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Protein

Zinc finger protein 654

Gene

ZNF654

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 47C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 224C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri297 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 654
Alternative name(s):
Melanoma-associated antigen
Gene namesi
Name:ZNF654
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000175105.5
HGNCiHGNC:25612 ZNF654
neXtProtiNX_Q8IZM8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55279
OpenTargetsiENSG00000175105
PharmGKBiPA134923001

Polymorphism and mutation databases

BioMutaiZNF654
DMDMi296453064

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119461 – 581Zinc finger protein 654Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei576PhosphoserineBy similarity1
Modified residuei580PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IZM8
MaxQBiQ8IZM8
PaxDbiQ8IZM8
PeptideAtlasiQ8IZM8
PRIDEiQ8IZM8
ProteomicsDBi71374

PTM databases

iPTMnetiQ8IZM8
PhosphoSitePlusiQ8IZM8

Expressioni

Gene expression databases

BgeeiENSG00000175105 Expressed in 195 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZNF654
ExpressionAtlasiQ8IZM8 baseline and differential
GenevisibleiQ8IZM8 HS

Organism-specific databases

HPAiHPA036172
HPA036173
HPA077939

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312141

Structurei

3D structure databases

ProteinModelPortaliQ8IZM8
SMRiQ8IZM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 80Poly-Ser6
Compositional biasi154 – 160Poly-Glu7

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri25 – 47C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 224C2H2-type 2PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri240 – 262C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 292C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri297 – 321C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00890000139400
HOGENOMiHOG000170898
HOVERGENiHBG108772
InParanoidiQ8IZM8
OrthoDBiEOG091G0B4Q
PhylomeDBiQ8IZM8
TreeFamiTF326007

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IZM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCNKEFLGG HIVRHAQAHQ KKGSFACVIC GRKFRNRGLM QKHLKNHVKK
60 70 80 90 100
IQRQQIAAAQ QDDQEVTALE EINCSSSSIS FENGNSDSKD LEVETLTASS
110 120 130 140 150
EGNKEVIPEH VAEFIEIPIS VPEDVIENVI ENGSPNNSLN NVFKPLTECG
160 170 180 190 200
DDYEEEEDEE GDYEEDDYDL NQETSVIHKI NGTVCHPKDI YATDQEGNFK
210 220 230 240 250
CPALGCVRIF KRIGFLNKHA MTVHPTDLNV RQTVMKWSKG KCKFCQRQFE
260 270 280 290 300
DSQHFIDHLN RHSYPNVYFC LHFNCNESFK LPFQLAQHTK SHRIFQAQCS
310 320 330 340 350
FPECHELFED LPLLYEHEAQ HYLSKTPESS AQPSETILWD VQTDSNPNQE
360 370 380 390 400
KDSSSNEKQT ISLPVSTSKS RKESTEPKTC IESMEKKTDS LVQNGNERSD
410 420 430 440 450
DTVSNISLID QKMPDIEPNS ENNCSSSDIV NGHSEIEQTP LVSSDPALKI
460 470 480 490 500
DTNRIRTENG SILPSVVPQE HNTLPVSQAP SKPNLTSEHT SYGLILTKPY
510 520 530 540 550
VRPLPPSYLD ERYLSMPKRR KFLTDRVDAC SDQDNVYKKS VKRLRCGKCL
560 570 580
TTYCNAEALE AHLAQKKCQT LFGFDSDDES A
Length:581
Mass (Da):65,854
Last modified:May 18, 2010 - v3
Checksum:i8B1FE6C4B1A72A12
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GWA0A0A1B0GWA0_HUMAN
Zinc finger protein 654
ZNF654
1,128Annotation score:

Sequence cautioni

The sequence AAN40504 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA91946 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15007 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti258H → Q in BAA91946 (PubMed:14702039).Curated1
Sequence conflicti294I → T in AAN40504 (Ref. 1) Curated1
Sequence conflicti294I → T in BAA91946 (PubMed:14702039).Curated1
Sequence conflicti548K → E in BAB15007 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543494 mRNA Translation: AAN40504.1 Different initiation.
AK001859 mRNA Translation: BAA91946.1 Different initiation.
AK024795 mRNA Translation: BAB15007.1 Different initiation.
AC119733 Genomic DNA No translation available.
AC128650 Genomic DNA No translation available.
RefSeqiNP_060763.2, NM_018293.2
UniGeneiHs.591650
Hs.661116

Genome annotation databases

EnsembliENST00000309495; ENSP00000312141; ENSG00000175105
UCSCiuc003dqv.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF543494 mRNA Translation: AAN40504.1 Different initiation.
AK001859 mRNA Translation: BAA91946.1 Different initiation.
AK024795 mRNA Translation: BAB15007.1 Different initiation.
AC119733 Genomic DNA No translation available.
AC128650 Genomic DNA No translation available.
RefSeqiNP_060763.2, NM_018293.2
UniGeneiHs.591650
Hs.661116

3D structure databases

ProteinModelPortaliQ8IZM8
SMRiQ8IZM8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312141

PTM databases

iPTMnetiQ8IZM8
PhosphoSitePlusiQ8IZM8

Polymorphism and mutation databases

BioMutaiZNF654
DMDMi296453064

Proteomic databases

EPDiQ8IZM8
MaxQBiQ8IZM8
PaxDbiQ8IZM8
PeptideAtlasiQ8IZM8
PRIDEiQ8IZM8
ProteomicsDBi71374

Protocols and materials databases

DNASUi55279
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309495; ENSP00000312141; ENSG00000175105
UCSCiuc003dqv.4 human

Organism-specific databases

DisGeNETi55279
EuPathDBiHostDB:ENSG00000175105.5
GeneCardsiZNF654
HGNCiHGNC:25612 ZNF654
HPAiHPA036172
HPA036173
HPA077939
neXtProtiNX_Q8IZM8
OpenTargetsiENSG00000175105
PharmGKBiPA134923001
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00890000139400
HOGENOMiHOG000170898
HOVERGENiHBG108772
InParanoidiQ8IZM8
OrthoDBiEOG091G0B4Q
PhylomeDBiQ8IZM8
TreeFamiTF326007

Miscellaneous databases

GenomeRNAii55279
PROiPR:Q8IZM8

Gene expression databases

BgeeiENSG00000175105 Expressed in 195 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZNF654
ExpressionAtlasiQ8IZM8 baseline and differential
GenevisibleiQ8IZM8 HS

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN654_HUMAN
AccessioniPrimary (citable) accession number: Q8IZM8
Secondary accession number(s): Q9H791, Q9NV14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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