UniProtKB - Q8IZP6 (R113B_HUMAN)
Protein
RING finger protein 113B
Gene
RNF113B
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 190 – 218 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 256 – 294 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- snoRNA splicing Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8IZP6 |
Names & Taxonomyi
Protein namesi | Recommended name: RING finger protein 113BAlternative name(s): Zinc finger protein 183-like 1 |
Gene namesi | Name:RNF113B Synonyms:RNF161, ZNF183L1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17267, RNF113B |
neXtProti | NX_Q8IZP6 |
VEuPathDBi | HostDB:ENSG00000139797.7 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000139797 |
PharmGKBi | PA38217 |
Miscellaneous databases
Pharosi | Q8IZP6, Tdark |
Genetic variation databases
BioMutai | RNF113B |
DMDMi | 51338806 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056088 | 1 – 322 | RING finger protein 113BAdd BLAST | 322 |
Proteomic databases
jPOSTi | Q8IZP6 |
MassIVEi | Q8IZP6 |
MaxQBi | Q8IZP6 |
PaxDbi | Q8IZP6 |
PeptideAtlasi | Q8IZP6 |
PRIDEi | Q8IZP6 |
ProteomicsDBi | 71393 |
PTM databases
iPTMneti | Q8IZP6 |
PhosphoSitePlusi | Q8IZP6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000139797, Expressed in testis and 30 other tissues |
Organism-specific databases
HPAi | ENSG00000139797, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 126603, 6 interactors |
IntActi | Q8IZP6, 4 interactors |
STRINGi | 9606.ENSP00000267291 |
Miscellaneous databases
RNActi | Q8IZP6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IZP6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8IZP6 |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 190 – 218 | C3H1-typePROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 256 – 294 | RING-typePROSITE-ProRule annotationAdd BLAST | 39 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1813, Eukaryota |
GeneTreei | ENSGT00390000016292 |
HOGENOMi | CLU_050460_1_0_1 |
InParanoidi | Q8IZP6 |
OMAi | GICEDEN |
OrthoDBi | 1420266at2759 |
PhylomeDBi | Q8IZP6 |
TreeFami | TF313469 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR039971, CWC24-like IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR12930, PTHR12930, 1 hit |
Pfami | View protein in Pfam PF00642, zf-CCCH, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00356, ZnF_C3H1, 1 hit |
SUPFAMi | SSF90229, SSF90229, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IZP6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG
60 70 80 90 100
DEGDTVAQPP RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA
110 120 130 140 150
KPVGPEDMGA TADFEQDTEK EHHTPTILKC SQRVQEALRG REHDHIYRGI
160 170 180 190 200
HSYLRYLKPK DTSMGNSSSG MARKGPIRAP GHLRATVRWD YQPDICKDYK
210 220 230 240 250
ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED ENHEVGSEEE
260 270 280 290 300
EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI
310 320
FNPAKELMAK LQKLQAAEGK KR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 56 | V → A in AAN33063 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052104 | 92 | V → M. Corresponds to variant dbSNP:rs16955011Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF539427 mRNA Translation: AAN33063.1 AL136300 Genomic DNA No translation available. BC017585 mRNA Translation: AAH17585.1 BC025388 mRNA Translation: AAH25388.1 |
CCDSi | CCDS9486.1 |
RefSeqi | NP_849192.1, NM_178861.4 |
Genome annotation databases
Ensembli | ENST00000267291; ENSP00000267291; ENSG00000139797 |
GeneIDi | 140432 |
KEGGi | hsa:140432 |
UCSCi | uc001vnk.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF539427 mRNA Translation: AAN33063.1 AL136300 Genomic DNA No translation available. BC017585 mRNA Translation: AAH17585.1 BC025388 mRNA Translation: AAH25388.1 |
CCDSi | CCDS9486.1 |
RefSeqi | NP_849192.1, NM_178861.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CSY | NMR | - | A | 246-313 | [»] | |
SMRi | Q8IZP6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126603, 6 interactors |
IntActi | Q8IZP6, 4 interactors |
STRINGi | 9606.ENSP00000267291 |
PTM databases
iPTMneti | Q8IZP6 |
PhosphoSitePlusi | Q8IZP6 |
Genetic variation databases
BioMutai | RNF113B |
DMDMi | 51338806 |
Proteomic databases
jPOSTi | Q8IZP6 |
MassIVEi | Q8IZP6 |
MaxQBi | Q8IZP6 |
PaxDbi | Q8IZP6 |
PeptideAtlasi | Q8IZP6 |
PRIDEi | Q8IZP6 |
ProteomicsDBi | 71393 |
Protocols and materials databases
Antibodypediai | 10782, 222 antibodies |
DNASUi | 140432 |
Genome annotation databases
Ensembli | ENST00000267291; ENSP00000267291; ENSG00000139797 |
GeneIDi | 140432 |
KEGGi | hsa:140432 |
UCSCi | uc001vnk.4, human |
Organism-specific databases
CTDi | 140432 |
GeneCardsi | RNF113B |
HGNCi | HGNC:17267, RNF113B |
HPAi | ENSG00000139797, Tissue enriched (testis) |
neXtProti | NX_Q8IZP6 |
OpenTargetsi | ENSG00000139797 |
PharmGKBi | PA38217 |
VEuPathDBi | HostDB:ENSG00000139797.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1813, Eukaryota |
GeneTreei | ENSGT00390000016292 |
HOGENOMi | CLU_050460_1_0_1 |
InParanoidi | Q8IZP6 |
OMAi | GICEDEN |
OrthoDBi | 1420266at2759 |
PhylomeDBi | Q8IZP6 |
TreeFami | TF313469 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZP6 |
Miscellaneous databases
BioGRID-ORCSi | 140432, 3 hits in 983 CRISPR screens |
EvolutionaryTracei | Q8IZP6 |
GenomeRNAii | 140432 |
Pharosi | Q8IZP6, Tdark |
PROi | PR:Q8IZP6 |
RNActi | Q8IZP6, protein |
Gene expression databases
Bgeei | ENSG00000139797, Expressed in testis and 30 other tissues |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR039971, CWC24-like IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
PANTHERi | PTHR12930, PTHR12930, 1 hit |
Pfami | View protein in Pfam PF00642, zf-CCCH, 1 hit |
SMARTi | View protein in SMART SM00184, RING, 1 hit SM00356, ZnF_C3H1, 1 hit |
SUPFAMi | SSF90229, SSF90229, 1 hit |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R113B_HUMAN | |
Accessioni | Q8IZP6Primary (citable) accession number: Q8IZP6 Secondary accession number(s): Q8WWF9, Q96QY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | August 16, 2004 | |
Last modified: | April 7, 2021 | |
This is version 147 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references