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UniProtKB - Q8IZU1 (FAM9A_HUMAN)
Protein
Protein FAM9A
Gene
FAM9A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- meiotic cell cycle Source: GO_Central
- spermatid development Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q8IZU1 |
SignaLinki | Q8IZU1 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM9A |
Gene namesi | Name:FAM9A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18403, FAM9A |
MIMi | 300477, gene |
neXtProti | NX_Q8IZU1 |
VEuPathDBi | HostDB:ENSG00000183304 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nucleolus Source: UniProtKB-SubCell
- synaptonemal complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 171482 |
OpenTargetsi | ENSG00000183304 |
PharmGKBi | PA27992 |
Miscellaneous databases
Pharosi | Q8IZU1, Tdark |
Genetic variation databases
BioMutai | FAM9A |
DMDMi | 29336759 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119032 | 1 – 332 | Protein FAM9AAdd BLAST | 332 |
Proteomic databases
MassIVEi | Q8IZU1 |
PaxDbi | Q8IZU1 |
PeptideAtlasi | Q8IZU1 |
PRIDEi | Q8IZU1 |
Expressioni
Tissue specificityi
Expressed exclusively in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000183304, Expressed in testis and 17 other tissues |
Genevisiblei | Q8IZU1, HS |
Organism-specific databases
HPAi | ENSG00000183304, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Q8IZU1
Protein-protein interaction databases
BioGRIDi | 128130, 83 interactors |
IntActi | Q8IZU1, 73 interactors |
MINTi | Q8IZU1 |
STRINGi | 9606.ENSP00000440163 |
Miscellaneous databases
RNActi | Q8IZU1, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q8IZU1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 114 | DisorderedSequence analysisAdd BLAST | 114 | |
Regioni | 186 – 293 | DisorderedSequence analysisAdd BLAST | 108 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 39 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 68 – 114 | Basic and acidic residuesSequence analysisAdd BLAST | 47 | |
Compositional biasi | 217 – 276 | Acidic residuesSequence analysisAdd BLAST | 60 |
Sequence similaritiesi
Belongs to the FAM9 family.Curated
Phylogenomic databases
eggNOGi | ENOG502TEZS, Eukaryota |
GeneTreei | ENSGT00390000000062 |
HOGENOMi | CLU_083208_0_0_1 |
InParanoidi | Q8IZU1 |
OMAi | MKLEYIA |
OrthoDBi | 1187915at2759 |
PhylomeDBi | Q8IZU1 |
i Sequence
Sequence statusi: Complete.
Q8IZU1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPVGRKRSR KAAKAQLEAQ VTAAQGATKE GSGIASNFPG QPTMEPVGRK
60 70 80 90 100
RSRKAAKAQL EAQVRAAPAK KHTGKDPVRD ECEERNPFTE TREEDVTDEH
110 120 130 140 150
GEREPFAEKD EHTGIHTMKL EHIAADIKKG LAAKREMIKI DKAAYRKTKN
160 170 180 190 200
TIERALKKKQ LKRQKRDYRH TRKLLNVLKE YIAEKQKDDE AEEAEAAAAA
210 220 230 240 250
AEAAAAAEAA AAAAEVIVVE DEEEEEKEEE EEKEEEEEEG EEEGGGEEGE
260 270 280 290 300
EGGGGGEGEE TEEEEEEEEE EEEEEQIKAF QEKQKRWQQP TGVRSWRLRE
310 320 330
MKPLLEQLLK AAKDTKDNYC IISSSEESEL DN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF494343 mRNA Translation: AAN07162.1 BC112022 mRNA Translation: AAI12023.1 BC113449 mRNA Translation: AAI13450.1 BC143805 mRNA Translation: AAI43806.1 |
CCDSi | CCDS14131.1 |
RefSeqi | NP_001164657.1, NM_001171186.1 NP_777611.1, NM_174951.3 |
Genome annotation databases
Ensembli | ENST00000381003.7; ENSP00000370391.3; ENSG00000183304.10 ENST00000543214.1; ENSP00000440163.1; ENSG00000183304.10 |
GeneIDi | 171482 |
KEGGi | hsa:171482 |
MANE-Selecti | ENST00000381003.7; ENSP00000370391.3; NM_174951.3; NP_777611.1 |
UCSCi | uc004csg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF494343 mRNA Translation: AAN07162.1 BC112022 mRNA Translation: AAI12023.1 BC113449 mRNA Translation: AAI13450.1 BC143805 mRNA Translation: AAI43806.1 |
CCDSi | CCDS14131.1 |
RefSeqi | NP_001164657.1, NM_001171186.1 NP_777611.1, NM_174951.3 |
3D structure databases
AlphaFoldDBi | Q8IZU1 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 128130, 83 interactors |
IntActi | Q8IZU1, 73 interactors |
MINTi | Q8IZU1 |
STRINGi | 9606.ENSP00000440163 |
Genetic variation databases
BioMutai | FAM9A |
DMDMi | 29336759 |
Proteomic databases
MassIVEi | Q8IZU1 |
PaxDbi | Q8IZU1 |
PeptideAtlasi | Q8IZU1 |
PRIDEi | Q8IZU1 |
Protocols and materials databases
Antibodypediai | 52846, 6 antibodies from 6 providers |
DNASUi | 171482 |
Genome annotation databases
Ensembli | ENST00000381003.7; ENSP00000370391.3; ENSG00000183304.10 ENST00000543214.1; ENSP00000440163.1; ENSG00000183304.10 |
GeneIDi | 171482 |
KEGGi | hsa:171482 |
MANE-Selecti | ENST00000381003.7; ENSP00000370391.3; NM_174951.3; NP_777611.1 |
UCSCi | uc004csg.4, human |
Organism-specific databases
CTDi | 171482 |
DisGeNETi | 171482 |
GeneCardsi | FAM9A |
HGNCi | HGNC:18403, FAM9A |
HPAi | ENSG00000183304, Tissue enriched (testis) |
MIMi | 300477, gene |
neXtProti | NX_Q8IZU1 |
OpenTargetsi | ENSG00000183304 |
PharmGKBi | PA27992 |
VEuPathDBi | HostDB:ENSG00000183304 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TEZS, Eukaryota |
GeneTreei | ENSGT00390000000062 |
HOGENOMi | CLU_083208_0_0_1 |
InParanoidi | Q8IZU1 |
OMAi | MKLEYIA |
OrthoDBi | 1187915at2759 |
PhylomeDBi | Q8IZU1 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZU1 |
SignaLinki | Q8IZU1 |
Miscellaneous databases
BioGRID-ORCSi | 171482, 15 hits in 697 CRISPR screens |
GenomeRNAii | 171482 |
Pharosi | Q8IZU1, Tdark |
PROi | PR:Q8IZU1 |
RNActi | Q8IZU1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183304, Expressed in testis and 17 other tissues |
Genevisiblei | Q8IZU1, HS |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | FAM9A_HUMAN | |
Accessioni | Q8IZU1Primary (citable) accession number: Q8IZU1 Secondary accession number(s): B7ZLH5, Q2M2D1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 25, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families