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Protein

Cysteine-rich venom protein triflin

Gene
N/A
Organism
Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks contraction of smooth muscle elicited by high potassium-induced depolarization (PubMed:12047379). May target voltage-gated calcium channels (Cav) on smooth muscle.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Protein family/group databases

TCDBi8.B.9.1.1 the triflin toxin (triflin or crisp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich venom protein triflin
Short name:
CRVP
OrganismiProtobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
Taxonomic identifieri88087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeProtobothrops

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000000628720 – 240Cysteine-rich venom protein triflinAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 153PROSITE-ProRule annotation1 Publication
Disulfide bondi92 ↔ 167PROSITE-ProRule annotation1 Publication
Disulfide bondi148 ↔ 164PROSITE-ProRule annotation1 Publication
Disulfide bondi186 ↔ 193PROSITE-ProRule annotation1 Publication
Disulfide bondi189 ↔ 198PROSITE-ProRule annotation1 Publication
Disulfide bondi202 ↔ 235PROSITE-ProRule annotation1 Publication
Disulfide bondi211 ↔ 229PROSITE-ProRule annotation1 Publication
Disulfide bondi220 ↔ 233PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8JI39

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Forms a stable, non-covalent complex with SSP-2.1 Publication

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8JI39
SMRiQ8JI39
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8JI39

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 166SCPAdd BLAST128
Domaini202 – 235ShKTPROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004184

Family and domain databases

CDDicd05383 SCP_CRISP, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR013871 Cysteine_rich_secretory
IPR034117 SCP_CRISP
IPR003582 ShKT_dom
IPR002413 V5_allergen
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
PS51670 SHKT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JI39-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIAFIVLPIL AAVLQQSSGN VDFDSESPRK PEIQNEIIDL HNSLRRSVNP
60 70 80 90 100
TASNMLKMEW YPEAAANAER WAYRCIESHS SRDSRVIGGI KCGENIYMAT
110 120 130 140 150
YPAKWTDIIH AWHGEYKDFK YGVGAVPSDA VIGHYTQIVW YKSYRAGCAA
160 170 180 190 200
AYCPSSKYSY FYVCQYCPAG NIIGKTATPY KSGPPCGDCP SDCDNGLCTN
210 220 230 240
PCTRENEFTN CDSLVQKSSC QDNYMKSKCP ASCFCQNKII
Length:240
Mass (Da):26,752
Last modified:October 1, 2002 - v1
Checksum:i1EE3C9C426D974A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384219 mRNA Translation: AAM45665.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384219 mRNA Translation: AAM45665.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WVRX-ray2.40A20-240[»]
ProteinModelPortaliQ8JI39
SMRiQ8JI39
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.9.1.1 the triflin toxin (triflin or crisp) family

Proteomic databases

PRIDEiQ8JI39

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004184

Miscellaneous databases

EvolutionaryTraceiQ8JI39

Family and domain databases

CDDicd05383 SCP_CRISP, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR013871 Cysteine_rich_secretory
IPR034117 SCP_CRISP
IPR003582 ShKT_dom
IPR002413 V5_allergen
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF08562 Crisp, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
PS51670 SHKT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRVP_PROFL
AccessioniPrimary (citable) accession number: Q8JI39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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