Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Delta and Notch-like epidermal growth factor-related receptor

Gene

Dner

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling.2 Publications

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Notch binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, Receptor
Biological processDifferentiation, Notch signaling pathway
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Delta and Notch-like epidermal growth factor-related receptor
Alternative name(s):
Brain EGF repeat-containing transmembrane protein
Gene namesi
Name:Dner
Synonyms:Bet, Bret
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2152889 Dner

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 640ExtracellularSequence analysisAdd BLAST615
Transmembranei641 – 661HelicalSequence analysisAdd BLAST21
Topological domaini662 – 737CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice show no obvious abnormality and no apparent survival disadvantage. However, they have delayed cerebellar histogenesis and exhibit motor discoordination at adult stages.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi677Y → A: Fails to be restricted to the somatodendritic compartment. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000025355826 – 737Delta and Notch-like epidermal growth factor-related receptorAdd BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 59PROSITE-ProRule annotation
Disulfide bondi53 ↔ 80PROSITE-ProRule annotation
Disulfide bondi82 ↔ 91PROSITE-ProRule annotation
Disulfide bondi98 ↔ 108PROSITE-ProRule annotation
Disulfide bondi103 ↔ 121PROSITE-ProRule annotation
Disulfide bondi123 ↔ 132PROSITE-ProRule annotation
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi319 ↔ 336PROSITE-ProRule annotation
Disulfide bondi338 ↔ 347PROSITE-ProRule annotation
Disulfide bondi353 ↔ 364PROSITE-ProRule annotation
Disulfide bondi358 ↔ 378PROSITE-ProRule annotation
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi396 ↔ 407PROSITE-ProRule annotation
Disulfide bondi401 ↔ 416PROSITE-ProRule annotation
Disulfide bondi418 ↔ 427PROSITE-ProRule annotation
Disulfide bondi434 ↔ 445PROSITE-ProRule annotation
Disulfide bondi439 ↔ 454PROSITE-ProRule annotation
Disulfide bondi456 ↔ 465PROSITE-ProRule annotation
Disulfide bondi472 ↔ 482PROSITE-ProRule annotation
Disulfide bondi477 ↔ 491PROSITE-ProRule annotation
Disulfide bondi493 ↔ 502PROSITE-ProRule annotation
Disulfide bondi509 ↔ 520PROSITE-ProRule annotation
Disulfide bondi514 ↔ 529PROSITE-ProRule annotation
Disulfide bondi531 ↔ 540PROSITE-ProRule annotation
Disulfide bondi547 ↔ 558PROSITE-ProRule annotation
Disulfide bondi552 ↔ 567PROSITE-ProRule annotation
Glycosylationi564N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi569 ↔ 578PROSITE-ProRule annotation
Disulfide bondi585 ↔ 596PROSITE-ProRule annotation
Disulfide bondi590 ↔ 605PROSITE-ProRule annotation
Disulfide bondi607 ↔ 616PROSITE-ProRule annotation
Modified residuei685PhosphoserineCombined sources1
Modified residuei711PhosphotyrosineCombined sources1
Modified residuei714PhosphothreonineCombined sources1
Modified residuei721PhosphotyrosineCombined sources1
Modified residuei722PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8JZM4
PaxDbiQ8JZM4
PeptideAtlasiQ8JZM4
PRIDEiQ8JZM4

PTM databases

iPTMnetiQ8JZM4
PhosphoSitePlusiQ8JZM4

Expressioni

Tissue specificityi

Specifically expressed in brain neurons (at protein level).2 Publications

Developmental stagei

Expression in the central nervous system starts at E11, peaks during postnatal development and declines in the adult brain. At P7 and P20, present in several types of post-mitotic neurons, including cortical and hippocampal pyramidal neurons, cerebellar granule cells and Purkinje cells. Absent from mitotic neuroblasts in the ventricular zones.2 Publications

Gene expression databases

BgeeiENSMUSG00000036766 Expressed in 233 organ(s), highest expression level in cerebellum lobe
CleanExiMM_DNER
ExpressionAtlasiQ8JZM4 baseline and differential
GenevisibleiQ8JZM4 MM

Interactioni

Subunit structurei

Interacts with AP1G1. Interacts with NOTCH1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230612, 1 interactor
STRINGi10090.ENSMUSP00000042927

Structurei

3D structure databases

ProteinModelPortaliQ8JZM4
SMRiQ8JZM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 92EGF-like 1PROSITE-ProRule annotationAdd BLAST49
Domaini94 – 133EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini309 – 348EGF-like 3PROSITE-ProRule annotationAdd BLAST40
Domaini349 – 390EGF-like 4PROSITE-ProRule annotationAdd BLAST42
Domaini392 – 428EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini430 – 466EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini468 – 503EGF-like 7PROSITE-ProRule annotationAdd BLAST36
Domaini505 – 541EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini543 – 579EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini581 – 617EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni44 – 133Interaction with NOTCH11 PublicationAdd BLAST90
Regioni677 – 680Interaction with AP1G1 and somatodendritic targeting1 Publication4

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR71 Eukaryota
ENOG410ZUAK LUCA
GeneTreeiENSGT00930000150895
HOGENOMiHOG000112241
HOVERGENiHBG060866
InParanoidiQ8JZM4
OMAiCESYKDP
OrthoDBiEOG091G01VZ
PhylomeDBiQ8JZM4
TreeFamiTF351322

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00008 EGF, 6 hits
PF12661 hEGF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 10 hits
PS01187 EGF_CA, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8JZM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPRRAQAPG APLLPVLALL PLLLGAGPQS GCLASPVSAA PLPAPGPCAS
60 70 80 90 100
QPCRNGGVCT PRSVTDQEHP AADAEPRYSC TCPAGVSGTY CQFVADPCAS
110 120 130 140 150
NPCHHGNCSS SSSSSSDSYL CICNDGYEGL NCEQPLPSIP TSGWTESTAP
160 170 180 190 200
RQLQPVPATQ EPDIILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVVPDV
210 220 230 240 250
ACGNASSNNS AGGRLVSFEV PQNTSVKIRQ DANSLLILLW KVTATGFQQC
260 270 280 290 300
SLIDGRSVTP LQAPGGLVLL EEMLALGPNH FIGFVNDSVA KSIVALRLTL
310 320 330 340 350
VVKASNCVPG DSHSNDLECS GKGKCATKPS EATFSCTCQD QYIGTFCEEF
360 370 380 390 400
DACQRKPCQN EASCIDANEK QDGSNFTCLC LPGYTGELCQ SKIDYCVLDP
410 420 430 440 450
CRNGATCVSS LSGFTCQCLE GYFGSACEEK VDPCMSSPCQ NNGTCYVDGV
460 470 480 490 500
HFTCSCSPGF TGPTCAQLVD FCALSPCAHG MCRSVGTSYK CLCDPGYHGL
510 520 530 540 550
YCEEEYNECL SAPCLNAATC RDLINGYECV CLAEYKGTHC ELYKDPCANI
560 570 580 590 600
SCLNGGTCDS EGLNGTCICA PGFTGEECDI DINECDSNPC HHAGTCLDQP
610 620 630 640 650
NGYTCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF
660 670 680 690 700
ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA
710 720 730
RFGKKSRPAM YDVTPIAYED YSPDDKPLVT LIKTKDL
Length:737
Mass (Da):78,747
Last modified:October 1, 2002 - v1
Checksum:i8C85694EB7420756
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSC4A0A087WSC4_MOUSE
Delta and Notch-like epidermal grow...
Dner
175Annotation score:
A0A087WRJ8A0A087WRJ8_MOUSE
Delta and Notch-like epidermal grow...
Dner
38Annotation score:

Sequence cautioni

The sequence BAE31470 differs from that shown. Reason: Frameshift at position 631.Curated
The sequence BAE31828 differs from that shown. Reason: Frameshift at position 631.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti424G → A in BAB72175 (PubMed:11997712).Curated1
Sequence conflicti509 – 510CL → SV in AAM14419 (PubMed:11950833).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032924 mRNA Translation: AAK50342.1
AF370126 mRNA Translation: AAM14419.1
AB067650 mRNA Translation: BAB72175.1
AK044597 mRNA Translation: BAC31995.1
AK152755 mRNA Translation: BAE31470.1 Frameshift.
AK153235 mRNA Translation: BAE31828.1 Frameshift.
BC022636 mRNA Translation: AAH22636.1
BC034634 mRNA Translation: AAH34634.1
CCDSiCCDS15105.1
RefSeqiNP_690879.1, NM_152915.1
UniGeneiMm.292560

Genome annotation databases

EnsembliENSMUST00000049126; ENSMUSP00000042927; ENSMUSG00000036766
GeneIDi227325
KEGGimmu:227325
UCSCiuc007bsw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032924 mRNA Translation: AAK50342.1
AF370126 mRNA Translation: AAM14419.1
AB067650 mRNA Translation: BAB72175.1
AK044597 mRNA Translation: BAC31995.1
AK152755 mRNA Translation: BAE31470.1 Frameshift.
AK153235 mRNA Translation: BAE31828.1 Frameshift.
BC022636 mRNA Translation: AAH22636.1
BC034634 mRNA Translation: AAH34634.1
CCDSiCCDS15105.1
RefSeqiNP_690879.1, NM_152915.1
UniGeneiMm.292560

3D structure databases

ProteinModelPortaliQ8JZM4
SMRiQ8JZM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230612, 1 interactor
STRINGi10090.ENSMUSP00000042927

PTM databases

iPTMnetiQ8JZM4
PhosphoSitePlusiQ8JZM4

Proteomic databases

MaxQBiQ8JZM4
PaxDbiQ8JZM4
PeptideAtlasiQ8JZM4
PRIDEiQ8JZM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049126; ENSMUSP00000042927; ENSMUSG00000036766
GeneIDi227325
KEGGimmu:227325
UCSCiuc007bsw.1 mouse

Organism-specific databases

CTDi92737
MGIiMGI:2152889 Dner

Phylogenomic databases

eggNOGiENOG410IR71 Eukaryota
ENOG410ZUAK LUCA
GeneTreeiENSGT00930000150895
HOGENOMiHOG000112241
HOVERGENiHBG060866
InParanoidiQ8JZM4
OMAiCESYKDP
OrthoDBiEOG091G01VZ
PhylomeDBiQ8JZM4
TreeFamiTF351322

Miscellaneous databases

ChiTaRSiDner mouse
PROiPR:Q8JZM4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036766 Expressed in 233 organ(s), highest expression level in cerebellum lobe
CleanExiMM_DNER
ExpressionAtlasiQ8JZM4 baseline and differential
GenevisibleiQ8JZM4 MM

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
PfamiView protein in Pfam
PF00008 EGF, 6 hits
PF12661 hEGF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits
SUPFAMiSSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 10 hits
PS01187 EGF_CA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDNER_MOUSE
AccessioniPrimary (citable) accession number: Q8JZM4
Secondary accession number(s): Q3U697
, Q8R226, Q8R4T6, Q8VD97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again