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Entry version 178 (18 Sep 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Abl interactor 1

Gene

ABI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IZP0

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8IZP0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Abl interactor 1
Alternative name(s):
Abelson interactor 1
Short name:
Abi-1
Abl-binding protein 4
Short name:
AblBP4
Eps8 SH3 domain-binding protein
Short name:
Eps8-binding protein
Nap1-binding protein
Short name:
Nap1BP
Spectrin SH3 domain-binding protein 1
e3B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABI1Imported
Synonyms:SSH3BP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11320 ABI1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603050 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZP0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation t(10;11)(p11.2;q23) with KMT2A/MLL1. ABI1 isoform 2 was found to be present in acute leukemia KMT2A/MLL1-ABI1 fusion transcript.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei95 – 96Breakpoint for translocation to form KMT2A/MLL1-ABI12

Organism-specific databases

DisGeNET

More...
DisGeNETi
10006

Open Targets

More...
OpenTargetsi
ENSG00000136754

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36144

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABI1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50400546

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917872 – 508Abl interactor 1Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei53PhosphotyrosineBy similarity1
Modified residuei174PhosphothreonineCombined sources1
Modified residuei178PhosphothreonineCombined sources1
Modified residuei183PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei213Phosphotyrosine; by ABL1Combined sources1 Publication1
Modified residuei215PhosphothreonineBy similarity1
Modified residuei216PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei319PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei455PhosphotyrosineBy similarity1
Modified residuei466PhosphoserineBy similarity1
Modified residuei507PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IZP0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IZP0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IZP0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IZP0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZP0

PeptideAtlas

More...
PeptideAtlasi
Q8IZP0

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZP0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
43294
71380 [Q8IZP0-1]
71381 [Q8IZP0-10]
71382 [Q8IZP0-11]
71383 [Q8IZP0-2]
71384 [Q8IZP0-3]
71385 [Q8IZP0-4]
71386 [Q8IZP0-5]
71387 [Q8IZP0-6]
71388 [Q8IZP0-7]
71389 [Q8IZP0-8]
71390 [Q8IZP0-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZP0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZP0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest expression in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136754 Expressed in 232 organ(s), highest expression level in mouth mucosa

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IZP0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IZP0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008375
HPA029973
HPA068407

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, and through its N-terminus with WASF1.

Part of a complex consisting of ABI1, STX1A and SNAP25.

Part of a complex consisting of ABI1, EPS8 and SOS1 (By similarity).

Interacts with SOS1, SOS2, GRB2, SPTA1 and the first SH3 domain of NCK1. Isoform 6 does not interact with NCK1.

Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2 (PubMed:16417406).

Interacts (via SH3 domain) with SHANK2 and SHANK3, but not SHANK1; the interaction is direct.

Interacts with the heterodimer MYC:MAX; the interaction may enhance MYC:MAX transcriptional activity.

Interacts with FNBP1L (via the SH3 domain), WASF2, and CDC42, but only in the presence of FNBP1L (PubMed:19798448).

By similarity7 Publications

(Microbial infection)

Interacts with human cytomegalovirus/HHV-5 protein UL135.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115324, 73 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IZP0

Database of interacting proteins

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DIPi
DIP-31118N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q8IZP0

Protein interaction database and analysis system

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IntActi
Q8IZP0, 126 interactors

Molecular INTeraction database

More...
MINTi
Q8IZP0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365312

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IZP0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 107t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63
Domaini446 – 505SH3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 79Required for binding to WASF1By similarityAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi260 – 418Pro-richAdd BLAST159

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABI family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPCV Eukaryota
ENOG410XQ3Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154811

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293213

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZP0

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGHGVKE

Database of Orthologous Groups

More...
OrthoDBi
1478981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZP0

TreeFam database of animal gene trees

More...
TreeFami
TF314303

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11971 SH3_Abi1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028457 ABI
IPR028456 ABI1
IPR035725 Abi1_SH3
IPR012849 Abl-interactor_HHR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR000727 T_SNARE_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10460 PTHR10460, 1 hit
PTHR10460:SF2 PTHR10460:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07815 Abi_HHR, 1 hit
PF00018 SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit
PS50192 T_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 12 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IZP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET
60 70 80 90 100
KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH
110 120 130 140 150
KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG
160 170 180 190 200
HGVKWLKAKH GNNQPARTGT LSRTNPPTQK PPSPPMSGRG TLGRNTPYKT
210 220 230 240 250
LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS GSSGGSGSRE
260 270 280 290 300
NSGSSSIGIP IAVPTPSPPT IGPENISVPP PSGAPPAPPL APLLPVSTVI
310 320 330 340 350
AAPGSAPGSQ YGTMTRQISR HNSTTSSTSS GGYRRTPSVT AQFSAQPHVN
360 370 380 390 400
GGPLYSQNSI SIAPPPPPMP QLTPQIPLTG FVARVQENIA DSPTPPPPPP
410 420 430 440 450
PDDIPMFDDS PPPPPPPPVD YEDEEAAVVQ YNDPYADGDP AWAPKNYIEK
460 470 480 490 500
VVAIYDYTKD KDDELSFMEG AIIYVIKKND DGWYEGVCNR VTGLFPGNYV

ESIMHYTD
Length:508
Mass (Da):55,081
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D76F305934127CB
GO
Isoform 2 (identifier: Q8IZP0-2) [UniParc]FASTAAdd to basket
Also known as: long, B48

The sequence of this isoform differs from the canonical sequence as follows:
     154-158: Missing.
     274-300: Missing.
     301-301: Missing.
     360-388: Missing.

Show »
Length:446
Mass (Da):48,678
Checksum:iFEDF9B1991B89955
GO
Isoform 3 (identifier: Q8IZP0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-300: Missing.
     360-388: Missing.

Show »
Length:452
Mass (Da):49,376
Checksum:i558B171EB1EABED4
GO
Isoform 4 (identifier: Q8IZP0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-300: Missing.
     301-301: Missing.
     360-388: Missing.

Show »
Length:451
Mass (Da):49,305
Checksum:i796AE1E3CA14C07B
GO
Isoform 5 (identifier: Q8IZP0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-158: Missing.
     274-300: Missing.

Show »
Length:476
Mass (Da):51,841
Checksum:i0321298AEFF40B9D
GO
Isoform 6 (identifier: Q8IZP0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-300: Missing.
     301-301: Missing.

Show »
Length:480
Mass (Da):52,397
Checksum:i4EA3699ECE77EE0E
GO
Isoform 7 (identifier: Q8IZP0-7) [UniParc]FASTAAdd to basket
Also known as: 4

The sequence of this isoform differs from the canonical sequence as follows:
     274-300: Missing.
     301-301: Missing.
     302-359: Missing.
     360-360: I → V

Show »
Length:422
Mass (Da):46,386
Checksum:i16FAAB5B29D7E506
GO
Isoform 8 (identifier: Q8IZP0-8) [UniParc]FASTAAdd to basket
Also known as: 5

The sequence of this isoform differs from the canonical sequence as follows:
     274-300: Missing.
     301-301: Missing.
     302-359: Missing.
     360-388: Missing.

Show »
Length:393
Mass (Da):43,309
Checksum:i522FF3E0941EE851
GO
Isoform 9 (identifier: Q8IZP0-9) [UniParc]FASTAAdd to basket
Also known as: 2

The sequence of this isoform differs from the canonical sequence as follows:
     274-300: Missing.

Show »
Length:481
Mass (Da):52,468
Checksum:iA29602C39221C826
GO
Isoform 10 (identifier: Q8IZP0-10) [UniParc]FASTAAdd to basket
Also known as: B30

The sequence of this isoform differs from the canonical sequence as follows:
     154-158: Missing.
     274-300: Missing.
     301-301: Missing.
     302-359: Missing.
     360-388: Missing.
     389-389: I → V

Show »
Length:388
Mass (Da):42,668
Checksum:iE63747A11D358E42
GO
Isoform 11 (identifier: Q8IZP0-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-159: Missing.
     274-300: Missing.
     301-301: Missing.
     302-359: Missing.
     360-388: Missing.
     389-389: I → V

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):35,920
Checksum:i5895AC905A5773F7
GO
Isoform 12 (identifier: Q8IZP0-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-38: I → IQRHGFAVLLCLLSNSWP
     360-388: Missing.

Note: No experimental confirmation available.
Show »
Length:496
Mass (Da):53,912
Checksum:iB6D85C58732FB5E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRT6A0A0A0MRT6_HUMAN
Abl interactor 1
ABI1
475Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B6VEX4B6VEX4_HUMAN
Abl interactor 1
ABI1
393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti177P → L in AAC39757 (PubMed:9593709).Curated1
Sequence conflicti410S → F in AAC39757 (PubMed:9593709).Curated1
Sequence conflicti410S → F in AAN28379 (PubMed:12681507).Curated1
Sequence conflicti437D → G in BAG54374 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048159331G → A. Corresponds to variant dbSNP:rs2306236Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04460438I → IQRHGFAVLLCLLSNSWP in isoform 12. 1 Publication1
Alternative sequenceiVSP_04340396 – 159Missing in isoform 11. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_010749154 – 158Missing in isoform 2, isoform 5 and isoform 10. 4 Publications5
Alternative sequenceiVSP_010750274 – 300Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 7 PublicationsAdd BLAST27
Alternative sequenceiVSP_010751301Missing in isoform 2, isoform 4, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 11. 6 Publications1
Alternative sequenceiVSP_010754302 – 359Missing in isoform 7, isoform 8, isoform 10 and isoform 11. 4 PublicationsAdd BLAST58
Alternative sequenceiVSP_010752360 – 388Missing in isoform 2, isoform 3, isoform 4, isoform 8, isoform 10, isoform 11 and isoform 12. 6 PublicationsAdd BLAST29
Alternative sequenceiVSP_010755360I → V in isoform 7. 1 Publication1
Alternative sequenceiVSP_010753389I → V in isoform 10 and isoform 11. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF006516 mRNA Translation: AAB62569.1
U87166 mRNA Translation: AAC39757.1
AB040151 mRNA Translation: BAB55675.1
AF540955 mRNA Translation: AAN28379.1
AF001628 mRNA Translation: AAD00897.1
AJ277065
, AJ277066, AJ277067, AJ277068, AJ277069, AJ277070, AJ277071, AJ277072, AJ277073, AJ277074 Genomic DNA Translation: CAB88006.1
AF260262 mRNA Translation: AAF70309.1
AK126803 mRNA Translation: BAG54374.1
AK298646 mRNA Translation: BAG60820.1
AK291823 mRNA Translation: BAF84512.1
AL139404, AL390961 Genomic DNA Translation: CAH73112.1
AL139404, AL390961 Genomic DNA Translation: CAH73113.1
AL139404, AL390961 Genomic DNA Translation: CAH73114.1
AL139404, AL390961 Genomic DNA Translation: CAH73115.1
AL139404, AL390961 Genomic DNA Translation: CAH73116.1
AL139404, AL390961 Genomic DNA Translation: CAH73117.1
AL139404, AL390961 Genomic DNA Translation: CAH73118.1
AL139404, AL390961 Genomic DNA Translation: CAH73119.1
AL390961, AL139404 Genomic DNA Translation: CAI17272.1
AL390961, AL139404 Genomic DNA Translation: CAI17273.1
AL390961, AL139404 Genomic DNA Translation: CAI17274.1
AL390961, AL139404 Genomic DNA Translation: CAI17275.1
AL390961, AL139404 Genomic DNA Translation: CAI17276.1
AL390961, AL139404 Genomic DNA Translation: CAI17277.1
AL390961, AL139404 Genomic DNA Translation: CAI17278.1
AL390961, AL139404 Genomic DNA Translation: CAI17279.1
CH471072 Genomic DNA Translation: EAW86079.1
CH471072 Genomic DNA Translation: EAW86080.1
BC024254 mRNA Translation: AAH24254.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31169.1 [Q8IZP0-5]
CCDS31170.1 [Q8IZP0-3]
CCDS31171.1 [Q8IZP0-9]
CCDS53497.1 [Q8IZP0-11]
CCDS53498.1 [Q8IZP0-2]
CCDS53499.1 [Q8IZP0-4]
CCDS53500.1 [Q8IZP0-6]
CCDS53501.1 [Q8IZP0-12]
CCDS7150.1 [Q8IZP0-1]
CCDS73077.1 [Q8IZP0-8]
CCDS73078.1 [Q8IZP0-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001012768.1, NM_001012750.2 [Q8IZP0-9]
NP_001012769.1, NM_001012751.2 [Q8IZP0-3]
NP_001012770.1, NM_001012752.2 [Q8IZP0-5]
NP_001171587.1, NM_001178116.1 [Q8IZP0-12]
NP_001171590.1, NM_001178119.1 [Q8IZP0-6]
NP_001171591.1, NM_001178120.1 [Q8IZP0-4]
NP_001171592.1, NM_001178121.1 [Q8IZP0-2]
NP_001171593.1, NM_001178122.1 [Q8IZP0-7]
NP_001171594.1, NM_001178123.1
NP_001171595.1, NM_001178124.1 [Q8IZP0-10]
NP_001171596.1, NM_001178125.1 [Q8IZP0-11]
NP_005461.2, NM_005470.3 [Q8IZP0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000346832; ENSP00000279599; ENSG00000136754 [Q8IZP0-12]
ENST00000359188; ENSP00000352114; ENSG00000136754 [Q8IZP0-6]
ENST00000376137; ENSP00000365307; ENSG00000136754 [Q8IZP0-7]
ENST00000376138; ENSP00000365308; ENSG00000136754 [Q8IZP0-3]
ENST00000376139; ENSP00000365309; ENSG00000136754 [Q8IZP0-5]
ENST00000376140; ENSP00000365310; ENSG00000136754 [Q8IZP0-9]
ENST00000376142; ENSP00000365312; ENSG00000136754 [Q8IZP0-1]
ENST00000376166; ENSP00000365336; ENSG00000136754 [Q8IZP0-2]
ENST00000376170; ENSP00000365340; ENSG00000136754 [Q8IZP0-4]
ENST00000490841; ENSP00000440101; ENSG00000136754 [Q8IZP0-11]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10006

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10006

UCSC genome browser

More...
UCSCi
uc001isx.4 human [Q8IZP0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006516 mRNA Translation: AAB62569.1
U87166 mRNA Translation: AAC39757.1
AB040151 mRNA Translation: BAB55675.1
AF540955 mRNA Translation: AAN28379.1
AF001628 mRNA Translation: AAD00897.1
AJ277065
, AJ277066, AJ277067, AJ277068, AJ277069, AJ277070, AJ277071, AJ277072, AJ277073, AJ277074 Genomic DNA Translation: CAB88006.1
AF260262 mRNA Translation: AAF70309.1
AK126803 mRNA Translation: BAG54374.1
AK298646 mRNA Translation: BAG60820.1
AK291823 mRNA Translation: BAF84512.1
AL139404, AL390961 Genomic DNA Translation: CAH73112.1
AL139404, AL390961 Genomic DNA Translation: CAH73113.1
AL139404, AL390961 Genomic DNA Translation: CAH73114.1
AL139404, AL390961 Genomic DNA Translation: CAH73115.1
AL139404, AL390961 Genomic DNA Translation: CAH73116.1
AL139404, AL390961 Genomic DNA Translation: CAH73117.1
AL139404, AL390961 Genomic DNA Translation: CAH73118.1
AL139404, AL390961 Genomic DNA Translation: CAH73119.1
AL390961, AL139404 Genomic DNA Translation: CAI17272.1
AL390961, AL139404 Genomic DNA Translation: CAI17273.1
AL390961, AL139404 Genomic DNA Translation: CAI17274.1
AL390961, AL139404 Genomic DNA Translation: CAI17275.1
AL390961, AL139404 Genomic DNA Translation: CAI17276.1
AL390961, AL139404 Genomic DNA Translation: CAI17277.1
AL390961, AL139404 Genomic DNA Translation: CAI17278.1
AL390961, AL139404 Genomic DNA Translation: CAI17279.1
CH471072 Genomic DNA Translation: EAW86079.1
CH471072 Genomic DNA Translation: EAW86080.1
BC024254 mRNA Translation: AAH24254.1
CCDSiCCDS31169.1 [Q8IZP0-5]
CCDS31170.1 [Q8IZP0-3]
CCDS31171.1 [Q8IZP0-9]
CCDS53497.1 [Q8IZP0-11]
CCDS53498.1 [Q8IZP0-2]
CCDS53499.1 [Q8IZP0-4]
CCDS53500.1 [Q8IZP0-6]
CCDS53501.1 [Q8IZP0-12]
CCDS7150.1 [Q8IZP0-1]
CCDS73077.1 [Q8IZP0-8]
CCDS73078.1 [Q8IZP0-7]
RefSeqiNP_001012768.1, NM_001012750.2 [Q8IZP0-9]
NP_001012769.1, NM_001012751.2 [Q8IZP0-3]
NP_001012770.1, NM_001012752.2 [Q8IZP0-5]
NP_001171587.1, NM_001178116.1 [Q8IZP0-12]
NP_001171590.1, NM_001178119.1 [Q8IZP0-6]
NP_001171591.1, NM_001178120.1 [Q8IZP0-4]
NP_001171592.1, NM_001178121.1 [Q8IZP0-2]
NP_001171593.1, NM_001178122.1 [Q8IZP0-7]
NP_001171594.1, NM_001178123.1
NP_001171595.1, NM_001178124.1 [Q8IZP0-10]
NP_001171596.1, NM_001178125.1 [Q8IZP0-11]
NP_005461.2, NM_005470.3 [Q8IZP0-1]

3D structure databases

SMRiQ8IZP0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115324, 73 interactors
CORUMiQ8IZP0
DIPiDIP-31118N
ELMiQ8IZP0
IntActiQ8IZP0, 126 interactors
MINTiQ8IZP0
STRINGi9606.ENSP00000365312

PTM databases

iPTMnetiQ8IZP0
PhosphoSitePlusiQ8IZP0

Polymorphism and mutation databases

BioMutaiABI1
DMDMi50400546

Proteomic databases

EPDiQ8IZP0
jPOSTiQ8IZP0
MassIVEiQ8IZP0
MaxQBiQ8IZP0
PaxDbiQ8IZP0
PeptideAtlasiQ8IZP0
PRIDEiQ8IZP0
ProteomicsDBi43294
71380 [Q8IZP0-1]
71381 [Q8IZP0-10]
71382 [Q8IZP0-11]
71383 [Q8IZP0-2]
71384 [Q8IZP0-3]
71385 [Q8IZP0-4]
71386 [Q8IZP0-5]
71387 [Q8IZP0-6]
71388 [Q8IZP0-7]
71389 [Q8IZP0-8]
71390 [Q8IZP0-9]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346832; ENSP00000279599; ENSG00000136754 [Q8IZP0-12]
ENST00000359188; ENSP00000352114; ENSG00000136754 [Q8IZP0-6]
ENST00000376137; ENSP00000365307; ENSG00000136754 [Q8IZP0-7]
ENST00000376138; ENSP00000365308; ENSG00000136754 [Q8IZP0-3]
ENST00000376139; ENSP00000365309; ENSG00000136754 [Q8IZP0-5]
ENST00000376140; ENSP00000365310; ENSG00000136754 [Q8IZP0-9]
ENST00000376142; ENSP00000365312; ENSG00000136754 [Q8IZP0-1]
ENST00000376166; ENSP00000365336; ENSG00000136754 [Q8IZP0-2]
ENST00000376170; ENSP00000365340; ENSG00000136754 [Q8IZP0-4]
ENST00000490841; ENSP00000440101; ENSG00000136754 [Q8IZP0-11]
GeneIDi10006
KEGGihsa:10006
UCSCiuc001isx.4 human [Q8IZP0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10006
DisGeNETi10006

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABI1
HGNCiHGNC:11320 ABI1
HPAiCAB008375
HPA029973
HPA068407
MIMi603050 gene
neXtProtiNX_Q8IZP0
OpenTargetsiENSG00000136754
PharmGKBiPA36144

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPCV Eukaryota
ENOG410XQ3Y LUCA
GeneTreeiENSGT00940000154811
HOGENOMiHOG000293213
InParanoidiQ8IZP0
OMAiVGHGVKE
OrthoDBi1478981at2759
PhylomeDBiQ8IZP0
TreeFamiTF314303

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
SignaLinkiQ8IZP0
SIGNORiQ8IZP0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABI1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ABI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10006

Pharos

More...
Pharosi
Q8IZP0

Protein Ontology

More...
PROi
PR:Q8IZP0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136754 Expressed in 232 organ(s), highest expression level in mouth mucosa
ExpressionAtlasiQ8IZP0 baseline and differential
GenevisibleiQ8IZP0 HS

Family and domain databases

CDDicd11971 SH3_Abi1, 1 hit
InterProiView protein in InterPro
IPR028457 ABI
IPR028456 ABI1
IPR035725 Abi1_SH3
IPR012849 Abl-interactor_HHR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR000727 T_SNARE_dom
PANTHERiPTHR10460 PTHR10460, 1 hit
PTHR10460:SF2 PTHR10460:SF2, 1 hit
PfamiView protein in Pfam
PF07815 Abi_HHR, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
PS50192 T_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZP0
Secondary accession number(s): A9Z1Y6
, B3KX62, B4DQ58, H7BXI6, O15147, O76049, O95060, Q5T2R3, Q5T2R4, Q5T2R6, Q5T2R7, Q5T2R9, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 178 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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