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Protein

Tyrosine-protein phosphatase

Gene

ptpn4a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei813SubstrateUniRule annotation1
Active sitei845Phosphocysteine intermediateUniRule annotation1
Binding sitei889SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:ptpn4aImported
Synonyms:ptpn4Imported
ORF Names:dZ37O5.1-001Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-030616-449 ptpn4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8JFS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 312FERMInterPro annotationAdd BLAST284
Domaini515 – 587PDZInterPro annotationAdd BLAST73
Domaini653 – 904Tyrosine-protein phosphataseInterPro annotationAdd BLAST252
Domaini824 – 895TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni845 – 851Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410KDUQ Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118823
HOVERGENiHBG008322
KOiK18037

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8JFS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARFRLPAG RSYNVRTTEL ARDRQRTEVV CNILLLDNTV QPFKVNKHDQ
60 70 80 90 100
GQILLDAVFK HLELTERDYF GLHLADEPSD SPRWLDPNKP IRKQLKRGSP
110 120 130 140 150
HHLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILSGRLP CPHNTAALLA
160 170 180 190 200
SYAVQSELGD YSEAENLPGY LSEFFFIPNQ PQGFEKDVAK HHQQHNGLNP
210 220 230 240 250
AQSEFNYLNT ARTLDLYGVE LHYARDQSNT EIYVGVLSAG IGIYKNRVRI
260 270 280 290 300
NYFPWLKIVK ISFKCKQFFI QLRKEAHDTR DTLLGFNMVN YRACKNLWKT
310 320 330 340 350
CVEHHTFFRL DRPVPPQKNF FAHYFSLGSR FRYCGRTEAQ SVQYGKEKGI
360 370 380 390 400
KDRVFASKPL ARKLMGVTDW EAVSRNSLSE ERLETRSLPT RSPPGTPNHN
410 420 430 440 450
SLFVQEGPRL RPSSMGHLVD HVIHASPSLP VFSNHKSASS TQANSISLES
460 470 480 490 500
TPSPEGVEGP PPALPPKQSR KNLSQLILSH SQQDLDNHIN EMYDVPTATD
510 520 530 540 550
KVMPNGVVPH DNLVLIKMKP DENGRFGFNV KGGSDQKMPI IVSRVAPGTS
560 570 580 590 600
ADLCVPRLNE GDQVVLINGR EIAEHSHDQV VMFIKASCES HSGELILLVR
610 620 630 640 650
PNAIYDVVEE KLETEPDFQY IPEKSPTDPS HLDQDAWRDS MLYLKEGLNS
660 670 680 690 700
GTILAQFDQL YRKRPGMTMS CAKLPQNISK NRYRDISPYD ATRVILKGTE
710 720 730 740 750
DYINANYINM EIPACSLINR YIACQGPLPN TCSDFWQMTW EQGSSMVVML
760 770 780 790 800
TTQVKCHQYW PNPSGSATYG GFQISCQTEE GNSAFLVREI TLTHIESGES
810 820 830 840 850
RELTQIQYLA WPDHGVPDDS TDFLDFVALV RNKRAGKDEP VVVHCSAGIG
860 870 880 890 900
RTGVLITMET AMCLMECSQP VFPLEIVRTM RDQRAMMIQT PSQFKFVCEA
910 920
ILKVYEEGLV KPLKSILYES N
Length:921
Mass (Da):104,670
Last modified:October 1, 2002 - v1
Checksum:i6CA7608EF99F9DAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294374 Genomic DNA No translation available.
CR853293 Genomic DNA No translation available.
FP103048 Genomic DNA No translation available.
AL672097 Genomic DNA Translation: CAD43435.2
RefSeqiNP_001007201.1, NM_001007200.1
UniGeneiDr.96224

Genome annotation databases

EnsembliENSDART00000183391; ENSDARP00000152804; ENSDARG00000000631
GeneIDi368448
KEGGidre:368448

Similar proteinsi

Entry informationi

Entry nameiQ8JFS7_DANRE
AccessioniPrimary (citable) accession number: Q8JFS7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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