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Entry version 142 (16 Jan 2019)
Sequence version 2 (05 May 2009)
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Protein

Adhesion G-protein coupled receptor G2

Gene

ADGRG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G21 Publication
Alternative name(s):
G-protein coupled receptor 64
Human epididymis-specific protein 6
Short name:
He6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRG2Imported
Synonyms:GPR641 Publication, HE6, TM7LN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000173698.17

Human Gene Nomenclature Database

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HGNCi
HGNC:4516 ADGRG2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300572 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZP9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini38 – 627ExtracellularCuratedAdd BLAST590
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei628 – 648Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini649 – 667CytoplasmicCuratedAdd BLAST19
Transmembranei668 – 688Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini689 – 693ExtracellularCurated5
Transmembranei694 – 714Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini715 – 737CytoplasmicCuratedAdd BLAST23
Transmembranei738 – 758Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini759 – 789ExtracellularCuratedAdd BLAST31
Transmembranei790 – 810Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini811 – 834CytoplasmicCuratedAdd BLAST24
Transmembranei835 – 855Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini856 – 857ExtracellularCurated2
Transmembranei858 – 878Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini879 – 1017CytoplasmicCuratedAdd BLAST139

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital bilateral aplasia of the vas deferens, X-linked (CBAVDX)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by bilateral absence of vas deferens, obstructive azoospermia, and infertility.
See also OMIM:300985

Organism-specific databases

DisGeNET

More...
DisGeNETi
10149

MalaCards human disease database

More...
MalaCardsi
ADGRG2
MIMi300985 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000173698

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
48 Congenital bilateral absence of vas deferens

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28908

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADGRG2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462874

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37Sequence analysisAdd BLAST37
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001288638 – 1017Adhesion G-protein coupled receptor G2Add BLAST980

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi528N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi542N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi857N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1010PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.Curated
Highly glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IZP9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8IZP9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IZP9

PeptideAtlas

More...
PeptideAtlasi
Q8IZP9

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZP9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71395
71396 [Q8IZP9-2]
71397 [Q8IZP9-3]
71398 [Q8IZP9-4]
71399 [Q8IZP9-5]
71400 [Q8IZP9-6]
71401 [Q8IZP9-7]
71402 [Q8IZP9-8]
71403 [Q8IZP9-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZP9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8IZP9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts. Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173698 Expressed in 135 organ(s), highest expression level in caput epididymis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZP9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001478
HPA050029

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115451, 11 interactors

Protein interaction database and analysis system

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IntActi
Q8IZP9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369198

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8IZP9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini567 – 618GPSPROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi672 – 677Poly-Leu6
Compositional biasi816 – 819Poly-Lys4
Compositional biasi925 – 930Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156341

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231476

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051817

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZP9

KEGG Orthology (KO)

More...
KOi
K08451

Identification of Orthologs from Complete Genome Data

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OMAi
VCLHDFS

Database of Orthologous Groups

More...
OrthoDBi
148879at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZP9

TreeFam database of animal gene trees

More...
TreeFami
TF321769

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303 GPS, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 10 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IZP9-1) [UniParc]FASTAAdd to basket
Also known as: Long splice variant

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP
60 70 80 90 100
PAKLSVVSFA PSSNGTPEVE TTSLNDVTLS LLPSNETEKT KITIVKTFNA
110 120 130 140 150
SGVKPQRNIC NLSSICNDSA FFRGEIMFQY DKESTVPQNQ HITNGTLTGV
160 170 180 190 200
LSLSELKRSE LNKTLQTLSE TYFIMCATAE AQSTLNCTFT IKLNNTMNAC
210 220 230 240 250
AVIAALERVK IRPMEHCCCS VRIPCPSSPE ELEKLQCDLQ DPIVCLADHP
260 270 280 290 300
RGPPFSSSQS IPVVPRATVL SQVPKATSFA EPPDYSPVTH NVPSPIGEIQ
310 320 330 340 350
PLSPQPSAPI ASSPAIDMPP QSETISSPMP QTHVSGTPPP VKASFSSPTV
360 370 380 390 400
SAPANVNTTS APPVQTDIVN TSSISDLENQ VLQMEKALSL GSLEPNLAGE
410 420 430 440 450
MINQVSRLLH SPPDMLAPLA QRLLKVVDDI GLQLNFSNTT ISLTSPSLAL
460 470 480 490 500
AVIRVNASSF NTTTFVAQDP ANLQVSLETQ APENSIGTIT LPSSLMNNLP
510 520 530 540 550
AHDMELASRV QFNFFETPAL FQDPSLENLS LISYVISSSV ANLTVRNLTR
560 570 580 590 600
NVTVTLKHIN PSQDELTVRC VFWDLGRNGG RGGWSDNGCS VKDRRLNETI
610 620 630 640 650
CTCSHLTSFG VLLDLSRTSV LPAQMMALTF ITYIGCGLSS IFLSVTLVTY
660 670 680 690 700
IAFEKIRRDY PSKILIQLCA ALLLLNLVFL LDSWIALYKM QGLCISVAVF
710 720 730 740 750
LHYFLLVSFT WMGLEAFHMY LALVKVFNTY IRKYILKFCI VGWGVPAVVV
760 770 780 790 800
TIILTISPDN YGLGSYGKFP NGSPDDFCWI NNNAVFYITV VGYFCVIFLL
810 820 830 840 850
NVSMFIVVLV QLCRIKKKKQ LGAQRKTSIQ DLRSIAGLTF LLGITWGFAF
860 870 880 890 900
FAWGPVNVTF MYLFAIFNTL QGFFIFIFYC VAKENVRKQW RRYLCCGKLR
910 920 930 940 950
LAENSDWSKT ATNGLKKQTV NQGVSSSSNS LQSSSNSTNS TTLLVNNDCS
960 970 980 990 1000
VHASGNGNAS TERNGVSFSV QNGDVCLHDF TGKQHMFNEK EDSCNGKGRM
1010
ALRRTSKRGS LHFIEQM
Length:1,017
Mass (Da):111,593
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E0839DB45B6C553
GO
Isoform 2 (identifier: Q8IZP9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-67: Missing.

Show »
Length:1,014
Mass (Da):111,337
Checksum:i2EFFA8C485F8AB9A
GO
Isoform 3 (identifier: Q8IZP9-3) [UniParc]FASTAAdd to basket
Also known as: d1

The sequence of this isoform differs from the canonical sequence as follows:
     51-66: Missing.

Show »
Length:1,001
Mass (Da):110,049
Checksum:i2FC89014C20F574B
GO
Isoform 4 (identifier: Q8IZP9-4) [UniParc]FASTAAdd to basket
Also known as: 24

The sequence of this isoform differs from the canonical sequence as follows:
     88-101: Missing.

Show »
Length:1,003
Mass (Da):110,031
Checksum:i71EF3C56C15E3FDE
GO
Isoform 5 (identifier: Q8IZP9-5) [UniParc]FASTAAdd to basket
Also known as: 23

The sequence of this isoform differs from the canonical sequence as follows:
     52-75: Missing.

Show »
Length:993
Mass (Da):109,175
Checksum:i6C0F14BEEB6BB6AD
GO
Isoform 6 (identifier: Q8IZP9-6) [UniParc]FASTAAdd to basket
Also known as: d3

The sequence of this isoform differs from the canonical sequence as follows:
     68-101: EVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

Show »
Length:995
Mass (Da):109,157
Checksum:iC351BA0D891CA0D3
GO
Isoform 7 (identifier: Q8IZP9-7) [UniParc]FASTAAdd to basket
Also known as: d2

The sequence of this isoform differs from the canonical sequence as follows:
     52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → EVETTSLNDVTLSLLPSNET

Show »
Length:987
Mass (Da):108,487
Checksum:iFD8CB3C2B139A78B
GO
Isoform 8 (identifier: Q8IZP9-8) [UniParc]FASTAAdd to basket
Also known as: 21

The sequence of this isoform differs from the canonical sequence as follows:
     52-101: AKLSVVSFAPSSNGTPEVETTSLNDVTLSLLPSNETEKTKITIVKTFNAS → DVTLSLLPSNET

Show »
Length:979
Mass (Da):107,613
Checksum:i49B0950AC074B2F1
GO
Isoform 9 (identifier: Q8IZP9-9) [UniParc]FASTAAdd to basket
Also known as: Delta exon 28

The sequence of this isoform differs from the canonical sequence as follows:
     906-956: Missing.

Show »
Length:966
Mass (Da):106,353
Checksum:i042D243C632F9B35
GO
Isoform 10 (identifier: Q8IZP9-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-66: Missing.
     88-101: Missing.
     474-562: Missing.

Note: No experimental confirmation available.
Show »
Length:898
Mass (Da):98,720
Checksum:iE4820F94AD64A73B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti202V → A in CAA57479 (PubMed:9150425).Curated1
Sequence conflicti202V → A in AAN33056 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN33064 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN33065 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN38971 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN38972 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN38973 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN38974 (PubMed:12420295).Curated1
Sequence conflicti202V → A in AAN75702 (PubMed:12420295).Curated1
Sequence conflicti233E → G in CAA57479 (PubMed:9150425).Curated1
Sequence conflicti233E → G in AAN33056 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN33064 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN33065 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN38971 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN38972 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN38973 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN38974 (PubMed:12420295).Curated1
Sequence conflicti233E → G in AAN75702 (PubMed:12420295).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08077364N → S Found in a family with intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs746638813Ensembl.1
Natural variantiVAR_076259224P → S1 PublicationCorresponds to variant dbSNP:rs140334931Ensembl.1
Natural variantiVAR_055289290H → Q. Corresponds to variant dbSNP:rs35974297Ensembl.1
Natural variantiVAR_055290771N → S. Corresponds to variant dbSNP:rs3924227Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00979251 – 66Missing in isoform 3 and isoform 10. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_00979652 – 101AKLSV…TFNAS → EVETTSLNDVTLSLLPSNET in isoform 7. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_00979752 – 101AKLSV…TFNAS → DVTLSLLPSNET in isoform 8. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_00979452 – 75Missing in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_00979165 – 67Missing in isoform 2. 1 Publication3
Alternative sequenceiVSP_00979568 – 101EVETT…TFNAS → DVTLSLLPSNET in isoform 6. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_00979388 – 101Missing in isoform 4 and isoform 10. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_054522474 – 562Missing in isoform 10. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_009798906 – 956Missing in isoform 9. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X81892 mRNA Translation: CAA57479.1
AF538954 mRNA Translation: AAN33056.1
AF539455 mRNA Translation: AAN33064.1
AF539456 mRNA Translation: AAN33065.1
AY143364 mRNA Translation: AAN38971.1
AY143365 mRNA Translation: AAN38972.1
AY143366 mRNA Translation: AAN38973.1
AY143367 mRNA Translation: AAN38974.1
AY148343 mRNA Translation: AAN75702.1
AL732509 Genomic DNA No translation available.
AL732578 Genomic DNA No translation available.
BC113979 mRNA Translation: AAI13980.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14191.1 [Q8IZP9-2]
CCDS43921.1 [Q8IZP9-6]
CCDS43922.1 [Q8IZP9-4]
CCDS43923.1 [Q8IZP9-1]
CCDS55376.1 [Q8IZP9-5]
CCDS55377.1 [Q8IZP9-7]
CCDS55378.1 [Q8IZP9-3]
CCDS55379.1 [Q8IZP9-9]

NCBI Reference Sequences

More...
RefSeqi
NP_001073327.1, NM_001079858.2 [Q8IZP9-1]
NP_001073328.1, NM_001079859.2 [Q8IZP9-4]
NP_001073329.1, NM_001079860.2 [Q8IZP9-6]
NP_001171762.1, NM_001184833.1 [Q8IZP9-3]
NP_001171763.1, NM_001184834.1 [Q8IZP9-9]
NP_001171764.1, NM_001184835.1 [Q8IZP9-8]
NP_001171765.1, NM_001184836.1 [Q8IZP9-5]
NP_001171766.1, NM_001184837.1 [Q8IZP9-7]
NP_005747.2, NM_005756.3 [Q8IZP9-2]
XP_006724518.1, XM_006724455.3 [Q8IZP9-1]
XP_011543736.1, XM_011545434.1 [Q8IZP9-1]
XP_011543737.1, XM_011545435.2 [Q8IZP9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.146978

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340581; ENSP00000344972; ENSG00000173698 [Q8IZP9-10]
ENST00000354791; ENSP00000346845; ENSG00000173698 [Q8IZP9-10]
ENST00000356606; ENSP00000349015; ENSG00000173698 [Q8IZP9-4]
ENST00000357544; ENSP00000350152; ENSG00000173698 [Q8IZP9-7]
ENST00000357991; ENSP00000350680; ENSG00000173698 [Q8IZP9-2]
ENST00000360279; ENSP00000353421; ENSG00000173698 [Q8IZP9-6]
ENST00000379869; ENSP00000369198; ENSG00000173698 [Q8IZP9-1]
ENST00000379873; ENSP00000369202; ENSG00000173698 [Q8IZP9-9]
ENST00000379876; ENSP00000369205; ENSG00000173698 [Q8IZP9-5]
ENST00000379878; ENSP00000369207; ENSG00000173698 [Q8IZP9-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10149

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10149

UCSC genome browser

More...
UCSCi
uc004cyx.4 human [Q8IZP9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81892 mRNA Translation: CAA57479.1
AF538954 mRNA Translation: AAN33056.1
AF539455 mRNA Translation: AAN33064.1
AF539456 mRNA Translation: AAN33065.1
AY143364 mRNA Translation: AAN38971.1
AY143365 mRNA Translation: AAN38972.1
AY143366 mRNA Translation: AAN38973.1
AY143367 mRNA Translation: AAN38974.1
AY148343 mRNA Translation: AAN75702.1
AL732509 Genomic DNA No translation available.
AL732578 Genomic DNA No translation available.
BC113979 mRNA Translation: AAI13980.1
CCDSiCCDS14191.1 [Q8IZP9-2]
CCDS43921.1 [Q8IZP9-6]
CCDS43922.1 [Q8IZP9-4]
CCDS43923.1 [Q8IZP9-1]
CCDS55376.1 [Q8IZP9-5]
CCDS55377.1 [Q8IZP9-7]
CCDS55378.1 [Q8IZP9-3]
CCDS55379.1 [Q8IZP9-9]
RefSeqiNP_001073327.1, NM_001079858.2 [Q8IZP9-1]
NP_001073328.1, NM_001079859.2 [Q8IZP9-4]
NP_001073329.1, NM_001079860.2 [Q8IZP9-6]
NP_001171762.1, NM_001184833.1 [Q8IZP9-3]
NP_001171763.1, NM_001184834.1 [Q8IZP9-9]
NP_001171764.1, NM_001184835.1 [Q8IZP9-8]
NP_001171765.1, NM_001184836.1 [Q8IZP9-5]
NP_001171766.1, NM_001184837.1 [Q8IZP9-7]
NP_005747.2, NM_005756.3 [Q8IZP9-2]
XP_006724518.1, XM_006724455.3 [Q8IZP9-1]
XP_011543736.1, XM_011545434.1 [Q8IZP9-1]
XP_011543737.1, XM_011545435.2 [Q8IZP9-1]
UniGeneiHs.146978

3D structure databases

ProteinModelPortaliQ8IZP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115451, 11 interactors
IntActiQ8IZP9, 1 interactor
STRINGi9606.ENSP00000369198

Protein family/group databases

MEROPSiP02.007

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ8IZP9
PhosphoSitePlusiQ8IZP9

Polymorphism and mutation databases

BioMutaiADGRG2
DMDMi229462874

Proteomic databases

jPOSTiQ8IZP9
MaxQBiQ8IZP9
PaxDbiQ8IZP9
PeptideAtlasiQ8IZP9
PRIDEiQ8IZP9
ProteomicsDBi71395
71396 [Q8IZP9-2]
71397 [Q8IZP9-3]
71398 [Q8IZP9-4]
71399 [Q8IZP9-5]
71400 [Q8IZP9-6]
71401 [Q8IZP9-7]
71402 [Q8IZP9-8]
71403 [Q8IZP9-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340581; ENSP00000344972; ENSG00000173698 [Q8IZP9-10]
ENST00000354791; ENSP00000346845; ENSG00000173698 [Q8IZP9-10]
ENST00000356606; ENSP00000349015; ENSG00000173698 [Q8IZP9-4]
ENST00000357544; ENSP00000350152; ENSG00000173698 [Q8IZP9-7]
ENST00000357991; ENSP00000350680; ENSG00000173698 [Q8IZP9-2]
ENST00000360279; ENSP00000353421; ENSG00000173698 [Q8IZP9-6]
ENST00000379869; ENSP00000369198; ENSG00000173698 [Q8IZP9-1]
ENST00000379873; ENSP00000369202; ENSG00000173698 [Q8IZP9-9]
ENST00000379876; ENSP00000369205; ENSG00000173698 [Q8IZP9-5]
ENST00000379878; ENSP00000369207; ENSG00000173698 [Q8IZP9-3]
GeneIDi10149
KEGGihsa:10149
UCSCiuc004cyx.4 human [Q8IZP9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10149
DisGeNETi10149
EuPathDBiHostDB:ENSG00000173698.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADGRG2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0016685
HGNCiHGNC:4516 ADGRG2
HPAiHPA001478
HPA050029
MalaCardsiADGRG2
MIMi300572 gene
300985 phenotype
neXtProtiNX_Q8IZP9
OpenTargetsiENSG00000173698
Orphaneti48 Congenital bilateral absence of vas deferens
PharmGKBiPA28908

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00940000156341
HOGENOMiHOG000231476
HOVERGENiHBG051817
InParanoidiQ8IZP9
KOiK08451
OMAiVCLHDFS
OrthoDBi148879at2759
PhylomeDBiQ8IZP9
TreeFamiTF321769

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GPR64

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10149

Protein Ontology

More...
PROi
PR:Q8IZP9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173698 Expressed in 135 organ(s), highest expression level in caput epididymis
GenevisibleiQ8IZP9 HS

Family and domain databases

InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRG2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZP9
Secondary accession number(s): B1AWB3
, B1AWB4, B1AWB6, B1AWB7, O00406, Q14CE0, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 5, 2009
Last modified: January 16, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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