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UniProtKB - Q8JVC2 (RDRP_PCVC)

Entry version 54 (29 Sep 2021)
Sequence version 1 (01 Oct 2002)
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Protein

RNA-directed RNA polymerase

Gene

p1

Organism
Penicillium chrysogenum virus (isolate Caston/2003) (PcV)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent RNA polymerase which replicates the viral genome.

Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
LigandNucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:p1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPenicillium chrysogenum virus (isolate Caston/2003) (PcV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri654932 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Duplornaviricota › Chrymotiviricetes › Ghabrivirales › Chrysoviridae › Alphachrysovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiPenicillium chrysogenum (Penicillium notatum) [TaxID: 5076]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006714 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004042681 – 1117RNA-directed RNA polymeraseAdd BLAST1117

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18Polar residuesSequence analysisAdd BLAST18

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001795, RNA-dir_pol_luteovirus

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02123, RdRP_4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56672, SSF56672, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8JVC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVSGRSSWQ NGKTTNAMRA GKLATERDLE SANYGSRSVE KLRHERAVGN 
        60         70         80         90        100
LNKGRFLGMN KWSDEQLKHS MARYEDLAAT RHNLFAVIMP SGCGKTSLAR 
       110        120        130        140        150
TYGMVDVDEL VSRAEHDQYV EMRNEIVCGR GDWHDHNTLW FARLNQTLAL 
       160        170        180        190        200
LDYSVPVVIF VHTEETALEI GARPVACLTL ETTAHEMNIS GRGPKFREFS 
       210        220        230        240        250
RESLRSCKPS NRVPNQYRFK SNKELEAFFL EVMNVSGLPV GAPFKYSTSI 
       260        270        280        290        300
WNSSYSRDVP GWILRGERAG TQQVSINELR LLFEQGKIPK ECVDYYVRAS 
       310        320        330        340        350
YVPTQFDFGV TMFEWSQALG QLPGCYNSRR DFDTLTDLMG VFPPHSPKEV 
       360        370        380        390        400
TRSNVTLRTL CHTFDILSMP DAKEIASYHV GEGHTLVTNL LANWKGITQF 
       410        420        430        440        450
TTVSHLVFPW FKVCERDWSD KMKTLHSLVR CSKFFMNTRI TEKDRQALMY 
       460        470        480        490        500
MDLLVGRGEY TVDEMAEVEL RTDDTYNTKH LSYDPNRQVF TNQQYKKDFI 
       510        520        530        540        550
TSVEEAYVRL KIEPKPVNVD GFIDFYHRRA SWLTKGGLVY NKLPPEMKKF 
       560        570        580        590        600
GGQVFDAIYN TCREIQGRHN KKSLFEVYEL AEVLQGANEN NFNLTKTQIK 
       610        620        630        640        650
YEVGKKDRTL LPGTLVHFVV FTYVLYLAEK QGQIGSVRLN TDSEVDIRYF 
       660        670        680        690        700
DKKMCTGVFH VLYDWADFNE QHSAWEMGVV VDYLKHLIVA PRDYAVFVEA 
       710        720        730        740        750
IVAGMYNMGL HDRDGNVHKI WRGLYSGWRG TTWINTVLNF CYVHIALQNV 
       760        770        780        790        800
ERLFGVRVVL YVDHGGDDID LGLSEPAVMP WFLEVMDAML FKANKWKQMF 
       810        820        830        840        850
GTRSEFFRNT ICDGRVYASP TRALASFVAG DWEGAGRATV KERVVSLLDQ 
       860        870        880        890        900
IAKLRRRGCS EELCQGLTIA TISHWCRIKD GEDWLSLPAE IIHGHPDDGG 
       910        920        930        940        950
LGVPDRDNNF WRLEEKVPEI NEEWYKVVVP DYKASRDYVN VLARDVEKFS 
       960        970        980        990       1000
LVIEEREKLA RKLSEDSYDI EKSVDHERWK HLLNFRTRVI AKELAVEPME 
      1010       1020       1030       1040       1050
DSVVFEGFLE YEVEEGTEKK FDLASRYQEF VSYLSLNGRA ITKEELLDLM 
      1060       1070       1080       1090       1100
SDGEVCLEAI EFQGDIYYAR LVPEFIAYRA TMFCKEAINK GVCDAISAQL 
      1110 
FFRTICWMSA SVFEHAI
Length:1,117
Mass (Da):128,548
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A59F9B85F5943B3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF296439 Genomic RNA Translation: AAM95601.1

NCBI Reference Sequences

More...RefSeqi		YP_392482.1, NC_007539.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5075912

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		vg:5075912

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296439 Genomic RNA Translation: AAM95601.1
RefSeqiYP_392482.1, NC_007539.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi5075912
KEGGivg:5075912

Family and domain databases

InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001795, RNA-dir_pol_luteovirus
PfamiView protein in Pfam
PF02123, RdRP_4, 1 hit
SUPFAMiSSF56672, SSF56672, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDRP_PCVC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8JVC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: October 1, 2002
Last modified: September 29, 2021
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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