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UniProtKB - Q8IZU0 (FAM9B_HUMAN)
Protein
Protein FAM9B
Gene
FAM9B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- meiotic cell cycle Source: GO_Central
- spermatid development Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q8IZU0 |
SignaLinki | Q8IZU0 |
Protein family/group databases
MoonDBi | Q8IZU0, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM9B |
Gene namesi | Name:FAM9B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18404, FAM9B |
MIMi | 300478, gene |
neXtProti | NX_Q8IZU0 |
VEuPathDBi | HostDB:ENSG00000177138 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
- synaptonemal complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000177138 |
PharmGKBi | PA27993 |
Miscellaneous databases
Pharosi | Q8IZU0, Tdark |
Genetic variation databases
BioMutai | FAM9B |
DMDMi | 29336758 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119033 | 1 – 186 | Protein FAM9BAdd BLAST | 186 |
Proteomic databases
jPOSTi | Q8IZU0 |
MassIVEi | Q8IZU0 |
PaxDbi | Q8IZU0 |
PeptideAtlasi | Q8IZU0 |
PRIDEi | Q8IZU0 |
Expressioni
Tissue specificityi
Expressed exclusively in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000177138, Expressed in testis and 58 other tissues |
ExpressionAtlasi | Q8IZU0, baseline and differential |
Genevisiblei | Q8IZU0, HS |
Organism-specific databases
HPAi | ENSG00000177138, Tissue enhanced (liver, testis) |
Interactioni
Binary interactionsi
Q8IZU0
Protein-protein interaction databases
BioGRIDi | 128131, 167 interactors |
IntActi | Q8IZU0, 138 interactors |
STRINGi | 9606.ENSP00000318716 |
Miscellaneous databases
RNActi | Q8IZU0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 93 | DisorderedSequence analysisAdd BLAST | 93 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 80 | Basic and acidic residuesSequence analysisAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the FAM9 family.Curated
Phylogenomic databases
eggNOGi | ENOG502TD36, Eukaryota |
GeneTreei | ENSGT00390000000062 |
HOGENOMi | CLU_083208_0_0_1 |
InParanoidi | Q8IZU0 |
OMAi | RMKMDKA |
OrthoDBi | 1187915at2759 |
PhylomeDBi | Q8IZU0 |
TreeFami | TF328876 |
Family and domain databases
InterProi | View protein in InterPro IPR006888, XLR/SYCP3/FAM9_dom |
Pfami | View protein in Pfam PF04803, Cor1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8IZU0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAWGKKHAG KDPVRDECEE RNRFTETREE DVTDEHGERE PFAETDEHTG
60 70 80 90 100
ANTKKPEDTA EDLTAKRKRM KMDKTCSKTK NKSKHALRKK QLKRQKRDYI
110 120 130 140 150
HSLKLLNVLE EYITDEQKEE EEEEGEEEEL IRIFQEQQKK WQQYRSVRRE
160 170 180
RLKEMKLLRD QFVKALEDFE DLCDRVFSDE DSELDN
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055087 | 1 | M → MPGFLSFLSVSLRSPGSGIA SSFPGQPATDPVGRRAAKAQ LEAQFM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_055088 | 61 – 93 | EDLTA…KKQLK → VGANNFKNYPVHIGVSSEQH ILLDCSLS in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF494344 mRNA Translation: AAN07163.1 AK097501 mRNA Translation: BAC05078.1 AC074281 Genomic DNA No translation available. AC119567 Genomic DNA No translation available. AC119618 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98763.1 BC120955 mRNA Translation: AAI20956.1 BC120956 mRNA Translation: AAI20957.1 |
CCDSi | CCDS14132.1 [Q8IZU0-1] |
RefSeqi | NP_995321.1, NM_205849.3 [Q8IZU0-1] XP_011543766.1, XM_011545464.2 |
Genome annotation databases
Ensembli | ENST00000327220; ENSP00000318716; ENSG00000177138 ENST00000362066; ENSP00000354770; ENSG00000177138 [Q8IZU0-2] ENST00000428477; ENSP00000412606; ENSG00000177138 ENST00000472522; ENSP00000431456; ENSG00000177138 ENST00000651278; ENSP00000498495; ENSG00000177138 |
GeneIDi | 171483 |
KEGGi | hsa:171483 |
MANE-Selecti | ENST00000327220.10; ENSP00000318716.5; NM_205849.3; NP_995321.1 |
UCSCi | uc004csh.4, human [Q8IZU0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF494344 mRNA Translation: AAN07163.1 AK097501 mRNA Translation: BAC05078.1 AC074281 Genomic DNA No translation available. AC119567 Genomic DNA No translation available. AC119618 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98763.1 BC120955 mRNA Translation: AAI20956.1 BC120956 mRNA Translation: AAI20957.1 |
CCDSi | CCDS14132.1 [Q8IZU0-1] |
RefSeqi | NP_995321.1, NM_205849.3 [Q8IZU0-1] XP_011543766.1, XM_011545464.2 |
3D structure databases
SMRi | Q8IZU0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128131, 167 interactors |
IntActi | Q8IZU0, 138 interactors |
STRINGi | 9606.ENSP00000318716 |
Protein family/group databases
MoonDBi | Q8IZU0, Predicted |
Genetic variation databases
BioMutai | FAM9B |
DMDMi | 29336758 |
Proteomic databases
jPOSTi | Q8IZU0 |
MassIVEi | Q8IZU0 |
PaxDbi | Q8IZU0 |
PeptideAtlasi | Q8IZU0 |
PRIDEi | Q8IZU0 |
Protocols and materials databases
Antibodypediai | 23614, 29 antibodies from 13 providers |
DNASUi | 171483 |
Genome annotation databases
Ensembli | ENST00000327220; ENSP00000318716; ENSG00000177138 ENST00000362066; ENSP00000354770; ENSG00000177138 [Q8IZU0-2] ENST00000428477; ENSP00000412606; ENSG00000177138 ENST00000472522; ENSP00000431456; ENSG00000177138 ENST00000651278; ENSP00000498495; ENSG00000177138 |
GeneIDi | 171483 |
KEGGi | hsa:171483 |
MANE-Selecti | ENST00000327220.10; ENSP00000318716.5; NM_205849.3; NP_995321.1 |
UCSCi | uc004csh.4, human [Q8IZU0-1] |
Organism-specific databases
CTDi | 171483 |
GeneCardsi | FAM9B |
HGNCi | HGNC:18404, FAM9B |
HPAi | ENSG00000177138, Tissue enhanced (liver, testis) |
MIMi | 300478, gene |
neXtProti | NX_Q8IZU0 |
OpenTargetsi | ENSG00000177138 |
PharmGKBi | PA27993 |
VEuPathDBi | HostDB:ENSG00000177138 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TD36, Eukaryota |
GeneTreei | ENSGT00390000000062 |
HOGENOMi | CLU_083208_0_0_1 |
InParanoidi | Q8IZU0 |
OMAi | RMKMDKA |
OrthoDBi | 1187915at2759 |
PhylomeDBi | Q8IZU0 |
TreeFami | TF328876 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZU0 |
SignaLinki | Q8IZU0 |
Miscellaneous databases
BioGRID-ORCSi | 171483, 12 hits in 655 CRISPR screens |
ChiTaRSi | FAM9B, human |
GenomeRNAii | 171483 |
Pharosi | Q8IZU0, Tdark |
PROi | PR:Q8IZU0 |
RNActi | Q8IZU0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177138, Expressed in testis and 58 other tissues |
ExpressionAtlasi | Q8IZU0, baseline and differential |
Genevisiblei | Q8IZU0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006888, XLR/SYCP3/FAM9_dom |
Pfami | View protein in Pfam PF04803, Cor1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FAM9B_HUMAN | |
Accessioni | Q8IZU0Primary (citable) accession number: Q8IZU0 Secondary accession number(s): Q0IJ68, Q8N7Z8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 25, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families