UniProtKB - Q8IZX4 (TAF1L_HUMAN)
Protein
Transcription initiation factor TFIID subunit 1-like
Gene
TAF1L
Organism
Homo sapiens (Human)
Status
Functioni
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.1 Publication
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- histone acetyltransferase activity Source: UniProtKB
- lysine-acetylated histone binding Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
- RNA polymerase II general transcription initiation factor activity Source: GO_Central
- TBP-class protein binding Source: UniProtKB
GO - Biological processi
- male meiotic nuclear division Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: Reactome
- regulation of transcription by RNA polymerase II Source: UniProtKB
- RNA polymerase II preinitiation complex assembly Source: GO_Central
- transcription by RNA polymerase II Source: Reactome
- transcription initiation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | DNA-binding |
Biological process | Cell cycle, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8IZX4 |
Reactomei | R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription initiation factor TFIID subunit 1-likeAlternative name(s): TAF(II)210 TBP-associated factor 1-like TBP-associated factor 210 kDa Transcription initiation factor TFIID 210 kDa subunit |
Gene namesi | Name:TAF1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18056, TAF1L |
MIMi | 607798, gene |
neXtProti | NX_Q8IZX4 |
VEuPathDBi | HostDB:ENSG00000122728.6 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: Reactome
- transcription factor TFIID complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 138474 |
OpenTargetsi | ENSG00000122728 |
PharmGKBi | PA134947802 |
Miscellaneous databases
Pharosi | Q8IZX4, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3108641 |
Genetic variation databases
BioMutai | TAF1L |
DMDMi | 57013082 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211217 | 1 – 1826 | Transcription initiation factor TFIID subunit 1-likeAdd BLAST | 1826 |
Proteomic databases
EPDi | Q8IZX4 |
jPOSTi | Q8IZX4 |
MassIVEi | Q8IZX4 |
MaxQBi | Q8IZX4 |
PaxDbi | Q8IZX4 |
PeptideAtlasi | Q8IZX4 |
PRIDEi | Q8IZX4 |
ProteomicsDBi | 71440 |
PTM databases
iPTMneti | Q8IZX4 |
PhosphoSitePlusi | Q8IZX4 |
Expressioni
Tissue specificityi
Testis specific, expressed apparently in germ cells.
Gene expression databases
Bgeei | ENSG00000122728, Expressed in mucosa of paranasal sinus and 74 other tissues |
Genevisiblei | Q8IZX4, HS |
Organism-specific databases
HPAi | ENSG00000122728, Tissue enriched (testis) |
Interactioni
Subunit structurei
Can bind directly to TATA-box binding protein (TBP).
Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro).
2 PublicationsGO - Molecular functioni
- lysine-acetylated histone binding Source: UniProtKB
- TBP-class protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 126514, 13 interactors |
IntActi | Q8IZX4, 4 interactors |
MINTi | Q8IZX4 |
STRINGi | 9606.ENSP00000418379 |
Chemistry databases
BindingDBi | Q8IZX4 |
Miscellaneous databases
RNActi | Q8IZX4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IZX4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8IZX4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1416 – 1486 | Bromo 1PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 1539 – 1609 | Bromo 2PROSITE-ProRule annotationAdd BLAST | 71 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1370 – 1377 | Nuclear localization signalSequence analysis | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 156 – 164 | Pro-rich | 9 |
Sequence similaritiesi
Belongs to the TAF1 family.Curated
Keywords - Domaini
Bromodomain, RepeatPhylogenomic databases
eggNOGi | KOG0008, Eukaryota |
GeneTreei | ENSGT00940000155242 |
HOGENOMi | CLU_000572_3_0_1 |
InParanoidi | Q8IZX4 |
OMAi | RENVRKC |
OrthoDBi | 103411at2759 |
PhylomeDBi | Q8IZX4 |
TreeFami | TF313573 |
Family and domain databases
Gene3Di | 1.10.1100.10, 1 hit 1.20.920.10, 2 hits |
InterProi | View protein in InterPro IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR040240, TAF1 IPR011177, TAF1_animal IPR009067, TAF_II_230-bd IPR036741, TAFII-230_TBP-bd_sf IPR022591, TFIID_sub1_DUF3591 IPR041670, Znf-CCHC_6 |
PANTHERi | PTHR13900, PTHR13900, 1 hit |
Pfami | View protein in Pfam PF00439, Bromodomain, 2 hits PF12157, DUF3591, 1 hit PF09247, TBP-binding, 1 hit PF15288, zf-CCHC_6, 1 hit |
PIRSFi | PIRSF003047, TAF1_animal, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00297, BROMO, 2 hits |
SUPFAMi | SSF47055, SSF47055, 1 hit SSF47370, SSF47370, 2 hits |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 2 hits PS50014, BROMODOMAIN_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q8IZX4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ
60 70 80 90 100
LEGESVLDDE CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI
110 120 130 140 150
RSTEDAVDYS DINEVAEDES QRHQQTMGSL QPLYHSDYDE DDYDADCEDI
160 170 180 190 200
DCKLMPPPPP PPGPMKKDKD QDAITCVSES GEDIILPSII APSFLASEKV
210 220 230 240 250
DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT KLLPSVTELF
260 270 280 290 300
PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS
310 320 330 340 350
VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV
360 370 380 390 400
TDTKPRVAEW RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM
410 420 430 440 450
MEEFRKLEES NGTDLLADEN FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA
460 470 480 490 500
SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD KPWYSIFPID NEDLVYGRWE
510 520 530 540 550
DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT SNSPSKESKK
560 570 580 590 600
ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR
610 620 630 640 650
GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP
660 670 680 690 700
GPHSVQPLLK HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA
710 720 730 740 750
EYSEENGPLM MQVGMATKIK NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL
760 770 780 790 800
GSLHPGQLLQ ALENNLFRAP VYLHKMPETD FLIIRTRQGY YIRELVDIFV
810 820 830 840 850
VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR PRRIRMEDIK
860 870 880 890 900
KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS
910 920 930 940 950
PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP
960 970 980 990 1000
WNTTRAFIAA MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP
1010 1020 1030 1040 1050
QAVKKTVTGT DADLRRLSLK NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT
1060 1070 1080 1090 1100
MSTEQAHSGE GPMSKFARGS RFSVAEHQER YKEECQRIFD LQNKVLSSTE
1110 1120 1130 1140 1150
VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW EEQERKELRR
1160 1170 1180 1190 1200
MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR
1210 1220 1230 1240 1250
CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL
1260 1270 1280 1290 1300
RRLKRNQEKE KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL
1310 1320 1330 1340 1350
YYQTNVPPSK PVAMTEEQEE ELEKTVIHND NEELIKVEGT KIVFGKQLIE
1360 1370 1380 1390 1400
NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT VHCDYLNIPH KSIHRRRTDP
1410 1420 1430 1440 1450
MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII TRPMDLQTLR
1460 1470 1480 1490 1500
ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL
1510 1520 1530 1540 1550
KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP
1560 1570 1580 1590 1600
VNKKFVPDYY KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK
1610 1620 1630 1640 1650
YNGPESQYTK TAQEIVNICY QTITEYDEHL TQLEKDICTA KEAALEEAEL
1660 1670 1680 1690 1700
ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD ASVFQDESNL SVLDISTATP
1710 1720 1730 1740 1750
EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG DGDLADEEEG
1760 1770 1780 1790 1800
TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV
1810 1820
GYGGIRPKQP FMLQHASGEH KDGHGK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041934 | 47 | G → A in a lung small cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041935 | 171 | Q → E1 PublicationCorresponds to variant dbSNP:rs56352331Ensembl. | 1 | |
Natural variantiVAR_041936 | 256 | G → A1 PublicationCorresponds to variant dbSNP:rs55991718Ensembl. | 1 | |
Natural variantiVAR_041937 | 371 | M → V1 PublicationCorresponds to variant dbSNP:rs17219559Ensembl. | 1 | |
Natural variantiVAR_041938 | 532 | I → N1 PublicationCorresponds to variant dbSNP:rs56128445Ensembl. | 1 | |
Natural variantiVAR_041939 | 637 | P → S1 PublicationCorresponds to variant dbSNP:rs56157814Ensembl. | 1 | |
Natural variantiVAR_041940 | 750 | L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041941 | 762 | L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041942 | 794 | E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041943 | 845 | R → Q1 PublicationCorresponds to variant dbSNP:rs34787787Ensembl. | 1 | |
Natural variantiVAR_041944 | 1016 | R → C1 PublicationCorresponds to variant dbSNP:rs35905429Ensembl. | 1 | |
Natural variantiVAR_041945 | 1038 | K → N1 PublicationCorresponds to variant dbSNP:rs55767137Ensembl. | 1 | |
Natural variantiVAR_041946 | 1169 | T → I1 PublicationCorresponds to variant dbSNP:rs55976674Ensembl. | 1 | |
Natural variantiVAR_041947 | 1312 | V → L1 PublicationCorresponds to variant dbSNP:rs55824107Ensembl. | 1 | |
Natural variantiVAR_041948 | 1356 | R → C1 PublicationCorresponds to variant dbSNP:rs56107531Ensembl. | 1 | |
Natural variantiVAR_041949 | 1389 | P → S1 PublicationCorresponds to variant dbSNP:rs56393725Ensembl. | 1 | |
Natural variantiVAR_041950 | 1411 | I → V1 PublicationCorresponds to variant dbSNP:rs34500740Ensembl. | 1 | |
Natural variantiVAR_041951 | 1540 | A → T1 PublicationCorresponds to variant dbSNP:rs55782058Ensembl. | 1 | |
Natural variantiVAR_041952 | 1549 | H → Y in a glioblastoma multiforme sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041953 | 1731 | K → N1 PublicationCorresponds to variant dbSNP:rs34241003Ensembl. | 1 | |
Natural variantiVAR_048435 | 1805 | I → V. Corresponds to variant dbSNP:rs16918393Ensembl. | 1 | |
Natural variantiVAR_041954 | 1810 | P → L1 PublicationCorresponds to variant dbSNP:rs56342342Ensembl. | 1 | |
Natural variantiVAR_041955 | 1824 | H → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF390562 mRNA Translation: AAN40840.1 |
CCDSi | CCDS35003.1 |
RefSeqi | NP_722516.1, NM_153809.2 |
Genome annotation databases
Ensembli | ENST00000242310; ENSP00000418379; ENSG00000122728 |
GeneIDi | 138474 |
KEGGi | hsa:138474 |
UCSCi | uc003zrg.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF390562 mRNA Translation: AAN40840.1 |
CCDSi | CCDS35003.1 |
RefSeqi | NP_722516.1, NM_153809.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3HMH | X-ray | 2.05 | A | 1523-1654 | [»] | |
5IGL | X-ray | 2.10 | A | 1523-1654 | [»] | |
SMRi | Q8IZX4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126514, 13 interactors |
IntActi | Q8IZX4, 4 interactors |
MINTi | Q8IZX4 |
STRINGi | 9606.ENSP00000418379 |
Chemistry databases
BindingDBi | Q8IZX4 |
ChEMBLi | CHEMBL3108641 |
PTM databases
iPTMneti | Q8IZX4 |
PhosphoSitePlusi | Q8IZX4 |
Genetic variation databases
BioMutai | TAF1L |
DMDMi | 57013082 |
Proteomic databases
EPDi | Q8IZX4 |
jPOSTi | Q8IZX4 |
MassIVEi | Q8IZX4 |
MaxQBi | Q8IZX4 |
PaxDbi | Q8IZX4 |
PeptideAtlasi | Q8IZX4 |
PRIDEi | Q8IZX4 |
ProteomicsDBi | 71440 |
Protocols and materials databases
Antibodypediai | 25077, 58 antibodies |
Genome annotation databases
Ensembli | ENST00000242310; ENSP00000418379; ENSG00000122728 |
GeneIDi | 138474 |
KEGGi | hsa:138474 |
UCSCi | uc003zrg.1, human |
Organism-specific databases
CTDi | 138474 |
DisGeNETi | 138474 |
GeneCardsi | TAF1L |
HGNCi | HGNC:18056, TAF1L |
HPAi | ENSG00000122728, Tissue enriched (testis) |
MIMi | 607798, gene |
neXtProti | NX_Q8IZX4 |
OpenTargetsi | ENSG00000122728 |
PharmGKBi | PA134947802 |
VEuPathDBi | HostDB:ENSG00000122728.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0008, Eukaryota |
GeneTreei | ENSGT00940000155242 |
HOGENOMi | CLU_000572_3_0_1 |
InParanoidi | Q8IZX4 |
OMAi | RENVRKC |
OrthoDBi | 103411at2759 |
PhylomeDBi | Q8IZX4 |
TreeFami | TF313573 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZX4 |
Reactomei | R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance |
Miscellaneous databases
BioGRID-ORCSi | 138474, 9 hits in 875 CRISPR screens |
EvolutionaryTracei | Q8IZX4 |
GenomeRNAii | 138474 |
Pharosi | Q8IZX4, Tchem |
PROi | PR:Q8IZX4 |
RNActi | Q8IZX4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122728, Expressed in mucosa of paranasal sinus and 74 other tissues |
Genevisiblei | Q8IZX4, HS |
Family and domain databases
Gene3Di | 1.10.1100.10, 1 hit 1.20.920.10, 2 hits |
InterProi | View protein in InterPro IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR040240, TAF1 IPR011177, TAF1_animal IPR009067, TAF_II_230-bd IPR036741, TAFII-230_TBP-bd_sf IPR022591, TFIID_sub1_DUF3591 IPR041670, Znf-CCHC_6 |
PANTHERi | PTHR13900, PTHR13900, 1 hit |
Pfami | View protein in Pfam PF00439, Bromodomain, 2 hits PF12157, DUF3591, 1 hit PF09247, TBP-binding, 1 hit PF15288, zf-CCHC_6, 1 hit |
PIRSFi | PIRSF003047, TAF1_animal, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00297, BROMO, 2 hits |
SUPFAMi | SSF47055, SSF47055, 1 hit SSF47370, SSF47370, 2 hits |
PROSITEi | View protein in PROSITE PS00633, BROMODOMAIN_1, 2 hits PS50014, BROMODOMAIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAF1L_HUMAN | |
Accessioni | Q8IZX4Primary (citable) accession number: Q8IZX4 Secondary accession number(s): Q0VG57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants