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Protein

Endo-1,4-beta-xylanase B

Gene

xynB

Organism
Talaromyces funiculosus (Fruitlet core rot fungus) (Penicillium funiculosum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.2 Publications

Activity regulationi

Significantly inhibited by the wheat xylanase inhibiting protein I (XIP-I) and the proteinaceous endoxylanase Triticum aestivum xylanase inhibitors I (TAXI-I), but not TAXI-II.2 Publications

Kineticsi

  1. KM=22 mg/ml for birchwood xylan2 Publications
  2. KM=29 mg/ml for insoluble fractions of wheat arabinoxylans2 Publications
  1. Vmax=506 µmol/min/mg enzyme toward birchwood xylan2 Publications
  2. Vmax=1080 µmol/min/mg enzyme toward insoluble fractions of wheat arabinoxylans2 Publications

pH dependencei

Optimum pH is 3.7-4.7 for birchwood xylan.2 Publications

Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei117NucleophilePROSITE-ProRule annotation1
Active sitei206Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

BRENDAi3.2.1.8 4616
UniPathwayi
UPA00114

Protein family/group databases

CAZyiCBM1 Carbohydrate-Binding Module Family 1
GH11 Glycoside Hydrolase Family 11
mycoCLAPiXYN11B_PENFN

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase B (EC:3.2.1.8)
Short name:
Xylanase B
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase B
Gene namesi
Name:xynB
OrganismiTalaromyces funiculosus (Fruitlet core rot fungus) (Penicillium funiculosum)
Taxonomic identifieri28572 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaeTalaromyces

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 391 PublicationAdd BLAST39
ChainiPRO_500006859340 – 282Endo-1,4-beta-xylanase BAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8J0K5
SMRiQ8J0K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 219GH11PROSITE-ProRule annotationAdd BLAST180
Domaini246 – 282CBM1PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi227 – 232Poly-Thr6

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.120.180, 1 hit
InterProiView protein in InterPro
IPR035971 CBD_sf
IPR000254 Cellulose-bd_dom_fun
IPR013320 ConA-like_dom_sf
IPR013319 GH11/12
IPR018208 GH11_AS_1
IPR033123 GH11_dom
IPR001137 Glyco_hydro_11
PfamiView protein in Pfam
PF00734 CBM_1, 1 hit
PF00457 Glyco_hydro_11, 1 hit
PRINTSiPR00911 GLHYDRLASE11
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001821 CBD_fun, 1 hit
SMARTiView protein in SMART
SM00236 fCBD, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57180 SSF57180, 1 hit
PROSITEiView protein in PROSITE
PS00562 CBM1_1, 1 hit
PS51164 CBM1_2, 1 hit
PS00776 GH11_1, 1 hit
PS51761 GH11_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8J0K5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGISSILLSA LIAGGALALP AAEPVSFDIR DENITLARRA EAINYNQDYI
60 70 80 90 100
ASGANVQYSP NMAAGSFSIN YNTQGDFVVG LGWQPGDANP ITYSGSFSAS
110 120 130 140 150
GVGILAVYGW STNPLVEYYV MEVHDGYQTA GTHKGTVTTD GGTYDIWEHQ
160 170 180 190 200
QVNQPSILGT STFNQYISIR QSPRTSGTVT VQNHFNAWAQ AGMNLGTLNY
210 220 230 240 250
QVMAVESWSG SGSGQISLSK GTGGGSTTTT PTGPTSTSTA PSSGGTGAAQ
260 270 280
WGQCGGIGWT GPTTCVAPYT CKYENAYYSQ CQ
Length:282
Mass (Da):29,475
Last modified:March 1, 2003 - v1
Checksum:i1ABD021D46A8F614
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ489605 Genomic DNA Translation: CAD33900.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ489605 Genomic DNA Translation: CAD33900.1

3D structure databases

ProteinModelPortaliQ8J0K5
SMRiQ8J0K5
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM1 Carbohydrate-Binding Module Family 1
GH11 Glycoside Hydrolase Family 11
mycoCLAPiXYN11B_PENFN

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00114

BRENDAi3.2.1.8 4616

Family and domain databases

Gene3Di2.60.120.180, 1 hit
InterProiView protein in InterPro
IPR035971 CBD_sf
IPR000254 Cellulose-bd_dom_fun
IPR013320 ConA-like_dom_sf
IPR013319 GH11/12
IPR018208 GH11_AS_1
IPR033123 GH11_dom
IPR001137 Glyco_hydro_11
PfamiView protein in Pfam
PF00734 CBM_1, 1 hit
PF00457 Glyco_hydro_11, 1 hit
PRINTSiPR00911 GLHYDRLASE11
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001821 CBD_fun, 1 hit
SMARTiView protein in SMART
SM00236 fCBD, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57180 SSF57180, 1 hit
PROSITEiView protein in PROSITE
PS00562 CBM1_1, 1 hit
PS51164 CBM1_2, 1 hit
PS00776 GH11_1, 1 hit
PS51761 GH11_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXYNB_TALFU
AccessioniPrimary (citable) accession number: Q8J0K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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