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Entry version 138 (07 Oct 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Band 4.1

Gene

epb41b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-bindingARBA annotation
Biological processCell cycle, Cell division, MitosisARBA annotation, TransportARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Band 4.1ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:epb41bImported
Synonyms:epb41Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030130-1, epb41b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q8JG61

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000029019, Expressed in spleen and 29 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000039745

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 283FERMInterPro annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1200 – 1244DisorderedSequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili401 – 421Sequence analysisAdd BLAST21
Coiled coili529 – 559Sequence analysisAdd BLAST31
Coiled coili1280 – 1317Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1200 – 1232PolyampholyteSequence analysisAdd BLAST33

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3527, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155617

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_247096_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
IDDDWFQ

Database of Orthologous Groups

More...
OrthoDBi
82289at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351626

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR021187, Band_41_protein_chordates
IPR000798, Ez/rad/moesin-like
IPR014847, FERM-adjacent
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR011993, PH-like_dom_sf
IPR007477, SAB_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR23280:SF12, PTHR23280:SF12, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08736, FA, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF04382, SAB, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935, BAND41
PR00661, ERMFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM01195, FA, 1 hit
SM01196, FERM_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8JG61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQCRVNFLD DTLFTWELER DSLGQDLFNK VCEHLNLLER DYFGLVMWDS
60 70 80 90 100
PTNRVWLDCA KEIRKQIKSP VAEFFFSIKF YPPDPSILAE DITRYFLCLH
110 120 130 140 150
LRKDILIGRL PCPSDILALL GSYTVQSTLG DYDPNLHKNN YVRKIVLAPN
160 170 180 190 200
QSKELEEKVM ELHATYRFMS PAQADLLFLE NVMGLPMYGV DLHPAKDASG
210 220 230 240 250
EDVMLGVCSE GLIVYEDGVK TNSFFWPRVL KISHKRNTFL LKMRPSEEDA
260 270 280 290 300
SEGNLSFSLA NYRACKQLWK CSVEHHSFFR NRLQDTKAKR LLTLGSRFRY
310 320 330 340 350
HGRKQSECVE ASSNITRAPP RFTRYSIKRK ANEEILDVLK LPVRAEVDDW
360 370 380 390 400
FLVYGPEKWH IYTSDDVMLE SQKLQEYKHH ADDWCVLLDG SPFSLSGVQQ
410 420 430 440 450
LLQTEEQRED LETSKEKLTD EFEIKQSYQV QVVHERSDVL EKELPDYEIM
460 470 480 490 500
RNLNEELLEV GGERIQRVVM TKEWTQTQDN GEKRVERVER RVIVTNEKMV
510 520 530 540 550
GSGDTSESLE IMEQRLEKVE AIGRKLVEVE ELRVGLQEVE SLEQRLQQAE
560 570 580 590 600
KEGLQLMKKD DWYIFLDCRP LTIIETLRER PGVVRDELQQ IVYVPKPIKK
610 620 630 640 650
EDDWFILFDV HPQTTEISQL LSDVSSSIPE GAQAEEVKRE VEKIELVLPE
660 670 680 690 700
KPKTLMREET IQSRVTTEEI QKEHQEQVTV NHGRSQTAIL EQRATEPQSN
710 720 730 740 750
QEDDWFVVLD GSPKTSASTV KSTSVEFHEE TREEVIQRTE QKLQVTVQDR
760 770 780 790 800
RPQPITVEKR TTQAGDVEDD WFIIFDVSPK ETVRGPAVEV FVESREQEIQ
810 820 830 840 850
SRVRKEERVI EVMTVSTREQ ITVPETKRIS VTQIPQFPVE PRDIDDDWFQ
860 870 880 890 900
LFDKVLYEEE SFPSVRGSAV EVFVESREQE IQSRVRKEER VIEVTTVSTR
910 920 930 940 950
EQITVPETKR ISVTQIPQFP VESRDIDDDW FQLFDKVLYE EESFPSVQGP
960 970 980 990 1000
AVEVFVESRE QEIQSRVRKE ERVIEVMTVG TREQITVPET KRISVTQIPQ
1010 1020 1030 1040 1050
FPVEPRDIDD DWFQLFDKVP YEEESFPSVQ GPAVFVESRE QQIESRVRKE
1060 1070 1080 1090 1100
ERVIKVMTVS TREQITVTKR ISVTQIPQFP VEPRDIDDDW FQLFDKVPYE
1110 1120 1130 1140 1150
KESFPSDIRS REFELRESKD QRVQRVVEEQ FREKRLIAEE RRVSIDERRK
1160 1170 1180 1190 1200
AAEVLPQMIP VEVREVDNDW FELLDQTSYQ KRSVPSVSVV SEERRIKEQE
1210 1220 1230 1240 1250
DRRVRQQQMR GREEEEERRL RKPEKPKQEL EARRAQPSIT VATHSQPQIE
1260 1270 1280 1290 1300
DDWFILFDVL PKETVVADVL KVERMAEEQK GRVEERKWIL EEERRKLEEE
1310 1320 1330 1340 1350
RRLLEKERRR REEEMWRREE EKRIQIKAEE RLKRAAVSEE RAVQLQTEVE
1360 1370 1380 1390 1400
DDWYMLMGIT LKDYIPSAPS TPVISPVSLP KLRPQIPVDQ PLTSTPTAQS
1410 1420 1430 1440 1450
ASITKTYKER TKDILDITVE SEAETESSLM RRTWTKKTEG ESIYVRHSIL
1460 1470 1480 1490 1500
MLEDLDVSQE MIMKHHASVT ELKRVFMEVK DDFGPTEWDR RLSSYSPTLK
1510 1520 1530
PQLPHANGEI LVKMGLMDEN GKTILLRTQE EIFA
Length:1,534
Mass (Da):180,267
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37FA6146DA30BE61
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX571761 Genomic DNA No translation available.
CR391910 Genomic DNA No translation available.
BC162616 mRNA Translation: AAI62616.1
AY124488 mRNA Translation: AAM94025.1

NCBI Reference Sequences

More...
RefSeqi
NP_778259.1, NM_175084.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000039746; ENSDARP00000039745; ENSDARG00000029019

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
326287

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:326287

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571761 Genomic DNA No translation available.
CR391910 Genomic DNA No translation available.
BC162616 mRNA Translation: AAI62616.1
AY124488 mRNA Translation: AAM94025.1
RefSeqiNP_778259.1, NM_175084.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000039745

Proteomic databases

PRIDEiQ8JG61

Genome annotation databases

EnsembliENSDART00000039746; ENSDARP00000039745; ENSDARG00000029019
GeneIDi326287
KEGGidre:326287

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
326287
ZFINiZDB-GENE-030130-1, epb41b

Phylogenomic databases

eggNOGiKOG3527, Eukaryota
GeneTreeiENSGT00940000155617
HOGENOMiCLU_247096_0_0_1
OMAiIDDDWFQ
OrthoDBi82289at2759
TreeFamiTF351626

Gene expression databases

BgeeiENSDARG00000029019, Expressed in spleen and 29 other tissues

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR021187, Band_41_protein_chordates
IPR000798, Ez/rad/moesin-like
IPR014847, FERM-adjacent
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR011993, PH-like_dom_sf
IPR007477, SAB_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR23280:SF12, PTHR23280:SF12, 5 hits
PfamiView protein in Pfam
PF08736, FA, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF04382, SAB, 1 hit
PRINTSiPR00935, BAND41
PR00661, ERMFAMILY
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM01195, FA, 1 hit
SM01196, FERM_C, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8JG61_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8JG61
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 7, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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