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UniProtKB - Q8IZX4 (TAF1L_HUMAN)

Protein

Transcription initiation factor TFIID subunit 1-like

Gene

TAF1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.1 Publication

GO - Molecular functioni

  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • histone acetyltransferase activity Source: UniProtKB
  • lysine-acetylated histone binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB
  • sequence-specific DNA binding Source: GO_Central
  • TBP-class protein binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1-like
Alternative name(s):
TAF(II)210
TBP-associated factor 1-like
TBP-associated factor 210 kDa
Transcription initiation factor TFIID 210 kDa subunit
Gene namesi
Name:TAF1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122728.6
HGNCiHGNC:18056 TAF1L
MIMi607798 gene
neXtProtiNX_Q8IZX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122728
PharmGKBiPA134947802

Chemistry databases

ChEMBLiCHEMBL3108641

Polymorphism and mutation databases

BioMutaiTAF1L
DMDMi57013082

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112171 – 1826Transcription initiation factor TFIID subunit 1-likeAdd BLAST1826

Proteomic databases

EPDiQ8IZX4
MaxQBiQ8IZX4
PaxDbiQ8IZX4
PeptideAtlasiQ8IZX4
PRIDEiQ8IZX4
ProteomicsDBi71440

PTM databases

iPTMnetiQ8IZX4
PhosphoSitePlusiQ8IZX4

Expressioni

Tissue specificityi

Testis specific, expressed apparently in germ cells.

Gene expression databases

BgeeiENSG00000122728 Expressed in 72 organ(s), highest expression level in mucosa of paranasal sinus
CleanExiHS_TAF1L
GenevisibleiQ8IZX4 HS

Organism-specific databases

HPAiHPA056605

Interactioni

Subunit structurei

Can bind directly to TATA-box binding protein (TBP). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro).2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi126514, 8 interactors
IntActiQ8IZX4, 3 interactors
MINTiQ8IZX4
STRINGi9606.ENSP00000418379

Chemistry databases

BindingDBiQ8IZX4

Structurei

Secondary structure

11826
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IZX4
SMRiQ8IZX4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IZX4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1416 – 1486Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1539 – 1609Bromo 2PROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1370 – 1377Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 164Pro-rich9

Sequence similaritiesi

Belongs to the TAF1 family.Curated

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

eggNOGiKOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA
GeneTreeiENSGT00910000144099
HOGENOMiHOG000020066
HOVERGENiHBG050223
InParanoidiQ8IZX4
KOiK03125
OMAiKIDDEVH
OrthoDBiEOG091G00MO
PhylomeDBiQ8IZX4
TreeFamiTF313573

Family and domain databases

Gene3Di1.10.1100.10, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PIRSFiPIRSF003047 TAF1_animal, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q8IZX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ 
        60         70         80         90        100
LEGESVLDDE CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI 
       110        120        130        140        150
RSTEDAVDYS DINEVAEDES QRHQQTMGSL QPLYHSDYDE DDYDADCEDI 
       160        170        180        190        200
DCKLMPPPPP PPGPMKKDKD QDAITCVSES GEDIILPSII APSFLASEKV 
       210        220        230        240        250
DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT KLLPSVTELF 
       260        270        280        290        300
PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS 
       310        320        330        340        350
VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV 
       360        370        380        390        400
TDTKPRVAEW RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM 
       410        420        430        440        450
MEEFRKLEES NGTDLLADEN FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA 
       460        470        480        490        500
SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD KPWYSIFPID NEDLVYGRWE 
       510        520        530        540        550
DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT SNSPSKESKK 
       560        570        580        590        600
ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR 
       610        620        630        640        650
GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP 
       660        670        680        690        700
GPHSVQPLLK HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA 
       710        720        730        740        750
EYSEENGPLM MQVGMATKIK NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL 
       760        770        780        790        800
GSLHPGQLLQ ALENNLFRAP VYLHKMPETD FLIIRTRQGY YIRELVDIFV 
       810        820        830        840        850
VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR PRRIRMEDIK 
       860        870        880        890        900
KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS 
       910        920        930        940        950
PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP 
       960        970        980        990       1000
WNTTRAFIAA MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP 
      1010       1020       1030       1040       1050
QAVKKTVTGT DADLRRLSLK NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT 
      1060       1070       1080       1090       1100
MSTEQAHSGE GPMSKFARGS RFSVAEHQER YKEECQRIFD LQNKVLSSTE 
      1110       1120       1130       1140       1150
VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW EEQERKELRR 
      1160       1170       1180       1190       1200
MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR 
      1210       1220       1230       1240       1250
CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL 
      1260       1270       1280       1290       1300
RRLKRNQEKE KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL 
      1310       1320       1330       1340       1350
YYQTNVPPSK PVAMTEEQEE ELEKTVIHND NEELIKVEGT KIVFGKQLIE 
      1360       1370       1380       1390       1400
NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT VHCDYLNIPH KSIHRRRTDP 
      1410       1420       1430       1440       1450
MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII TRPMDLQTLR 
      1460       1470       1480       1490       1500
ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL 
      1510       1520       1530       1540       1550
KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP 
      1560       1570       1580       1590       1600
VNKKFVPDYY KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK 
      1610       1620       1630       1640       1650
YNGPESQYTK TAQEIVNICY QTITEYDEHL TQLEKDICTA KEAALEEAEL 
      1660       1670       1680       1690       1700
ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD ASVFQDESNL SVLDISTATP 
      1710       1720       1730       1740       1750
EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG DGDLADEEEG 
      1760       1770       1780       1790       1800
TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV 
      1810       1820 
GYGGIRPKQP FMLQHASGEH KDGHGK
Length:1,826
Mass (Da):207,302
Last modified:March 1, 2003 - v1
Checksum:i35D780E749AC9B17
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04193447G → A in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041935171Q → E1 PublicationCorresponds to variant dbSNP:rs56352331Ensembl.1
Natural variantiVAR_041936256G → A1 PublicationCorresponds to variant dbSNP:rs55991718Ensembl.1
Natural variantiVAR_041937371M → V1 PublicationCorresponds to variant dbSNP:rs17219559Ensembl.1
Natural variantiVAR_041938532I → N1 PublicationCorresponds to variant dbSNP:rs56128445Ensembl.1
Natural variantiVAR_041939637P → S1 PublicationCorresponds to variant dbSNP:rs56157814Ensembl.1
Natural variantiVAR_041940750L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041941762L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041942794E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041943845R → Q1 PublicationCorresponds to variant dbSNP:rs34787787Ensembl.1
Natural variantiVAR_0419441016R → C1 PublicationCorresponds to variant dbSNP:rs35905429Ensembl.1
Natural variantiVAR_0419451038K → N1 PublicationCorresponds to variant dbSNP:rs55767137Ensembl.1
Natural variantiVAR_0419461169T → I1 PublicationCorresponds to variant dbSNP:rs55976674Ensembl.1
Natural variantiVAR_0419471312V → L1 PublicationCorresponds to variant dbSNP:rs55824107Ensembl.1
Natural variantiVAR_0419481356R → C1 PublicationCorresponds to variant dbSNP:rs56107531Ensembl.1
Natural variantiVAR_0419491389P → S1 PublicationCorresponds to variant dbSNP:rs56393725Ensembl.1
Natural variantiVAR_0419501411I → V1 PublicationCorresponds to variant dbSNP:rs34500740Ensembl.1
Natural variantiVAR_0419511540A → T1 PublicationCorresponds to variant dbSNP:rs55782058Ensembl.1
Natural variantiVAR_0419521549H → Y in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_0419531731K → N1 PublicationCorresponds to variant dbSNP:rs34241003Ensembl.1
Natural variantiVAR_0484351805I → V. Corresponds to variant dbSNP:rs16918393Ensembl.1
Natural variantiVAR_0419541810P → L1 PublicationCorresponds to variant dbSNP:rs56342342Ensembl.1
Natural variantiVAR_0419551824H → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390562 mRNA Translation: AAN40840.1
CCDSiCCDS35003.1
RefSeqiNP_722516.1, NM_153809.2
UniGeneiHs.591086

Genome annotation databases

EnsembliENST00000242310; ENSP00000418379; ENSG00000122728
GeneIDi138474
KEGGihsa:138474
UCSCiuc003zrg.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390562 mRNA Translation: AAN40840.1
CCDSiCCDS35003.1
RefSeqiNP_722516.1, NM_153809.2
UniGeneiHs.591086

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HMHX-ray2.05A1523-1654[»]
5IGLX-ray2.10A1523-1654[»]
ProteinModelPortaliQ8IZX4
SMRiQ8IZX4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126514, 8 interactors
IntActiQ8IZX4, 3 interactors
MINTiQ8IZX4
STRINGi9606.ENSP00000418379

Chemistry databases

BindingDBiQ8IZX4
ChEMBLiCHEMBL3108641

PTM databases

iPTMnetiQ8IZX4
PhosphoSitePlusiQ8IZX4

Polymorphism and mutation databases

BioMutaiTAF1L
DMDMi57013082

Proteomic databases

EPDiQ8IZX4
MaxQBiQ8IZX4
PaxDbiQ8IZX4
PeptideAtlasiQ8IZX4
PRIDEiQ8IZX4
ProteomicsDBi71440

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242310; ENSP00000418379; ENSG00000122728
GeneIDi138474
KEGGihsa:138474
UCSCiuc003zrg.1 human

Organism-specific databases

CTDi138474
EuPathDBiHostDB:ENSG00000122728.6
GeneCardsiTAF1L
H-InvDBiHIX0169078
HGNCiHGNC:18056 TAF1L
HPAiHPA056605
MIMi607798 gene
neXtProtiNX_Q8IZX4
OpenTargetsiENSG00000122728
PharmGKBiPA134947802
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0008 Eukaryota
COG5076 LUCA
COG5179 LUCA
GeneTreeiENSGT00910000144099
HOGENOMiHOG000020066
HOVERGENiHBG050223
InParanoidiQ8IZX4
KOiK03125
OMAiKIDDEVH
OrthoDBiEOG091G00MO
PhylomeDBiQ8IZX4
TreeFamiTF313573

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

EvolutionaryTraceiQ8IZX4
GenomeRNAii138474
PROiPR:Q8IZX4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122728 Expressed in 72 organ(s), highest expression level in mucosa of paranasal sinus
CleanExiHS_TAF1L
GenevisibleiQ8IZX4 HS

Family and domain databases

Gene3Di1.10.1100.10, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR011177 TAF1_animal
IPR009067 TAF_II_230-bd
IPR036741 TAFII-230_TBP-bd_sf
IPR022591 TFIID_sub1_DUF3591
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF12157 DUF3591, 1 hit
PF09247 TBP-binding, 1 hit
PIRSFiPIRSF003047 TAF1_animal, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47055 SSF47055, 1 hit
SSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 2 hits
PS50014 BROMODOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTAF1L_HUMAN
AccessioniPrimary (citable) accession number: Q8IZX4
Secondary accession number(s): Q0VG57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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