UniProtKB - Q8JGT4 (UN5BA_XENLA)
Protein
Netrin receptor UNC5B-a
Gene
unc5b-a
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Plays a role in cell-cell adhesion during embryonic development. Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity).By similarity
GO - Molecular functioni
- netrin receptor activity Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, Receptor |
Names & Taxonomyi
Protein namesi | Recommended name: Netrin receptor UNC5B-aAlternative name(s): Protein Xunc-5 Protein unc-5 homolog-a |
Gene namesi | Name:unc5b-a |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-6046969, unc5b.L |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 31 – 380 | ExtracellularSequence analysisAdd BLAST | 350 | |
Transmembranei | 381 – 401 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 402 – 943 | CytoplasmicSequence analysisAdd BLAST | 542 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000036074 | 31 – 943 | Netrin receptor UNC5B-aAdd BLAST | 913 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 72 ↔ 133 | By similarity | ||
Disulfide bondi | 84 ↔ 131 | By similarity | ||
Disulfide bondi | 177 ↔ 228 | By similarity | ||
Glycosylationi | 225 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 261 ↔ 298 | By similarity | ||
Disulfide bondi | 265 ↔ 302 | By similarity | ||
Disulfide bondi | 276 ↔ 288 | By similarity | ||
Disulfide bondi | 317 ↔ 351 | By similarity | ||
Disulfide bondi | 321 ↔ 356 | By similarity | ||
Disulfide bondi | 329 ↔ 341 | By similarity | ||
Glycosylationi | 350 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated on cytoplasmic tyrosine residues.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | Q8JGT4 |
Expressioni
Tissue specificityi
In the developing visual system, it is expressed within the developing optic vesicles and later become restricted to the dorsal ciliary marginal zone, a site of retinoblast proliferation and differentiation.1 Publication
Interactioni
Subunit structurei
Interacts (via extracellular domain) with flrt3 (via extracellular domain).
Interacts with rnd1.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 148 | Ig-likeAdd BLAST | 98 | |
Domaini | 150 – 245 | Ig-like C2-typeAdd BLAST | 96 | |
Domaini | 249 – 303 | TSP type-1 1PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 305 – 357 | TSP type-1 2PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 542 – 685 | ZU5PROSITE-ProRule annotationAdd BLAST | 144 | |
Domaini | 863 – 941 | DeathAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 688 – 836 | UPA domainBy similarityAdd BLAST | 149 |
Sequence similaritiesi
Belongs to the unc-5 family.Curated
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd08802, Death_UNC5B, 1 hit |
Gene3Di | 2.20.100.10, 2 hits 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR042156, Death_UNC5B IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR037936, UNC5 IPR033772, UPA IPR000906, ZU5_dom |
PANTHERi | PTHR12582, PTHR12582, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF07679, I-set, 1 hit PF00090, TSP_1, 2 hits PF17217, UPA, 1 hit PF00791, ZU5, 1 hit |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00409, IG, 2 hits SM00408, IGc2, 1 hit SM00209, TSP1, 2 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48726, SSF48726, 2 hits SSF82895, SSF82895, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS50092, TSP1, 2 hits PS51145, ZU5, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8JGT4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYLSRNPSGA ALAAILVALI LSCNFPSSTA GIEYSDVLPD SFPSAPAESL
60 70 80 90 100
PHFLLEPEDA YIVKNKPVEL VCKANPATQI YFKCNGEWVN QNDHITKERV
110 120 130 140 150
DDVTGLVVRE VQIEVSRQQV EELFGLEDYW CQCVAWSSAG TTKSKRSYVR
160 170 180 190 200
IAYLRKNFDQ EPLGKEVALE QEALLQCRPP EGVPPAEVEW LKNEEIIDPT
210 220 230 240 250
KDTNFLITID HNLIIKQARL SDTANYTCVS KNIVAKRRST TATVIVFVNG
260 270 280 290 300
GWSSWTEWSP CNNRCGHGWQ KRTRTCTNPA PLNGGTMCEG QQYQKFACNT
310 320 330 340 350
MCPVDGGWTE WSKWSACSTE CTHWRSRECN APTPKNGGKD CSGMLLDSKN
360 370 380 390 400
CTDGLCMQNK RVLGETKSRL LESTGDVALY AGLVVAIFIV IILLMAVGIV
410 420 430 440 450
VYRRNCREFD TDITDSSAAL TGGFHPVNFK TSRHDNSQLI HPAMQPDLTA
460 470 480 490 500
NAGIYRGNMY ALQDSADKIP MTNSPLLDPL PNLKIKVYNS STVGSSPGIH
510 520 530 540 550
DGNNLLGTKP TGTYPSDNNI MNARNKNMSM QHLLTLPRDS SNSVTGTFGS
560 570 580 590 600
LGGRLTFPNT GVSLLIPQGA IPQGKYYEMY LMINKRENTV LPSEGTQTIL
610 620 630 640 650
SPIITCGPTG LLLCKPVILT VPHCADINTS DWILQLKTQS HQGNWEEVVT
660 670 680 690 700
LNEETLNTPC YCQLESHSCH TLLDQLGTYA FVGESYSRSA IKRLQLAIFA
710 720 730 740 750
PMLCTSLEYN LKVYCVEDTP DALKEVLELE KTLGGYLVEE PKLLMFKDSY
760 770 780 790 800
HNLRLSIHDI PHSLWRSKLM AKYQEIPFYH IWSGSQRTLH CTFTLERYSL
810 820 830 840 850
AATELTCKIC VRQVEGEGQI FQLHTLLEEN VKSFDPFCSQ AENSVTTHLG
860 870 880 890 900
PYAFKIPFSI RQKICNSLDA PNSRGNDWRL LAQKLCMDRY LNYFATKASP
910 920 930 940
TGVILDLWEA LHQDDGDLNT LASALEEMGK SEMMLVMATD GDC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY099459 mRNA Translation: AAM34486.1 |
RefSeqi | NP_001082302.1, NM_001088833.1 |
Genome annotation databases
GeneIDi | 398393 |
KEGGi | xla:398393 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY099459 mRNA Translation: AAM34486.1 |
RefSeqi | NP_001082302.1, NM_001088833.1 |
3D structure databases
SMRi | Q8JGT4 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q8JGT4 |
Genome annotation databases
GeneIDi | 398393 |
KEGGi | xla:398393 |
Organism-specific databases
CTDi | 398393 |
Xenbasei | XB-GENE-6046969, unc5b.L |
Family and domain databases
CDDi | cd08802, Death_UNC5B, 1 hit |
Gene3Di | 2.20.100.10, 2 hits 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR042156, Death_UNC5B IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR037936, UNC5 IPR033772, UPA IPR000906, ZU5_dom |
PANTHERi | PTHR12582, PTHR12582, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF07679, I-set, 1 hit PF00090, TSP_1, 2 hits PF17217, UPA, 1 hit PF00791, ZU5, 1 hit |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00409, IG, 2 hits SM00408, IGc2, 1 hit SM00209, TSP1, 2 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48726, SSF48726, 2 hits SSF82895, SSF82895, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS50092, TSP1, 2 hits PS51145, ZU5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UN5BA_XENLA | |
Accessioni | Q8JGT4Primary (citable) accession number: Q8JGT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |