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Protein

Tensin-4

Gene

TNS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • protein localization Source: UniProtKB

Keywordsi

Molecular functionActin-binding
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-8875513 MET interacts with TNS proteins
SignaLinkiQ8IZW8

Names & Taxonomyi

Protein namesi
Recommended name:
Tensin-4
Alternative name(s):
C-terminal tensin-like protein
Gene namesi
Name:TNS4
Synonyms:CTEN
ORF Names:PP14434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131746.12
HGNCiHGNC:24352 TNS4
MIMi608385 gene
neXtProtiNX_Q8IZW8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi506D → A: No effect on cleavage by caspase-3. 1 Publication1
Mutagenesisi570D → A: Abolishes cleavage by caspase-3. 1 Publication1

Organism-specific databases

DisGeNETi84951
OpenTargetsiENSG00000131746
PharmGKBiPA142670717

Polymorphism and mutation databases

BioMutaiTNS4
DMDMi229463025

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000024821319 – 715Tensin-4Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Post-translational modificationi

Proteolytically cleaved by caspase-3 during apoptosis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei570 – 571Cleavage; by caspase-32

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IZW8
MaxQBiQ8IZW8
PaxDbiQ8IZW8
PeptideAtlasiQ8IZW8
PRIDEiQ8IZW8
ProteomicsDBi71438

PTM databases

iPTMnetiQ8IZW8
PhosphoSitePlusiQ8IZW8

Miscellaneous databases

PMAP-CutDBiQ8IZW8

Expressioni

Tissue specificityi

Prostate and placenta. Down regulated in prostate cancer.1 Publication

Gene expression databases

BgeeiENSG00000131746 Expressed in 173 organ(s), highest expression level in skin of abdomen
CleanExiHS_TNS4
ExpressionAtlasiQ8IZW8 baseline and differential
GenevisibleiQ8IZW8 HS

Interactioni

Subunit structurei

Binds to actin filaments and interacts with phosphotyrosine-containing proteins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124383, 20 interactors
IntActiQ8IZW8, 22 interactors
MINTiQ8IZW8
STRINGi9606.ENSP00000254051

Structurei

3D structure databases

ProteinModelPortaliQ8IZW8
SMRiQ8IZW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini449 – 556SH2PROSITE-ProRule annotationAdd BLAST108
Domaini548 – 714Phosphatase tensin-typeAdd BLAST167

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 324Ser-richAdd BLAST157

Keywords - Domaini

SH2 domain, Signal

Phylogenomic databases

eggNOGiENOG410IUIK Eukaryota
ENOG41125SH LUCA
GeneTreeiENSGT00760000119113
HOGENOMiHOG000230981
HOVERGENiHBG080039
InParanoidiQ8IZW8
KOiK18080
OMAiGPQRCSS
OrthoDBiEOG091G0G8Y
PhylomeDBiQ8IZW8
TreeFamiTF315996

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR033929 Tensin_PTB
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IZW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQVMSSPLL AGGHAVSLAP CDEPRRTLHP APSPSLPPQC SYYTTEGWGA
60 70 80 90 100
QALMAPVPCM GPPGRLQQAP QVEAKATCFL PSPGEKALGT PEDLDSYIDF
110 120 130 140 150
SLESLNQMIL ELDPTFQLLP PGTGGSQAEL AQSTMSMRKK EESEALDIKY
160 170 180 190 200
IEVTSARSRC HDGPQHCSSP SVTPPFGSLR SGGLLLSRDV PRETRSSSES
210 220 230 240 250
LIFSGNQGRG HQRPLPPSEG LSPRPPNSPS ISIPCMGSKA SSPHGLGSPL
260 270 280 290 300
VASPRLEKRL GGLAPQRGSR ISVLSASPVS DVSYMFGSSQ SLLHSSNSSH
310 320 330 340 350
QSSSRSLESP ANSSSSLHSL GSVSLCTRPS DFQAPRNPTL TMGQPRTPHS
360 370 380 390 400
PPLAKEHASS CPPSITNSMV DIPIVLINGC PEPGSSPPQR TPGHQNSVQP
410 420 430 440 450
GAASPSNPCP ATRSNSQTLS DAPFTTCPEG PARDMQPTMK FVMDTSKYWF
460 470 480 490 500
KPNITREQAI ELLRKEEPGA FVIRDSSSYR GSFGLALKVQ EVPASAQSRP
510 520 530 540 550
GEDSNDLIRH FLIESSAKGV HLKGADEEPY FGSLSAFVCQ HSIMALALPC
560 570 580 590 600
KLTIPQRELG GADGASDSTD SPASCQKKSA GCHTLYLSSV SVETLTGALA
610 620 630 640 650
VQKAISTTFE RDILPTPTVV HFKVTEQGIT LTDVQRKVFF RRHYPLTTLR
660 670 680 690 700
FCGMDPEQRK WQKYCKPSWI FGFVAKSQTE PQENVCHLFA EYDMVQPASQ
710
VIGLVTALLQ DAERM
Length:715
Mass (Da):76,764
Last modified:May 5, 2009 - v3
Checksum:iE6AD7CB6B6DDA5D2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLA4J3QLA4_HUMAN
Tensin-4
TNS4
33Annotation score:

Sequence cautioni

The sequence AAQ15257 differs from that shown. Reason: Frameshift at positions 85, 296, 472 and 602.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163G → W in AAN32666 (PubMed:12154022).Curated1
Sequence conflicti360S → I in AAN32666 (PubMed:12154022).Curated1
Sequence conflicti360S → I in BAB55413 (PubMed:14702039).Curated1
Sequence conflicti623K → E in AAN32666 (PubMed:12154022).Curated1
Sequence conflicti623K → E in BAB55413 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027264179L → P1 PublicationCorresponds to variant dbSNP:rs3764424Ensembl.1
Natural variantiVAR_055292327T → K. Corresponds to variant dbSNP:rs33923045Ensembl.1
Natural variantiVAR_027265498S → N2 PublicationsCorresponds to variant dbSNP:rs2290207Ensembl.1
Natural variantiVAR_036515642R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs148022611Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF417488 mRNA Translation: AAN32666.1
AF370421 mRNA Translation: AAQ15257.1 Frameshift.
AK027856 mRNA Translation: BAB55413.1
AC018629 Genomic DNA No translation available.
BC018706 mRNA Translation: AAH18706.1
CCDSiCCDS11368.1
RefSeqiNP_116254.4, NM_032865.5
UniGeneiHs.438292

Genome annotation databases

EnsembliENST00000254051; ENSP00000254051; ENSG00000131746
GeneIDi84951
KEGGihsa:84951
UCSCiuc010cxb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF417488 mRNA Translation: AAN32666.1
AF370421 mRNA Translation: AAQ15257.1 Frameshift.
AK027856 mRNA Translation: BAB55413.1
AC018629 Genomic DNA No translation available.
BC018706 mRNA Translation: AAH18706.1
CCDSiCCDS11368.1
RefSeqiNP_116254.4, NM_032865.5
UniGeneiHs.438292

3D structure databases

ProteinModelPortaliQ8IZW8
SMRiQ8IZW8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124383, 20 interactors
IntActiQ8IZW8, 22 interactors
MINTiQ8IZW8
STRINGi9606.ENSP00000254051

PTM databases

iPTMnetiQ8IZW8
PhosphoSitePlusiQ8IZW8

Polymorphism and mutation databases

BioMutaiTNS4
DMDMi229463025

Proteomic databases

EPDiQ8IZW8
MaxQBiQ8IZW8
PaxDbiQ8IZW8
PeptideAtlasiQ8IZW8
PRIDEiQ8IZW8
ProteomicsDBi71438

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254051; ENSP00000254051; ENSG00000131746
GeneIDi84951
KEGGihsa:84951
UCSCiuc010cxb.4 human

Organism-specific databases

CTDi84951
DisGeNETi84951
EuPathDBiHostDB:ENSG00000131746.12
GeneCardsiTNS4
H-InvDBiHIX0013799
HGNCiHGNC:24352 TNS4
MIMi608385 gene
neXtProtiNX_Q8IZW8
OpenTargetsiENSG00000131746
PharmGKBiPA142670717
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUIK Eukaryota
ENOG41125SH LUCA
GeneTreeiENSGT00760000119113
HOGENOMiHOG000230981
HOVERGENiHBG080039
InParanoidiQ8IZW8
KOiK18080
OMAiGPQRCSS
OrthoDBiEOG091G0G8Y
PhylomeDBiQ8IZW8
TreeFamiTF315996

Enzyme and pathway databases

ReactomeiR-HSA-8875513 MET interacts with TNS proteins
SignaLinkiQ8IZW8

Miscellaneous databases

ChiTaRSiTNS4 human
GeneWikiiTNS4
GenomeRNAii84951
PMAP-CutDBiQ8IZW8
PROiPR:Q8IZW8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131746 Expressed in 173 organ(s), highest expression level in skin of abdomen
CleanExiHS_TNS4
ExpressionAtlasiQ8IZW8 baseline and differential
GenevisibleiQ8IZW8 HS

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR033929 Tensin_PTB
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTENS4_HUMAN
AccessioniPrimary (citable) accession number: Q8IZW8
Secondary accession number(s): A6NMJ7
, Q71RB7, Q8WV64, Q96JV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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