UniProtKB - Q8JH68 (MXA_DANRE)
Protein
Interferon-induced GTP-binding protein MxA
Gene
mxa
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 44 – 51 | GTPSequence analysis | 8 | |
Nucleotide bindingi | 145 – 149 | GTPSequence analysis | 5 | |
Nucleotide bindingi | 214 – 217 | GTPSequence analysis | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- microtubule binding Source: GO_Central
GO - Biological processi
- dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
- membrane fusion Source: GO_Central
- mitochondrial fission Source: GO_Central
- postsynaptic neurotransmitter receptor internalization Source: GO_Central
- receptor internalization Source: GO_Central
- regulation of synapse structure or activity Source: GO_Central
- response to arsenic-containing substance Source: ZFIN
- response to bacterium Source: ZFIN
- response to virus Source: ZFIN
- synaptic vesicle budding from presynaptic endocytic zone membrane Source: GO_Central
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DRE-1169408, ISG15 antiviral mechanism |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon-induced GTP-binding protein MxAAlternative name(s): IFN-inducible antiviral protein MxA Interferon-inducible MxA protein |
Gene namesi | Name:mxa |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030721-5, mxa |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- microtubule cytoskeleton Source: GO_Central
Mitochondrion
- mitochondrial membrane Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
- postsynaptic endocytic zone membrane Source: GO_Central
Other locations
- axon Source: GO_Central
- cytoplasm Source: GO_Central
- cytoplasmic vesicle Source: GO_Central
- dendritic spine head Source: GO_Central
- membrane Source: GO_Central
- postsynaptic density Source: GO_Central
- presynapse Source: GOC
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292867 | 1 – 646 | Interferon-induced GTP-binding protein MxAAdd BLAST | 646 |
Proteomic databases
PaxDbi | Q8JH68 |
Expressioni
Inductioni
By interferons.
Interactioni
GO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000106285 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 307 | Dynamin-type GPROSITE-ProRule annotationAdd BLAST | 274 | |
Domaini | 546 – 637 | GEDPROSITE-ProRule annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 44 – 51 | G1 motifPROSITE-ProRule annotation | 8 | |
Regioni | 69 – 71 | G2 motifPROSITE-ProRule annotation | 3 | |
Regioni | 145 – 148 | G3 motifPROSITE-ProRule annotation | 4 | |
Regioni | 214 – 217 | G4 motifPROSITE-ProRule annotation | 4 | |
Regioni | 246 – 249 | G5 motifPROSITE-ProRule annotation | 4 |
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0446, Eukaryota |
InParanoidi | Q8JH68 |
PhylomeDBi | Q8JH68 |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
InterProi | View protein in InterPro IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8JH68-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKLSYTFSQ QYEEKIRPCI DTIDNLRSLG VEKDLALPAI AVIGDQSSGK
60 70 80 90 100
SSVLEALSGV PLPRGSGIVT RCPLELKMIR TKDQDRWHGR ISYKTCEEDF
110 120 130 140 150
DDPAEVEKKI RQAQDEMAGA GVGISEELIS LQITSADVPD LTLIDLPGIA
160 170 180 190 200
RVAVKGQPEN IGDQIKRLIR KFVTRQETIN LVVVPCNVDI ATTEALQMAQ
210 220 230 240 250
AEDPDGERTL GILTKPDLVD KGTEGTVVDI VHNEVIHLTK GYMIVRCRGQ
260 270 280 290 300
KEIMDQVTLN EATETESAFF KDHPHFSKLY EEGFATIPKL AEKLTIELVH
310 320 330 340 350
HIQKSLPRLE EQIETKLAET QKELEAYGNG PPSEPAARLS FFIDKVTAFN
360 370 380 390 400
QDMLNLTTGE DVKCTTDLLL FPELRQEFAK WSHILDRSGD SFNKKIEKEV
410 420 430 440 450
DNYEVKYRGR ELPGFINYKT FEGLVRDQIK LLEEPALKTL KTVSDVVRKK
460 470 480 490 500
FIQLAQCSFI GFPNLLKIAK TKIEGIKLNK ESLAESMLKT QFKMELIVYS
510 520 530 540 550
QDGTYSQSLK HAKDKLEEME KERPQPKIKL PLLSSFDLGT DNHATLREMR
560 570 580 590 600
LHLKSYYTIA SKRLADQIPM VIRYMLLQEA ALELQRNMLQ LLQDKDGVDN
610 620 630 640
LLKEDCDIGQ KRENLLSRQT RLIEGTQPLG HLLEVTFIDY CNILMQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB8JKI3 | B8JKI3_DANRE | Interferon-induced GTP-binding prot... | mxa | 632 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF533769 mRNA Translation: AAN01189.1 AJ544823 mRNA Translation: CAD67755.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF533769 mRNA Translation: AAN01189.1 AJ544823 mRNA Translation: CAD67755.1 |
3D structure databases
SMRi | Q8JH68 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000106285 |
Proteomic databases
PaxDbi | Q8JH68 |
Organism-specific databases
ZFINi | ZDB-GENE-030721-5, mxa |
Phylogenomic databases
eggNOGi | KOG0446, Eukaryota |
InParanoidi | Q8JH68 |
PhylomeDBi | Q8JH68 |
Enzyme and pathway databases
Reactomei | R-DRE-1169408, ISG15 antiviral mechanism |
Miscellaneous databases
PROi | PR:Q8JH68 |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
InterProi | View protein in InterPro IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MXA_DANRE | |
Accessioni | Q8JH68Primary (citable) accession number: Q8JH68 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families