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Protein

Fructose-bisphosphate aldolase C-B

Gene

aldocb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (gpib), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpib), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpia), Glucose-6-phosphate isomerase (gpib)
  3. ATP-dependent 6-phosphofructokinase (pfkpa), ATP-dependent 6-phosphofructokinase (pfkma), ATP-dependent 6-phosphofructokinase (pfkla), ATP-dependent 6-phosphofructokinase (pfklb), ATP-dependent 6-phosphofructokinase, ATP-dependent 6-phosphofructokinase (pfkpa), ATP-dependent 6-phosphofructokinase (pfkpb), ATP-dependent 6-phosphofructokinase, ATP-dependent 6-phosphofructokinase, ATP-dependent 6-phosphofructokinase (pfkla), ATP-dependent 6-phosphofructokinase (pfkpa), ATP-dependent 6-phosphofructokinase (pfkpb), ATP-dependent 6-phosphofructokinase (pfkpa), ATP-dependent 6-phosphofructokinase (pfkmb), ATP-dependent 6-phosphofructokinase (pfkmb), ATP-dependent 6-phosphofructokinase (pfkmb)
  4. Fructose-bisphosphate aldolase C-A (aldoca), Fructose-bisphosphate aldolase C-B (aldocb), Fructose-bisphosphate aldolase B (aldob), Fructose-bisphosphate aldolase (aldoaa), Fructose-bisphosphate aldolase (aldoab), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (aldocb), Fructose-bisphosphate aldolase (aldoca), Fructose-bisphosphate aldolase (aldob), Fructose-bisphosphate aldolase (aldob), Fructose-bisphosphate aldolase (aldob), Fructose-bisphosphate aldolase (aldoaa)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei363Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase C-B (EC:4.1.2.13)
Alternative name(s):
Brain-type aldolase-B
Gene namesi
Name:aldocb
Synonyms:aldoc
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-030821-1 aldocb

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002916122 – 363Fructose-bisphosphate aldolase C-BAdd BLAST362

Proteomic databases

PaxDbiQ8JH70
PRIDEiQ8JH70

Expressioni

Gene expression databases

BgeeiENSDARG00000019702 Expressed in 46 organ(s), highest expression level in retina
ExpressionAtlasiQ8JH70 baseline and differential

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024492

Structurei

3D structure databases

ProteinModelPortaliQ8JH70
SMRiQ8JH70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
GeneTreeiENSGT00390000010235
HOGENOMiHOG000220876
HOVERGENiHBG002386
InParanoidiQ8JH70
KOiK01623
OMAiMTHQYPA
OrthoDBiEOG091G0A9T
PhylomeDBiQ8JH70
TreeFamiTF314203

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JH70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHQYPALTA EQKKELQDIA QRIVAPGKGI LAADESTGSM AKRLNPIGVE
60 70 80 90 100
NTEENRRLYR QLLFSADERI DKCIGGVIFF HETLYQNTDD GTNFAQLIKD
110 120 130 140 150
RGIVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRS
160 170 180 190 200
VLKISDTTPS ELAIMENANV LARYASICQQ NGIVPIVEPE ILPDGEHDLK
210 220 230 240 250
RCQYVTEKVL AACYKALSDH HVYLEGTLLK PNMVTAGHSC PTKYSSEEIA
260 270 280 290 300
MATVTALRRT VPPAVSGVTF LSGGQSEEEA SVNLNSINNC PLAKPWPLTF
310 320 330 340 350
SYGRALQASA LSAWRGAKSN EKAATEEFIK RAEANGLAAQ GKYVSSGTCG
360
AAGQSLYVAN HAY
Length:363
Mass (Da):39,259
Last modified:October 1, 2002 - v1
Checksum:i84D269B36579E6A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533647 mRNA Translation: AAN04478.1
BC053192 mRNA Translation: AAH53192.1
RefSeqiNP_919365.1, NM_194384.1
UniGeneiDr.19223

Genome annotation databases

EnsembliENSDART00000026766; ENSDARP00000024492; ENSDARG00000019702
ENSDART00000183995; ENSDARP00000151215; ENSDARG00000019702
GeneIDi369193
KEGGidre:369193

Similar proteinsi

Entry informationi

Entry nameiALDCB_DANRE
AccessioniPrimary (citable) accession number: Q8JH70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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