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Protein

Nucleoprotein

Gene

NP

Organism
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:NP
OrganismiReston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Taxonomic identifieri386032 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000138664 Componenti: Genome
  • UP000007207 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • helical viral capsid Source: UniProtKB-KW
  • host cell cytoplasm Source: UniProtKB-SubCell
  • viral nucleocapsid Source: CACAO

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002450521 – 739NucleoproteinAdd BLAST739

Post-translational modificationi

Phosphorylated and O-glycosylated by host.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8JPY1

Interactioni

Subunit structurei

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 (By similarity).By similarity

Structurei

3D structure databases

SMRiQ8JPY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili334 – 363Sequence analysisAdd BLAST30

Domaini

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half.By similarity

Sequence similaritiesi

Belongs to the filoviruses nucleoprotein family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

OrthoDBiVOG09000031

Family and domain databases

InterProiView protein in InterPro
IPR008609 Ebola_NP
PfamiView protein in Pfam
PF05505 Ebola_NP, 1 hit
PIRSFiPIRSF003900 N_FiloV, 1 hit

Sequencei

Sequence statusi: Complete.

Q8JPY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRGTRRIWV SQNQGDTDLD YHKILTAGLT VQQGIVRQKI ISVYLVDNLE
60 70 80 90 100
AMCQLVIQAF EAGIDFQENA DSFLLMLCLH HAYQGDYKLF LESNAVQYLE
110 120 130 140 150
GHGFKFELRK KDGVNRLEEL LPAATSGKNI RRTLAALPEE ETTEANAGQF
160 170 180 190 200
LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTA WQSVGHMMVI
210 220 230 240 250
FRLMRTNFLI KYLLIHQGMH MVAGHDANDA VIANSVAQAR FSGLLIVKTV
260 270 280 290 300
LDHILQKTDQ GVRLHPLART AKVRNEVNAF KAALSSLAKH GEYAPFARLL
310 320 330 340 350
NLSGVNNLEH GLYPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA
360 370 380 390 400
EKQLQQYAES RELDSLGLDD QERRILMNFH QKKNEISFQQ TNAMVTLRKE
410 420 430 440 450
RLAKLTEAIT LASRPNLGSR QDDGNEIPFP GPISNNPDQD HLEDDPRDSR
460 470 480 490 500
DTIIPNGAID PEDGDFENYN GYHDDEVGTA GDLVLFDLDD HEDDNKAFEP
510 520 530 540 550
QDSSPQSQRE IERERLIHPP PGNNKDDNRA SDNNQQSADS EEQGGQYNWH
560 570 580 590 600
RGPERTTANR RLSPVHEEDT LMDQGDDDPS SLPPLESDDD DASSSQQDPD
610 620 630 640 650
YTAVAPPAPV YRSAEAHEPP HKSSNEPAET SQLNEDPDIG QSKSMQKLEE
660 670 680 690 700
TYHHLLRTQG PFEAINYYHM MKDEPVIFST DDGKEYTYPD SLEEAYPPWL
710 720 730
TEKERLDKEN RYIYINNQQF FWPVMSPRDK FLAILQHHQ
Length:739
Mass (Da):83,453
Last modified:October 1, 2002 - v1
Checksum:iAB1BFE0970BB2A86
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti28G → V in strain: Isolate Pennsylvania-89. 1
Natural varianti67Q → R in strain: Isolate Pennsylvania-89. 1
Natural varianti373R → G in strain: Isolate Pennsylvania-89. 1
Natural varianti483L → W in strain: Isolate Pennsylvania-89. 1
Natural varianti517I → T in strain: Isolate Pennsylvania-89. 1
Natural varianti721F → S in strain: Isolate Pennsylvania-89. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522874 Genomic RNA Translation: AAN04448.1
AY769362 Genomic RNA Translation: AAV48574.1
RefSeqiNP_690580.1, NC_004161.1

Genome annotation databases

GeneIDi955194
KEGGivg:955194

Similar proteinsi

Entry informationi

Entry nameiNCAP_EBORR
AccessioniPrimary (citable) accession number: Q8JPY1
Secondary accession number(s): Q5UAL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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