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Entry version 140 (13 Feb 2019)
Sequence version 1 (01 Oct 2002)
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Protein

Delta and Notch-like epidermal growth factor-related receptor

Gene

Dner

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Notch binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, Receptor
Biological processDifferentiation, Notch signaling pathway
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta and Notch-like epidermal growth factor-related receptor
Alternative name(s):
Brain EGF repeat-containing transmembrane protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dner
Synonyms:Bet, Bret
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2152889 Dner

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 640ExtracellularSequence analysisAdd BLAST615
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei641 – 661HelicalSequence analysisAdd BLAST21
Topological domaini662 – 737CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show no obvious abnormality and no apparent survival disadvantage. However, they have delayed cerebellar histogenesis and exhibit motor discoordination at adult stages.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi677Y → A: Fails to be restricted to the somatodendritic compartment. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025355826 – 737Delta and Notch-like epidermal growth factor-related receptorAdd BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 59PROSITE-ProRule annotation
Disulfide bondi53 ↔ 80PROSITE-ProRule annotation
Disulfide bondi82 ↔ 91PROSITE-ProRule annotation
Disulfide bondi98 ↔ 108PROSITE-ProRule annotation
Disulfide bondi103 ↔ 121PROSITE-ProRule annotation
Disulfide bondi123 ↔ 132PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi319 ↔ 336PROSITE-ProRule annotation
Disulfide bondi338 ↔ 347PROSITE-ProRule annotation
Disulfide bondi353 ↔ 364PROSITE-ProRule annotation
Disulfide bondi358 ↔ 378PROSITE-ProRule annotation
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi396 ↔ 407PROSITE-ProRule annotation
Disulfide bondi401 ↔ 416PROSITE-ProRule annotation
Disulfide bondi418 ↔ 427PROSITE-ProRule annotation
Disulfide bondi434 ↔ 445PROSITE-ProRule annotation
Disulfide bondi439 ↔ 454PROSITE-ProRule annotation
Disulfide bondi456 ↔ 465PROSITE-ProRule annotation
Disulfide bondi472 ↔ 482PROSITE-ProRule annotation
Disulfide bondi477 ↔ 491PROSITE-ProRule annotation
Disulfide bondi493 ↔ 502PROSITE-ProRule annotation
Disulfide bondi509 ↔ 520PROSITE-ProRule annotation
Disulfide bondi514 ↔ 529PROSITE-ProRule annotation
Disulfide bondi531 ↔ 540PROSITE-ProRule annotation
Disulfide bondi547 ↔ 558PROSITE-ProRule annotation
Disulfide bondi552 ↔ 567PROSITE-ProRule annotation
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi569 ↔ 578PROSITE-ProRule annotation
Disulfide bondi585 ↔ 596PROSITE-ProRule annotation
Disulfide bondi590 ↔ 605PROSITE-ProRule annotation
Disulfide bondi607 ↔ 616PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei685PhosphoserineCombined sources1
Modified residuei711PhosphotyrosineCombined sources1
Modified residuei714PhosphothreonineCombined sources1
Modified residuei721PhosphotyrosineCombined sources1
Modified residuei722PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8JZM4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8JZM4

PeptideAtlas

More...
PeptideAtlasi
Q8JZM4

PRoteomics IDEntifications database

More...
PRIDEi
Q8JZM4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8JZM4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8JZM4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in brain neurons (at protein level).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression in the central nervous system starts at 11 dpc, peaks during postnatal development and declines in the adult brain. At P7 and P20, present in several types of post-mitotic neurons, including cortical and hippocampal pyramidal neurons, cerebellar granule cells and Purkinje cells. Absent from mitotic neuroblasts in the ventricular zones.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036766 Expressed in 233 organ(s), highest expression level in cerebellum lobe

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8JZM4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8JZM4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AP1G1. Interacts with NOTCH1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
230612, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000042927

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8JZM4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8JZM4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 92EGF-like 1PROSITE-ProRule annotationAdd BLAST49
Domaini94 – 133EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini309 – 348EGF-like 3PROSITE-ProRule annotationAdd BLAST40
Domaini349 – 390EGF-like 4PROSITE-ProRule annotationAdd BLAST42
Domaini392 – 428EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini430 – 466EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini468 – 503EGF-like 7PROSITE-ProRule annotationAdd BLAST36
Domaini505 – 541EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini543 – 579EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini581 – 617EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni44 – 133Interaction with NOTCH11 PublicationAdd BLAST90
Regioni677 – 680Interaction with AP1G1 and somatodendritic targeting1 Publication4

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IR71 Eukaryota
ENOG410ZUAK LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158872

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112241

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG060866

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8JZM4

Identification of Orthologs from Complete Genome Data

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OMAi
CESYKDP

Database of Orthologous Groups

More...
OrthoDBi
243316at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8JZM4

TreeFam database of animal gene trees

More...
TreeFami
TF351322

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 6 hits
PF12661 hEGF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57184 SSF57184, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 10 hits
PS01187 EGF_CA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8JZM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPRRAQAPG APLLPVLALL PLLLGAGPQS GCLASPVSAA PLPAPGPCAS
60 70 80 90 100
QPCRNGGVCT PRSVTDQEHP AADAEPRYSC TCPAGVSGTY CQFVADPCAS
110 120 130 140 150
NPCHHGNCSS SSSSSSDSYL CICNDGYEGL NCEQPLPSIP TSGWTESTAP
160 170 180 190 200
RQLQPVPATQ EPDIILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVVPDV
210 220 230 240 250
ACGNASSNNS AGGRLVSFEV PQNTSVKIRQ DANSLLILLW KVTATGFQQC
260 270 280 290 300
SLIDGRSVTP LQAPGGLVLL EEMLALGPNH FIGFVNDSVA KSIVALRLTL
310 320 330 340 350
VVKASNCVPG DSHSNDLECS GKGKCATKPS EATFSCTCQD QYIGTFCEEF
360 370 380 390 400
DACQRKPCQN EASCIDANEK QDGSNFTCLC LPGYTGELCQ SKIDYCVLDP
410 420 430 440 450
CRNGATCVSS LSGFTCQCLE GYFGSACEEK VDPCMSSPCQ NNGTCYVDGV
460 470 480 490 500
HFTCSCSPGF TGPTCAQLVD FCALSPCAHG MCRSVGTSYK CLCDPGYHGL
510 520 530 540 550
YCEEEYNECL SAPCLNAATC RDLINGYECV CLAEYKGTHC ELYKDPCANI
560 570 580 590 600
SCLNGGTCDS EGLNGTCICA PGFTGEECDI DINECDSNPC HHAGTCLDQP
610 620 630 640 650
NGYTCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF
660 670 680 690 700
ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA
710 720 730
RFGKKSRPAM YDVTPIAYED YSPDDKPLVT LIKTKDL
Length:737
Mass (Da):78,747
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C85694EB7420756
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSC4A0A087WSC4_MOUSE
Delta and Notch-like epidermal grow...
Dner
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WRJ8A0A087WRJ8_MOUSE
Delta and Notch-like epidermal grow...
Dner
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE31470 differs from that shown. Reason: Frameshift at position 631.Curated
The sequence BAE31828 differs from that shown. Reason: Frameshift at position 631.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti424G → A in BAB72175 (PubMed:11997712).Curated1
Sequence conflicti509 – 510CL → SV in AAM14419 (PubMed:11950833).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY032924 mRNA Translation: AAK50342.1
AF370126 mRNA Translation: AAM14419.1
AB067650 mRNA Translation: BAB72175.1
AK044597 mRNA Translation: BAC31995.1
AK152755 mRNA Translation: BAE31470.1 Frameshift.
AK153235 mRNA Translation: BAE31828.1 Frameshift.
BC022636 mRNA Translation: AAH22636.1
BC034634 mRNA Translation: AAH34634.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS15105.1

NCBI Reference Sequences

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RefSeqi
NP_690879.1, NM_152915.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.292560

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000049126; ENSMUSP00000042927; ENSMUSG00000036766

Database of genes from NCBI RefSeq genomes

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GeneIDi
227325

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:227325

UCSC genome browser

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UCSCi
uc007bsw.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032924 mRNA Translation: AAK50342.1
AF370126 mRNA Translation: AAM14419.1
AB067650 mRNA Translation: BAB72175.1
AK044597 mRNA Translation: BAC31995.1
AK152755 mRNA Translation: BAE31470.1 Frameshift.
AK153235 mRNA Translation: BAE31828.1 Frameshift.
BC022636 mRNA Translation: AAH22636.1
BC034634 mRNA Translation: AAH34634.1
CCDSiCCDS15105.1
RefSeqiNP_690879.1, NM_152915.1
UniGeneiMm.292560

3D structure databases

ProteinModelPortaliQ8JZM4
SMRiQ8JZM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230612, 1 interactor
STRINGi10090.ENSMUSP00000042927

PTM databases

iPTMnetiQ8JZM4
PhosphoSitePlusiQ8JZM4

Proteomic databases

MaxQBiQ8JZM4
PaxDbiQ8JZM4
PeptideAtlasiQ8JZM4
PRIDEiQ8JZM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049126; ENSMUSP00000042927; ENSMUSG00000036766
GeneIDi227325
KEGGimmu:227325
UCSCiuc007bsw.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
92737
MGIiMGI:2152889 Dner

Phylogenomic databases

eggNOGiENOG410IR71 Eukaryota
ENOG410ZUAK LUCA
GeneTreeiENSGT00940000158872
HOGENOMiHOG000112241
HOVERGENiHBG060866
InParanoidiQ8JZM4
OMAiCESYKDP
OrthoDBi243316at2759
PhylomeDBiQ8JZM4
TreeFamiTF351322

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dner mouse

Protein Ontology

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PROi
PR:Q8JZM4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036766 Expressed in 233 organ(s), highest expression level in cerebellum lobe
ExpressionAtlasiQ8JZM4 baseline and differential
GenevisibleiQ8JZM4 MM

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00008 EGF, 6 hits
PF12661 hEGF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 10 hits
PS01187 EGF_CA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNER_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8JZM4
Secondary accession number(s): Q3U697
, Q8R226, Q8R4T6, Q8VD97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: February 13, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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