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Protein

T-complex protein 1 subunit eta

Gene

cct7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit etaUniRule annotation
Short name:
TCP-1-etaUniRule annotation
Alternative name(s):
CCT-etaUniRule annotation
Gene namesi
Name:cct7Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-020419-7 cct7

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8JHG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
HOVERGENiHBG001052
KOiK09499
PhylomeDBiQ8JHG7

Family and domain databases

CDDicd03340 TCP1_eta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012720 Chap_CCT_eta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF22 PTHR11353:SF22, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02345 chap_CCT_eta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8JHG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSTPVILLK EGTDTSQGVP QLVSNINACQ VVAEAVRTTL GPRGMDKLVV
60 70 80 90 100
DNRGKATISN DGATILKLLD VVHPAAKTLV DIARSQDAEV GDGTTSVTLL
110 120 130 140 150
AAEFLKQLKP YVEEGLHPQT IIRAFRIATQ LAVKKIKEIA VTIKKDDKQE
160 170 180 190 200
QRRLLEKCAA TALNSKLIAG QKDFFSKMVV DAVMMLDDLL PLKMIGVKKV
210 220 230 240 250
QGGALEESQL VAGVAFKKTF SYAGFEMQPK RYMNPKIALL NIELELKAEK
260 270 280 290 300
DNAEVRVNSM EDYQAIVDAE WNILYDKLEK IHKSGAKVVL SKLPIGDVAT
310 320 330 340 350
QYFAYRNLFC AARVVEENLK RTMMACGGSI QTSVGSLTDD VLGQCELFEE
360 370 380 390 400
VQVGGERYNF FKGCPKAKTC TIILRGGAEQ FMEETDRSLH DAIMIVRRAI
410 420 430 440 450
KNDSIVAGGG AIEMELSKYL RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC
460 470 480 490 500
DNAGFDATNI LNKLRAKHAQ GGMWYGVDVN NEDIADNFQA CVWEPSIVRI
510 520 530 540
NALTAASEAA CLILSVDETI KNPRSSVDGP PAAAGRGRGR GRPAHAH
Length:547
Mass (Da):59,799
Last modified:October 1, 2002 - v1
Checksum:i2E1307E7B86CC76C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506229 mRNA Translation: AAM34673.1
RefSeqiNP_775355.1, NM_173248.1
UniGeneiDr.134

Genome annotation databases

GeneIDi192324
KEGGidre:192324

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506229 mRNA Translation: AAM34673.1
RefSeqiNP_775355.1, NM_173248.1
UniGeneiDr.134

3D structure databases

ProteinModelPortaliQ8JHG7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi192324
KEGGidre:192324

Organism-specific databases

CTDi10574
ZFINiZDB-GENE-020419-7 cct7

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
HOVERGENiHBG001052
KOiK09499
PhylomeDBiQ8JHG7

Family and domain databases

CDDicd03340 TCP1_eta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012720 Chap_CCT_eta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF22 PTHR11353:SF22, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02345 chap_CCT_eta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8JHG7_DANRE
AccessioniPrimary (citable) accession number: Q8JHG7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 10, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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