Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 144 (29 Sep 2021)
Sequence version 2 (25 Nov 2008)
Previous versions | rss
Add a publicationFeedback
Protein

WD repeat-containing protein 17

Gene

WDR17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IZU2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IZU2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16661, WDR17

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609005, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZU2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000150627

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
116966

Open Targets

More...
OpenTargetsi
ENSG00000150627

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38181

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IZU2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR17

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273912

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513641 – 1322WD repeat-containing protein 17Add BLAST1322

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IZU2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IZU2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IZU2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IZU2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZU2

PeptideAtlas

More...
PeptideAtlasi
Q8IZU2

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZU2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17667
71430 [Q8IZU2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZU2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZU2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000150627, Expressed in endothelial cell and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZU2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZU2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000150627, Tissue enhanced (brain, parathyroid gland, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125544, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IZU2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000280190

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IZU2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati81 – 121WD 1Add BLAST41
Repeati123 – 164WD 2Add BLAST42
Repeati171 – 211WD 3Add BLAST41
Repeati221 – 261WD 4Add BLAST41
Repeati266 – 307WD 5Add BLAST42
Repeati391 – 431WD 6Add BLAST41
Repeati434 – 474WD 7Add BLAST41
Repeati478 – 518WD 8Add BLAST41
Repeati519 – 559WD 9Add BLAST41
Repeati564 – 604WD 10Add BLAST41
Repeati607 – 647WD 11Add BLAST41
Repeati650 – 690WD 12Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni328 – 352DisorderedSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0273, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158602

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004491_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZU2

Identification of Orthologs from Complete Genome Data

More...
OMAi
PWEEIIG

Database of Orthologous Groups

More...
OrthoDBi
167285at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZU2

TreeFam database of animal gene trees

More...
TreeFami
TF323190

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977, Apc4_WD40_dom
IPR020472, G-protein_beta_WD-40_rep
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894, ANAPC4_WD40, 1 hit
PF00400, WD40, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320, GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit
SSF50998, SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 5 hits
PS50294, WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IZU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAWMTYISNW FEQDDWYEGL QRANMSQVRQ VGLLAAGCQP WNKDVCAASG
60 70 80 90 100
DRFAYCATLA IYIYQLDHRY NEFKLHAIMS EHKKTITAIS WCPHNPDLFA
110 120 130 140 150
SGSTDNLVII WNVAEQKVIA KLDSTKGIPA SLSWCWNAED VVAFVSHRGP
160 170 180 190 200
LFIWTISGPD SGVIVHKDAH SFLSDICMFR WHTHQKGKVV FGHIDGSLSI
210 220 230 240 250
FHPGNKNQKH VLRPESLEGT DEEDPVTALE WDPLSTDYLL VVNLHYGIRL
260 270 280 290 300
VDSESLSCIT TFNLPSAAAS VQCLAWVPSA PGMFITGDSQ VGVLRIWNVS
310 320 330 340 350
RTTPIDNLKL KKTGFHCLHV LNSPPRKKFS VQSPTKNHYT SSTSEAVPPP
360 370 380 390 400
TLTQNQAFSL PPGHAVCCFL DGGVGLYDMG AKKWDFLRDL GHVETIFDCK
410 420 430 440 450
FKPDDPNLLA TASFDGTIKV WDINTLTAVY TSPGNEGVIY SLSWAPGGLN
460 470 480 490 500
CIAGGTSRNG AFIWNVQKGK IIQRFNEHGT NGIFCIAWSH KDSKRIATCS
510 520 530 540 550
SDGFCIIRTI DGKVLHKYKH PAAVFGCDWS QNNKDMIATG CEDTNVRVYY
560 570 580 590 600
VATSSDQPLK VFSGHTAKVF HVKWSPLREG ILCSGSDDGT VRIWDYTQDA
610 620 630 640 650
CINILNGHTA PVRGLMWNTE IPYLLISGSW DYTIKVWDTR EGTCVDTVYD
660 670 680 690 700
HGADVYGLTC HPSRPFTMAS CSRDSTVRLW SLTALVTPVQ INILADRSWE
710 720 730 740 750
EIIGNTDYAI EPGTPPLLCG KVSRDIRQEI EKLTANSQVK KLRWFSECLS
760 770 780 790 800
PPGGSDNLWN LVAVIKGQDD SLLPQNYCKG IMHLKHLIKF RTSEAQELTT
810 820 830 840 850
VKMSKFGGGI GVPAKEERLK EAAEIHLRLG QIQRYCELMV ELGEWDKALS
860 870 880 890 900
IAPGVSVKYW KKLMQRRADQ LIQEDKDDVI PYCIAIGDVK KLVHFFMSRG
910 920 930 940 950
QLKEALLVAQ AACEGNMQPL HVSVPKGASY SDDIYKEDFN ELLHKVSKEL
960 970 980 990 1000
AEWYFQDGRA VLAACCHLAI DNIELAMAYL IRGNELELAV CVGTVLGESA
1010 1020 1030 1040 1050
APATHYALEL LARKCMMISV CFPCVGYSVP FCYVNRNLAA DLLLMIPDNE
1060 1070 1080 1090 1100
LHLIKLCAFY PGCTEEINDL HDKCKLPTVE ECMQLAETAR ADDNIFETVK
1110 1120 1130 1140 1150
YYLLSQEPEK ALPIGISFVK EYISSSDWTL DTIYPVLDLL SYIRTEKLLL
1160 1170 1180 1190 1200
HTCTEARNEL LILCGYIGAL LAIRRQYQSI VPALYEYTSQ LLKRREVSVP
1210 1220 1230 1240 1250
LKIEYLSEEL DAWRACTQST NRSLEDSPYT PPSDSQRMIY ATLLKRLKEE
1260 1270 1280 1290 1300
SLKGIIGPDY VTGSNLPSHS DIHISCLTGL KIQGPVFFLE DGKSAISLND
1310 1320
ALMWAKVNPF SPLGTGIRLN PF
Length:1,322
Mass (Da):147,703
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99FFCE51B9EA8175
GO
Isoform 2 (identifier: Q8IZU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     1021-1036: CFPCVGYSVPFCYVNR → W

Show »
Length:1,283
Mass (Da):143,016
Checksum:i805643CB01B5A6B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESC9E7ESC9_HUMAN
WD repeat-containing protein 17
WDR17
1,297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFA2E9PFA2_HUMAN
WD repeat-containing protein 17
WDR17
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAE4H0YAE4_HUMAN
WD repeat-containing protein 17
WDR17
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAG1H0YAG1_HUMAN
WD repeat-containing protein 17
WDR17
557Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BC146812 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213R → S in BC146812 (PubMed:15489334).Curated1
Sequence conflicti783H → Q in BC146812 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062101418I → V. Corresponds to variant dbSNP:rs59567138Ensembl.1
Natural variantiVAR_047399814A → T1 PublicationCorresponds to variant dbSNP:rs4690661Ensembl.1
Natural variantiVAR_047400913C → S1 PublicationCorresponds to variant dbSNP:rs7693453Ensembl.1
Natural variantiVAR_047401952E → K. Corresponds to variant dbSNP:rs6810394Ensembl.1
Natural variantiVAR_0474021215A → T1 PublicationCorresponds to variant dbSNP:rs17625943Ensembl.1
Natural variantiVAR_0474031295A → T1 PublicationCorresponds to variant dbSNP:rs11736872Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0472011 – 24Missing in isoform 2. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_0472021021 – 1036CFPCV…CYVNR → W in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF492460 mRNA Translation: AAN64030.1
AC093605 Genomic DNA No translation available.
BC146812 mRNA No translation available.
DQ426895 mRNA Translation: ABD90546.1
DQ426896 mRNA Translation: ABD90547.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3825.1 [Q8IZU2-1]
CCDS43284.2 [Q8IZU2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_733828.2, NM_170710.4 [Q8IZU2-1]
NP_851782.3, NM_181265.3 [Q8IZU2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280190; ENSP00000280190; ENSG00000150627 [Q8IZU2-1]
ENST00000508596; ENSP00000422763; ENSG00000150627 [Q8IZU2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
116966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:116966

UCSC genome browser

More...
UCSCi
uc003iuj.4, human [Q8IZU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492460 mRNA Translation: AAN64030.1
AC093605 Genomic DNA No translation available.
BC146812 mRNA No translation available.
DQ426895 mRNA Translation: ABD90546.1
DQ426896 mRNA Translation: ABD90547.1
CCDSiCCDS3825.1 [Q8IZU2-1]
CCDS43284.2 [Q8IZU2-2]
RefSeqiNP_733828.2, NM_170710.4 [Q8IZU2-1]
NP_851782.3, NM_181265.3 [Q8IZU2-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125544, 2 interactors
IntActiQ8IZU2, 1 interactor
STRINGi9606.ENSP00000280190

PTM databases

iPTMnetiQ8IZU2
PhosphoSitePlusiQ8IZU2

Genetic variation databases

BioMutaiWDR17
DMDMi215273912

Proteomic databases

EPDiQ8IZU2
jPOSTiQ8IZU2
MassIVEiQ8IZU2
MaxQBiQ8IZU2
PaxDbiQ8IZU2
PeptideAtlasiQ8IZU2
PRIDEiQ8IZU2
ProteomicsDBi17667
71430 [Q8IZU2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51087, 12 antibodies

The DNASU plasmid repository

More...
DNASUi
116966

Genome annotation databases

EnsembliENST00000280190; ENSP00000280190; ENSG00000150627 [Q8IZU2-1]
ENST00000508596; ENSP00000422763; ENSG00000150627 [Q8IZU2-2]
GeneIDi116966
KEGGihsa:116966
UCSCiuc003iuj.4, human [Q8IZU2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
116966
DisGeNETi116966

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR17
HGNCiHGNC:16661, WDR17
HPAiENSG00000150627, Tissue enhanced (brain, parathyroid gland, pituitary gland)
MIMi609005, gene
neXtProtiNX_Q8IZU2
OpenTargetsiENSG00000150627
PharmGKBiPA38181
VEuPathDBiHostDB:ENSG00000150627

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0273, Eukaryota
GeneTreeiENSGT00940000158602
HOGENOMiCLU_004491_1_0_1
InParanoidiQ8IZU2
OMAiPWEEIIG
OrthoDBi167285at2759
PhylomeDBiQ8IZU2
TreeFamiTF323190

Enzyme and pathway databases

PathwayCommonsiQ8IZU2
SignaLinkiQ8IZU2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
116966, 6 hits in 1006 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
116966
PharosiQ8IZU2, Tdark

Protein Ontology

More...
PROi
PR:Q8IZU2
RNActiQ8IZU2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000150627, Expressed in endothelial cell and 158 other tissues
ExpressionAtlasiQ8IZU2, baseline and differential
GenevisibleiQ8IZU2, HS

Family and domain databases

Gene3Di2.130.10.10, 4 hits
InterProiView protein in InterPro
IPR024977, Apc4_WD40_dom
IPR020472, G-protein_beta_WD-40_rep
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12894, ANAPC4_WD40, 1 hit
PF00400, WD40, 4 hits
PRINTSiPR00320, GPROTEINBRPT
SMARTiView protein in SMART
SM00320, WD40, 11 hits
SUPFAMiSSF50978, SSF50978, 1 hit
SSF50998, SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 5 hits
PS50294, WD_REPEATS_REGION, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZU2
Secondary accession number(s): E7EQX0, Q0QD35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 25, 2008
Last modified: September 29, 2021
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again