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UniProtKB - Q8IZX4 (TAF1L_HUMAN)

Entry version 151 (10 Feb 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Transcription initiation factor TFIID subunit 1-like

Gene

TAF1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IZX4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 1-like
Alternative name(s):
TAF(II)210
TBP-associated factor 1-like
TBP-associated factor 210 kDa
Transcription initiation factor TFIID 210 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18056, TAF1L

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607798, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IZX4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000122728.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		138474

Open Targets

More...OpenTargetsi		ENSG00000122728

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134947802

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IZX4, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3108641

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TAF1L

Domain mapping of disease mutations (DMDM)

More...DMDMi		57013082

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002112171 – 1826Transcription initiation factor TFIID subunit 1-likeAdd BLAST1826

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IZX4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IZX4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IZX4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IZX4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IZX4

PeptideAtlas

More...PeptideAtlasi		Q8IZX4

PRoteomics IDEntifications database

More...PRIDEi		Q8IZX4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71440

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IZX4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IZX4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis specific, expressed apparently in germ cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000122728, Expressed in mucosa of paranasal sinus and 74 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IZX4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000122728, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can bind directly to TATA-box binding protein (TBP).

Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro).

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126514, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q8IZX4, 4 interactors

Molecular INTeraction database

More...MINTi		Q8IZX4

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000418379

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8IZX4

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IZX4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11826
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IZX4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8IZX4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1416 – 1486Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1539 – 1609Bromo 2PROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1370 – 1377Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi156 – 164Pro-rich9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF1 family.Curated

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0008, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155242

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000572_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IZX4

Identification of Orthologs from Complete Genome Data

More...OMAi		RENVRKC

Database of Orthologous Groups

More...OrthoDBi		103411at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IZX4

TreeFam database of animal gene trees

More...TreeFami		TF313573

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1100.10, 1 hit
1.20.920.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR040240, TAF1
IPR011177, TAF1_animal
IPR009067, TAF_II_230-bd
IPR036741, TAFII-230_TBP-bd_sf
IPR022591, TFIID_sub1_DUF3591
IPR041670, Znf-CCHC_6

The PANTHER Classification System

More...PANTHERi		PTHR13900, PTHR13900, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00439, Bromodomain, 2 hits
PF12157, DUF3591, 1 hit
PF09247, TBP-binding, 1 hit
PF15288, zf-CCHC_6, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF003047, TAF1_animal, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00297, BROMO, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47055, SSF47055, 1 hit
SSF47370, SSF47370, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00633, BROMODOMAIN_1, 2 hits
PS50014, BROMODOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IZX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPGCDLLLR AAATVTAAIM SDSDSEEDSS GGGPFTLAGI LFGNISGAGQ 
        60         70         80         90        100
LEGESVLDDE CKKHLAGLGA LGLGSLITEL TANEELTGTG GALVNDEGWI 
       110        120        130        140        150
RSTEDAVDYS DINEVAEDES QRHQQTMGSL QPLYHSDYDE DDYDADCEDI 
       160        170        180        190        200
DCKLMPPPPP PPGPMKKDKD QDAITCVSES GEDIILPSII APSFLASEKV 
       210        220        230        240        250
DFSSYSDSES EMGPQEATQA ESEDGKLTLP LAGIMQHDAT KLLPSVTELF 
       260        270        280        290        300
PEFRPGKVLR FLHLFGPGKN VPSVWRSARR KRKKHRELIQ EEQIQEVECS 
       310        320        330        340        350
VESEVSQKSL WNYDYAPPPP PEQCLADDEI TMMVPVESKF SQSTGDVDKV 
       360        370        380        390        400
TDTKPRVAEW RYGPARLWYD MLGVSEDGSG FDYGFKLRKT QHEPVIKSRM 
       410        420        430        440        450
MEEFRKLEES NGTDLLADEN FLMVTQLHWE DSIIWDGEDI KHKGTKPQGA 
       460        470        480        490        500
SLAGWLPSIK TRNVMAYNVQ QGFAPTLDDD KPWYSIFPID NEDLVYGRWE 
       510        520        530        540        550
DNIIWDAQAM PRLLEPPVLA LDPNDENLIL EIPDEKEEAT SNSPSKESKK 
       560        570        580        590        600
ESSLKKSRIL LGKTGVIREE PQQNMSQPEV KDPWNLSNDE YYFPKQQGLR 
       610        620        630        640        650
GTFGGNIIQH SIPAMELWQP FFPTHMGPIK IRQFHRPPLK KYSFGALSQP 
       660        670        680        690        700
GPHSVQPLLK HIKKKAKMRE QERQASGGGE LFFMRTPQDL TGKDGDLILA 
       710        720        730        740        750
EYSEENGPLM MQVGMATKIK NYYKRKPGKD PGAPDCKYGE TVYCHTSPFL 
       760        770        780        790        800
GSLHPGQLLQ ALENNLFRAP VYLHKMPETD FLIIRTRQGY YIRELVDIFV 
       810        820        830        840        850
VGQQCPLFEV PGPNSRRANM HIRDFLQVFI YRLFWKSKDR PRRIRMEDIK 
       860        870        880        890        900
KAFPSHSESS IRKRLKLCAD FKRTGMDSNW WVLKSDFRLP TEEEIRAKVS 
       910        920        930        940        950
PEQCCAYYSM IAAKQRLKDA GYGEKSFFAP EEENEEDFQM KIDDEVHAAP 
       960        970        980        990       1000
WNTTRAFIAA MKGKCLLEVT GVADPTGCGE GFSYVKIPNK PTQQKDDKEP 
      1010       1020       1030       1040       1050
QAVKKTVTGT DADLRRLSLK NAKQLLRKFG VPEEEIKKLS RWEVIDVVRT 
      1060       1070       1080       1090       1100
MSTEQAHSGE GPMSKFARGS RFSVAEHQER YKEECQRIFD LQNKVLSSTE 
      1110       1120       1130       1140       1150
VLSTDTDSIS AEDSDFEEMG KNIENMLQNK KTSSQLSREW EEQERKELRR 
      1160       1170       1180       1190       1200
MLLVAGSAAS GNNHRDDVTA SMTSLKSSAT GHCLKIYRTF RDEEGKEYVR 
      1210       1220       1230       1240       1250
CETVRKPAVI DAYVRIRTTK DEKFIQKFAL FDEKHREEMR KERRRIQEQL 
      1260       1270       1280       1290       1300
RRLKRNQEKE KLKGPPEKKP KKMKERPDLK LKCGACGAIG HMRTNKFCPL 
      1310       1320       1330       1340       1350
YYQTNVPPSK PVAMTEEQEE ELEKTVIHND NEELIKVEGT KIVFGKQLIE 
      1360       1370       1380       1390       1400
NVHEVRRKSL VLKFPKQQLP PKKKRRVGTT VHCDYLNIPH KSIHRRRTDP 
      1410       1420       1430       1440       1450
MVTLSSILES IINDMRDLPN THPFHTPVNA KVVKDYYKII TRPMDLQTLR 
      1460       1470       1480       1490       1500
ENVRKCLYPS REEFREHLEL IVKNSATYNG PKHSLTQISQ SMLDLCDEKL 
      1510       1520       1530       1540       1550
KEKEDKLARL EKAINPLLDD DDQVAFSFIL DNIVTQKMMA VPDSWPFHHP 
      1560       1570       1580       1590       1600
VNKKFVPDYY KMIVNPVDLE TIRKNISKHK YQSRESFLDD VNLILANSVK 
      1610       1620       1630       1640       1650
YNGPESQYTK TAQEIVNICY QTITEYDEHL TQLEKDICTA KEAALEEAEL 
      1660       1670       1680       1690       1700
ESLDPMTPGP YTSQPPDMYD TNTSLSTSRD ASVFQDESNL SVLDISTATP 
      1710       1720       1730       1740       1750
EKQMCQGQGR LGEEDSDVDV EGYDDEEEDG KPKPPAPEGG DGDLADEEEG 
      1760       1770       1780       1790       1800
TVQQPEASVL YEDLLISEGE DDEEDAGSDE EGDNPFSAIQ LSESGSDSDV 
      1810       1820 
GYGGIRPKQP FMLQHASGEH KDGHGK
Length:1,826
Mass (Da):207,302
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35D780E749AC9B17
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04193447G → A in a lung small cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041935171Q → E1 PublicationCorresponds to variant dbSNP:rs56352331Ensembl.1
Natural variantiVAR_041936256G → A1 PublicationCorresponds to variant dbSNP:rs55991718Ensembl.1
Natural variantiVAR_041937371M → V1 PublicationCorresponds to variant dbSNP:rs17219559Ensembl.1
Natural variantiVAR_041938532I → N1 PublicationCorresponds to variant dbSNP:rs56128445Ensembl.1
Natural variantiVAR_041939637P → S1 PublicationCorresponds to variant dbSNP:rs56157814Ensembl.1
Natural variantiVAR_041940750L → F in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041941762L → I in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041942794E → D in a lung adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041943845R → Q1 PublicationCorresponds to variant dbSNP:rs34787787Ensembl.1
Natural variantiVAR_0419441016R → C1 PublicationCorresponds to variant dbSNP:rs35905429Ensembl.1
Natural variantiVAR_0419451038K → N1 PublicationCorresponds to variant dbSNP:rs55767137Ensembl.1
Natural variantiVAR_0419461169T → I1 PublicationCorresponds to variant dbSNP:rs55976674Ensembl.1
Natural variantiVAR_0419471312V → L1 PublicationCorresponds to variant dbSNP:rs55824107Ensembl.1
Natural variantiVAR_0419481356R → C1 PublicationCorresponds to variant dbSNP:rs56107531Ensembl.1
Natural variantiVAR_0419491389P → S1 PublicationCorresponds to variant dbSNP:rs56393725Ensembl.1
Natural variantiVAR_0419501411I → V1 PublicationCorresponds to variant dbSNP:rs34500740Ensembl.1
Natural variantiVAR_0419511540A → T1 PublicationCorresponds to variant dbSNP:rs55782058Ensembl.1
Natural variantiVAR_0419521549H → Y in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_0419531731K → N1 PublicationCorresponds to variant dbSNP:rs34241003Ensembl.1
Natural variantiVAR_0484351805I → V. Corresponds to variant dbSNP:rs16918393Ensembl.1
Natural variantiVAR_0419541810P → L1 PublicationCorresponds to variant dbSNP:rs56342342Ensembl.1
Natural variantiVAR_0419551824H → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF390562 mRNA Translation: AAN40840.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35003.1

NCBI Reference Sequences

More...RefSeqi		NP_722516.1, NM_153809.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000242310; ENSP00000418379; ENSG00000122728

Database of genes from NCBI RefSeq genomes

More...GeneIDi		138474

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:138474

UCSC genome browser

More...UCSCi		uc003zrg.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF390562 mRNA Translation: AAN40840.1
CCDSiCCDS35003.1
RefSeqiNP_722516.1, NM_153809.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HMHX-ray2.05A1523-1654[»]
5IGLX-ray2.10A1523-1654[»]
SMRiQ8IZX4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi126514, 13 interactors
IntActiQ8IZX4, 4 interactors
MINTiQ8IZX4
STRINGi9606.ENSP00000418379

Chemistry databases

BindingDBiQ8IZX4
ChEMBLiCHEMBL3108641

PTM databases

iPTMnetiQ8IZX4
PhosphoSitePlusiQ8IZX4

Genetic variation databases

BioMutaiTAF1L
DMDMi57013082

Proteomic databases

EPDiQ8IZX4
jPOSTiQ8IZX4
MassIVEiQ8IZX4
MaxQBiQ8IZX4
PaxDbiQ8IZX4
PeptideAtlasiQ8IZX4
PRIDEiQ8IZX4
ProteomicsDBi71440

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25077, 58 antibodies

Genome annotation databases

EnsembliENST00000242310; ENSP00000418379; ENSG00000122728
GeneIDi138474
KEGGihsa:138474
UCSCiuc003zrg.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		138474
DisGeNETi138474

GeneCards: human genes, protein and diseases

More...GeneCardsi		TAF1L
HGNCiHGNC:18056, TAF1L
HPAiENSG00000122728, Tissue enriched (testis)
MIMi607798, gene
neXtProtiNX_Q8IZX4
OpenTargetsiENSG00000122728
PharmGKBiPA134947802
VEuPathDBiHostDB:ENSG00000122728.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0008, Eukaryota
GeneTreeiENSGT00940000155242
HOGENOMiCLU_000572_3_0_1
InParanoidiQ8IZX4
OMAiRENVRKC
OrthoDBi103411at2759
PhylomeDBiQ8IZX4
TreeFamiTF313573

Enzyme and pathway databases

PathwayCommonsiQ8IZX4
ReactomeiR-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		138474, 9 hits in 875 CRISPR screens
EvolutionaryTraceiQ8IZX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		138474
PharosiQ8IZX4, Tchem

Protein Ontology

More...PROi		PR:Q8IZX4
RNActiQ8IZX4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000122728, Expressed in mucosa of paranasal sinus and 74 other tissues
GenevisibleiQ8IZX4, HS

Family and domain databases

Gene3Di1.10.1100.10, 1 hit
1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR040240, TAF1
IPR011177, TAF1_animal
IPR009067, TAF_II_230-bd
IPR036741, TAFII-230_TBP-bd_sf
IPR022591, TFIID_sub1_DUF3591
IPR041670, Znf-CCHC_6
PANTHERiPTHR13900, PTHR13900, 1 hit
PfamiView protein in Pfam
PF00439, Bromodomain, 2 hits
PF12157, DUF3591, 1 hit
PF09247, TBP-binding, 1 hit
PF15288, zf-CCHC_6, 1 hit
PIRSFiPIRSF003047, TAF1_animal, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 2 hits
SUPFAMiSSF47055, SSF47055, 1 hit
SSF47370, SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 2 hits
PS50014, BROMODOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZX4
Secondary accession number(s): Q0VG57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2003
Last modified: February 10, 2021
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with genetic variants
    List of human entries with genetic variants
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