Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 75 (18 Sep 2019)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Borna disease virus 1 (BoDV-1)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays RNA-directed RNA polymerase activity. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently three subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. In replicase mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication
LigandATP-binding, Nucleotide-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBorna disease virus 1 (BoDV-1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1714621 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaHaploviricotinaMonjiviricetesMononegaviralesBornaviridaeOrthobornavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBos taurus (Bovine) [TaxID: 9913]
Bradypodidae (three-fingered sloths) [TaxID: 9352]
Capra hircus (Goat) [TaxID: 9925]
Cervidae (deer) [TaxID: 9850]
Crocidura leucodon (Bicoloured white-toothed shrew) (Celebes shrew) [TaxID: 109474]
Equidae (horses) [TaxID: 9788]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Hexaprotodon liberiensis (Pygmy hippopotamus) (Choeropsis liberiensis) [TaxID: 56798]
Lama glama (Llama) [TaxID: 9844]
Oryctolagus cuniculus (Rabbit) [TaxID: 9986]
Ovis aries (Sheep) [TaxID: 9940]
Struthio camelus (Common ostrich) [TaxID: 8801]
Varecia variegata (Black-and-white ruffed lemur) (Lemur variegatus) [TaxID: 9455]
Vicugna pacos (Alpaca) (Lama pacos) [TaxID: 30538]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000185272 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000117149 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004053491 – 1711RNA-directed RNA polymerase LAdd BLAST1711

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8JMN0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the P protein.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8JMN0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini543 – 715RdRp catalyticPROSITE-ProRule annotationAdd BLAST173

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi844 – 852Nuclear localization signalBy similarity9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Large structural protein (identifier: Q8JMN0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFHASLLRE EETPRPVAGI NRTDQSLKNP LLGTEVSFCL KSSSLPHHVR
60 70 80 90 100
ALGQIKAKNL ASCDYYLLFR QVVLPPEVYP IGVLIRAAEA ILTVIVSAWK
110 120 130 140 150
LDHMTKTLYS SVRYALTNPR VRAQLELHIA YQRIVGQVSY SREADIGPKR
160 170 180 190 200
LGNMSLQFIQ SLVIATIDTT SCLMTYNHFL AAADTAKSRC HLLIASVVQG
210 220 230 240 250
ALWEQGSFLD HIINMIDTID SINLPHDDYF TIIKSISPYS QGLVMGRHNV
260 270 280 290 300
SVSSDFASVF TIPESCPQLD SLLKKLLQLD PVLLLMVSSV QKSWYFPEIR
310 320 330 340 350
MVDGSREQLH KMRVELETPQ ALLSYGHTLL SIFRAEFIKG YVSKNAKWPP
360 370 380 390 400
VHLLPGCDKS IKNARELGRW SPVFDRRWQL FAKVVILRIA DLDMDPDFND
410 420 430 440 450
IVSDKAIISS RRDWVFEYNA AAFWKKYSER LERPPARSGP SRLVNALIDG
460 470 480 490 500
RLDNIPALLE PFYRGAVEFE DRLTVLVPKE KELKVKGRFF SKQTLAIRIY
510 520 530 540 550
QVVAEAALKN EVMPYLKTHS MTMSSTALTH LLNRLSHTIT KGDSFVINLD
560 570 580 590 600
YSSWCNGFRP ELQAPLCRQL DQMFNCGYFF RTGCTLPCFT TFIIQDRFNP
610 620 630 640 650
PYSFRGEPVE DGVTCAVGTK TMGEGMRQKL WTILTSCWEI IALREINVTF
660 670 680 690 700
NILGQGDNQT IIVHKSASQN NQLLAERALG ALYKHARLAG HNLKVEECWV
710 720 730 740 750
SDCLYEYGKK LFFRGVPVPG CLKQLSRVTD STGELFPNLY SKLACLTSSC
760 770 780 790 800
LSAAMADTSP WVALATGVCL YLIELYVELP PAIMQDESLL TTLCLVGPSI
810 820 830 840 850
GGLPTPATLP SVFFRGMSDP LPFQLALLQT LIKTTGVTCS LVNRVVKLRI
860 870 880 890 900
APYPDWLSLV TDPTSLNIAQ VYRPERQIRR WIEEAIATSS HSSRIATFFQ
910 920 930 940 950
QPLTEMAQLL ARDLSTMMPL RPRDMSALFA LSNVAYGLSI IDLFQKSSTV
960 970 980 990 1000
VSASQAVHIE DVALESVRYK ESIIQGLLDT TEGYNMQPYL EGCTYLAAKQ
1010 1020 1030 1040 1050
LRRLTWGRDL VGVTMPFVAE QFHPHSSVGA KAELYLDAII YCPQETLRSH
1060 1070 1080 1090 1100
HLTTRGDQPL YLGSNTAVKV QRGEITGLTK SRAANLVKDT LVLHQWYKVR
1110 1120 1130 1140 1150
KVTDPHLNTL MARFLLEKGY TSDARPSIQG GTLTHRLPSR GDSRQGLTGY
1160 1170 1180 1190 1200
VNILSTWLRF SSDYLHSFSK SSDDYTIHFQ HVFTYGCLYA DSVIRSGGVI
1210 1220 1230 1240 1250
STPYLLSASC KTCFEKIDSE EFVLACEPQY RGAEWLISKP VTVPEQIIDA
1260 1270 1280 1290 1300
EVEFDPCVSA SYCLGILIGK SFLVDIRASG HDIMEQRTWA NLERFSVSDM
1310 1320 1330 1340 1350
QKLPWSIVIR SLWRFLIGAR LLQFEKAGLI RMLYAATGPT FSFLMKVFQD
1360 1370 1380 1390 1400
SALLMDCAPL DRLSPRINFH SRGDLVAKLV LLPFINPGIV EIEVSRINSK
1410 1420 1430 1440 1450
YHAVSEANMD LYIAAAKSVG VKPTQFVEET NDFTARGHHH GCYSLSWSKS
1460 1470 1480 1490 1500
RNQSQVLKMV VRKLKLCVLY IYPTVDPAVA LDLCHLPALT IILVLGGDPA
1510 1520 1530 1540 1550
YYERLLEMDL CGAVSSRVDI PHSLAARTHR GFTIGPDAGP GVIRLDKLES
1560 1570 1580 1590 1600
VCYAHPCLEE LEFNAYLDSE LVDISDMCCL PLATPCKALF RPVYRSLQSF
1610 1620 1630 1640 1650
RLALMDNYSF VMDLITIRGV DIRPHLEEFD ELLVVGQHIL GQPVLVEVVY
1660 1670 1680 1690 1700
YVGVVGKRPV LARHPWSADL KRITVGGRAP CPSAAGLRDE DCRGSLLVGL
1710
PAGLTQLLVV D
Length:1,711
Mass (Da):191,646
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10338AFE9A9CAD24
GO
Isoform Matrix protein (identifier: P0C794-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0C794.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:142
Mass (Da):16,258
GO
Isoform Envelope glycoprotein p57 precursor (identifier: Q8BB27-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8BB27.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:503
Mass (Da):56,704
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA20667 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 5MSFHA → LCFLT in AAA20667 (PubMed:7906311).Curated5
Sequence conflicti902P → A in AAA20667 (PubMed:7906311).Curated1
Sequence conflicti1069K → T in AAA20667 (PubMed:7906311).Curated1
Sequence conflicti1222F → V in AAA20667 (PubMed:7906311).Curated1
Sequence conflicti1364S → Y in AAA20667 (PubMed:7906311).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY114161 Genomic RNA Translation: AAM68139.1
L27077 Genomic RNA Translation: AAA20667.2 Different initiation.

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114161 Genomic RNA Translation: AAM68139.1
L27077 Genomic RNA Translation: AAA20667.2 Different initiation.

3D structure databases

SMRiQ8JMN0
ModBaseiSearch...

Proteomic databases

PRIDEiQ8JMN0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR026890 Mononeg_mRNAcap
IPR014023 Mononeg_RNA_pol_cat
PfamiView protein in Pfam
PF14318 Mononeg_mRNAcap, 1 hit
PF00946 Mononeg_RNA_pol, 1 hit
PROSITEiView protein in PROSITE
PS50526 RDRP_SSRNA_NEG_NONSEG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_BDV1
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8JMN0
Secondary accession number(s): Q88627
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: October 1, 2002
Last modified: September 18, 2019
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again