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Protein

Fructose-bisphosphate aldolase B

Gene

aldob

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (gpib), Glucose-6-phosphate isomerase (gpib), Glucose-6-phosphate isomerase (gpib), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpia)
  3. ATP-dependent 6-phosphofructokinase (pfkpa), ATP-dependent 6-phosphofructokinase (pfkpb), ATP-dependent 6-phosphofructokinase (pfkla), ATP-dependent 6-phosphofructokinase (pfkmb), ATP-dependent 6-phosphofructokinase (pfkpb), ATP-dependent 6-phosphofructokinase (pfkpb), ATP-dependent 6-phosphofructokinase (pfkmb), ATP-dependent 6-phosphofructokinase (pfkpa), ATP-dependent 6-phosphofructokinase (pfklb), ATP-dependent 6-phosphofructokinase (pfkmb), ATP-dependent 6-phosphofructokinase (pfkpa), ATP-dependent 6-phosphofructokinase (pfkla), ATP-dependent 6-phosphofructokinase (pfkpb), ATP-dependent 6-phosphofructokinase (pfkpa), ATP-dependent 6-phosphofructokinase (pfkmb), ATP-dependent 6-phosphofructokinase (pfkma)
  4. Fructose-bisphosphate aldolase C-B (aldocb), Fructose-bisphosphate aldolase C-A (aldoca), Fructose-bisphosphate aldolase B (aldob), Fructose-bisphosphate aldolase (aldob), Fructose-bisphosphate aldolase (aldoca), Fructose-bisphosphate aldolase (aldob), Fructose-bisphosphate aldolase (aldoca), Fructose-bisphosphate aldolase (aldocb), Fructose-bisphosphate aldolase (aldob), Fructose-bisphosphate aldolase (aldoaa), Fructose-bisphosphate aldolase (aldoaa), Fructose-bisphosphate aldolase (aldoab)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-DRE-70171 Glycolysis
R-DRE-70263 Gluconeogenesis
R-DRE-70350 Fructose catabolism
UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Liver-type aldolase
Gene namesi
Name:aldob
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-030131-383 aldob

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002916112 – 364Fructose-bisphosphate aldolase BAdd BLAST363

Proteomic databases

PaxDbiQ8JH71
PRIDEiQ8JH71

Expressioni

Gene expression databases

BgeeiENSDARG00000053684 Expressed in 33 organ(s), highest expression level in gastrula
ExpressionAtlasiQ8JH71 baseline and differential

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000070225

Structurei

3D structure databases

ProteinModelPortaliQ8JH71
SMRiQ8JH71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
HOVERGENiHBG002386
InParanoidiQ8JH71
KOiK01623
OMAiPLCKPWA
OrthoDBiEOG091G0A9T
PhylomeDBiQ8JH71
TreeFamiTF314203

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8JH71-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHQFPALST EQKKELATIA ERIVAPGKGI LAADESTGTM AKRFQKINVE
60 70 80 90 100
NTEENRRSFR DLLFSVDDSI SESIGGVILF HETLYQKSDK GVLFPKVIKD
110 120 130 140 150
KGIVVGIKVD KGTAGLAGTD GETTTQGLDG LSERCAQYKK DGCDFAKWRC
160 170 180 190 200
VLKISDSCPS ALGIAENANV LARYASICQQ NGLVPIVEPE ILPDGDHDLK
210 220 230 240 250
QCQYATEKVL AAVYKALSDH HVYLEGTLLK PNMVTAGHSC TKKYTPLEVA
260 270 280 290 300
MATVTALRRT VPAAVPGICF LSGGQSEEEA SLNLNAMNQL SLHRPWKLSF
310 320 330 340 350
SYGRALQASA LSAWKGQAAN KKASQDAFVT RAKINSLASK GEYKPSGQAG
360
QASTQSLFTA SYTY
Length:364
Mass (Da):39,288
Last modified:October 1, 2002 - v1
Checksum:iFB2DD9CDDCF4DB9E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QF34E9QF34_DANRE
Fructose-bisphosphate aldolase
aldob
285Annotation score:
A0A2R8QH08A0A2R8QH08_DANRE
Fructose-bisphosphate aldolase
aldob
368Annotation score:
E9QBQ4E9QBQ4_DANRE
Fructose-bisphosphate aldolase B
aldob
208Annotation score:
A0A0R4IU94A0A0R4IU94_DANRE
Fructose-bisphosphate aldolase B
aldob
136Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533646 mRNA Translation: AAN04477.1
AY394965 mRNA Translation: AAQ94592.1
BC062830 mRNA Translation: AAH62830.1
RefSeqiNP_919348.3, NM_194367.3
UniGeneiDr.76309

Genome annotation databases

EnsembliENSDART00000075744; ENSDARP00000070225; ENSDARG00000053684
GeneIDi321664
KEGGidre:321664

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533646 mRNA Translation: AAN04477.1
AY394965 mRNA Translation: AAQ94592.1
BC062830 mRNA Translation: AAH62830.1
RefSeqiNP_919348.3, NM_194367.3
UniGeneiDr.76309

3D structure databases

ProteinModelPortaliQ8JH71
SMRiQ8JH71
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000070225

Proteomic databases

PaxDbiQ8JH71
PRIDEiQ8JH71

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000075744; ENSDARP00000070225; ENSDARG00000053684
GeneIDi321664
KEGGidre:321664

Organism-specific databases

CTDi229
ZFINiZDB-GENE-030131-383 aldob

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
HOVERGENiHBG002386
InParanoidiQ8JH71
KOiK01623
OMAiPLCKPWA
OrthoDBiEOG091G0A9T
PhylomeDBiQ8JH71
TreeFamiTF314203

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

ReactomeiR-DRE-70171 Glycolysis
R-DRE-70263 Gluconeogenesis
R-DRE-70350 Fructose catabolism

Miscellaneous databases

PROiPR:Q8JH71

Gene expression databases

BgeeiENSDARG00000053684 Expressed in 33 organ(s), highest expression level in gastrula
ExpressionAtlasiQ8JH71 baseline and differential

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALDOB_DANRE
AccessioniPrimary (citable) accession number: Q8JH71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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