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UniProtKB - Q8IZV5 (RDH10_HUMAN)
Protein
Retinol dehydrogenase 10
Gene
RDH10
Organism
Homo sapiens (Human)
Status
Functioni
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.
1 PublicationCatalytic activityi
- EC:1.1.1.3001 Publication
: retinol metabolism Pathwayi
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 197 | SubstrateBy similarity | 1 | |
Active sitei | 210 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 64 | NADPBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- NADP-retinol dehydrogenase activity Source: Reactome
- NAD-retinol dehydrogenase activity Source: UniProtKB
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: GO_Central
GO - Biological processi
- bud elongation involved in lung branching Source: Ensembl
- ear development Source: Ensembl
- embryonic camera-type eye development Source: Ensembl
- embryonic forelimb morphogenesis Source: Ensembl
- embryonic viscerocranium morphogenesis Source: Ensembl
- gonad development Source: Ensembl
- in utero embryonic development Source: Ensembl
- metanephros development Source: Ensembl
- neural crest cell development Source: Ensembl
- nose development Source: Ensembl
- positive regulation of retinoic acid biosynthetic process Source: Ensembl
- primary lung bud formation Source: Ensembl
- retinal metabolic process Source: UniProtKB
- retinoic acid biosynthetic process Source: Ensembl
- retinoid metabolic process Source: Reactome
- retinol metabolic process Source: UniProtKB
- visual perception Source: MGI
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Lipid metabolism |
Ligand | NADP |
Enzyme and pathway databases
BRENDAi | 1.1.1.105, 2681 1.1.1.315, 2681 |
PathwayCommonsi | Q8IZV5 |
Reactomei | R-HSA-2453902, The canonical retinoid cycle in rods (twilight vision) R-HSA-5365859, RA biosynthesis pathway |
SignaLinki | Q8IZV5 |
SIGNORi | Q8IZV5 |
UniPathwayi | UPA00912 |
Chemistry databases
SwissLipidsi | SLP:000001866 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinol dehydrogenase 10 (EC:1.1.1.300)Alternative name(s): Short chain dehydrogenase/reductase family 16C member 4 |
Gene namesi | Name:RDH10 Synonyms:SDR16C4 ORF Names:UNQ9375/PRO34191 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19975, RDH10 |
MIMi | 607599, gene |
neXtProti | NX_Q8IZV5 |
VEuPathDBi | HostDB:ENSG00000121039 |
Subcellular locationi
Endoplasmic reticulum
- Microsome membrane Curated; Single-pass membrane protein Curated
- Endoplasmic reticulum membrane Curated; Single-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB
- lipid droplet Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 3 – 23 | Helical; Signal-anchorSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 157506 |
OpenTargetsi | ENSG00000121039 |
PharmGKBi | PA134989620 |
Miscellaneous databases
Pharosi | Q8IZV5, Tbio |
Genetic variation databases
BioMutai | RDH10 |
DMDMi | 74750799 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307682 | 1 – 341 | Retinol dehydrogenase 10Add BLAST | 341 |
Proteomic databases
EPDi | Q8IZV5 |
jPOSTi | Q8IZV5 |
MassIVEi | Q8IZV5 |
MaxQBi | Q8IZV5 |
PaxDbi | Q8IZV5 |
PeptideAtlasi | Q8IZV5 |
PRIDEi | Q8IZV5 |
ProteomicsDBi | 71436 |
PTM databases
iPTMneti | Q8IZV5 |
PhosphoSitePlusi | Q8IZV5 |
SwissPalmi | Q8IZV5 |
Expressioni
Tissue specificityi
Detected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle.2 Publications
Gene expression databases
Bgeei | ENSG00000121039, Expressed in nasal cavity epithelium and 207 other tissues |
ExpressionAtlasi | Q8IZV5, baseline and differential |
Genevisiblei | Q8IZV5, HS |
Organism-specific databases
HPAi | ENSG00000121039, Low tissue specificity |
Interactioni
Binary interactionsi
Q8IZV5
With | #Exp. | IntAct |
---|---|---|
ACSF2 [Q96CM8] | 3 | EBI-11913715,EBI-2876502 |
DDA1 [Q9BW61] | 3 | EBI-11913715,EBI-2510241 |
GAD2 [Q05329] | 3 | EBI-11913715,EBI-9304251 |
RMDN2 [Q96LZ7] | 3 | EBI-11913715,EBI-2806908 |
Protein-protein interaction databases
BioGRIDi | 127600, 18 interactors |
IntActi | Q8IZV5, 5 interactors |
STRINGi | 9606.ENSP00000240285 |
Miscellaneous databases
RNActi | Q8IZV5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1201, Eukaryota |
GeneTreei | ENSGT00940000157063 |
HOGENOMi | CLU_010194_2_5_1 |
InParanoidi | Q8IZV5 |
OMAi | DQIQMSL |
OrthoDBi | 1373099at2759 |
PhylomeDBi | Q8IZV5 |
TreeFami | TF312837 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR032970, RDH10 IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PANTHERi | PTHR24322:SF731, PTHR24322:SF731, 1 hit |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8IZV5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR
60 70 80 90 100
LFALEFARRR ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG
110 120 130 140 150
EEEILPHCNL QVFTYTCDVG KRENVYLTAE RVRKEVGEVS VLVNNAGVVS
160 170 180 190 200
GHHLLECPDE LIERTMMVNC HAHFWTTKAF LPTMLEINHG HIVTVASSLG
210 220 230 240 250
LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL VCPYLVDTGM
260 270 280 290 300
FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK
310 320 330 340
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RK48 | E5RK48_HUMAN | NADP-retinol dehydrogenase | RDH10 | 176 | Annotation score: | ||
E5RHJ9 | E5RHJ9_HUMAN | NADP-retinol dehydrogenase | RDH10 | 62 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF456765 mRNA Translation: AAN64747.1 AY358270 mRNA Translation: AAQ88637.1 BC067131 mRNA Translation: AAH67131.1 |
CCDSi | CCDS6213.1 |
RefSeqi | NP_742034.1, NM_172037.4 |
Genome annotation databases
Ensembli | ENST00000240285; ENSP00000240285; ENSG00000121039 |
GeneIDi | 157506 |
KEGGi | hsa:157506 |
MANE-Selecti | ENST00000240285.10; ENSP00000240285.5; NM_172037.5; NP_742034.1 |
UCSCi | uc003xzi.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF456765 mRNA Translation: AAN64747.1 AY358270 mRNA Translation: AAQ88637.1 BC067131 mRNA Translation: AAH67131.1 |
CCDSi | CCDS6213.1 |
RefSeqi | NP_742034.1, NM_172037.4 |
3D structure databases
SMRi | Q8IZV5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127600, 18 interactors |
IntActi | Q8IZV5, 5 interactors |
STRINGi | 9606.ENSP00000240285 |
Chemistry databases
SwissLipidsi | SLP:000001866 |
PTM databases
iPTMneti | Q8IZV5 |
PhosphoSitePlusi | Q8IZV5 |
SwissPalmi | Q8IZV5 |
Genetic variation databases
BioMutai | RDH10 |
DMDMi | 74750799 |
Proteomic databases
EPDi | Q8IZV5 |
jPOSTi | Q8IZV5 |
MassIVEi | Q8IZV5 |
MaxQBi | Q8IZV5 |
PaxDbi | Q8IZV5 |
PeptideAtlasi | Q8IZV5 |
PRIDEi | Q8IZV5 |
ProteomicsDBi | 71436 |
Protocols and materials databases
Antibodypediai | 42541, 151 antibodies from 24 providers |
DNASUi | 157506 |
Genome annotation databases
Ensembli | ENST00000240285; ENSP00000240285; ENSG00000121039 |
GeneIDi | 157506 |
KEGGi | hsa:157506 |
MANE-Selecti | ENST00000240285.10; ENSP00000240285.5; NM_172037.5; NP_742034.1 |
UCSCi | uc003xzi.4, human |
Organism-specific databases
CTDi | 157506 |
DisGeNETi | 157506 |
GeneCardsi | RDH10 |
HGNCi | HGNC:19975, RDH10 |
HPAi | ENSG00000121039, Low tissue specificity |
MIMi | 607599, gene |
neXtProti | NX_Q8IZV5 |
OpenTargetsi | ENSG00000121039 |
PharmGKBi | PA134989620 |
VEuPathDBi | HostDB:ENSG00000121039 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1201, Eukaryota |
GeneTreei | ENSGT00940000157063 |
HOGENOMi | CLU_010194_2_5_1 |
InParanoidi | Q8IZV5 |
OMAi | DQIQMSL |
OrthoDBi | 1373099at2759 |
PhylomeDBi | Q8IZV5 |
TreeFami | TF312837 |
Enzyme and pathway databases
UniPathwayi | UPA00912 |
BRENDAi | 1.1.1.105, 2681 1.1.1.315, 2681 |
PathwayCommonsi | Q8IZV5 |
Reactomei | R-HSA-2453902, The canonical retinoid cycle in rods (twilight vision) R-HSA-5365859, RA biosynthesis pathway |
SignaLinki | Q8IZV5 |
SIGNORi | Q8IZV5 |
Miscellaneous databases
BioGRID-ORCSi | 157506, 7 hits in 1050 CRISPR screens |
ChiTaRSi | RDH10, human |
GenomeRNAii | 157506 |
Pharosi | Q8IZV5, Tbio |
PROi | PR:Q8IZV5 |
RNActi | Q8IZV5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121039, Expressed in nasal cavity epithelium and 207 other tissues |
ExpressionAtlasi | Q8IZV5, baseline and differential |
Genevisiblei | Q8IZV5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR032970, RDH10 IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PANTHERi | PTHR24322:SF731, PTHR24322:SF731, 1 hit |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDH10_HUMAN | |
Accessioni | Q8IZV5Primary (citable) accession number: Q8IZV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families