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Entry version 103 (29 Sep 2021)
Sequence version 2 (29 Sep 2021)
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Protein

Mucin-4

Gene

Muc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-913709, O-linked glycosylation of mucins
R-MMU-977068, Termination of O-glycan biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-4
Short name:
MUC-4
Alternative name(s):
Ascites sialoglycoprotein
Short name:
ASGP
Pancreatic adenocarcinoma mucin
Testis mucin
Cleaved into the following 2 chains:
Alternative name(s):
Ascites sialoglycoprotein 1
Short name:
ASGP-1
Alternative name(s):
Ascites sialoglycoprotein 2
Short name:
ASGP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Muc4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2153525, Muc4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3432 – 3452HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027422729 – 3470Mucin-4Add BLAST3442
ChainiPRO_000027422829 – 2745Mucin-4 alpha chainBy similarityAdd BLAST2717
ChainiPRO_00002742292746 – 3470Mucin-4 beta chainBy similarityAdd BLAST725

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi42O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi44O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi65O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi68O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi87O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi91O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi96O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi97O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi98O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi99O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi100O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi103O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi104O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi106O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi117O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi130O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi131O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi132O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi145O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi146O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi150O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi151O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi152O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi155O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi241O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi357O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi370O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi371O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi372O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi385O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi423O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi494O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi513O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi542O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi545O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi550N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi584O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi585O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi586O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi587O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi588O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi592O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi594O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi599O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi605O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi618O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi619O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi620O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi633O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi634O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi639O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi640O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi655O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi674N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi702O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi708O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi709O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi710O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi711O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi716O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi718N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi743O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi744O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi757O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi758O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi798N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi826O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi832O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi833O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi834O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi839O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi840O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi842O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi846O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi853O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi875N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi901O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi902O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi922N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi950O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi952O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi956O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi957O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi958O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi959O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi963O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi964O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi966N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi990O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi991O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi992O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1005O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1006O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1011O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1012O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1015O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1024N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1025O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1026O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1027O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1029O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1038O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1046N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1072N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1091N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1125O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1126O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1127O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1128O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1132O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1133O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1135O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1140O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1174O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1198O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1207O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1243O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1245O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1249O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1250O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1251O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1252O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1256O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1257O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1259O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1263O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1270O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1283O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1284O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1285O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1298O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1299O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1304O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1305O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1318O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1319O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1341O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1342O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1355O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1356O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1365O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1368O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1372O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1375O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1376O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1377O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1379O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1426O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1430O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1431O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1440O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1451O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1453O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1464O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1465O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1466O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1479O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1480O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1499O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1512O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1554O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1555O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1557O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1562O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1588O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1589O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1590O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1604O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1609O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1627O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1635O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1636O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1644N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1672O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1674O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1678O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1679O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1680O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1681O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1685O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1686O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1688O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1699O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1714O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1721N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1770N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1838O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1839O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1840O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1854O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1873O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1874O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1888O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1889O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1891O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1896N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1930O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1931O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1932O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1933O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1937O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1938O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1940O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1964O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1965O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1966O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi1980O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2022N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2056O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2057O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2090O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2091O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2092O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2105O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2106O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2225N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2264O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2352O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2354O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2359O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2360O-linked (GalNAc...) threonineSequence analysis1
Glycosylationi2755N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2773N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2801N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2827N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2844N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2853N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2888N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2909N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2916N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2932N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2958N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2985N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3003N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3014N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3054N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3079N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3174N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3177 ↔ 3188PROSITE-ProRule annotation
Disulfide bondi3182 ↔ 3200PROSITE-ProRule annotation
Disulfide bondi3202 ↔ 3211PROSITE-ProRule annotation
Glycosylationi3240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3353N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3385 ↔ 3396PROSITE-ProRule annotation
Disulfide bondi3390 ↔ 3405PROSITE-ProRule annotation
Disulfide bondi3407 ↔ 3420PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain.By similarity
Highly O-glycosylated.By similarity
Predominantly N-glycosylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2745 – 2746CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8JZM8

PeptideAtlas

More...
PeptideAtlasi
Q8JZM8

PRoteomics IDEntifications database

More...
PRIDEi
Q8JZM8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
286084

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8JZM8, 54 sites

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in trachea, duodenum and intestine. Lower expression in stomach, salivary glands, liver, gallbladder, and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079620, Expressed in cornea and 203 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3.

By similarity

GO - Molecular functioni

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8JZM8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2458 – 2613NIDOPROSITE-ProRule annotationAdd BLAST156
Domaini2614 – 2726AMOPPROSITE-ProRule annotationAdd BLAST113
Domaini2738 – 2937VWFDPROSITE-ProRule annotationAdd BLAST200
Domaini3173 – 3212EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini3382 – 3421EGF-like 2PROSITE-ProRule annotationAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni43 – 2501Variable number of tandem repeats (VNTR)By similarityAdd BLAST2459
Regioni1046 – 2186DisorderedSequence analysisAdd BLAST1141
Regioni2205 – 2249DisorderedSequence analysisAdd BLAST45
Regioni2266 – 2369DisorderedSequence analysisAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 717Polar residuesSequence analysisAdd BLAST686
Compositional biasi1048 – 1135Polar residuesSequence analysisAdd BLAST88
Compositional biasi1144 – 2186Polar residuesSequence analysisAdd BLAST1043
Compositional biasi2266 – 2306Polar residuesSequence analysisAdd BLAST41
Compositional biasi2313 – 2369Polar residuesSequence analysisAdd BLAST57

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Essentially composed of an array of serine- and threonine-rich tandem repeats which is highly polymorphic, the variable number of tandem repeats (VNTR) region.By similarity

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QUJ0, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_224850_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8JZM8

Identification of Orthologs from Complete Genome Data

More...
OMAi
NSQWTNA

Database of Orthologous Groups

More...
OrthoDBi
668024at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8JZM8

TreeFam database of animal gene trees

More...
TreeFami
TF330652

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005533, AMOP_dom
IPR000742, EGF-like_dom
IPR003886, NIDO_dom
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06119, NIDO, 1 hit
PF00094, VWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00723, AMOP, 1 hit
SM00181, EGF, 3 hits
SM00539, NIDO, 1 hit
SM00216, VWD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50856, AMOP, 1 hit
PS00022, EGF_1, 1 hit
PS50026, EGF_3, 2 hits
PS51220, NIDO, 1 hit
PS51233, VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGPHWRVPW LCLSCLYSCL LLLPDALATT STQTPMSLSS STRTSQMSSQ
60 70 80 90 100
ASTSSTSSDR RTSKTEQTST RDTPSSITTV SQSHHTTSME TSKPQTTTTT
110 120 130 140 150
EVTTSTPSAS SRDQIQTETS SQRTISPDGT TTSHAPSISS SAPSTTHMLT
160 170 180 190 200
TTSSTESTSV DSGHTTAITT QGLTPATAQV SLTPSSQNMS TVSTPITSTL
210 220 230 240 250
TQRQHTGSKQ TSSKSQVNIV TSTLSTSTSD STPAQTMSQV TSSSDKRTKP
260 270 280 290 300
STSGVSSTSL TTTEVLTQTS STDSAPGNTT LRITQNSTTH TTKVSTTSTP
310 320 330 340 350
QKLSPVSTLI NSSQKMSTLP QNQHTESMDT SRQPQTTTTI EVTTSTPSAS
360 370 380 390 400
SLHQIQTETN SPKTISPGET TTSHAPNMRS SPPKTSQILT TMPSTKSTSV
410 420 430 440 450
DTKQTKAITT KVSTPDTTQV SMTPSSQKLP THSTSTQELT SSYSQHIQSK
460 470 480 490 500
GTSSKSQTTT NTKVNTSTPS ASSRDKIQTE TSSQRTNSPG EKRTSHAPSM
510 520 530 540 550
SSSAPSTTHM LSTTSSNQST SVDTGQTTSV TAQGSTPAIT QTSLTPSSQN
560 570 580 590 600
TSTVSTPITS THKLSTLSQS QHTGSKGTSS NPQTTTTTEV TTSTPSATTH
610 620 630 640 650
DQIQTETSSQ NTISPGETTT SYAPIMSSSA PSTTHMLSTT SSTQSTSVDT
660 670 680 690 700
RHTTTLTNQG STPATTQVSP SSQNMSTVSA PITSTQILST FPQSQHTGSK
710 720 730 740 750
GTSSNPQTTT TPVVTTSNPS ATSRDQIQTE TSSQRTISPG ETTTSYASIM
760 770 780 790 800
SSSAPSTTHM LTTTSSTQST SVDTRHTIAV RTQGSTPATT QVSPSSQNMS
810 820 830 840 850
TVSTPITSTQ ILSTLPQSQH TGSKGTSSNP QTTTSPVVTT STPSGTSGDQ
860 870 880 890 900
IQTETSSQRT ISPGKTTTSH ALNINSSAPS TTHMLSTTSS TQSTSGDTRH
910 920 930 940 950
TTAGRTQGST PATTQVSPSS QNMSTVSAPI TSIQMLSTLP QSQHTESKST
960 970 980 990 1000
STNPQTTTTP EVTTSNPSAT SHDQIETETS SQRTISPGET TTSYAPIMSS
1010 1020 1030 1040 1050
SAPSTTHMLS TTSSTQSTSV DTRNTTTLTT QGSTPATTQV SPSSKNMSTV
1060 1070 1080 1090 1100
STPITSTHKL STLPQSQHTG SNGTSSSSST PATHRSHLHP NMSTVSTPIT
1110 1120 1130 1140 1150
TTHKLSTLSQ SQHTGSKGTS SNPQTTTTPV MTTSTPSATT HDQIQTETSS
1160 1170 1180 1190 1200
QRTISHGETT TSYAPIMSSS APSTTHMLST ASSTQITSVD TRHTTAITTQ
1210 1220 1230 1240 1250
GSTPATTQVS PSSQNMSTVS APITSIQILS TLPQSQHTGS KGTSTNPQTT
1260 1270 1280 1290 1300
TTPEVTTSTP SATSRDQIQT ETSSQRTISP GETTTSHAPI MSSSAPSTTH
1310 1320 1330 1340 1350
MLSTTSSTQS TSVDTRHTTA GRTQGSTPAT TQVSPSSQNM TTTSHALMSS
1360 1370 1380 1390 1400
SAPSTTHMLS TTSSTQSTSV DTRHTTTVTT QGSTPATTQV LPSSQNMSTV
1410 1420 1430 1440 1450
SAPITSTQIL STLPQSQHTG SKGTSTNPQT TTNAEVTTST PSATSHDQIE
1460 1470 1480 1490 1500
TETSSQRTIS PGETTTSHAP NMSSSAPSTT HMLSSTSSTQ ITSVDTGHTS
1510 1520 1530 1540 1550
AGRTQGSTPA TTQVSPSSQN MSTVSAPITS THILSTLPKS QHTGSKGTSS
1560 1570 1580 1590 1600
NPQTTITPVV TTSTPSASSR DQIQTETSFQ RTISPGETTT SHAPSMSSSA
1610 1620 1630 1640 1650
PSSTHMLSTA SSTQITSVDT RHTTAITTQG STPATTQVSP SSQNMSTVSA
1660 1670 1680 1690 1700
PITSIQMLST LPQSQHTESK STSTNPQTTT TPRVTTSTPS ASSRDQIQTE
1710 1720 1730 1740 1750
TSSQRTISPG KTTTSHVPNM NSSAPSTTHI LSTTSSIQST SGDTRHTTAV
1760 1770 1780 1790 1800
RTQGSTPATT QVSLAPSSQN MSTLSAPITS PQHFSTLPQN QHTGSMGTSS
1810 1820 1830 1840 1850
NPQSTTIPEV TTSTLSASSR DQVQTETSSQ RTISPGETTT SHASSLSSSA
1860 1870 1880 1890 1900
PSSTHMLSTA SSTEITSGDT RHTTAIVTQG STPATTQTTL TPSSQNMSTV
1910 1920 1930 1940 1950
STPITSTHKL SPLPQSQHTE NMGTSSNPQT TTTPEVTTST PSATSYDQIQ
1960 1970 1980 1990 2000
TETSFQRTIS PGETTTSHAP SMSNSAPSST HKLSTASSTE ITSVDTRHTI
2010 2020 2030 2040 2050
AITTQGSTLA TTQTSLTPSS QNMSTVSAPI TSSQILSTLR QSQHTGSKGT
2060 2070 2080 2090 2100
SSNHQTTTTP VVTTSTSSAT SRDQIQTETS SLRTISPDGT TTSHASSMSS
2110 2120 2130 2140 2150
SSPNTTHLLI TTSSTESTSV DTGYSTVITT HGSTLATTQV SLTPSSQNMS
2160 2170 2180 2190 2200
TVSMPSTSSQ ELTSLPQRQH TGNMETSSQP QNITPTVVTT STLLSFSRGS
2210 2220 2230 2240 2250
TELQTMSWGT SSSGTINTLS TPVRNTSPAS TSGILTSTLT TSGNTGYTGV
2260 2270 2280 2290 2300
TRSLGVITSR VTSTSLPGKS TVVHSTPAQP LSAHSQSHQT YGTGTPSMSQ
2310 2320 2330 2340 2350
TSILPDMTSE KRVASSPGPT VTESFSHVSS SSGLTTKTDN DRNTAVSATS
2360 2370 2380 2390 2400
STLTSPSPTT ASRSTVPLPS LLPDQGISLF PYGSEVGDQN LFARTVDFNS
2410 2420 2430 2440 2450
PIFKILIGFP LGSSLRDSFY VTDNGQIIFP ESDYDVFSYP NPPQRGFTGR
2460 2470 2480 2490 2500
ERVAMVAPFW ADADFSSSRG AIFYQEYVTF YNEHHQLIRE VETLINDFTS
2510 2520 2530 2540 2550
SWGYRAKWTL KVTWVNVPAY TAQESFGTNT YQAILSTDGS RSYALFLYQN
2560 2570 2580 2590 2600
SGMRWDVTQE PYNRVLMGFS SGDGYFENSP LTFRPAMEKY RPDRFLNSKL
2610 2620 2630 2640 2650
GIRGLQVYRL HREERPNYRL KCLQWLESQP QQPSWGWSSV SCPCSWQQGQ
2660 2670 2680 2690 2700
RDFRFRPINP GWWDRQLCSF SSGRGGVCCS YGAWGEFREG WRMHSPWQFD
2710 2720 2730 2740 2750
EEQEAQNWCC QWNDKPSFCV WYQLRRPRVS CAGYRPPRPA WTFGDPHITT
2760 2770 2780 2790 2800
LDNANFTFNG LGDFLLVQAQ DRNSSFLLEG RTAQTGTAKA TNFIAFAAQY
2810 2820 2830 2840 2850
NTSSLKSPIT VQWFLEPSDK IRVVYNNQTV AFNTRDTEVL PIFNTTGVLL
2860 2870 2880 2890 2900
TQNGSQVSAN FDGTVTISVI ARSNILHASS SLSEEYRNHT EGLLGVWNDN
2910 2920 2930 2940 2950
PEDDFRMPNG STIPSNSSEE TLFYYGMTWH VNGTGLLGIR ADPLPTKFTP
2960 2970 2980 2990 3000
IFLSQLLNQS ASGEDLASGC KGDRKCMFDI LATGNRTIGQ STNSILNEFQ
3010 3020 3030 3040 3050
HMNDTLNQYP PSINCSSKIQ AYKGQTVTTE ITSNSKDATL SLSKKCSGFK
3060 3070 3080 3090 3100
LFENGSLQWT PTSPEACTLE ILARDVRTNL SWVLQPKTVA CFCSKEEQCL
3110 3120 3130 3140 3150
YNETSKEGNS SLEVTSCKCD GDTFGRLCER SKDPCDEPCF PNVNCIPGKG
3160 3170 3180 3190 3200
CEACPPNTTG DGRHCAALED SCPNRSCPMN YCYNNGHCDI SEAPGCQPTC
3210 3220 3230 3240 3250
TCPPAFTDNR CFLAGNSFTP TISMELPLRT IVLSLREDEN ASAADVNASV
3260 3270 3280 3290 3300
ANILENLDMR AFFSNSLVEL IRTSPGAQPS SKSIHHWKVT SHFKYRPRGP
3310 3320 3330 3340 3350
LIHYLNNQLI GAVMEAFLLQ ARQERQKRSG EARKDVHFFP ISRADVQDQM
3360 3370 3380 3390 3400
ALNLSMLEEY FTCDGYKGYH LVYSPQDGVT CVSPCSEGYC HNGGQCKHLP
3410 3420 3430 3440 3450
DGPQCSCASF TIYSSSGEHC EHLSVKLGAF YGILFGTLGA LLLLGILAFM
3460 3470
IFHFCGCSKN KFSYPLDSEL
Length:3,470
Mass (Da):368,411
Last modified:September 29, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE54B9CF74CCFA475
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG02256 differs from that shown. The sequence differs significantly from the reference genome sequence for various reasons.Curated
The sequence AAH96477 differs from that shown. The sequence differs significantly from the reference genome sequence for various reasons.Curated
The sequence AAM66254 differs from that shown. The sequence differs significantly from the reference genome sequence for various reasons.Curated
The sequence AAM66746 differs from that shown. The sequence differs significantly from the reference genome sequence for various reasons.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3208D → G in AAF25480 (PubMed:12107190).Curated1
Sequence conflicti3411T → I in AAD43349 (Ref. 6) Curated1
Sequence conflicti3414S → T in AAD43349 (Ref. 6) Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The variable number of tandem repeats (VNTR) region, an array of serine- and threonine-rich tandem repeats, is encoded by a single exon (exon 2) which is highly polymorphic.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC139244 Genomic DNA No translation available.
AC161755 Genomic DNA No translation available.
AF441786 mRNA Translation: AAM66254.1 Sequence problems.
AF520422, AF520421 Genomic DNA Translation: AAM66746.1 Sequence problems.
AY007202 mRNA Translation: AAG02256.1 Sequence problems.
BC096477 mRNA Translation: AAH96477.1 Sequence problems.
AF218819 mRNA Translation: AAF25480.1
AF161256 mRNA Translation: AAD43349.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139244 Genomic DNA No translation available.
AC161755 Genomic DNA No translation available.
AF441786 mRNA Translation: AAM66254.1 Sequence problems.
AF520422, AF520421 Genomic DNA Translation: AAM66746.1 Sequence problems.
AY007202 mRNA Translation: AAG02256.1 Sequence problems.
BC096477 mRNA Translation: AAH96477.1 Sequence problems.
AF218819 mRNA Translation: AAF25480.1
AF161256 mRNA Translation: AAD43349.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

GlyGeniQ8JZM8, 54 sites

Proteomic databases

MaxQBiQ8JZM8
PeptideAtlasiQ8JZM8
PRIDEiQ8JZM8
ProteomicsDBi286084

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
140474

Organism-specific databases

MGIiMGI:2153525, Muc4

Phylogenomic databases

eggNOGiENOG502QUJ0, Eukaryota
HOGENOMiCLU_224850_0_0_1
InParanoidiQ8JZM8
OMAiNSQWTNA
OrthoDBi668024at2759
PhylomeDBiQ8JZM8
TreeFamiTF330652

Enzyme and pathway databases

ReactomeiR-MMU-913709, O-linked glycosylation of mucins
R-MMU-977068, Termination of O-glycan biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Muc4, mouse

Protein Ontology

More...
PROi
PR:Q8JZM8
RNActiQ8JZM8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079620, Expressed in cornea and 203 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR005533, AMOP_dom
IPR000742, EGF-like_dom
IPR003886, NIDO_dom
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF06119, NIDO, 1 hit
PF00094, VWD, 1 hit
SMARTiView protein in SMART
SM00723, AMOP, 1 hit
SM00181, EGF, 3 hits
SM00539, NIDO, 1 hit
SM00216, VWD, 1 hit
PROSITEiView protein in PROSITE
PS50856, AMOP, 1 hit
PS00022, EGF_1, 1 hit
PS50026, EGF_3, 2 hits
PS51220, NIDO, 1 hit
PS51233, VWFD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUC4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8JZM8
Secondary accession number(s): Q4VAA3
, Q9ERB8, Q9QXG0, Q9WV36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: September 29, 2021
Last modified: September 29, 2021
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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