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UniProtKB - Q8JFV8 (VAT1_DANRE)
Protein
Synaptic vesicle membrane protein VAT-1 homolog
Gene
vat1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- oxidoreductase activity Source: UniProtKB-KW
- zinc ion binding Source: InterPro
GO - Biological processi
- negative regulation of mitochondrial fusion Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Enzyme and pathway databases
Reactomei | R-DRE-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:vat1Imported ORF Names:si:dz163l24.2 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030616-178, vat1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160920 | 1 – 484 | Synaptic vesicle membrane protein VAT-1 homologAdd BLAST | 484 |
Proteomic databases
PaxDbi | Q8JFV8 |
Expressioni
Developmental stagei
First detected at the 8-somite stage in the trigeminal nuclei. At the 10-somite stage, also expressed in the forming hindbrain and in the neural tube. By the 20-somite stage, expression has extended to the dorsorostral, ventrorostral and ventrocaudal neuron clusters, the epiphysis and the hindbrain. At 24 hours post-fertilization (hpf), detected in the developing gut. At later stages, expression is lost from the neural tube but continues in the brain and also appears in the retina and pharyngeal cavity.1 Publication
Gene expression databases
Bgeei | ENSDARG00000056481, Expressed in multi-cellular organism and 42 other tissues |
Interactioni
Protein-protein interaction databases
IntActi | Q8JFV8, 1 interactor |
MINTi | Q8JFV8 |
STRINGi | 7955.ENSDARP00000073439 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 65 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 402 – 484 | DisorderedSequence analysisAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 409 – 484 | Basic and acidic residuesSequence analysisAdd BLAST | 76 |
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.Sequence analysis
Phylogenomic databases
eggNOGi | KOG1197, Eukaryota |
GeneTreei | ENSGT00940000157579 |
HOGENOMi | CLU_026673_3_1_1 |
InParanoidi | Q8JFV8 |
OMAi | WGLYNTK |
PhylomeDBi | Q8JFV8 |
TreeFami | TF314255 |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8JFV8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGEDAPAQQ QNAEEQKQQE TKTPAESPKT ESKPDPPPTS ASTEAAATAA
60 70 80 90 100
AAADTPAPAA EKAPEEDTFT YRALVLTGYG GYDKVKLQVK KGKPALKSGE
110 120 130 140 150
VMVRVKMCGL NFADLMARQG LYDRLPSPPV TPGMECSGVI EAVGEEVTDR
160 170 180 190 200
KVGDKVLVLN RSGMWQEVVV VASTHTFLMP EGMSFEEAAA LPVNYITAYM
210 220 230 240 250
MLFDFGHLRP NQSVLVHMAA GGVGIAATQL CKTVNDVTVF GTASASKHEV
260 270 280 290 300
ISQGGVTHPI DYRTRDYVEE VRKISPKGLD IVLDPLGGSD THKGYNLLKP
310 320 330 340 350
MGKLISYGAA NMLAGQKKNL FAVAKTWYQQ FSVHTLSLIQ GNRSVCGFHL
360 370 380 390 400
GYLDSETELI DQAMTAVMDL YRQGKVKPRI DSTYHLEQVG DAMRRMQERN
410 420 430 440 450
NIGKIILTTE PMKEEEKKEE AKKDEEKKDD KKKDDKKKDD KKKEDKKKDE
460 470 480
AKKEEKKDEK KKEEAKKDDK KAEEKKEEVK KEEN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 355 | S → C in AAS37669 (PubMed:15533823).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY534888 mRNA Translation: AAS37669.1 AL591669 Genomic DNA Translation: CAD43425.1 BC066463 mRNA Translation: AAH66463.1 |
Genome annotation databases
Ensembli | ENSDART00000078982; ENSDARP00000073439; ENSDARG00000056481 ENSDART00000193837; ENSDARP00000147945; ENSDARG00000111382 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY534888 mRNA Translation: AAS37669.1 AL591669 Genomic DNA Translation: CAD43425.1 BC066463 mRNA Translation: AAH66463.1 |
3D structure databases
SMRi | Q8JFV8 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8JFV8, 1 interactor |
MINTi | Q8JFV8 |
STRINGi | 7955.ENSDARP00000073439 |
Proteomic databases
PaxDbi | Q8JFV8 |
Genome annotation databases
Ensembli | ENSDART00000078982; ENSDARP00000073439; ENSDARG00000056481 ENSDART00000193837; ENSDARP00000147945; ENSDARG00000111382 |
Organism-specific databases
ZFINi | ZDB-GENE-030616-178, vat1 |
Phylogenomic databases
eggNOGi | KOG1197, Eukaryota |
GeneTreei | ENSGT00940000157579 |
HOGENOMi | CLU_026673_3_1_1 |
InParanoidi | Q8JFV8 |
OMAi | WGLYNTK |
PhylomeDBi | Q8JFV8 |
TreeFami | TF314255 |
Enzyme and pathway databases
Reactomei | R-DRE-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:Q8JFV8 |
Gene expression databases
Bgeei | ENSDARG00000056481, Expressed in multi-cellular organism and 42 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR002364, Quin_OxRdtase/zeta-crystal_CS |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS01162, QOR_ZETA_CRYSTAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VAT1_DANRE | |
Accessioni | Q8JFV8Primary (citable) accession number: Q8JFV8 Secondary accession number(s): Q5SF06, Q6NYU0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families