UniProtKB - Q8IZP0 (ABI1_HUMAN)
Abl interactor 1
ABI1
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cytoskeletal protein binding Source: ProtInc
- protein tyrosine kinase activator activity Source: Ensembl
- SH3 domain binding Source: UniProtKB
GO - Biological processi
- actin polymerization or depolymerization Source: UniProtKB
- dendrite morphogenesis Source: Ensembl
- Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
- lamellipodium morphogenesis Source: Ensembl
- megakaryocyte development Source: Ensembl
- negative regulation of cell population proliferation Source: ProtInc
- peptidyl-tyrosine phosphorylation Source: MGI
- somitogenesis Source: Ensembl
- transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc
- vascular endothelial growth factor receptor signaling pathway Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q8IZP0 |
Reactomei | R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs R-HSA-9664422, FCGR3A-mediated phagocytosis |
SignaLinki | Q8IZP0 |
SIGNORi | Q8IZP0 |
Names & Taxonomyi
Protein namesi | Recommended name: Abl interactor 1Alternative name(s): Abelson interactor 1 Short name: Abi-1 Abl-binding protein 4 Short name: AblBP4 Eps8 SH3 domain-binding protein Short name: Eps8-binding protein Nap1-binding protein Short name: Nap1BP Spectrin SH3 domain-binding protein 1 e3B1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11320, ABI1 |
MIMi | 603050, gene |
neXtProti | NX_Q8IZP0 |
VEuPathDBi | HostDB:ENSG00000136754.16 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
- lamellipodium By similarity
- filopodium By similarity
- growth cone By similarity
- postsynaptic density By similarity
Note: Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity).By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: ProtInc
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- aggresome Source: HPA
- cell junction Source: HPA
- filopodium tip Source: UniProtKB
- growth cone Source: UniProtKB-SubCell
- lamellipodium Source: UniProtKB
- postsynaptic density Source: UniProtKB-SubCell
- SCAR complex Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus, SynapsePathology & Biotechi
Involvement in diseasei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 95 – 96 | Breakpoint for translocation to form KMT2A/MLL1-ABI1 | 2 |
Organism-specific databases
DisGeNETi | 10006 |
OpenTargetsi | ENSG00000136754 |
PharmGKBi | PA36144 |
Miscellaneous databases
Pharosi | Q8IZP0, Tbio |
Genetic variation databases
BioMutai | ABI1 |
DMDMi | 50400546 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources2 Publications | |||
ChainiPRO_0000191787 | 2 – 508 | Abl interactor 1Add BLAST | 507 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 53 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 174 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 178 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 183 | PhosphoserineCombined sources | 1 | |
Modified residuei | 187 | PhosphoserineCombined sources | 1 | |
Modified residuei | 213 | Phosphotyrosine; by ABL1Combined sources1 Publication | 1 | |
Modified residuei | 215 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 216 | PhosphoserineCombined sources | 1 | |
Modified residuei | 222 | PhosphoserineCombined sources | 1 | |
Modified residuei | 225 | PhosphoserineCombined sources | 1 | |
Modified residuei | 319 | PhosphoserineCombined sources | 1 | |
Modified residuei | 323 | PhosphoserineCombined sources | 1 | |
Modified residuei | 455 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 466 | PhosphoserineBy similarity | 1 | |
Modified residuei | 507 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q8IZP0 |
jPOSTi | Q8IZP0 |
MassIVEi | Q8IZP0 |
MaxQBi | Q8IZP0 |
PaxDbi | Q8IZP0 |
PeptideAtlasi | Q8IZP0 |
PRIDEi | Q8IZP0 |
ProteomicsDBi | 43294 71380 [Q8IZP0-1] 71381 [Q8IZP0-10] 71382 [Q8IZP0-11] 71383 [Q8IZP0-2] 71384 [Q8IZP0-3] 71385 [Q8IZP0-4] 71386 [Q8IZP0-5] 71387 [Q8IZP0-6] 71388 [Q8IZP0-7] 71389 [Q8IZP0-8] 71390 [Q8IZP0-9] |
PTM databases
iPTMneti | Q8IZP0 |
PhosphoSitePlusi | Q8IZP0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000136754, Expressed in mouth mucosa and 243 other tissues |
ExpressionAtlasi | Q8IZP0, baseline and differential |
Genevisiblei | Q8IZP0, HS |
Organism-specific databases
HPAi | ENSG00000136754, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, and through its N-terminus with WASF1.
Part of a complex consisting of ABI1, STX1A and SNAP25.
Part of a complex consisting of ABI1, EPS8 and SOS1 (By similarity).
Interacts with SOS1, SOS2, GRB2, SPTA1 and the first SH3 domain of NCK1. Isoform 6 does not interact with NCK1.
Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2 (PubMed:16417406).
Interacts (via SH3 domain) with SHANK2 and SHANK3, but not SHANK1; the interaction is direct.
Interacts with the heterodimer MYC:MAX; the interaction may enhance MYC:MAX transcriptional activity.
Interacts with FNBP1L (via the SH3 domain), WASF2, and CDC42, but only in the presence of FNBP1L (PubMed:19798448).
By similarity7 Publications(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL135.
1 PublicationBinary interactionsi
Hide detailsQ8IZP0
Isoform 2 [Q8IZP0-2]
With | #Exp. | IntAct |
---|---|---|
CBL [P22681] | 3 | EBI-7358775,EBI-518228 |
ITGA4 [P13612] | 2 | EBI-7358775,EBI-703044 |
Isoform 4 [Q8IZP0-4]
With | #Exp. | IntAct |
---|---|---|
Abl1 - isoform IV [P00520-4] from Mus musculus. | 5 | EBI-8593095,EBI-8593082 |
Isoform 5 [Q8IZP0-5]
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- cytoskeletal protein binding Source: ProtInc
- SH3 domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115324, 131 interactors |
CORUMi | Q8IZP0 |
DIPi | DIP-31118N |
ELMi | Q8IZP0 |
IntActi | Q8IZP0, 153 interactors |
MINTi | Q8IZP0 |
STRINGi | 9606.ENSP00000365312 |
Miscellaneous databases
RNActi | Q8IZP0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 107 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 446 – 505 | SH3PROSITE-ProRule annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 18 – 79 | Required for binding to WASF1By similarityAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 260 – 418 | Pro-richAdd BLAST | 159 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG2546, Eukaryota |
GeneTreei | ENSGT00940000154811 |
InParanoidi | Q8IZP0 |
OMAi | VGHGVKE |
OrthoDBi | 1478981at2759 |
PhylomeDBi | Q8IZP0 |
TreeFami | TF314303 |
Family and domain databases
CDDi | cd11971, SH3_Abi1, 1 hit |
InterProi | View protein in InterPro IPR028457, ABI IPR028456, ABI1 IPR035725, Abi1_SH3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR000727, T_SNARE_dom |
PANTHERi | PTHR10460, PTHR10460, 1 hit PTHR10460:SF2, PTHR10460:SF2, 1 hit |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50192, T_SNARE, 1 hit |
s (12+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 12 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 12 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET
60 70 80 90 100
KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH
110 120 130 140 150
KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG
160 170 180 190 200
HGVKWLKAKH GNNQPARTGT LSRTNPPTQK PPSPPMSGRG TLGRNTPYKT
210 220 230 240 250
LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS GSSGGSGSRE
260 270 280 290 300
NSGSSSIGIP IAVPTPSPPT IGPENISVPP PSGAPPAPPL APLLPVSTVI
310 320 330 340 350
AAPGSAPGSQ YGTMTRQISR HNSTTSSTSS GGYRRTPSVT AQFSAQPHVN
360 370 380 390 400
GGPLYSQNSI SIAPPPPPMP QLTPQIPLTG FVARVQENIA DSPTPPPPPP
410 420 430 440 450
PDDIPMFDDS PPPPPPPPVD YEDEEAAVVQ YNDPYADGDP AWAPKNYIEK
460 470 480 490 500
VVAIYDYTKD KDDELSFMEG AIIYVIKKND DGWYEGVCNR VTGLFPGNYV
ESIMHYTD
The sequence of this isoform differs from the canonical sequence as follows:
154-158: Missing.
274-300: Missing.
301-301: Missing.
302-359: Missing.
360-388: Missing.
389-389: I → V
The sequence of this isoform differs from the canonical sequence as follows:
96-159: Missing.
274-300: Missing.
301-301: Missing.
302-359: Missing.
360-388: Missing.
389-389: I → V
The sequence of this isoform differs from the canonical sequence as follows:
38-38: I → IQRHGFAVLLCLLSNSWP
360-388: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRT6 | A0A0A0MRT6_HUMAN | Abl interactor 1 | ABI1 | 475 | Annotation score: | ||
B6VEX4 | B6VEX4_HUMAN | Abl interactor 1 | ABI1 | 393 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 177 | P → L in AAC39757 (PubMed:9593709).Curated | 1 | |
Sequence conflicti | 410 | S → F in AAC39757 (PubMed:9593709).Curated | 1 | |
Sequence conflicti | 410 | S → F in AAN28379 (PubMed:12681507).Curated | 1 | |
Sequence conflicti | 437 | D → G in BAG54374 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048159 | 331 | G → A. Corresponds to variant dbSNP:rs2306236Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044604 | 38 | I → IQRHGFAVLLCLLSNSWP in isoform 12. 1 Publication | 1 | |
Alternative sequenceiVSP_043403 | 96 – 159 | Missing in isoform 11. 1 PublicationAdd BLAST | 64 | |
Alternative sequenceiVSP_010749 | 154 – 158 | Missing in isoform 2, isoform 5 and isoform 10. 4 Publications | 5 | |
Alternative sequenceiVSP_010750 | 274 – 300 | Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 7 PublicationsAdd BLAST | 27 | |
Alternative sequenceiVSP_010751 | 301 | Missing in isoform 2, isoform 4, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 11. 6 Publications | 1 | |
Alternative sequenceiVSP_010754 | 302 – 359 | Missing in isoform 7, isoform 8, isoform 10 and isoform 11. 4 PublicationsAdd BLAST | 58 | |
Alternative sequenceiVSP_010752 | 360 – 388 | Missing in isoform 2, isoform 3, isoform 4, isoform 8, isoform 10, isoform 11 and isoform 12. 6 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_010755 | 360 | I → V in isoform 7. 1 Publication | 1 | |
Alternative sequenceiVSP_010753 | 389 | I → V in isoform 10 and isoform 11. 1 Publication | 1 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
SMRi | Q8IZP0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115324, 131 interactors |
CORUMi | Q8IZP0 |
DIPi | DIP-31118N |
ELMi | Q8IZP0 |
IntActi | Q8IZP0, 153 interactors |
MINTi | Q8IZP0 |
STRINGi | 9606.ENSP00000365312 |
PTM databases
iPTMneti | Q8IZP0 |
PhosphoSitePlusi | Q8IZP0 |
Genetic variation databases
BioMutai | ABI1 |
DMDMi | 50400546 |
Proteomic databases
EPDi | Q8IZP0 |
jPOSTi | Q8IZP0 |
MassIVEi | Q8IZP0 |
MaxQBi | Q8IZP0 |
PaxDbi | Q8IZP0 |
PeptideAtlasi | Q8IZP0 |
PRIDEi | Q8IZP0 |
ProteomicsDBi | 43294 71380 [Q8IZP0-1] 71381 [Q8IZP0-10] 71382 [Q8IZP0-11] 71383 [Q8IZP0-2] 71384 [Q8IZP0-3] 71385 [Q8IZP0-4] 71386 [Q8IZP0-5] 71387 [Q8IZP0-6] 71388 [Q8IZP0-7] 71389 [Q8IZP0-8] 71390 [Q8IZP0-9] |
Protocols and materials databases
Antibodypediai | 3646, 336 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 10006 |
DisGeNETi | 10006 |
GeneCardsi | ABI1 |
HGNCi | HGNC:11320, ABI1 |
HPAi | ENSG00000136754, Low tissue specificity |
MIMi | 603050, gene |
neXtProti | NX_Q8IZP0 |
OpenTargetsi | ENSG00000136754 |
PharmGKBi | PA36144 |
VEuPathDBi | HostDB:ENSG00000136754.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2546, Eukaryota |
GeneTreei | ENSGT00940000154811 |
InParanoidi | Q8IZP0 |
OMAi | VGHGVKE |
OrthoDBi | 1478981at2759 |
PhylomeDBi | Q8IZP0 |
TreeFami | TF314303 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZP0 |
Reactomei | R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs R-HSA-9664422, FCGR3A-mediated phagocytosis |
SignaLinki | Q8IZP0 |
SIGNORi | Q8IZP0 |
Miscellaneous databases
BioGRID-ORCSi | 10006, 27 hits in 883 CRISPR screens |
ChiTaRSi | ABI1, human |
GeneWikii | ABI1 |
GenomeRNAii | 10006 |
Pharosi | Q8IZP0, Tbio |
PROi | PR:Q8IZP0 |
RNActi | Q8IZP0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136754, Expressed in mouth mucosa and 243 other tissues |
ExpressionAtlasi | Q8IZP0, baseline and differential |
Genevisiblei | Q8IZP0, HS |
Family and domain databases
CDDi | cd11971, SH3_Abi1, 1 hit |
InterProi | View protein in InterPro IPR028457, ABI IPR028456, ABI1 IPR035725, Abi1_SH3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR000727, T_SNARE_dom |
PANTHERi | PTHR10460, PTHR10460, 1 hit PTHR10460:SF2, PTHR10460:SF2, 1 hit |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABI1_HUMAN | |
Accessioni | Q8IZP0Primary (citable) accession number: Q8IZP0 Secondary accession number(s): A9Z1Y6 Q9NYB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 188 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families