Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial Rho GTPase 2

Gene

Rhot2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTP 1Sequence analysis8
Nucleotide bindingi57 – 61GTP 1Sequence analysis5
Nucleotide bindingi118 – 121GTP 1Sequence analysis4
Calcium bindingi197 – 2081PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi317 – 3282PROSITE-ProRule annotationAdd BLAST12
Nucleotide bindingi424 – 431GTP 2Sequence analysis8
Nucleotide bindingi461 – 465GTP 2Sequence analysis5
Nucleotide bindingi526 – 529GTP 2Sequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, GTP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial Rho GTPase 2 (EC:3.6.5.-)
Short name:
MIRO-2
Alternative name(s):
Ras homolog gene family member T2
Gene namesi
Name:Rhot2
Synonyms:Arht2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2384892 Rhot2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 594Mitochondrial intermembraneSequence analysisAdd BLAST594
Transmembranei595 – 617Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST23
Topological domaini618 – 620CytoplasmicSequence analysis3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393191 – 620Mitochondrial Rho GTPase 2Add BLAST620

Proteomic databases

EPDiQ8JZN7
MaxQBiQ8JZN7
PaxDbiQ8JZN7
PeptideAtlasiQ8JZN7
PRIDEiQ8JZN7

PTM databases

iPTMnetiQ8JZN7
PhosphoSitePlusiQ8JZN7
SwissPalmiQ8JZN7

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000025733 Expressed in 265 organ(s), highest expression level in heart left ventricle
CleanExiMM_RHOT2
ExpressionAtlasiQ8JZN7 baseline and differential
GenevisibleiQ8JZN7 MM

Interactioni

Subunit structurei

Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (By similarity). Interacts with ARMCX3 (PubMed:22569362). Found in a complex with KIF5B, OGT, RHOT1 and TRAK1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi229580, 1 interactor
STRINGi10090.ENSMUSP00000044639

Structurei

3D structure databases

ProteinModelPortaliQ8JZN7
SMRiQ8JZN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 177Miro 1Add BLAST177
Domaini184 – 219EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini304 – 339EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini411 – 620Miro 2Add BLAST210

Sequence similaritiesi

Belongs to the mitochondrial Rho GTPase family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1707 Eukaryota
ENOG410XRHW LUCA
GeneTreeiENSGT00390000014374
HOGENOMiHOG000215553
HOVERGENiHBG079778
InParanoidiQ8JZN7
KOiK07871
OMAiTELNHFG
OrthoDBiEOG091G04UF
PhylomeDBiQ8JZN7
TreeFamiTF300814

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR013566 EF_hand_assoc_1
IPR013567 EF_hand_assoc_2
IPR002048 EF_hand_dom
IPR021181 Miro
IPR020860 MIRO_dom
IPR027417 P-loop_NTPase
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF08355 EF_assoc_1, 1 hit
PF08356 EF_assoc_2, 1 hit
PF00071 Ras, 1 hit
PIRSFiPIRSF037488 Mt_Rho_GTPase, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 2 hits
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS51423 MIRO, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8JZN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRDVRILLL GEAQVGKTSL ILSLVGEEFP EEVPARAEEI TIPADVTPEK
60 70 80 90 100
VPTHIVDYSE AEQTEEELQE EIHKANVVCV VYDVSEETTI EKIRTKWIPL
110 120 130 140 150
VNGRTATGPR LPIILVGNKS DLRPGSTMEA VLPIMSQFPE IETCVECSAK
160 170 180 190 200
HLRNISELFY YAQKAVLHPT APLYDPEAKQ LRPACAQALT RIFRLSDQDR
210 220 230 240 250
DHGLSDEELN AFQKSCFGHP LAPQALEDVK RVVCKNVSGG VQNDRLTLEG
260 270 280 290 300
FLFLNTLFIQ RGRHETTWTI LRRFGYSDSL ELTPDYLYPA LHVPPGCSTE
310 320 330 340 350
LNHRGYQFVQ RMFEKHDQDH DGVLSPTELQ NLFSVFSGAP WGPELLHTVP
360 370 380 390 400
TQAGCLPLHG YLCQWTLMTY LDVQQCLAHL GYLGYPTLCE QDSQAQAITV
410 420 430 440 450
TREKKLDQEK GQTQRSVLMC KVLGARGVGK SAFLQAFLGN SLGEARDPPE
460 470 480 490 500
KFPLHTINTV RVNGQEKYLI LCEVNADSLL DTSLDTTCDV ACLMFDSSDP
510 520 530 540 550
KTFVHCATIY KRYYMDGQTP CLFIASKADL PEGVAPPGLS PAEFCRRHRL
560 570 580 590 600
PAPASFSCLG PAMPSTDVFT QLATMATFPH LVHTELHPTS FWLRGVLVAV
610 620
GTAVAAVLSF SLYRVLVKSR
Length:620
Mass (Da):69,071
Last modified:October 1, 2002 - v1
Checksum:i439D7AA800730B53
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BL14H3BL14_MOUSE
Mitochondrial Rho GTPase 2
Rhot2
172Annotation score:
H3BKL2H3BKL2_MOUSE
Mitochondrial Rho GTPase 2
Rhot2
121Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY311390 mRNA Translation: AAP78906.1
BC029777 mRNA Translation: AAH29777.1
BC034062 mRNA Translation: AAH34062.1
CCDSiCCDS37505.1
RefSeqiNP_666111.1, NM_145999.2
UniGeneiMm.40907
Mm.490420

Genome annotation databases

EnsembliENSMUST00000043897; ENSMUSP00000044639; ENSMUSG00000025733
GeneIDi214952
KEGGimmu:214952
UCSCiuc008bch.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY311390 mRNA Translation: AAP78906.1
BC029777 mRNA Translation: AAH29777.1
BC034062 mRNA Translation: AAH34062.1
CCDSiCCDS37505.1
RefSeqiNP_666111.1, NM_145999.2
UniGeneiMm.40907
Mm.490420

3D structure databases

ProteinModelPortaliQ8JZN7
SMRiQ8JZN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229580, 1 interactor
STRINGi10090.ENSMUSP00000044639

PTM databases

iPTMnetiQ8JZN7
PhosphoSitePlusiQ8JZN7
SwissPalmiQ8JZN7

Proteomic databases

EPDiQ8JZN7
MaxQBiQ8JZN7
PaxDbiQ8JZN7
PeptideAtlasiQ8JZN7
PRIDEiQ8JZN7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043897; ENSMUSP00000044639; ENSMUSG00000025733
GeneIDi214952
KEGGimmu:214952
UCSCiuc008bch.1 mouse

Organism-specific databases

CTDi89941
MGIiMGI:2384892 Rhot2

Phylogenomic databases

eggNOGiKOG1707 Eukaryota
ENOG410XRHW LUCA
GeneTreeiENSGT00390000014374
HOGENOMiHOG000215553
HOVERGENiHBG079778
InParanoidiQ8JZN7
KOiK07871
OMAiTELNHFG
OrthoDBiEOG091G04UF
PhylomeDBiQ8JZN7
TreeFamiTF300814

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

PROiPR:Q8JZN7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025733 Expressed in 265 organ(s), highest expression level in heart left ventricle
CleanExiMM_RHOT2
ExpressionAtlasiQ8JZN7 baseline and differential
GenevisibleiQ8JZN7 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR013566 EF_hand_assoc_1
IPR013567 EF_hand_assoc_2
IPR002048 EF_hand_dom
IPR021181 Miro
IPR020860 MIRO_dom
IPR027417 P-loop_NTPase
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF08355 EF_assoc_1, 1 hit
PF08356 EF_assoc_2, 1 hit
PF00071 Ras, 1 hit
PIRSFiPIRSF037488 Mt_Rho_GTPase, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 2 hits
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS51423 MIRO, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMIRO2_MOUSE
AccessioniPrimary (citable) accession number: Q8JZN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again