Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 82 (31 Jul 2019)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.By similarity
RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication
LigandATP-binding, Nucleotide-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 4 domains:
RNA-directed RNA polymerase (EC:2.7.7.48By similarity)
mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56By similarity)
GDP polyribonucleotidyltransferase (EC:2.7.7.88By similarity)
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC:2.1.1.296By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiReston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri386032 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaHaploviricotinaMonjiviricetesMononegaviralesFiloviridaeEbolavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
Sus scrofa (Pig) [TaxID: 9823]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000138664 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000007207 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002450481 – 2212RNA-directed RNA polymerase LAdd BLAST2212

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8JPX5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini625 – 809RdRp catalyticPROSITE-ProRule annotationAdd BLAST185
Domaini1803 – 2001Mononegavirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST199

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039736 L_poly_C
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat
IPR025786 Mononega_L_MeTrfase
IPR017235 RNA-dir_pol_L_filovirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037548 RNA_pol_Filoviridae, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04198 paramyx_RNAcap, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590 SAM_MT_MNV_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8JPX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATQHTQYPD ARLSSPIVLD QCDLVTRACG LYSSYSLNPQ LRQCKLPKHI
60 70 80 90 100
YRLKFDTIVS KFLSDTPVAT LPIDYLVPIL LRSLTGHGDR PLTPTCNQFL
110 120 130 140 150
DEIINYTLHD AAFLDYYLKA TGAQDHLTNI ATREKLKNEI LNNDYVHQLF
160 170 180 190 200
FWHDLSILAR RGRLNRGNNR STWFVHDEFI DILGYGDYIF WKIPLSLLPV
210 220 230 240 250
TIDGVPHAAT DWYQPTLFKE SILGHSQILS VSTAEILIMC KDIITCRFNT
260 270 280 290 300
SLIASIAKLE DVDVSDYPDP SDILKIYNAG DYVISILGSE GYKIIKYLEP
310 320 330 340 350
LCLAKIQLCS KFTERKGRFL TQMHLSVIND LRELISNRRL KDYQQEKIRD
360 370 380 390 400
FHKILLQLQL SPQQFCELFS VQKHWGHPIL HSEKAIQKVK RHATILKALR
410 420 430 440 450
PNVIFETYCV FKYNIAKHYF DSQGTWYSVI SDRNLTPGLN SFIKRNHFPS
460 470 480 490 500
LPMIKDLLWE FYHLNHPPLF STKVISDLSI FIKDRATAVE QTCWDAVFEP
510 520 530 540 550
NVLGYNPPNK FSTKRVPEQF LEQEDFSIES VLNYAQELHY LLPQNRNFSF
560 570 580 590 600
SLKEKELNIG RTFGKLPYLT RNVQTLCEAL LADGLAKAFP SNMMVVTERE
610 620 630 640 650
QKESLLHQAS WHHTSDDFGE NATVRGSSFV TDLEKYNLAF RYEFTAPFIE
660 670 680 690 700
YCNHCYGVRN VFNWMHYLIP QCYMHVSDYY NPPHNVNLSN REYPPEGPSS
710 720 730 740 750
YRGHLGGIEG LQQKLWTSIS CAQISLVEIK TGFKLRSAVM GDNQCITVLS
760 770 780 790 800
VFPLKTDPEE QEQSAEDNAA RVAASLAKVT SACGIFLKPD ETFVHSGFIY
810 820 830 840 850
FGKKQYLNGV QLPQSLKTAA RMAPLSDAIF DDLQGTLASI GTAFERAISE
860 870 880 890 900
TRHILPCRIV AAFHTYFAVR ILQYHHLGFN KGIDLGQLSL SKPLDYGTIT
910 920 930 940 950
LTLAVPQVLG GLSFLNPEKC FYRNFGDPVT SGLFQLRVYL EMVNMKDLFC
960 970 980 990 1000
PLISKNPGNC SAIDFVLNPS GLNVPGSQDL TSFLRQIVRR SITLTARNKL
1010 1020 1030 1040 1050
INTLFHASAD LEDEMVCKWL LSSNPVMSRF AADIFSRTPS GKRLQILGYL
1060 1070 1080 1090 1100
EGTRTLLASK IINNNSETPV LDKLRKITLQ RWNLWFSYLD HCDQLLADAL
1110 1120 1130 1140 1150
QKISCTVDLA QILREYTWSH ILEGRSLIGA TLPCMVEQFK VKWLGQYEPC
1160 1170 1180 1190 1200
PECLNKKGSN AYVSVAVKDQ VVSAWPNTSR ISWTIGSGVP YIGSRTEDKI
1210 1220 1230 1240 1250
GQPAIKPRCP SSALKEAIEL ASRLTWVTQG GSNSEQLIRP FLEARVNLSV
1260 1270 1280 1290 1300
SEVLQMTPSH YSGNIVHRYN DQYSPHSFMA NRMSNTATRL IVSTNTLGEF
1310 1320 1330 1340 1350
SGGGQAARDS NIIFQNVINL AVALYDIRFR NTNTSDIRHN RAHLHLTECC
1360 1370 1380 1390 1400
TKEVPAQYLT YTSALNLDLS RYRDNELIYD SNPLKGGLNC NLTIDSPLVK
1410 1420 1430 1440 1450
GPRLNMIEDD LLRFPHLSGW ELAKTVVQSI ISDNSNSSTD PISSGETRSF
1460 1470 1480 1490 1500
TTHFLTYPQI GLLYSFGAVL CFYLGNTILW TKKLDYEQFL YYLHNQLHNL
1510 1520 1530 1540 1550
PHRALRVFKP TFKHASVMSR LMEIDSNFSI YIGGTSGDRG LSDAARLFLR
1560 1570 1580 1590 1600
TAIASFLQFL KSWIIDRQKT IPLWIVYPLE GQQPESINEF LHKILGLLKQ
1610 1620 1630 1640 1650
GPKSIPKEVS IQNDGHLDLA ENNYVYNSKS TASNFFHASL AYWRSRKSRK
1660 1670 1680 1690 1700
TQDHNDFSRG DGTLTEPVRK FSSNHQSDEK YYNVTCGKSP KPQERKDFSQ
1710 1720 1730 1740 1750
YRLSNNGQTM SNHRKKGKFH KWNPCKMLME SQRGTVLTEG DYFQNNTPPT
1760 1770 1780 1790 1800
DDVSSPHRLI LPFFKLGNHN HAHDQDAQEL MNQNIKQYLH QLRSMLDTTI
1810 1820 1830 1840 1850
YCRFTGIVSS MHYKLDEVLL EYNSFDSAIT LAEGEGSGAL LLLQKYSTRL
1860 1870 1880 1890 1900
LFLNTLATEH SIESEVVSGF STPRMLLPIM QKVHEGQVTV ILNNSASQIT
1910 1920 1930 1940 1950
DITSSMWLSN QKYNLPCQVE IIMMDAETTE NLNRSQLYRA VYNLILDHID
1960 1970 1980 1990 2000
PQYLKVVVLK VFLSDIEGIL WINDYLAPLF GAGYLIKPIT SSARSSEWYL
2010 2020 2030 2040 2050
CLSNLISTNR RSAHQTHKAC LGVIRDALQA QVQRGVYWLS HIAQYATKNL
2060 2070 2080 2090 2100
HCEYIGLGFP SLEKVLYHRY NLVDTGLGPL SSVIRHLTNL QAEIRDLVLD
2110 2120 2130 2140 2150
YNLMRESRTQ TYHFIKTAKG RITKLVNDFL KFSLIVQALK NNSSWYTELK
2160 2170 2180 2190 2200
KLPEVINVCN RFYHTHNCEC QEKFFVQTLY LQRLRDAEIK LIERLTGLMR
2210
FYPEGLIYSN HT
Length:2,212
Mass (Da):252,549
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC28CE580881136E3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti192K → R in strain: Isolate Pennsylvania-89. 1
Natural varianti324H → R in strain: Isolate Pennsylvania-89. 1
Natural varianti442F → V in strain: Isolate Pennsylvania-89. 1
Natural varianti600E → G in strain: Isolate Pennsylvania-89. 1
Natural varianti755K → E in strain: Isolate Pennsylvania-89. 1
Natural varianti1374D → G in strain: Isolate Pennsylvania-89. 1
Natural varianti1487E → D in strain: Isolate Pennsylvania-89. 1
Natural varianti1679E → A in strain: Isolate Pennsylvania-89. 1
Natural varianti1896 – 1898ASQ → SSH in strain: Isolate Pennsylvania-89. 3
Natural varianti1909S → SS in strain: Isolate Pennsylvania-89. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF522874 Genomic RNA Translation: AAN04454.1
AY769362 Genomic RNA Translation: AAV48581.1

NCBI Reference Sequences

More...
RefSeqi
NP_690587.1, NC_004161.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
955191

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:955191

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522874 Genomic RNA Translation: AAN04454.1
AY769362 Genomic RNA Translation: AAV48581.1
RefSeqiNP_690587.1, NC_004161.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ8JPX5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi955191
KEGGivg:955191

Family and domain databases

InterProiView protein in InterPro
IPR039736 L_poly_C
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat
IPR025786 Mononega_L_MeTrfase
IPR017235 RNA-dir_pol_L_filovirus
PfamiView protein in Pfam
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit
PIRSFiPIRSF037548 RNA_pol_Filoviridae, 1 hit
TIGRFAMsiTIGR04198 paramyx_RNAcap, 1 hit
PROSITEiView protein in PROSITE
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590 SAM_MT_MNV_L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_EBORR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8JPX5
Secondary accession number(s): Q5UAK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2002
Last modified: July 31, 2019
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again