Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 117 (07 Oct 2020)
Sequence version 2 (25 Jul 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Thrombospondin-3a

Gene

thbs3a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • heparin binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-186797, Signaling by PDGF
R-DRE-216083, Integrin cell surface interactions
R-DRE-3000178, ECM proteoglycans

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thrombospondin-3a
Short name:
Thbs3a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:thbs3a
Synonyms:thbs3, tsp3
ORF Names:zgc:103461
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-020708-3, thbs3a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003585124 – 962Thrombospondin-3aAdd BLAST939

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi269InterchainPROSITE-ProRule annotationBy similarity
Disulfide bondi272InterchainPROSITE-ProRule annotationBy similarity
Disulfide bondi281 ↔ 292PROSITE-ProRule annotationBy similarity
Disulfide bondi286 ↔ 303PROSITE-ProRule annotationBy similarity
Disulfide bondi306 ↔ 317PROSITE-ProRule annotationBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi313N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi323 ↔ 335PROSITE-ProRule annotationBy similarity
Disulfide bondi329 ↔ 344PROSITE-ProRule annotationBy similarity
Disulfide bondi347 ↔ 371PROSITE-ProRule annotationBy similarity
Disulfide bondi377 ↔ 390PROSITE-ProRule annotationBy similarity
Disulfide bondi384 ↔ 399PROSITE-ProRule annotationBy similarity
Disulfide bondi402 ↔ 414PROSITE-ProRule annotationBy similarity
Glycosylationi409N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi420 ↔ 434PROSITE-ProRule annotationBy similarity
Disulfide bondi428 ↔ 444PROSITE-ProRule annotationBy similarity
Disulfide bondi446 ↔ 457PROSITE-ProRule annotationBy similarity
Disulfide bondi473 ↔ 480PROSITE-ProRule annotationBy similarity
Disulfide bondi485 ↔ 505PROSITE-ProRule annotationBy similarity
Disulfide bondi521 ↔ 541PROSITE-ProRule annotationBy similarity
Disulfide bondi544 ↔ 564PROSITE-ProRule annotationBy similarity
Disulfide bondi580 ↔ 600PROSITE-ProRule annotationBy similarity
Disulfide bondi603 ↔ 623PROSITE-ProRule annotationBy similarity
Disulfide bondi641 ↔ 661PROSITE-ProRule annotationBy similarity
Glycosylationi646N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi684 ↔ 704PROSITE-ProRule annotationBy similarity
Glycosylationi710N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi720 ↔ 941PROSITE-ProRule annotationBy similarity
Glycosylationi942N-linked (GlcNAc...) asparagineCurated1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8JHW2

PRoteomics IDEntifications database

More...
PRIDEi
Q8JHW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Present at the gastrulation and post-segmentation stages.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer; disulfide-linked.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000057304

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8JHW2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 196Laminin G-likeAdd BLAST173
Domaini277 – 318EGF-like 1PROSITE-ProRule annotationCuratedAdd BLAST42
Domaini319 – 358EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini373 – 412EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini416 – 458EGF-like 4PROSITE-ProRule annotationCuratedAdd BLAST43
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati459 – 493TSP type-3 1Add BLAST35
Repeati494 – 529TSP type-3 2Add BLAST36
Repeati530 – 552TSP type-3 3Add BLAST23
Repeati553 – 588TSP type-3 4Add BLAST36
Repeati589 – 611TSP type-3 5Add BLAST23
Repeati612 – 649TSP type-3 6Add BLAST38
Repeati650 – 692TSP type-3 7Add BLAST43
Repeati693 – 728TSP type-3 8Add BLAST36
Domaini732 – 946TSP C-terminalPROSITE-ProRule annotationAdd BLAST215

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRK8, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8JHW2

KEGG Orthology (KO)

More...
KOi
K04659

Database of Orthologous Groups

More...
OrthoDBi
120983at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8JHW2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1080.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR001791, Laminin_G
IPR024665, Thbs/COMP_coiled-coil
IPR028507, Thrombospondin-3
IPR003367, Thrombospondin_3-like_rpt
IPR017897, Thrombospondin_3_rpt
IPR008859, Thrombospondin_C
IPR028974, TSP_type-3_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR10199:SF114, PTHR10199:SF114, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11598, COMP, 1 hit
PF07645, EGF_CA, 2 hits
PF02412, TSP_3, 7 hits
PF05735, TSP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 4 hits
SM00179, EGF_CA, 2 hits
SM00210, TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103647, SSF103647, 3 hits
SSF49899, SSF49899, 2 hits
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 4 hits
PS01187, EGF_CA, 2 hits
PS51234, TSP3, 8 hits
PS51236, TSP_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8JHW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQMFVHIWV SLVVLMSVWS AQSDKKQDVP VIDVLGLEDV KQTVAAVEKL
60 70 80 90 100
SLALKTLSDV YVMSTFRLPP KLGGVLLGLY NKQDNKKYLE VAIMSKINKV
110 120 130 140 150
LVRYVREDGK LHTVNMQSPN VADGRPQSLI LRVGGLRREY LSLELYVNCR
160 170 180 190 200
LADSAQRLPP LVDLPRDAEL VEIRNGHKAY ARMQGSMDTL KLALGGTVAQ
210 220 230 240 250
AGALTDCPFQ GDASSYNIVN GEVNSILGDH TKALIGQLII FNQILGELRE
260 270 280 290 300
DIREQVKEMS LVRNAILECQ MCGFHEPRSR CQPNPCFKGV SCMETFEYPG
310 320 330 340 350
YRCGPCPDGM TGNGTHCQDI DECSEAQPCY TPGACVNTAR GFTCESCPPG
360 370 380 390 400
MWGPPLSGVG VEYAKSHRQE CSDIDECVDL ANACTPNSVC INIIGSFRCG
410 420 430 440 450
QCKTGYVGNQ TAGCFPRKSC SSLSFNPCDA NAHCVMQRNG DVSCACNVGW
460 470 480 490 500
AGNGHTCGKD TDIDGYPDRS LPCMDNHKHC RQDNCVYTPN SGQEDADNDG
510 520 530 540 550
IGDQCDEDAD GDGIKNVEDN CRLVSNKDQQ NSDTDSFGDA CDNCPTVPNI
560 570 580 590 600
DQKDTDSNGE GDACDDDIDG DGIQNVLDNC PKVPNPMQTD RDRDGVGDAC
610 620 630 640 650
DSCPEISNPM QTDVDNDLVG DVCDTNQDTD GDGHQDTRDN CPDIPNSSQL
660 670 680 690 700
DSDNDGIGDD CDEDDDNDGI PDNHAINGIG PDNCRLISNP NQKDSDSNGV
710 720 730 740 750
GDVCENDFDN DSVMDLVDVC PESAEVTLTD FRAYQTVILD PEGDAQIDPN
760 770 780 790 800
WVVLNQGMEI VQTMNSDPGL AVGYTAFNGV DFEGTFHVNT VTDDDCAGSI
810 820 830 840 850
FGYQDSSSFY VVMWKQTEQT YWQSIPFRAM AEPGLQLKAV KSRTGPGEFL
860 870 880 890 900
RNALWHAGDT DGEVKLLWKD PRNVGWLDKT SYRWQLSHRP QVGYIRVKLY
910 920 930 940 950
EGSEMVADSD VVIDTSMRGG RLGVFCFSQE NIIWSNLRYR CNDTVPEDFS
960
SHRKQVLMHI KV
Length:962
Mass (Da):105,591
Last modified:July 25, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15D18A2A4E67373E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QKL1F1QKL1_DANRE
Thrombospondin-3a
thbs3a
962Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2E → K in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti17S → F in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti393I → T in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti430A → T in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti796C → Y in AAM88772 (PubMed:12592708).Curated1
Sequence conflicti799S → F in AAM88772 (PubMed:12592708).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF462310 mRNA Translation: AAM88772.1
BC085524 mRNA Translation: AAH85524.1

NCBI Reference Sequences

More...
RefSeqi
NP_775332.1, NM_173225.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
252849

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:252849

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462310 mRNA Translation: AAM88772.1
BC085524 mRNA Translation: AAH85524.1
RefSeqiNP_775332.1, NM_173225.1

3D structure databases

SMRiQ8JHW2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000057304

Proteomic databases

PaxDbiQ8JHW2
PRIDEiQ8JHW2

Genome annotation databases

GeneIDi252849
KEGGidre:252849

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
252849
ZFINiZDB-GENE-020708-3, thbs3a

Phylogenomic databases

eggNOGiENOG502QRK8, Eukaryota
InParanoidiQ8JHW2
KOiK04659
OrthoDBi120983at2759
PhylomeDBiQ8JHW2

Enzyme and pathway databases

ReactomeiR-DRE-186797, Signaling by PDGF
R-DRE-216083, Integrin cell surface interactions
R-DRE-3000178, ECM proteoglycans

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8JHW2

Family and domain databases

Gene3Di4.10.1080.10, 3 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR001791, Laminin_G
IPR024665, Thbs/COMP_coiled-coil
IPR028507, Thrombospondin-3
IPR003367, Thrombospondin_3-like_rpt
IPR017897, Thrombospondin_3_rpt
IPR008859, Thrombospondin_C
IPR028974, TSP_type-3_rpt
PANTHERiPTHR10199:SF114, PTHR10199:SF114, 1 hit
PfamiView protein in Pfam
PF11598, COMP, 1 hit
PF07645, EGF_CA, 2 hits
PF02412, TSP_3, 7 hits
PF05735, TSP_C, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 4 hits
SM00179, EGF_CA, 2 hits
SM00210, TSPN, 1 hit
SUPFAMiSSF103647, SSF103647, 3 hits
SSF49899, SSF49899, 2 hits
SSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 4 hits
PS01187, EGF_CA, 2 hits
PS51234, TSP3, 8 hits
PS51236, TSP_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSP3A_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8JHW2
Secondary accession number(s): Q5U3J1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 25, 2006
Last modified: October 7, 2020
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again