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UniProtKB - Q8IZY5 (BLID_HUMAN)
Protein
BH3-like motif-containing cell death inducer
Gene
BLID
Organism
Homo sapiens (Human)
Status
Functioni
Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death.
1 PublicationGO - Biological processi
- apoptotic process Source: UniProtKB-KW
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q8IZY5 |
SignaLinki | Q8IZY5 |
Names & Taxonomyi
Protein namesi | Recommended name: BH3-like motif-containing cell death inducerAlternative name(s): Breast cancer cell protein 2 |
Gene namesi | Name:BLID Synonyms:BRCC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33495, BLID |
MIMi | 608853, gene |
neXtProti | NX_Q8IZY5 |
VEuPathDBi | HostDB:ENSG00000259571 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Lower abundance in mitochondrion than in cytoplasm.
Cytosol
- cytosol Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 5 | L → E: Fails to induce apoptosis. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 414899 |
OpenTargetsi | ENSG00000259571 |
PharmGKBi | PA162377555 |
Miscellaneous databases
Pharosi | Q8IZY5, Tbio |
Genetic variation databases
BioMutai | BLID |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000301669 | 1 – 108 | BH3-like motif-containing cell death inducerAdd BLAST | 108 |
Proteomic databases
PaxDbi | Q8IZY5 |
PeptideAtlasi | Q8IZY5 |
PRIDEi | Q8IZY5 |
ProteomicsDBi | 71443 |
PTM databases
iPTMneti | Q8IZY5 |
PhosphoSitePlusi | Q8IZY5 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000259571, Expressed in corpus callosum and 42 other tissues |
Genevisiblei | Q8IZY5, HS |
Organism-specific databases
HPAi | ENSG00000259571, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 136097, 11 interactors |
IntActi | Q8IZY5, 9 interactors |
MINTi | Q8IZY5 |
STRINGi | 9606.ENSP00000453153 |
Miscellaneous databases
RNActi | Q8IZY5, protein |
Structurei
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 5 – 12 | BH3-like | 8 |
Phylogenomic databases
eggNOGi | ENOG502TGWD, Eukaryota |
GeneTreei | ENSGT00520000061087 |
HOGENOMi | CLU_2202905_0_0_1 |
InParanoidi | Q8IZY5 |
OMAi | KEPMLPK |
OrthoDBi | 1579454at2759 |
i Sequence
Sequence statusi: Complete.
Q8IZY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVTLLPIEGQ EIHFFEILES ECVLYTGWIE RASGSSIYPE AKARLPLEAL
60 70 80 90 100
LGSNKEPMLP KETVLSLKRY NLGSSAMKRN VPGHVLQRPS YLTRIQVTLL
CNSSAEAL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | I → V in AAN31127 (PubMed:15069058).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056750 | 76 | A → D. Corresponds to variant dbSNP:rs7116084Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF303179 mRNA Translation: AAN31127.1 BC130361 mRNA Translation: AAI30362.1 BC130363 mRNA Translation: AAI30364.1 |
CCDSi | CCDS31693.1 |
RefSeqi | NP_001001786.2, NM_001001786.2 |
Genome annotation databases
Ensembli | ENST00000560104; ENSP00000453153; ENSG00000259571 |
GeneIDi | 414899 |
KEGGi | hsa:414899 |
MANE-Selecti | ENST00000560104.2; ENSP00000453153.1; NM_001001786.3; NP_001001786.2 |
UCSCi | uc001pyf.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF303179 mRNA Translation: AAN31127.1 BC130361 mRNA Translation: AAI30362.1 BC130363 mRNA Translation: AAI30364.1 |
CCDSi | CCDS31693.1 |
RefSeqi | NP_001001786.2, NM_001001786.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 136097, 11 interactors |
IntActi | Q8IZY5, 9 interactors |
MINTi | Q8IZY5 |
STRINGi | 9606.ENSP00000453153 |
PTM databases
iPTMneti | Q8IZY5 |
PhosphoSitePlusi | Q8IZY5 |
Genetic variation databases
BioMutai | BLID |
Proteomic databases
PaxDbi | Q8IZY5 |
PeptideAtlasi | Q8IZY5 |
PRIDEi | Q8IZY5 |
ProteomicsDBi | 71443 |
Protocols and materials databases
Antibodypediai | 55634, 64 antibodies from 16 providers |
DNASUi | 414899 |
Genome annotation databases
Ensembli | ENST00000560104; ENSP00000453153; ENSG00000259571 |
GeneIDi | 414899 |
KEGGi | hsa:414899 |
MANE-Selecti | ENST00000560104.2; ENSP00000453153.1; NM_001001786.3; NP_001001786.2 |
UCSCi | uc001pyf.3, human |
Organism-specific databases
CTDi | 414899 |
DisGeNETi | 414899 |
GeneCardsi | BLID |
HGNCi | HGNC:33495, BLID |
HPAi | ENSG00000259571, Tissue enriched (brain) |
MIMi | 608853, gene |
neXtProti | NX_Q8IZY5 |
OpenTargetsi | ENSG00000259571 |
PharmGKBi | PA162377555 |
VEuPathDBi | HostDB:ENSG00000259571 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TGWD, Eukaryota |
GeneTreei | ENSGT00520000061087 |
HOGENOMi | CLU_2202905_0_0_1 |
InParanoidi | Q8IZY5 |
OMAi | KEPMLPK |
OrthoDBi | 1579454at2759 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZY5 |
SignaLinki | Q8IZY5 |
Miscellaneous databases
BioGRID-ORCSi | 414899, 6 hits in 1033 CRISPR screens |
GenomeRNAii | 414899 |
Pharosi | Q8IZY5, Tbio |
PROi | PR:Q8IZY5 |
RNActi | Q8IZY5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000259571, Expressed in corpus callosum and 42 other tissues |
Genevisiblei | Q8IZY5, HS |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | BLID_HUMAN | |
Accessioni | Q8IZY5Primary (citable) accession number: Q8IZY5 Secondary accession number(s): A1L416 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 23, 2022 | |
This is version 100 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot