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UniProtKB - Q8J0F5 (MLCB_PENCI)

Entry version 106 (02 Dec 2020)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Compactin diketide synthase mlcB

Gene

mlcB

Organism
Penicillium citrinum
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Diketide synthase; part of the gene cluster that mediates the biosynthesis of compactin, also known as mevastatin or ML-236B, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:12172803, PubMed:12242508). Compactin biosynthesis is performed in two stages (PubMed:12172803). The first stage is catalyzed by the nonaketide synthase mlcA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:12172803). This PKS stage is completed by the action of dehydrogenase mlcG, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mlcA-mediated biosynthesis of the nonaketide chain and leads to dihydro-ML-236C carboxylate (PubMed:12172803). Covalently bound dihydro-ML-236C carboxylate is released from mlcA by the mlcF esterase (PubMed:12172803). Conversion of dihydro-ML-236C carboxylate into ML-236A carboxylate is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mlcC (PubMed:12172803). Finally, mlcH performs the conversion of ML-236A carboxylate to ML-236B/compactin carboxylate through the addition of the side-chain diketide moiety produced by the diketide synthase mlcB (PubMed:12172803).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Polyketide biosynthesis

This protein is involved in Polyketide biosynthesis.Curated
View all proteins of this organism that are known to be involved in Polyketide biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei202For beta-ketoacyl synthase activityPROSITE-ProRule annotation1
Active sitei658For malonyltransferase activityPROSITE-ProRule annotation1
Active sitei998For beta-hydroxyacyl dehydratase activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Methyltransferase, Multifunctional enzyme, Oxidoreductase, Transferase
LigandNADP, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Compactin diketide synthase mlcB1 Publication (EC:2.3.1.2441 Publication)
Alternative name(s):
Compactin biosynthesis protein B1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mlcB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPenicillium citrinum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5077 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Penicillium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Compactin (also known as mevastatin or ML-236B) and the intermediary metabolites Ml-236C and ML-236A are inhibitors of HMG-CoA reductase involved in cholesterogenesis (PubMed:1010803). Their hypocholesterolemic activity might be useful for lowering cholesterol levels in the blood and reduce artherosclerosis and coronary heart disease (PubMed:1010803).1 Publication

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impairs the production of compactin and leads to the accumulation of the ML-236A intermediate (PubMed:12172803).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004362821 – 2563Compactin diketide synthase mlcBAdd BLAST2563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2522O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced at the beginning of the stationary phase, which is consistent with the timing of compactin production (PubMed:12172803). Expression is controlled by the ML-236B/compactin cluster transcription regulator mlcR (PubMed:12436257).2 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8J0F5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2485 – 2562CarrierPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 452Beta-ketoacyl synthaseBy similarityAdd BLAST431
Regioni568 – 915Acyl and malonyl transferaseBy similarityAdd BLAST348
Regioni998 – 1010Dehydratase-likeBy similarityAdd BLAST13
Regioni1542 – 1579MethyltransferaseBy similarityAdd BLAST38

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR013149, ADH_C
IPR011032, GroES-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR013217, Methyltransf_12
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR029063, SAM-dependent_MTases
IPR016039, Thiolase-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF00107, ADH_zinc_N, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF08242, Methyltransf_12, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00827, PKS_AT, 1 hit
SM00826, PKS_DH, 1 hit
SM00829, PKS_ER, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53335, SSF53335, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit
PS00012, PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8J0F5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNTPAVTAT ATATATATAM AGSACSNTST PIAIVGMGCR FAGDATSPQK 
        60         70         80         90        100
LWEMVERGGS AWSKVPSSRF NVRGVYHPNG ERVGSTHVKG GHFIDEDPAL 
       110        120        130        140        150
FDAAFFNMTT EVASCMDPQY RLMLEVVYES LESAGITIDG MAGSNTSVFG 
       160        170        180        190        200
GVMYHDYQDS LNRDPETVPR YFITGNSGTM LSNRISHFYD LRGPSVTVDT 
       210        220        230        240        250
ACSTTLTALH LACQSLRTGE SDTAIVIGAN LLLNPDVFVT MSNLGFLSPD 
       260        270        280        290        300
GISYSFDPRA NGYGRGEGIA ALVIKALPNA LRDQDPIRAV IRETALNQDG 
       310        320        330        340        350
KTPAITAPSD VAQKSLIQEC YDKAGLDMSL TSYVEAHGTG TPTGDPLEIS 
       360        370        380        390        400
AISAAFKGHP LHLGSVKANI GHTEAASGLA SIIKVALALE KGLIPPNARF 
       410        420        430        440        450
LQKNSKLMLD QKNIKIPMSA QDWPVKDGTR RASVNNFGFG GSNAHVILES 
       460        470        480        490        500
YDRASLALPE DQVHVNGNSE HGRVEDGSKQ SRIYVVRAKD EQACRRTIAS 
       510        520        530        540        550
LRDYIKSVAD IDGEPFLASL AYTLGSRRSI LPWTSVYVAD SLGGLVSALS 
       560        570        580        590        600
DESNQPKRAN EKVRLGFVFT GQGAQWHAMG RELVNTFPVF KQAILECDGY 
       610        620        630        640        650
IKQLGASWNF MEELHRDELT TRVNDAEYSL PLSTAIQIAL VRLLWSWGIR 
       660        670        680        690        700
PTGITSHSSG EAAAAYAAGA LSARSAIGIT YIRGVLTTKP KPALAAKGGM 
       710        720        730        740        750
MAVGLGRSET NVYISRLNQE DGCVVVGCIN SQCSVTVSGD LGAIEKLEKL 
       760        770        780        790        800
LHADGIFTRK LKVTEAFHSS HMRPMADAFG ASLRDLFNSD NNNDNPNADT 
       810        820        830        840        850
SKGVLYSSPK TGSRMTDLKL LLDPTHWMDS MLQPVEFESS LREMCFDPNT 
       860        870        880        890        900
KEKAVDVIIE IGPHGALGGP INQVMQDLGL KGTDINYLSC LSRGRSSLET 
       910        920        930        940        950
MYRAATELIS KGYGLKMDAI NFPHGRKEPR VKVLSDLPAY PWNHQTRYWR 
       960        970        980        990       1000
EPRGSRESKQ RTHPPHTLIG SRESLSPQFA PKWKHVLRLS DIPWIRDHVV 
      1010       1020       1030       1040       1050
GSSIIFPGAG FISMAIEGFS QVCPPVAGAS INYNLRDVEL AQALIIPADA 
      1060       1070       1080       1090       1100
EAEVDLRLTI RSCEERSLGT KNWHQFSVHS ISGENNTWTE HCTGLIRSES 
      1110       1120       1130       1140       1150
ERSHLDCSTV EASRRLNLGS DNRSIDPNDL WESLHANGIC HGPIFQNIQR 
      1160       1170       1180       1190       1200
IQNNGQGSFC RFSIADTASA MPHSYENRHI VHPTTLDSVI QAAYTVLPYA 
      1210       1220       1230       1240       1250
GTRMKTAMVP RRLRNVKISS SLADLEAGDA LDAQASIKDR NSQSFSTDLA 
      1260       1270       1280       1290       1300
VFDDYDSGSS PSDGIPVIEI EGLVFQSVGS SFSDQKSDSN DTENACSSWV 
      1310       1320       1330       1340       1350
WAPDISLGDS TWLKEKLSTE AETKETELMM DLRRCTINFI QEAVTDLTNS 
      1360       1370       1380       1390       1400
DIQHLDGHLQ KYFDWMNVQL DLARQNKLSP ASCDWLSDDA EQKKCLQARV 
      1410       1420       1430       1440       1450
AGESVNGEMI SRLGPQLIAM LRRETEPLEL MMQDQLLSRY YVNAIKWSRS 
      1460       1470       1480       1490       1500
NAQASELIRL CAHKNPRSRI LEIGGGTGGC TKLIVNALGN TKPIDRYDFT 
      1510       1520       1530       1540       1550
DVSAGFFESA REQFADWQDV MTFKKLDIES DPEQQGFECA TYDVVVACQV 
      1560       1570       1580       1590       1600
LHATRCMKRT LSNVRKLLKP GGNLILVETT RDQLDLFFTF GLLPGWWLSE 
      1610       1620       1630       1640       1650
EPERKSTPSL TTDLWNTMLD TSGFNGVELE VRDCEDDEFY MISTMLSTAR 
      1660       1670       1680       1690       1700
KENTTPDTVA ESEVLLLHGA LRPPSSWLES LQAAICEKTS SSPSINALGE 
      1710       1720       1730       1740       1750
VDTTGRTCIF LGEMESSLLG EVGSETFKSI TAMLNNCNAL LWVSRGAAMS 
      1760       1770       1780       1790       1800
SEDPWKALHI GLLRTIRNEN NGKEYVSLDL DPSRNAYTHE SLYAICNIFN 
      1810       1820       1830       1840       1850
GRLGDLSEDK EFEFAERNGV IHVPRLFNDP HWKDQEAVEV TLQPFEQPGR 
      1860       1870       1880       1890       1900
RLRMEVETPG LLDSLQFRDD EGREGKDLPD DWVEIEPKAF GLNFRDVMVA 
      1910       1920       1930       1940       1950
MGQLEANRVM GFECAGVITK LGGAAAASQG LRLGDRVCAL LKGHWATRTQ 
      1960       1970       1980       1990       2000
TPYTNVVRIP DEMGFPEAAS VPLAFTTAYI ALYTTAKLRR GERVLIHSGA 
      2010       2020       2030       2040       2050
GGVGQAAIIL SQLAGAEVFV TAGTQAKRDF VGDKFGINPD HIFSSRNDLF 
      2060       2070       2080       2090       2100
VDGIKAYTGG LGVHVVLNSL AGQLLQASFD CMAEFGRFVE IGKKDLEQNS 
      2110       2120       2130       2140       2150
RLDMLPFTRD VSFTSIDLLS WQRAKSEEVS EALNHVTKLL ETKAIGLIGP 
      2160       2170       2180       2190       2200
IQQHSLSNIE KAFRTMQSGQ HVGKVVVNVS GDELVPVGDG GFSLKLKPDS 
      2210       2220       2230       2240       2250
SYLVAGGLGG IGKQICQWLV DHGAKHLIIL SRSAKASPFI TSLQNQQCAV 
      2260       2270       2280       2290       2300
YLHACDISDQ DQVTKVLRLC EEAHAPPIRG IIQGAMVLKD ALLSRMTLDE 
      2310       2320       2330       2340       2350
FNAATRPKVQ GSWYLHKIAQ DVDFFVMLSS LVGVMGGAGQ ANYAAAGAFQ 
      2360       2370       2380       2390       2400
DALAHHRRAH GMPAVTIDLG MVKSVGYVAE TGRGVADRLA RIGYKPMHEK 
      2410       2420       2430       2440       2450
DVMDVLEKAI LCSSPQFPSP PAAVVTGINT SPGAHWTEAN WIQEQRFVGL 
      2460       2470       2480       2490       2500
KYRQVLHADQ SFVSSHKKGP DGVRAQLSRV TSHDEAISIV LKAMTEKLMR 
      2510       2520       2530       2540       2550
MFGLAEDDMS SSKNLAGVGV DSLVAIELRN WITSEIHVDV SIFELMNGNT 
      2560 
IAGLVELVVA KCS
Length:2,563
Mass (Da):280,159
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i304BFF399BFBFEFC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB072893 Genomic DNA Translation: BAC20566.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072893 Genomic DNA Translation: BAC20566.1

3D structure databases

SMRiQ8J0F5
ModBaseiSearch...

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.10.129.110, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227, Ac_transferase_dom_sf
IPR036736, ACP-like_sf
IPR014043, Acyl_transferase
IPR016035, Acyl_Trfase/lysoPLipase
IPR013149, ADH_C
IPR011032, GroES-like_sf
IPR018201, Ketoacyl_synth_AS
IPR014031, Ketoacyl_synth_C
IPR014030, Ketoacyl_synth_N
IPR016036, Malonyl_transacylase_ACP-bd
IPR013217, Methyltransf_12
IPR036291, NAD(P)-bd_dom_sf
IPR032821, PKS_assoc
IPR020841, PKS_Beta-ketoAc_synthase_dom
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR029063, SAM-dependent_MTases
IPR016039, Thiolase-like
PfamiView protein in Pfam
PF00698, Acyl_transf_1, 1 hit
PF00107, ADH_zinc_N, 1 hit
PF16197, KAsynt_C_assoc, 1 hit
PF00109, ketoacyl-synt, 1 hit
PF02801, Ketoacyl-synt_C, 1 hit
PF08659, KR, 1 hit
PF08242, Methyltransf_12, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
SMARTiView protein in SMART
SM00827, PKS_AT, 1 hit
SM00826, PKS_DH, 1 hit
SM00829, PKS_ER, 1 hit
SM00825, PKS_KS, 1 hit
SM00823, PKS_PP, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF52151, SSF52151, 1 hit
SSF53335, SSF53335, 1 hit
SSF53901, SSF53901, 1 hit
SSF55048, SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00606, B_KETOACYL_SYNTHASE, 1 hit
PS50075, CARRIER, 1 hit
PS00012, PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLCB_PENCI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8J0F5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: March 1, 2003
Last modified: December 2, 2020
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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