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Entry version 147 (22 Apr 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Transcription initiation factor TFIID subunit 1-like

Gene

TAF1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1-like
Alternative name(s):
TAF(II)210
TBP-associated factor 1-like
TBP-associated factor 210 kDa
Transcription initiation factor TFIID 210 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18056 TAF1L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607798 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZX4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
138474

Open Targets

More...
OpenTargetsi
ENSG00000122728

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134947802

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IZX4 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3108641

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAF1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
57013082

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112171 – 1826Transcription initiation factor TFIID subunit 1-likeAdd BLAST1826

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IZX4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IZX4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IZX4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8IZX4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZX4

PeptideAtlas

More...
PeptideAtlasi
Q8IZX4

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZX4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
71440

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific, expressed apparently in germ cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122728 Expressed in mucosa of paranasal sinus and 71 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IZX4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000122728 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can bind directly to TATA-box binding protein (TBP).

Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro).

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126514, 11 interactors

Protein interaction database and analysis system

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IntActi
Q8IZX4, 4 interactors

Molecular INTeraction database

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MINTi
Q8IZX4

STRING: functional protein association networks

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STRINGi
9606.ENSP00000418379

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8IZX4

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IZX4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11826
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IZX4

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IZX4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1416 – 1486Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1539 – 1609Bromo 2PROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1370 – 1377Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi156 – 164Pro-rich9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF1 family.Curated

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155242

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000572_3_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IZX4

KEGG Orthology (KO)

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KOi
K03125

Identification of Orthologs from Complete Genome Data

More...
OMAi
RENVRKC

Database of Orthologous Groups

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OrthoDBi
103411at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZX4

TreeFam database of animal gene trees

More...
TreeFami
TF313573

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1100.10, 1 hit
1.20.920.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR040240 TAF1
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
IPR041670 Znf-CCHC_6

The PANTHER Classification System

More...
PANTHERi
PTHR13900 PTHR13900, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PF15288 zf-CCHC_6, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003047 TAF1_animal, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IZX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ
60 70 80 90 100
LEGESVLDDE CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI
110 120 130 140 150
RSTEDAVDYS DINEVAEDES QRHQQTMGSL QPLYHSDYDE DDYDADCEDI
160 170 180 190 200
DCKLMPPPPP PPGPMKKDKD QDAITCVSES GEDIILPSII APSFLASEKV
210 220 230 240 250
DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT KLLPSVTELF
260 270 280 290 300
PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS
310 320 330 340 350
VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV
360 370 380 390 400
TDTKPRVAEW RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM
410 420 430 440 450
MEEFRKLEES NGTDLLADEN FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA
460 470 480 490 500
SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD KPWYSIFPID NEDLVYGRWE
510 520 530 540 550
DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT SNSPSKESKK
560 570 580 590 600
ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR
610 620 630 640 650
GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP
660 670 680 690 700
GPHSVQPLLK HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA
710 720 730 740 750
EYSEENGPLM MQVGMATKIK NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL
760 770 780 790 800
GSLHPGQLLQ ALENNLFRAP VYLHKMPETD FLIIRTRQGY YIRELVDIFV
810 820 830 840 850
VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR PRRIRMEDIK
860 870 880 890 900
KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS
910 920 930 940 950
PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP
960 970 980 990 1000
WNTTRAFIAA MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP
1010 1020 1030 1040 1050
QAVKKTVTGT DADLRRLSLK NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT
1060 1070 1080 1090 1100
MSTEQAHSGE GPMSKFARGS RFSVAEHQER YKEECQRIFD LQNKVLSSTE
1110 1120 1130 1140 1150
VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW EEQERKELRR
1160 1170 1180 1190 1200
MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR
1210 1220 1230 1240 1250
CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL
1260 1270 1280 1290 1300
RRLKRNQEKE KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL
1310 1320 1330 1340 1350
YYQTNVPPSK PVAMTEEQEE ELEKTVIHND NEELIKVEGT KIVFGKQLIE
1360 1370 1380 1390 1400
NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT VHCDYLNIPH KSIHRRRTDP
1410 1420 1430 1440 1450
MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII TRPMDLQTLR
1460 1470 1480 1490 1500
ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL
1510 1520 1530 1540 1550
KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP
1560 1570 1580 1590 1600
VNKKFVPDYY KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK
1610 1620 1630 1640 1650
YNGPESQYTK TAQEIVNICY QTITEYDEHL TQLEKDICTA KEAALEEAEL
1660 1670 1680 1690 1700
ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD ASVFQDESNL SVLDISTATP
1710 1720 1730 1740 1750
EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG DGDLADEEEG
1760 1770 1780 1790 1800
TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV
1810 1820
GYGGIRPKQP FMLQHASGEH KDGHGK
Length:1,826
Mass (Da):207,302
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35D780E749AC9B17
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04193447G → A in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041935171Q → E1 PublicationCorresponds to variant dbSNP:rs56352331Ensembl.1
Natural variantiVAR_041936256G → A1 PublicationCorresponds to variant dbSNP:rs55991718Ensembl.1
Natural variantiVAR_041937371M → V1 PublicationCorresponds to variant dbSNP:rs17219559Ensembl.1
Natural variantiVAR_041938532I → N1 PublicationCorresponds to variant dbSNP:rs56128445Ensembl.1
Natural variantiVAR_041939637P → S1 PublicationCorresponds to variant dbSNP:rs56157814Ensembl.1
Natural variantiVAR_041940750L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041941762L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041942794E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041943845R → Q1 PublicationCorresponds to variant dbSNP:rs34787787Ensembl.1
Natural variantiVAR_0419441016R → C1 PublicationCorresponds to variant dbSNP:rs35905429Ensembl.1
Natural variantiVAR_0419451038K → N1 PublicationCorresponds to variant dbSNP:rs55767137Ensembl.1
Natural variantiVAR_0419461169T → I1 PublicationCorresponds to variant dbSNP:rs55976674Ensembl.1
Natural variantiVAR_0419471312V → L1 PublicationCorresponds to variant dbSNP:rs55824107Ensembl.1
Natural variantiVAR_0419481356R → C1 PublicationCorresponds to variant dbSNP:rs56107531Ensembl.1
Natural variantiVAR_0419491389P → S1 PublicationCorresponds to variant dbSNP:rs56393725Ensembl.1
Natural variantiVAR_0419501411I → V1 PublicationCorresponds to variant dbSNP:rs34500740Ensembl.1
Natural variantiVAR_0419511540A → T1 PublicationCorresponds to variant dbSNP:rs55782058Ensembl.1
Natural variantiVAR_0419521549H → Y in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_0419531731K → N1 PublicationCorresponds to variant dbSNP:rs34241003Ensembl.1
Natural variantiVAR_0484351805I → V. Corresponds to variant dbSNP:rs16918393Ensembl.1
Natural variantiVAR_0419541810P → L1 PublicationCorresponds to variant dbSNP:rs56342342Ensembl.1
Natural variantiVAR_0419551824H → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF390562 mRNA Translation: AAN40840.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35003.1

NCBI Reference Sequences

More...
RefSeqi
NP_722516.1, NM_153809.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000242310; ENSP00000418379; ENSG00000122728

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
138474

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:138474

UCSC genome browser

More...
UCSCi
uc003zrg.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390562 mRNA Translation: AAN40840.1
CCDSiCCDS35003.1
RefSeqiNP_722516.1, NM_153809.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HMHX-ray2.05A1523-1654[»]
5IGLX-ray2.10A1523-1654[»]
SMRiQ8IZX4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi126514, 11 interactors
IntActiQ8IZX4, 4 interactors
MINTiQ8IZX4
STRINGi9606.ENSP00000418379

Chemistry databases

BindingDBiQ8IZX4
ChEMBLiCHEMBL3108641

PTM databases

iPTMnetiQ8IZX4
PhosphoSitePlusiQ8IZX4

Polymorphism and mutation databases

BioMutaiTAF1L
DMDMi57013082

Proteomic databases

EPDiQ8IZX4
jPOSTiQ8IZX4
MassIVEiQ8IZX4
MaxQBiQ8IZX4
PaxDbiQ8IZX4
PeptideAtlasiQ8IZX4
PRIDEiQ8IZX4
ProteomicsDBi71440

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25077 58 antibodies

Genome annotation databases

EnsembliENST00000242310; ENSP00000418379; ENSG00000122728
GeneIDi138474
KEGGihsa:138474
UCSCiuc003zrg.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
138474
DisGeNETi138474

GeneCards: human genes, protein and diseases

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GeneCardsi
TAF1L
HGNCiHGNC:18056 TAF1L
HPAiENSG00000122728 Tissue enriched (testis)
MIMi607798 gene
neXtProtiNX_Q8IZX4
OpenTargetsiENSG00000122728
PharmGKBiPA134947802

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA
GeneTreeiENSGT00940000155242
HOGENOMiCLU_000572_3_0_1
InParanoidiQ8IZX4
KOiK03125
OMAiRENVRKC
OrthoDBi103411at2759
PhylomeDBiQ8IZX4
TreeFamiTF313573

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

EvolutionaryTraceiQ8IZX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
138474
PharosiQ8IZX4 Tchem

Protein Ontology

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PROi
PR:Q8IZX4
RNActiQ8IZX4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000122728 Expressed in mucosa of paranasal sinus and 71 other tissues
GenevisibleiQ8IZX4 HS

Family and domain databases

Gene3Di1.10.1100.10, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR040240 TAF1
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
IPR041670 Znf-CCHC_6
PANTHERiPTHR13900 PTHR13900, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PF15288 zf-CCHC_6, 1 hit
PIRSFiPIRSF003047 TAF1_animal, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZX4
Secondary accession number(s): Q0VG57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2003
Last modified: April 22, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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