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Protein

Alternative oxidase, mitochondrial

Gene

AOX

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures (By similarity).By similarity

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi157Iron 1By similarity1
Metal bindingi196Iron 1By similarity1
Metal bindingi196Iron 2By similarity1
Metal bindingi199Iron 1; via pros nitrogenBy similarity1
Metal bindingi247Iron 2By similarity1
Metal bindingi301Iron 1By similarity1
Metal bindingi301Iron 2By similarity1
Metal bindingi304Iron 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alternative oxidase, mitochondrial (EC:1.-.-.-)
Gene namesi
Name:AOX
Ordered Locus Names:YALI0E00814g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000001729? – 353Alternative oxidase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_503388.1

Family & Domainsi

Sequence similaritiesi

Belongs to the alternative oxidase family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000178442
InParanoidiQ8J0I8
OMAiPSTCHRF
OrthoDBiEOG092C366X

Family and domain databases

CDDicd01053 AOX, 1 hit
Gene3Di1.20.1260.140, 1 hit
InterProiView protein in InterPro
IPR002680 AOX
IPR038659 AOX_sf
PANTHERiPTHR31803 PTHR31803, 1 hit
PfamiView protein in Pfam
PF01786 AOX, 1 hit
PIRSFiPIRSF005229 AOX, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8J0I8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVRDWANRG QTYVNARAPN LLGRFRSTDD EDENNPSTEL ATDTTSAYGS
60 70 80 90 100
TAASVVTMAN SKPDDVSLYA TSSHHHEYFT GSAWIHPVYT KEQMDALEVN
110 120 130 140 150
HRKTETFSDR VALRAILLMR IIFDLCTGYK HPKEGEAHLP KFRMTTRQWL
160 170 180 190 200
DRFLFLESIA GVPGMVAGMI RHLHSLRALR RDRAWIESLV EEAYNERMHL
210 220 230 240 250
LTFLKLQKPS VQMRTGLLIG QIIFYNLFFI SYLISPATCH RFVGYLEEEA
260 270 280 290 300
VITYTRCLED IDAGRLPELA SMEVPDIART YWHMEDDCTM RDLIQYVRAD
310 320 330 340 350
EAKHCEVNHT FGNLHQTSDR NPFALVIDNG RPQPSKDLTT FRSVGWRRDE

IAN
Length:353
Mass (Da):40,652
Last modified:March 1, 2003 - v1
Checksum:i0711E211A020BB48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428416 Genomic DNA Translation: CAD21442.1
CR382131 Genomic DNA Translation: CAG78967.1
RefSeqiXP_503388.1, XM_503388.1

Genome annotation databases

EnsemblFungiiCAG78967; CAG78967; YALI0_E00814g
GeneIDi2912419
KEGGiyli:YALI0E00814g

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428416 Genomic DNA Translation: CAD21442.1
CR382131 Genomic DNA Translation: CAG78967.1
RefSeqiXP_503388.1, XM_503388.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4952.XP_503388.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG78967; CAG78967; YALI0_E00814g
GeneIDi2912419
KEGGiyli:YALI0E00814g

Phylogenomic databases

HOGENOMiHOG000178442
InParanoidiQ8J0I8
OMAiPSTCHRF
OrthoDBiEOG092C366X

Family and domain databases

CDDicd01053 AOX, 1 hit
Gene3Di1.20.1260.140, 1 hit
InterProiView protein in InterPro
IPR002680 AOX
IPR038659 AOX_sf
PANTHERiPTHR31803 PTHR31803, 1 hit
PfamiView protein in Pfam
PF01786 AOX, 1 hit
PIRSFiPIRSF005229 AOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAOX_YARLI
AccessioniPrimary (citable) accession number: Q8J0I8
Secondary accession number(s): Q6C7H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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