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Entry version 118 (12 Aug 2020)
Sequence version 2 (20 Feb 2007)
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Protein

Dermatan-sulfate epimerase-like protein

Gene

DSEL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.1.3.19, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IZU8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022923, Dermatan sulfate biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dermatan-sulfate epimerase-like protein (EC:5.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSEL
Synonyms:C18orf4, NCAG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000171451.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18144, DSEL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611125, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZU8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei764 – 784HelicalSequence analysisAdd BLAST21
Transmembranei803 – 823HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92126

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162384097

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IZU8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DSEL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126215700

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027828821 – 1212Dermatan-sulfate epimerase-like proteinAdd BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi709N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi874N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IZU8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IZU8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IZU8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IZU8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZU8

PeptideAtlas

More...
PeptideAtlasi
Q8IZU8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZU8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71432

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8IZU8, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZU8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZU8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in different brain areas as well as in multiple other peripheral tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171451, Expressed in female gonad and 193 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZU8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171451, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124911, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IZU8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310565

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IZU8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IZU8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dermatan-sulfate isomerase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPWZ, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011348_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZU8

Database of Orthologous Groups

More...
OrthoDBi
588663at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZU8

TreeFam database of animal gene trees

More...
TreeFami
TF334118

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008929, Chondroitin_lyas
IPR027417, P-loop_NTPase
IPR000863, Sulfotransferase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00685, Sulfotransfer_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZU8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALMFTGHLL FLALLMFAFS TFEESVSNYS EWAVFTDDID QFKTQKVQDF
60 70 80 90 100
RPNQKLKKSM LHPSLYFDAG EIQAMRQKSR ASHLHLFRAI RSAVTVMLSN
110 120 130 140 150
PTYYLPPPKH ADFAAKWNEI YGNNLPPLAL YCLLCPEDKV AFEFVLEYMD
160 170 180 190 200
RMVGYKDWLV ENAPGDEVPI GHSLTGFATA FDFLYNLLDN HRRQKYLEKI
210 220 230 240 250
WVITEEMYEY SKVRSWGKQL LHNHQATNMI ALLTGALVTG VDKGSKANIW
260 270 280 290 300
KQAVVDVMEK TMFLLNHIVD GSLDEGVAYG SYTAKSVTQY VFLAQRHFNI
310 320 330 340 350
NNLDNNWLKM HFWFYYATLL PGFQRTVGIA DSNYNWFYGP ESQLVFLDKF
360 370 380 390 400
ILKNGAGNWL AQQIRKHRPK DGPMVPSTAQ RWSTLHTEYI WYDPQLTPQP
410 420 430 440 450
PADYGTAKIH TFPNWGVVTY GAGLPNTQTN TFVSFKSGKL GGRAVYDIVH
460 470 480 490 500
FQPYSWIDGW RSFNPGHEHP DQNSFTFAPN GQVFVSEALY GPKLSHLNNV
510 520 530 540 550
LVFAPSPSSQ CNKPWEGQLG ECAQWLKWTG EEVGDAAGEI ITASQHGEMV
560 570 580 590 600
FVSGEAVSAY SSAMRLKSVY RALLLLNSQT LLVVDHIERQ EDSPINSVSA
610 620 630 640 650
FFHNLDIDFK YIPYKFMNRY NGAMMDVWDA HYKMFWFDHH GNSPMASIQE
660 670 680 690 700
AEQAAEFKKR WTQFVNVTFQ MEPTITRIAY VFYGPYINVS SCRFIDSSNP
710 720 730 740 750
GLQISLNVNN TEHVVSIVTD YHNLKTRFNY LGFGGFASVA DQGQITRFGL
760 770 780 790 800
GTQAIVKPVR HDRIIFPFGF KFNIAVGLIL CISLVILTFQ WRFYLSFRKL
810 820 830 840 850
MRWILILVIA LWFIELLDVW STCSQPICAK WTRTEAEGSK KSLSSEGHHM
860 870 880 890 900
DLPDVVITSL PGSGAEILKQ LFFNSSDFLY IRVPTAYIDI PETELEIDSF
910 920 930 940 950
VDACEWKVSD IRSGHFRLLR GWLQSLVQDT KLHLQNIHLH EPNRGKLAQY
960 970 980 990 1000
FAMNKDKKRK FKRRESLPEQ RSQMKGAFDR DAEYIRALRR HLVYYPSARP
1010 1020 1030 1040 1050
VLSLSSGSWT LKLHFFQEVL GASMRALYIV RDPRAWIYSM LYNSKPSLYS
1060 1070 1080 1090 1100
LKNVPEHLAK LFKIEGGKGK CNLNSGYAFE YEPLRKELSK SKSNAVSLLS
1110 1120 1130 1140 1150
HLWLANTAAA LRINTDLLPT SYQLVKFEDI VHFPQKTTER IFAFLGIPLS
1160 1170 1180 1190 1200
PASLNQILFA TSTNLFYLPY EGEISPTNTN VWKQNLPRDE IKLIENICWT
1210
LMDRLGYPKF MD
Length:1,212
Mass (Da):139,238
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3C52221661234BD
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI17326 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAN32895 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188Missing in AAI17326 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030833673P → S. Corresponds to variant dbSNP:rs2279269Ensembl.1
Natural variantiVAR_030834730Y → C. Corresponds to variant dbSNP:rs12953840Ensembl.1
Natural variantiVAR_057759832T → S. Corresponds to variant dbSNP:rs35479856Ensembl.1
Natural variantiVAR_0365281090K → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF480435 mRNA Translation: AAN32895.1 Different initiation.
AC110597 Genomic DNA No translation available.
BC062557 mRNA Translation: AAH62557.1 Different termination.
BC117325 mRNA Translation: AAI17326.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11995.1

NCBI Reference Sequences

More...
RefSeqi
NP_115536.1, NM_032160.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310045; ENSP00000310565; ENSG00000171451
ENST00000572659; ENSP00000460321; ENSG00000262102

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92126

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92126

UCSC genome browser

More...
UCSCi
uc002lke.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480435 mRNA Translation: AAN32895.1 Different initiation.
AC110597 Genomic DNA No translation available.
BC062557 mRNA Translation: AAH62557.1 Different termination.
BC117325 mRNA Translation: AAI17326.1 Different initiation.
CCDSiCCDS11995.1
RefSeqiNP_115536.1, NM_032160.2

3D structure databases

SMRiQ8IZU8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124911, 2 interactors
IntActiQ8IZU8, 1 interactor
STRINGi9606.ENSP00000310565

PTM databases

GlyGeniQ8IZU8, 5 sites
iPTMnetiQ8IZU8
PhosphoSitePlusiQ8IZU8

Polymorphism and mutation databases

BioMutaiDSEL
DMDMi126215700

Proteomic databases

EPDiQ8IZU8
jPOSTiQ8IZU8
MassIVEiQ8IZU8
MaxQBiQ8IZU8
PaxDbiQ8IZU8
PeptideAtlasiQ8IZU8
PRIDEiQ8IZU8
ProteomicsDBi71432

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
77494, 4 antibodies

Genome annotation databases

EnsembliENST00000310045; ENSP00000310565; ENSG00000171451
ENST00000572659; ENSP00000460321; ENSG00000262102
GeneIDi92126
KEGGihsa:92126
UCSCiuc002lke.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92126
DisGeNETi92126
EuPathDBiHostDB:ENSG00000171451.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DSEL
HGNCiHGNC:18144, DSEL
HPAiENSG00000171451, Low tissue specificity
MIMi611125, gene
neXtProtiNX_Q8IZU8
PharmGKBiPA162384097

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QPWZ, Eukaryota
HOGENOMiCLU_011348_0_0_1
InParanoidiQ8IZU8
OrthoDBi588663at2759
PhylomeDBiQ8IZU8
TreeFamiTF334118

Enzyme and pathway databases

BRENDAi5.1.3.19, 2681
PathwayCommonsiQ8IZU8
ReactomeiR-HSA-2022923, Dermatan sulfate biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
92126, 17 hits in 866 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92126
PharosiQ8IZU8, Tdark

Protein Ontology

More...
PROi
PR:Q8IZU8
RNActiQ8IZU8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171451, Expressed in female gonad and 193 other tissues
GenevisibleiQ8IZU8, HS

Family and domain databases

Gene3Di1.50.10.100, 1 hit
InterProiView protein in InterPro
IPR008929, Chondroitin_lyas
IPR027417, P-loop_NTPase
IPR000863, Sulfotransferase_dom
PfamiView protein in Pfam
PF00685, Sulfotransfer_1, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDSEL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZU8
Secondary accession number(s): Q17RH1, Q6P5Z3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: August 12, 2020
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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