UniProtKB - Q8IZQ8 (MYCD_HUMAN)
Myocardin
MYOCD
Functioni
GO - Molecular functioni
- histone acetyltransferase binding Source: Ensembl
- histone deacetylase binding Source: Ensembl
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- R-SMAD binding Source: Ensembl
- transcription coactivator activity Source: UniProtKB
- transcription factor binding Source: UniProtKB
GO - Biological processi
- cardiac muscle cell differentiation Source: BHF-UCL
- cardiac ventricle development Source: Ensembl
- cardiocyte differentiation Source: UniProtKB
- cellular component maintenance Source: Ensembl
- digestive tract development Source: Ensembl
- ductus arteriosus closure Source: Ensembl
- lung alveolus development Source: Ensembl
- negative regulation of amyloid-beta clearance Source: BHF-UCL
- negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
- negative regulation of cell adhesion molecule production Source: Ensembl
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
- negative regulation of myotube differentiation Source: Ensembl
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway Source: Ensembl
- negative regulation of skeletal muscle cell differentiation Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- negative regulation of vascular associated smooth muscle cell migration Source: Ensembl
- negative regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
- positive regulation of cardiac muscle cell differentiation Source: BHF-UCL
- positive regulation of cardiac vascular smooth muscle cell differentiation Source: BHF-UCL
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of DNA binding Source: Ensembl
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
- positive regulation of smooth muscle cell differentiation Source: BHF-UCL
- positive regulation of smooth muscle contraction Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
- positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation Source: BHF-UCL
- positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- regulation of cell growth by extracellular stimulus Source: Ensembl
- regulation of histone acetylation Source: UniProtKB
- regulation of myoblast differentiation Source: Ensembl
- regulation of phenotypic switching Source: Ensembl
- regulation of smooth muscle cell differentiation Source: BHF-UCL
- response to hypoxia Source: BHF-UCL
- smooth muscle cell differentiation Source: BHF-UCL
- urinary bladder development Source: UniProtKB
- uterus development Source: Ensembl
- vascular associated smooth muscle cell differentiation Source: Ensembl
- vasculogenesis Source: Ensembl
- ventricular cardiac muscle cell differentiation Source: Ensembl
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8IZQ8 |
SIGNORi | Q8IZQ8 |
Names & Taxonomyi
Protein namesi | Recommended name: Myocardin |
Gene namesi | Name:MYOCD Synonyms:MYCD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141052.17 |
HGNCi | HGNC:16067, MYOCD |
MIMi | 606127, gene |
neXtProti | NX_Q8IZQ8 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nuclear chromatin Source: Ensembl
- nucleus Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Megabladder, congenital (MGBL)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083482 | 115 – 938 | Missing in MGBL; loss of function in trascriptional activation. 1 PublicationAdd BLAST | 824 | |
Natural variantiVAR_083483 | 530 | E → G in MGBL; unknown pathological significance; decreased function in trascriptional activation. 1 Publication | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 93649 |
MalaCardsi | MYOCD |
MIMi | 618719, phenotype |
OpenTargetsi | ENSG00000141052 |
PharmGKBi | PA134946896 |
Miscellaneous databases
Pharosi | Q8IZQ8, Tbio |
Polymorphism and mutation databases
BioMutai | MYOCD |
DMDMi | 32363335 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000126631 | 1 – 938 | MyocardinAdd BLAST | 938 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 451 | Phosphoserine; by GSK3-betaBy similarity | 1 | |
Modified residuei | 455 | Phosphoserine; by GSK3-betaBy similarity | 1 | |
Modified residuei | 459 | Phosphoserine; by GSK3-betaBy similarity | 1 | |
Modified residuei | 463 | Phosphoserine; by GSK3-betaBy similarity | 1 | |
Modified residuei | 626 | Phosphoserine; by GSK3-betaBy similarity | 1 | |
Modified residuei | 630 | Phosphoserine; by GSK3-betaBy similarity | 1 | |
Modified residuei | 634 | Phosphoserine; by GSK3-betaBy similarity | 1 | |
Modified residuei | 638 | Phosphoserine; by GSK3-betaBy similarity | 1 | |
Modified residuei | 815 | Phosphoserine; by MAPK1 AND MAPK3By similarity | 1 | |
Modified residuei | 862 | Phosphoserine; by MAPK1 and MAPK3By similarity | 1 | |
Modified residuei | 869 | Phosphoserine; by MAPK1 and MAPK3By similarity | 1 | |
Modified residuei | 896 | Phosphothreonine; by MAPK1 and MAPK3By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8IZQ8 |
MassIVEi | Q8IZQ8 |
MaxQBi | Q8IZQ8 |
PaxDbi | Q8IZQ8 |
PeptideAtlasi | Q8IZQ8 |
PRIDEi | Q8IZQ8 |
ProteomicsDBi | 71407 [Q8IZQ8-1] 71408 [Q8IZQ8-2] 71409 [Q8IZQ8-3] |
PTM databases
iPTMneti | Q8IZQ8 |
PhosphoSitePlusi | Q8IZQ8 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000141052, Expressed in cauda epididymis and 155 other tissues |
ExpressionAtlasi | Q8IZQ8, baseline and differential |
Genevisiblei | Q8IZQ8, HS |
Organism-specific databases
HPAi | ENSG00000141052, Tissue enhanced (smooth) |
Interactioni
Subunit structurei
Homodimer.
Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation (By similarity).
Interacts with MLLT7/FOXO4.
Interacts (via C-terminal) with EP300 (via the CREB-binding domain).
Interacts with HDAC4 and HDAC5 (By similarity).
Interacts with MEF2C (By similarity).
By similarityBinary interactionsi
Hide detailsGO - Molecular functioni
- histone acetyltransferase binding Source: Ensembl
- histone deacetylase binding Source: Ensembl
- RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL
- R-SMAD binding Source: Ensembl
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 125044, 15 interactors |
CORUMi | Q8IZQ8 |
IntActi | Q8IZQ8, 3 interactors |
STRINGi | 9606.ENSP00000401678 |
Miscellaneous databases
RNActi | Q8IZQ8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 18 – 43 | RPEL 1Add BLAST | 26 | |
Repeati | 62 – 87 | RPEL 2Add BLAST | 26 | |
Repeati | 106 – 131 | RPEL 3Add BLAST | 26 | |
Domaini | 371 – 405 | SAPPROSITE-ProRule annotationAdd BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 153 – 205 | HDAC5-bindingBy similarityAdd BLAST | 53 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 516 – 561 | Sequence analysisAdd BLAST | 46 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 12 – 27 | MEF2C-bindingBy similarityAdd BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 291 – 322 | Gln-richAdd BLAST | 32 | |
Compositional biasi | 435 – 508 | Ser-richAdd BLAST | 74 |
Domaini
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | ENOG502QTAN, Eukaryota |
GeneTreei | ENSGT00950000182979 |
HOGENOMi | CLU_007042_2_0_1 |
InParanoidi | Q8IZQ8 |
OMAi | QEQRHVE |
OrthoDBi | 190145at2759 |
PhylomeDBi | Q8IZQ8 |
TreeFami | TF326024 |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit |
InterProi | View protein in InterPro IPR043451, Myocardin-like IPR028721, MYOCD IPR004018, RPEL_repeat IPR003034, SAP_dom IPR036361, SAP_dom_sf |
PANTHERi | PTHR22793, PTHR22793, 2 hits PTHR22793:SF11, PTHR22793:SF11, 2 hits |
Pfami | View protein in Pfam PF02755, RPEL, 1 hit PF02037, SAP, 1 hit |
SMARTi | View protein in SMART SM00707, RPEL, 3 hits SM00513, SAP, 1 hit |
SUPFAMi | SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51073, RPEL, 3 hits PS50800, SAP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTLLGSEHSL LIRSKFRSVL QLRLQQRRTQ EQLANQGIIP PLKRPAEFHE
60 70 80 90 100
QRKHLDSDKA KNSLKRKARN RCNSADLVNM HILQASTAER SIPTAQMKLK
110 120 130 140 150
RARLADDLNE KIALRPGPLE LVEKNILPVD SAVKEAIKGN QVSFSKSTDA
160 170 180 190 200
FAFEEDSSSD GLSPDQTRSE DPQNSAGSPP DAKASDTPST GSLGTNQDLA
210 220 230 240 250
SGSENDRNDS ASQPSHQSDA GKQGLGPPST PIAVHAAVKS KSLGDSKNRH
260 270 280 290 300
KKPKDPKPKV KKLKYHQYIP PDQKAEKSPP PMDSAYARLL QQQQLFLQLQ
310 320 330 340 350
ILSQQQQQQQ HRFSYLGMHQ AQLKEPNEQM VRNPNSSSTP LSNTPLSPVK
360 370 380 390 400
NSFSGQTGVS SFKPGPLPPN LDDLKVSELR QQLRIRGLPV SGTKTALMDR
410 420 430 440 450
LRPFQDCSGN PVPNFGDITT VTFPVTPNTL PNYQSSSSTS ALSNGFYHFG
460 470 480 490 500
STSSSPPISP ASSDLSVAGS LPDTFNDASP SFGLHPSPVH VCTEESLMSS
510 520 530 540 550
LNGGSVPSEL DGLDSEKDKM LVEKQKVINE LTWKLQQEQR QVEELRMQLQ
560 570 580 590 600
KQKRNNCSEK KPLPFLAASI KQEEAVSSCP FASQVPVKRQ SSSSECHPPA
610 620 630 640 650
CEAAQLQPLG NAHCVESSDQ TNVLSSTFLS PQCSPQHSPL GAVKSPQHIS
660 670 680 690 700
LPPSPNNPHF LPSSSGAQGE GHRVSSPISS QVCTAQMAGL HSSDKVGPKF
710 720 730 740 750
SIPSPTFSKS SSAISEVTQP PSYEDAVKQQ MTRSQQMDEL LDVLIESGEM
760 770 780 790 800
PADAREDHSC LQKVPKIPRS SRSPTAVLTK PSASFEQASS GSQIPFDPYA
810 820 830 840 850
TDSDEHLEVL LNSQSPLGKM SDVTLLKIGS EEPHFDGIMD GFSGKAAEDL
860 870 880 890 900
FNAHEILPGP LSPMQTQFSP SSVDSNGLQL SFTESPWETM EWLDLTPPNS
910 920 930
TPGFSALTTS SPSIFNIDFL DVTDLNLNSS MDLHLQQW
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6N065 | Q6N065_HUMAN | Myocardin | MYOCD DKFZp686O15128 | 648 | Annotation score: | ||
J3KSX3 | J3KSX3_HUMAN | Myocardin | MYOCD | 41 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083482 | 115 – 938 | Missing in MGBL; loss of function in trascriptional activation. 1 PublicationAdd BLAST | 824 | |
Natural variantiVAR_083483 | 530 | E → G in MGBL; unknown pathological significance; decreased function in trascriptional activation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007658 | 1 – 96 | Missing in isoform 2. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_007659 | 686 | Q → QNSGAHDGHPPSFSPHSSSL HPPFSGAQADSSHGAGGNPC PKSPCVQQK in isoform 2 and isoform 3. 4 Publications | 1 | |
Alternative sequenceiVSP_007660 | 730 – 732 | QMT → VTM in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_007661 | 733 – 938 | Missing in isoform 2. 1 PublicationAdd BLAST | 206 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF532596 mRNA Translation: AAN33040.1 AY764180 mRNA Translation: AAV33439.1 AK292885 mRNA Translation: BAF85574.1 AK097821 mRNA Translation: BAC05177.1 AC005358 Genomic DNA No translation available. BC126307 mRNA Translation: AAI26308.1 BC143391 mRNA Translation: AAI43392.1 |
CCDSi | CCDS11163.1 [Q8IZQ8-1] CCDS54091.1 [Q8IZQ8-3] |
RefSeqi | NP_001139784.1, NM_001146312.2 [Q8IZQ8-3] NP_705832.1, NM_153604.3 [Q8IZQ8-1] |
Genome annotation databases
Ensembli | ENST00000343344; ENSP00000341835; ENSG00000141052 [Q8IZQ8-1] ENST00000425538; ENSP00000401678; ENSG00000141052 [Q8IZQ8-3] |
GeneIDi | 93649 |
KEGGi | hsa:93649 |
UCSCi | uc002gnn.4, human [Q8IZQ8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF532596 mRNA Translation: AAN33040.1 AY764180 mRNA Translation: AAV33439.1 AK292885 mRNA Translation: BAF85574.1 AK097821 mRNA Translation: BAC05177.1 AC005358 Genomic DNA No translation available. BC126307 mRNA Translation: AAI26308.1 BC143391 mRNA Translation: AAI43392.1 |
CCDSi | CCDS11163.1 [Q8IZQ8-1] CCDS54091.1 [Q8IZQ8-3] |
RefSeqi | NP_001139784.1, NM_001146312.2 [Q8IZQ8-3] NP_705832.1, NM_153604.3 [Q8IZQ8-1] |
3D structure databases
SMRi | Q8IZQ8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125044, 15 interactors |
CORUMi | Q8IZQ8 |
IntActi | Q8IZQ8, 3 interactors |
STRINGi | 9606.ENSP00000401678 |
PTM databases
iPTMneti | Q8IZQ8 |
PhosphoSitePlusi | Q8IZQ8 |
Polymorphism and mutation databases
BioMutai | MYOCD |
DMDMi | 32363335 |
Proteomic databases
jPOSTi | Q8IZQ8 |
MassIVEi | Q8IZQ8 |
MaxQBi | Q8IZQ8 |
PaxDbi | Q8IZQ8 |
PeptideAtlasi | Q8IZQ8 |
PRIDEi | Q8IZQ8 |
ProteomicsDBi | 71407 [Q8IZQ8-1] 71408 [Q8IZQ8-2] 71409 [Q8IZQ8-3] |
Protocols and materials databases
Antibodypediai | 25055, 116 antibodies |
Genome annotation databases
Ensembli | ENST00000343344; ENSP00000341835; ENSG00000141052 [Q8IZQ8-1] ENST00000425538; ENSP00000401678; ENSG00000141052 [Q8IZQ8-3] |
GeneIDi | 93649 |
KEGGi | hsa:93649 |
UCSCi | uc002gnn.4, human [Q8IZQ8-1] |
Organism-specific databases
CTDi | 93649 |
DisGeNETi | 93649 |
EuPathDBi | HostDB:ENSG00000141052.17 |
GeneCardsi | MYOCD |
HGNCi | HGNC:16067, MYOCD |
HPAi | ENSG00000141052, Tissue enhanced (smooth) |
MalaCardsi | MYOCD |
MIMi | 606127, gene 618719, phenotype |
neXtProti | NX_Q8IZQ8 |
OpenTargetsi | ENSG00000141052 |
PharmGKBi | PA134946896 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTAN, Eukaryota |
GeneTreei | ENSGT00950000182979 |
HOGENOMi | CLU_007042_2_0_1 |
InParanoidi | Q8IZQ8 |
OMAi | QEQRHVE |
OrthoDBi | 190145at2759 |
PhylomeDBi | Q8IZQ8 |
TreeFami | TF326024 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZQ8 |
SIGNORi | Q8IZQ8 |
Miscellaneous databases
BioGRID-ORCSi | 93649, 5 hits in 849 CRISPR screens |
ChiTaRSi | MYOCD, human |
GeneWikii | MYOCD |
GenomeRNAii | 93649 |
Pharosi | Q8IZQ8, Tbio |
PROi | PR:Q8IZQ8 |
RNActi | Q8IZQ8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141052, Expressed in cauda epididymis and 155 other tissues |
ExpressionAtlasi | Q8IZQ8, baseline and differential |
Genevisiblei | Q8IZQ8, HS |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit |
InterProi | View protein in InterPro IPR043451, Myocardin-like IPR028721, MYOCD IPR004018, RPEL_repeat IPR003034, SAP_dom IPR036361, SAP_dom_sf |
PANTHERi | PTHR22793, PTHR22793, 2 hits PTHR22793:SF11, PTHR22793:SF11, 2 hits |
Pfami | View protein in Pfam PF02755, RPEL, 1 hit PF02037, SAP, 1 hit |
SMARTi | View protein in SMART SM00707, RPEL, 3 hits SM00513, SAP, 1 hit |
SUPFAMi | SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS51073, RPEL, 3 hits PS50800, SAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYCD_HUMAN | |
Accessioni | Q8IZQ8Primary (citable) accession number: Q8IZQ8 Secondary accession number(s): Q5UBU5, Q8N7Q1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations