral cortex
CleanExiMM_SYN3
ExpressionAtlasiQ8JZP2 baseline and differential
GenevisibleiQ8JZP2 MM

Interactioni

Subunit structurei

Interacts with CAPON.By similarity

Protein-protein interaction databases

BioGridi205126, 1 interactor
IntActiQ8JZP2, 2 interactors
MINTiQ8JZP2
STRINGi10090.ENSMUSP00000113720

Structurei

3D structure databases

ProteinModelPortaliQ8JZP2
SMRiQ8JZP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28AAdd BLAST28
Regioni28 – 90B; linkerAdd BLAST63
Regioni91 – 398C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni399 – 530J; Pro-rich linkerAdd BLAST132
Regioni531 – 579EAdd BLAST49

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
GeneTreeiENSGT00530000063319
HOGENOMiHOG000231323
HOVERGENiHBG016354
InParanoidiQ8JZP2
KOiK19941
OMAiNHKPMLT
OrthoDBiEOG091G0BZ1
TreeFamiTF319919

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028712 SYN3
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PTHR10841:SF6 PTHR10841:SF6, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8JZP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFLRRRLSD SSFVANLPNG YMPDLQRPES SSSSPASPAT ERRHPQPLAA
60 70 80 90 100
SFSSPGSSLF SSFSGAMKQT PQAPSGLMEP PTPVTPVVQR PRILLVIDDA
110 120 130 140 150
HTDWSKYFHG KKVNGDIEIR VEQAEFSELN LAAYVTGGCM VDMQVVRNGT
160 170 180 190 200
KIVRSFKPDF ILVRQHAYSM ALAEDYRSLV IGLQYGGLPA VNSLYSVYNF
210 220 230 240 250
CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP NFPVVIKLGH
260 270 280 290 300
AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN
310 320 330 340 350
YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV
360 370 380 390 400
KAVHSKDGRD YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQLLVPGA
410 420 430 440 450
TVPSPLRPWG PQTKPAKSPG QGQLGPLLGQ PQPRPPPQGG PRQAQSPQPP
460 470 480 490 500
RSRSPSQQRL SPQGQQPVSP QSGSPQQQRS PGSPQLSRAS GGSSPNQASK
510 520 530 540 550
PSASLSSHNR PPVQGRSTSQ QGEEPQKSAS PHPHLNKSQS LTNSLSTSDT
560 570
SHRGTPSEDE AKAETIRNLR KSFASLFSD
Length:579
Mass (Da):63,315
Last modified:July 27, 2011 - v2
Checksum:i2B84E36A1663D50F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z620D3Z620_MOUSE
Synapsin-3
Syn3
243Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65G → S in AAM22969 (PubMed:11471062).Curated1
Sequence conflicti65G → S in AAM22970 (PubMed:11471062).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498252 mRNA Translation: AAM22969.1
AF498253 mRNA Translation: AAM22970.1
AC122919 Genomic DNA No translation available.
AC124614 Genomic DNA No translation available.
AC125060 Genomic DNA No translation available.
AC145076 Genomic DNA No translation available.
AC150899 Genomic DNA No translation available.
CCDSiCCDS24096.1
RefSeqiNP_038750.2, NM_013722.3
XP_006513761.1, XM_006513698.2
XP_006513762.1, XM_006513699.3
XP_006513763.1, XM_006513700.3
UniGeneiMm.394931
Mm.444790

Genome annotation databases

EnsembliENSMUST00000120638; ENSMUSP00000113720; ENSMUSG00000059602
GeneIDi27204
KEGGimmu:27204
UCSCiuc007gnn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498252 mRNA Translation: AAM22969.1
AF498253 mRNA Translation: AAM22970.1
AC122919 Genomic DNA No translation available.
AC124614 Genomic DNA No translation available.
AC125060 Genomic DNA No translation available.
AC145076 Genomic DNA No translation available.
AC150899 Genomic DNA No translation available.
CCDSiCCDS24096.1
RefSeqiNP_038750.2, NM_013722.3
XP_006513761.1, XM_006513698.2
XP_006513762.1, XM_006513699.3
XP_006513763.1, XM_006513700.3
UniGeneiMm.394931
Mm.444790

3D structure databases

ProteinModelPortaliQ8JZP2
SMRiQ8JZP2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205126, 1 interactor
IntActiQ8JZP2, 2 interactors
MINTiQ8JZP2
STRINGi10090.ENSMUSP00000113720

PTM databases

iPTMnetiQ8JZP2
PhosphoSitePlusiQ8JZP2

Proteomic databases

MaxQBiQ8JZP2
PaxDbiQ8JZP2
PRIDEiQ8JZP2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120638; ENSMUSP00000113720; ENSMUSG00000059602
GeneIDi27204
KEGGimmu:27204
UCSCiuc007gnn.2 mouse

Organism-specific databases

CTDi8224
MGIiMGI:1351334 Syn3

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
GeneTreeiENSGT00530000063319
HOGENOMiHOG000231323
HOVERGENiHBG016354
InParanoidiQ8JZP2
KOiK19941
OMAiNHKPMLT
OrthoDBiEOG091G0BZ1
TreeFamiTF319919

Enzyme and pathway databases

ReactomeiR-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle

Miscellaneous databases

ChiTaRSiSyn3 mouse
PROiPR:Q8JZP2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059602 Expressed in 53 organ(s), highest expression level in cerebral cortex
CleanExiMM_SYN3
ExpressionAtlasiQ8JZP2 baseline and differential
GenevisibleiQ8JZP2 MM

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028712 SYN3
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PTHR10841:SF6 PTHR10841:SF6, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYN3_MOUSE
AccessioniPrimary (citable) accession number: Q8JZP2
Secondary accession number(s): E9QNQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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