UniProtKB - Q8JZM4 (DNER_MOUSE)

BLAST

>sp|Q8JZM4|DNER_MOUSE Delta and Notch-like epidermal growth factor-related receptor OS=Mus musculus OX=10090 GN=Dner PE=1 SV=1
MPPRRAQAPGAPLLPVLALLPLLLGAGPQSGCLASPVSAAPLPAPGPCASQPCRNGGVCT
PRSVTDQEHPAADAEPRYSCTCPAGVSGTYCQFVADPCASNPCHHGNCSSSSSSSSDSYL
CICNDGYEGLNCEQPLPSIPTSGWTESTAPRQLQPVPATQEPDIILPRSQATVTLPTWQP
KTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQDANSLLILLW
KVTATGFQQCSLIDGRSVTPLQAPGGLVLLEEMLALGPNHFIGFVNDSVAKSIVALRLTL
VVKASNCVPGDSHSNDLECSGKGKCATKPSEATFSCTCQDQYIGTFCEEFDACQRKPCQN
EASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLE
GYFGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCALSPCAHG
MCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLINGYECVCLAEYKGTHC
ELYKDPCANISCLNGGTCDSEGLNGTCICAPGFTGEECDIDINECDSNPCHHAGTCLDQP
NGYTCHCPHGWVGANCEIHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVG
ICRISRIEYQGSSRPAYEEFYNCRSIDSEFSNAIASIRHARFGKKSRPAMYDVTPIAYED
YSPDDKPLVTLIKTKDL

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History
Entry version 137 (07 Nov 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Delta and Notch-like epidermal growth factor-related receptor

Gene

Dner

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling.2 Publications

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
Notch binding
Source: MGI
Inferred from physical interactionⁱ
- 15965470

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

central nervous system development Source: Ensembl
glial cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 15965470
Notch receptor processing
Source: MGI
Inferred from direct assayⁱ
- 15965470
Notch signaling pathway Source: UniProtKB-KW
skeletal muscle fiber development
Source: MGI
Inferred from direct assayⁱ
- 15965470

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, Receptor
Biological process	Differentiation, Notch signaling pathway
Ligand	Calcium

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Delta and Notch-like epidermal growth factor-related receptor Alternative name(s): Brain EGF repeat-containing transmembrane protein
Gene namesⁱ	Name:Dner Synonyms:Bet, Bret
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:2152889 Dner

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 640	ExtracellularSequence analysisAdd BLAST	615
Transmembraneⁱ	641 – 661	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	662 – 737	CytoplasmicSequence analysisAdd BLAST	76

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice show no obvious abnormality and no apparent survival disadvantage. However, they have delayed cerebellar histogenesis and exhibit motor discoordination at adult stages.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	677	Y → A: Fails to be restricted to the somatodendritic compartment. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000253558	26 – 737	Delta and Notch-like epidermal growth factor-related receptorAdd BLAST		712

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	48 ↔ 59	PROSITE-ProRule annotation
Disulfide bondⁱ	53 ↔ 80	PROSITE-ProRule annotation
Disulfide bondⁱ	82 ↔ 91	PROSITE-ProRule annotation
Disulfide bondⁱ	98 ↔ 108	PROSITE-ProRule annotation
Disulfide bondⁱ	103 ↔ 121	PROSITE-ProRule annotation
Disulfide bondⁱ	123 ↔ 132	PROSITE-ProRule annotation
Glycosylationⁱ	204	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	319 ↔ 336	PROSITE-ProRule annotation
Disulfide bondⁱ	338 ↔ 347	PROSITE-ProRule annotation
Disulfide bondⁱ	353 ↔ 364	PROSITE-ProRule annotation
Disulfide bondⁱ	358 ↔ 378	PROSITE-ProRule annotation
Disulfide bondⁱ	380 ↔ 389	PROSITE-ProRule annotation
Disulfide bondⁱ	396 ↔ 407	PROSITE-ProRule annotation
Disulfide bondⁱ	401 ↔ 416	PROSITE-ProRule annotation
Disulfide bondⁱ	418 ↔ 427	PROSITE-ProRule annotation
Disulfide bondⁱ	434 ↔ 445	PROSITE-ProRule annotation
Disulfide bondⁱ	439 ↔ 454	PROSITE-ProRule annotation
Disulfide bondⁱ	456 ↔ 465	PROSITE-ProRule annotation
Disulfide bondⁱ	472 ↔ 482	PROSITE-ProRule annotation
Disulfide bondⁱ	477 ↔ 491	PROSITE-ProRule annotation
Disulfide bondⁱ	493 ↔ 502	PROSITE-ProRule annotation
Disulfide bondⁱ	509 ↔ 520	PROSITE-ProRule annotation
Disulfide bondⁱ	514 ↔ 529	PROSITE-ProRule annotation
Disulfide bondⁱ	531 ↔ 540	PROSITE-ProRule annotation
Disulfide bondⁱ	547 ↔ 558	PROSITE-ProRule annotation
Disulfide bondⁱ	552 ↔ 567	PROSITE-ProRule annotation
Glycosylationⁱ	564	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	569 ↔ 578	PROSITE-ProRule annotation
Disulfide bondⁱ	585 ↔ 596	PROSITE-ProRule annotation
Disulfide bondⁱ	590 ↔ 605	PROSITE-ProRule annotation
Disulfide bondⁱ	607 ↔ 616	PROSITE-ProRule annotation
Modified residueⁱ	685	PhosphoserineCombined sources	1
Modified residueⁱ	711	PhosphotyrosineCombined sources	1
Modified residueⁱ	714	PhosphothreonineCombined sources	1
Modified residueⁱ	721	PhosphotyrosineCombined sources	1
Modified residueⁱ	722	PhosphoserineCombined sources	1

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8JZM4
PaxDbⁱ	Q8JZM4
PeptideAtlas More...PeptideAtlasⁱ	Q8JZM4
PRIDEⁱ	Q8JZM4

PTM databases

iPTMnetⁱ	Q8JZM4
PhosphoSitePlusⁱ	Q8JZM4

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in brain neurons (at protein level).2 Publications

Developmental stageⁱ

Expression in the central nervous system starts at E11, peaks during postnatal development and declines in the adult brain. At P7 and P20, present in several types of post-mitotic neurons, including cortical and hippocampal pyramidal neurons, cerebellar granule cells and Purkinje cells. Absent from mitotic neuroblasts in the ventricular zones.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000036766 Expressed in 233 organ(s), highest expression level in cerebellum lobe
CleanExⁱ	MM_DNER
ExpressionAtlasⁱ	Q8JZM4 baseline and differential
Genevisibleⁱ	Q8JZM4 MM

Interactionⁱ

Subunit structureⁱ

Interacts with AP1G1. Interacts with NOTCH1.2 Publications

GO - Molecular functionⁱ

Notch binding
Source: MGI
Inferred from physical interactionⁱ
- 15965470

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	230612, 1 interactor
STRINGⁱ	10090.ENSMUSP00000042927

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8JZM4
SMRⁱ	Q8JZM4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	44 – 92	EGF-like 1PROSITE-ProRule annotationAdd BLAST	49
Domainⁱ	94 – 133	EGF-like 2PROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	309 – 348	EGF-like 3PROSITE-ProRule annotationAdd BLAST	40
Domainⁱ	349 – 390	EGF-like 4PROSITE-ProRule annotationAdd BLAST	42
Domainⁱ	392 – 428	EGF-like 5PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	430 – 466	EGF-like 6PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	468 – 503	EGF-like 7PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	505 – 541	EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	543 – 579	EGF-like 9PROSITE-ProRule annotationAdd BLAST	37
Domainⁱ	581 – 617	EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST	37

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	44 – 133	Interaction with NOTCH11 PublicationAdd BLAST		90
Regionⁱ	677 – 680	Interaction with AP1G1 and somatodendritic targeting1 Publication		4

Keywords - Domainⁱ

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IR71 Eukaryota ENOG410ZUAK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150895
HOGENOMⁱ	HOG000112241
HOVERGENⁱ	HBG060866
InParanoidⁱ	Q8JZM4
OMAⁱ	CESYKDP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01VZ
PhylomeDBⁱ	Q8JZM4
TreeFamⁱ	TF351322

Family and domain databases

InterProⁱ	View protein in InterPro IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR009030 Growth_fac_rcpt_cys_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00008 EGF, 6 hits PF12661 hEGF, 1 hit
SMARTⁱ	View protein in SMART SM00181 EGF, 10 hits SM00179 EGF_CA, 7 hits
SUPFAMⁱ	SSF57184 SSF57184, 2 hits
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 2 hits PS00022 EGF_1, 10 hits PS01186 EGF_2, 7 hits PS50026 EGF_3, 10 hits PS01187 EGF_CA, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q8JZM4-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MPPRRAQAPG APLLPVLALL PLLLGAGPQS GCLASPVSAA PLPAPGPCAS 
        60         70         80         90        100
QPCRNGGVCT PRSVTDQEHP AADAEPRYSC TCPAGVSGTY CQFVADPCAS 
       110        120        130        140        150
NPCHHGNCSS SSSSSSDSYL CICNDGYEGL NCEQPLPSIP TSGWTESTAP 
       160        170        180        190        200
RQLQPVPATQ EPDIILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVVPDV 
       210        220        230        240        250
ACGNASSNNS AGGRLVSFEV PQNTSVKIRQ DANSLLILLW KVTATGFQQC 
       260        270        280        290        300
SLIDGRSVTP LQAPGGLVLL EEMLALGPNH FIGFVNDSVA KSIVALRLTL 
       310        320        330        340        350
VVKASNCVPG DSHSNDLECS GKGKCATKPS EATFSCTCQD QYIGTFCEEF 
       360        370        380        390        400
DACQRKPCQN EASCIDANEK QDGSNFTCLC LPGYTGELCQ SKIDYCVLDP 
       410        420        430        440        450
CRNGATCVSS LSGFTCQCLE GYFGSACEEK VDPCMSSPCQ NNGTCYVDGV 
       460        470        480        490        500
HFTCSCSPGF TGPTCAQLVD FCALSPCAHG MCRSVGTSYK CLCDPGYHGL 
       510        520        530        540        550
YCEEEYNECL SAPCLNAATC RDLINGYECV CLAEYKGTHC ELYKDPCANI 
       560        570        580        590        600
SCLNGGTCDS EGLNGTCICA PGFTGEECDI DINECDSNPC HHAGTCLDQP 
       610        620        630        640        650
NGYTCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF 
       660        670        680        690        700
ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA 
       710        720        730 
RFGKKSRPAM YDVTPIAYED YSPDDKPLVT LIKTKDL

Length:737

Mass (Da):78,747

Last modified:October 1, 2002 - v1

Checksum:ⁱ8C85694EB7420756

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WSC4	A0A087WSC4_MOUSE	Delta and Notch-like epidermal grow... Delta and Notch-like epidermal growth factor-related receptor	Dner	175	Annotation score:
A0A087WRJ8	A0A087WRJ8_MOUSE	Delta and Notch-like epidermal grow... Delta and Notch-like epidermal growth factor-related receptor	Dner	38	Annotation score:

Sequence cautionⁱ

The sequence BAE31470 differs from that shown. Reason: Frameshift at position 631.Curated

The sequence BAE31828 differs from that shown. Reason: Frameshift at position 631.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	424	G → A in BAB72175 (PubMed:11997712).Curated		1
Sequence conflictⁱ	509 – 510	CL → SV in AAM14419 (PubMed:11950833).Curated		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY032924 mRNA Translation: AAK50342.1 AF370126 mRNA Translation: AAM14419.1 AB067650 mRNA Translation: BAB72175.1 AK044597 mRNA Translation: BAC31995.1 AK152755 mRNA Translation: BAE31470.1 Frameshift. AK153235 mRNA Translation: BAE31828.1 Frameshift. BC022636 mRNA Translation: AAH22636.1 BC034634 mRNA Translation: AAH34634.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15105.1
NCBI Reference Sequences More...RefSeqⁱ	NP_690879.1, NM_152915.1
UniGeneⁱ	Mm.292560

Genome annotation databases

Ensemblⁱ	ENSMUST00000049126; ENSMUSP00000042927; ENSMUSG00000036766
GeneIDⁱ	227325
KEGGⁱ	mmu:227325
UCSC genome browser More...UCSCⁱ	uc007bsw.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8JZM4	Delta/notch-like EGF repeat-containing		RAT		746	UniRef90_Q8JZM4
Uncharacterized protein (Fragment)		MACMU		651
Uncharacterized protein		MANLE		650
Delta/notch like EGF repeat containing		SAIBB		647
Uncharacterized protein (Fragment)		MACFA		646
+16

Protein	Similar proteins		Species	Score	Length	Source
Q8JZM4	Delta and Notch-like epidermal growth factor-related receptor		HUMAN		737	UniRef50_Q8JZM4
Delta/notch-like EGF repeat-containing		RAT		746
Uncharacterized protein (Fragment)		MACMU		651
Uncharacterized protein		MANLE		650
Delta/notch like EGF repeat containing		SAIBB		647
+219

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY032924 mRNA Translation: AAK50342.1 AF370126 mRNA Translation: AAM14419.1 AB067650 mRNA Translation: BAB72175.1 AK044597 mRNA Translation: BAC31995.1 AK152755 mRNA Translation: BAE31470.1 Frameshift. AK153235 mRNA Translation: BAE31828.1 Frameshift. BC022636 mRNA Translation: AAH22636.1 BC034634 mRNA Translation: AAH34634.1
CCDSⁱ	CCDS15105.1
RefSeqⁱ	NP_690879.1, NM_152915.1
UniGeneⁱ	Mm.292560

3D structure databases

ProteinModelPortalⁱ	Q8JZM4
SMRⁱ	Q8JZM4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	230612, 1 interactor
STRINGⁱ	10090.ENSMUSP00000042927

PTM databases

iPTMnetⁱ	Q8JZM4
PhosphoSitePlusⁱ	Q8JZM4

Proteomic databases

MaxQBⁱ	Q8JZM4
PaxDbⁱ	Q8JZM4
PeptideAtlasⁱ	Q8JZM4
PRIDEⁱ	Q8JZM4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000049126; ENSMUSP00000042927; ENSMUSG00000036766
GeneIDⁱ	227325
KEGGⁱ	mmu:227325
UCSCⁱ	uc007bsw.1 mouse

Organism-specific databases

CTDⁱ	92737
MGIⁱ	MGI:2152889 Dner

Phylogenomic databases

eggNOGⁱ	ENOG410IR71 Eukaryota ENOG410ZUAK LUCA
GeneTreeⁱ	ENSGT00930000150895
HOGENOMⁱ	HOG000112241
HOVERGENⁱ	HBG060866
InParanoidⁱ	Q8JZM4
OMAⁱ	CESYKDP
OrthoDBⁱ	EOG091G01VZ
PhylomeDBⁱ	Q8JZM4
TreeFamⁱ	TF351322

Miscellaneous databases

ChiTaRSⁱ	Dner mouse
Protein Ontology More...PROⁱ	PR:Q8JZM4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000036766 Expressed in 233 organ(s), highest expression level in cerebellum lobe
CleanExⁱ	MM_DNER
ExpressionAtlasⁱ	Q8JZM4 baseline and differential
Genevisibleⁱ	Q8JZM4 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR001881 EGF-like_Ca-bd_dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom IPR000152 EGF-type_Asp/Asn_hydroxyl_site IPR018097 EGF_Ca-bd_CS IPR009030 Growth_fac_rcpt_cys_sf
Pfamⁱ	View protein in Pfam PF00008 EGF, 6 hits PF12661 hEGF, 1 hit
SMARTⁱ	View protein in SMART SM00181 EGF, 10 hits SM00179 EGF_CA, 7 hits
SUPFAMⁱ	SSF57184 SSF57184, 2 hits
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 2 hits PS00022 EGF_1, 10 hits PS01186 EGF_2, 7 hits PS50026 EGF_3, 10 hits PS01187 EGF_CA, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DNER_MOUSE
Accessionⁱ	Q8JZM4Primary (citable) accession number: Q8JZM4 Secondary accession number(s): Q3U697 , Q8R226, Q8R4T6, Q8VD97
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8JZM4 (DNER_MOUSE)

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Delta and Notch-like epidermal growth factor-related receptor

Dner

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ