TAF1L

Functionⁱ

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.1 Publication

GO - Molecular functionⁱ

histone acetyltransferase activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 12217962
lysine-acetylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22464331
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 12217962
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly Source: GO_Central
sequence-specific DNA binding Source: GO_Central
TBP-class protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12217962

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

male meiotic nuclear division
Source: UniProtKB
Inferred from expression patternⁱ
- 12217962
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 12217962
positive regulation of transcription by RNA polymerase II Source: GO_Central
regulation of signal transduction by p53 class mediator Source: Reactome
regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 12217962
transcription by RNA polymerase II Source: Reactome
transcription initiation from RNA polymerase II promoter Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167161 HIV Transcription Initiation R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167172 Transcription of the HIV genome R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Reactomeⁱ

R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription initiation factor TFIID subunit 1-like Alternative name(s): TAF(II)210 TBP-associated factor 1-like TBP-associated factor 210 kDa Transcription initiation factor TFIID 210 kDa subunit
Gene namesⁱ	Name:TAF1L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122728.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18056 TAF1L
MIMⁱ	607798 gene
neXtProtⁱ	NX_Q8IZX4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000122728
PharmGKBⁱ	PA134947802

Chemistry databases

ChEMBLⁱ	CHEMBL3108641

ChEMBLⁱ

CHEMBL3108641

Polymorphism and mutation databases

BioMutaⁱ	TAF1L
DMDMⁱ	57013082

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211217	1 – 1826	Transcription initiation factor TFIID subunit 1-likeAdd BLAST		1826

Proteomic databases

EPDⁱ	Q8IZX4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IZX4
PaxDbⁱ	Q8IZX4
PeptideAtlas More...PeptideAtlasⁱ	Q8IZX4
PRIDEⁱ	Q8IZX4
ProteomicsDBⁱ	71440

PTM databases

iPTMnetⁱ	Q8IZX4
PhosphoSitePlusⁱ	Q8IZX4

Expressionⁱ

Tissue specificityⁱ

Testis specific, expressed apparently in germ cells.

Gene expression databases

Bgeeⁱ	ENSG00000122728
CleanExⁱ	HS_TAF1L
Genevisibleⁱ	Q8IZX4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA056605

HPAⁱ

HPA056605

Interactionⁱ

Subunit structureⁱ

Can bind directly to TATA-box binding protein (TBP). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro).2 Publications

GO - Molecular functionⁱ

lysine-acetylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22464331
TBP-class protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12217962

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	126514, 8 interactors
IntActⁱ	Q8IZX4, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q8IZX4
STRINGⁱ	9606.ENSP00000418379

Chemistry databases

BindingDBⁱ

Q8IZX4

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	1523 – 1536	Combined sources	14
Turnⁱ	1537 – 1540	Combined sources	4
Helixⁱ	1545 – 1547	Combined sources	3
Turnⁱ	1553 – 1555	Combined sources	3
Helixⁱ	1557 – 1562	Combined sources	6
Helixⁱ	1569 – 1577	Combined sources	9
Helixⁱ	1584 – 1602	Combined sources	19
Helixⁱ	1607 – 1625	Combined sources	19
Helixⁱ	1627 – 1649	Combined sources	23

3D structure databases

ProteinModelPortalⁱ	Q8IZX4
SMRⁱ	Q8IZX4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q8IZX4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1416 – 1486	Bromo 1PROSITE-ProRule annotationAdd BLAST		71
Domainⁱ	1539 – 1609	Bromo 2PROSITE-ProRule annotationAdd BLAST		71

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	1370 – 1377	Nuclear localization signalSequence analysis		8

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	156 – 164	Pro-rich		9

Sequence similaritiesⁱ

Belongs to the TAF1 family.Curated

Keywords - Domainⁱ

Bromodomain, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0008 Eukaryota COG5076 LUCA COG5179 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144099
HOGENOMⁱ	HOG000020066
HOVERGENⁱ	HBG050223
InParanoidⁱ	Q8IZX4
KEGG Orthology (KO) More...KOⁱ	K03125
OMAⁱ	KIDDEVH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00MO
PhylomeDBⁱ	Q8IZX4
TreeFamⁱ	TF313573

Family and domain databases

Gene3Dⁱ	1.10.1100.10, 1 hit 1.20.920.10, 2 hits
InterProⁱ	View protein in InterPro IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR011177 TAF1_animal IPR009067 TAF_II_230-bd IPR036741 TAFII-230_TBP-bd_sf IPR022591 TFIID_sub1_DUF3591
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00439 Bromodomain, 2 hits PF12157 DUF3591, 1 hit PF09247 TBP-binding, 1 hit
PIRSFⁱ	PIRSF003047 TAF1_animal, 1 hit
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297 BROMO, 2 hits
SUPFAMⁱ	SSF47055 SSF47055, 1 hit SSF47370 SSF47370, 2 hits
PROSITEⁱ	View protein in PROSITE PS00633 BROMODOMAIN_1, 2 hits PS50014 BROMODOMAIN_2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8IZX4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ 
        60         70         80         90        100
LEGESVLDDE CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI 
       110        120        130        140        150
RSTEDAVDYS DINEVAEDES QRHQQTMGSL QPLYHSDYDE DDYDADCEDI 
       160        170        180        190        200
DCKLMPPPPP PPGPMKKDKD QDAITCVSES GEDIILPSII APSFLASEKV 
       210        220        230        240        250
DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT KLLPSVTELF 
       260        270        280        290        300
PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS 
       310        320        330        340        350
VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV 
       360        370        380        390        400
TDTKPRVAEW RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM 
       410        420        430        440        450
MEEFRKLEES NGTDLLADEN FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA 
       460        470        480        490        500
SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD KPWYSIFPID NEDLVYGRWE 
       510        520        530        540        550
DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT SNSPSKESKK 
       560        570        580        590        600
ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR 
       610        620        630        640        650
GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP 
       660        670        680        690        700
GPHSVQPLLK HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA 
       710        720        730        740        750
EYSEENGPLM MQVGMATKIK NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL 
       760        770        780        790        800
GSLHPGQLLQ ALENNLFRAP VYLHKMPETD FLIIRTRQGY YIRELVDIFV 
       810        820        830        840        850
VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR PRRIRMEDIK 
       860        870        880        890        900
KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS 
       910        920        930        940        950
PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP 
       960        970        980        990       1000
WNTTRAFIAA MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP 
      1010       1020       1030       1040       1050
QAVKKTVTGT DADLRRLSLK NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT 
      1060       1070       1080       1090       1100
MSTEQAHSGE GPMSKFARGS RFSVAEHQER YKEECQRIFD LQNKVLSSTE 
      1110       1120       1130       1140       1150
VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW EEQERKELRR 
      1160       1170       1180       1190       1200
MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR 
      1210       1220       1230       1240       1250
CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL 
      1260       1270       1280       1290       1300
RRLKRNQEKE KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL 
      1310       1320       1330       1340       1350
YYQTNVPPSK PVAMTEEQEE ELEKTVIHND NEELIKVEGT KIVFGKQLIE 
      1360       1370       1380       1390       1400
NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT VHCDYLNIPH KSIHRRRTDP 
      1410       1420       1430       1440       1450
MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII TRPMDLQTLR 
      1460       1470       1480       1490       1500
ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL 
      1510       1520       1530       1540       1550
KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP 
      1560       1570       1580       1590       1600
VNKKFVPDYY KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK 
      1610       1620       1630       1640       1650
YNGPESQYTK TAQEIVNICY QTITEYDEHL TQLEKDICTA KEAALEEAEL 
      1660       1670       1680       1690       1700
ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD ASVFQDESNL SVLDISTATP 
      1710       1720       1730       1740       1750
EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG DGDLADEEEG 
      1760       1770       1780       1790       1800
TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV 
      1810       1820 
GYGGIRPKQP FMLQHASGEH KDGHGK

Length:1,826

Mass (Da):207,302

Last modified:March 1, 2003 - v1

Checksum:ⁱ35D780E749AC9B17

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041934	47	G → A in a lung small cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041935	171	Q → E1 PublicationCorresponds to variant dbSNP:rs56352331Ensembl.	1
Natural variantⁱVAR_041936	256	G → A1 PublicationCorresponds to variant dbSNP:rs55991718Ensembl.	1
Natural variantⁱVAR_041937	371	M → V1 PublicationCorresponds to variant dbSNP:rs17219559Ensembl.	1
Natural variantⁱVAR_041938	532	I → N1 PublicationCorresponds to variant dbSNP:rs56128445Ensembl.	1
Natural variantⁱVAR_041939	637	P → S1 PublicationCorresponds to variant dbSNP:rs56157814Ensembl.	1
Natural variantⁱVAR_041940	750	L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041941	762	L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041942	794	E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041943	845	R → Q1 PublicationCorresponds to variant dbSNP:rs34787787Ensembl.	1
Natural variantⁱVAR_041944	1016	R → C1 PublicationCorresponds to variant dbSNP:rs35905429Ensembl.	1
Natural variantⁱVAR_041945	1038	K → N1 PublicationCorresponds to variant dbSNP:rs55767137Ensembl.	1
Natural variantⁱVAR_041946	1169	T → I1 PublicationCorresponds to variant dbSNP:rs55976674Ensembl.	1
Natural variantⁱVAR_041947	1312	V → L1 PublicationCorresponds to variant dbSNP:rs55824107Ensembl.	1
Natural variantⁱVAR_041948	1356	R → C1 PublicationCorresponds to variant dbSNP:rs56107531Ensembl.	1
Natural variantⁱVAR_041949	1389	P → S1 PublicationCorresponds to variant dbSNP:rs56393725Ensembl.	1
Natural variantⁱVAR_041950	1411	I → V1 PublicationCorresponds to variant dbSNP:rs34500740Ensembl.	1
Natural variantⁱVAR_041951	1540	A → T1 PublicationCorresponds to variant dbSNP:rs55782058Ensembl.	1
Natural variantⁱVAR_041952	1549	H → Y in a glioblastoma multiforme sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041953	1731	K → N1 PublicationCorresponds to variant dbSNP:rs34241003Ensembl.	1
Natural variantⁱVAR_048435	1805	I → V. Corresponds to variant dbSNP:rs16918393Ensembl.	1
Natural variantⁱVAR_041954	1810	P → L1 PublicationCorresponds to variant dbSNP:rs56342342Ensembl.	1
Natural variantⁱVAR_041955	1824	H → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF390562 mRNA Translation: AAN40840.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35003.1
NCBI Reference Sequences More...RefSeqⁱ	NP_722516.1, NM_153809.2
UniGeneⁱ	Hs.591086

Genome annotation databases

Ensemblⁱ	ENST00000242310; ENSP00000418379; ENSG00000122728
GeneIDⁱ	138474
KEGGⁱ	hsa:138474
UCSC genome browser More...UCSCⁱ	uc003zrg.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8IZX4	UPI000A2B272B		PIG		2001
UPI000B4E8BFA		MERUN		144
UPI0004D041F2		GALVR		1988
UPI000CEAB170		PHYCD		1967
UPI000BB9197D		DELLE		1964
+330

Protein	Similar proteins		Species	Score	Length
Q8IZX4	UPI000A2B272B		PIG		2001
UPI000B4E8BFA		MERUN		144
UPI0004D041F2		GALVR		1988
UPI000CEAB170		PHYCD		1967
UPI000BB9197D		DELLE		1964
+392

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF390562 mRNA Translation: AAN40840.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35003.1
NCBI Reference Sequences More...RefSeqⁱ	NP_722516.1, NM_153809.2
UniGeneⁱ	Hs.591086

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3HMH	X-ray	2.05	A	1523-1654	[»]
	5IGL	X-ray	2.10	A	1523-1654	[»]
ProteinModelPortalⁱ	Q8IZX4
SMRⁱ	Q8IZX4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126514, 8 interactors
IntActⁱ	Q8IZX4, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q8IZX4
STRINGⁱ	9606.ENSP00000418379

Chemistry databases

BindingDBⁱ	Q8IZX4
ChEMBLⁱ	CHEMBL3108641

PTM databases

iPTMnetⁱ	Q8IZX4
PhosphoSitePlusⁱ	Q8IZX4

Polymorphism and mutation databases

BioMutaⁱ	TAF1L
DMDMⁱ	57013082

Proteomic databases

EPDⁱ	Q8IZX4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IZX4
PaxDbⁱ	Q8IZX4
PeptideAtlas More...PeptideAtlasⁱ	Q8IZX4
PRIDEⁱ	Q8IZX4
ProteomicsDBⁱ	71440

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000242310; ENSP00000418379; ENSG00000122728
GeneIDⁱ	138474
KEGGⁱ	hsa:138474
UCSC genome browser More...UCSCⁱ	uc003zrg.1 human

Organism-specific databases

CTDⁱ	138474
EuPathDBⁱ	HostDB:ENSG00000122728.6
GeneCardsⁱ	TAF1L
H-InvDBⁱ	HIX0169078
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18056 TAF1L
Human Protein Atlas More...HPAⁱ	HPA056605
MIMⁱ	607798 gene
neXtProtⁱ	NX_Q8IZX4
Open Targets More...OpenTargetsⁱ	ENSG00000122728
PharmGKBⁱ	PA134947802
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0008 Eukaryota COG5076 LUCA COG5179 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144099
HOGENOMⁱ	HOG000020066
HOVERGENⁱ	HBG050223
InParanoidⁱ	Q8IZX4
KEGG Orthology (KO) More...KOⁱ	K03125
OMAⁱ	KIDDEVH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00MO
PhylomeDBⁱ	Q8IZX4
TreeFamⁱ	TF313573

Enzyme and pathway databases

Reactomeⁱ	R-HSA-167161 HIV Transcription Initiation R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167172 Transcription of the HIV genome R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Reactomeⁱ

R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

EvolutionaryTraceⁱ	Q8IZX4
GenomeRNAiⁱ	138474
Protein Ontology More...PROⁱ	PR:Q8IZX4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122728
CleanExⁱ	HS_TAF1L
Genevisibleⁱ	Q8IZX4 HS

Family and domain databases

Gene3Dⁱ	1.10.1100.10, 1 hit 1.20.920.10, 2 hits
InterProⁱ	View protein in InterPro IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR018359 Bromodomain_CS IPR011177 TAF1_animal IPR009067 TAF_II_230-bd IPR036741 TAFII-230_TBP-bd_sf IPR022591 TFIID_sub1_DUF3591
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00439 Bromodomain, 2 hits PF12157 DUF3591, 1 hit PF09247 TBP-binding, 1 hit
PIRSFⁱ	PIRSF003047 TAF1_animal, 1 hit
PRINTSⁱ	PR00503 BROMODOMAIN
SMARTⁱ	View protein in SMART SM00297 BROMO, 2 hits
SUPFAMⁱ	SSF47055 SSF47055, 1 hit SSF47370 SSF47370, 2 hits
PROSITEⁱ	View protein in PROSITE PS00633 BROMODOMAIN_1, 2 hits PS50014 BROMODOMAIN_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF1L_HUMAN
Accessionⁱ	Q8IZX4Primary (citable) accession number: Q8IZX4 Secondary accession number(s): Q0VG57
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
	Last sequence update:	March 1, 2003
	Last modified:	July 18, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - Q8IZX4 (TAF1L_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Transcription initiation factor TFIID subunit 1-like

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ