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UniProtKB - Q8IZL8 (PELP1_HUMAN)

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Protein

Proline-, glutamic acid- and leucine-rich protein 1

Gene

PELP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211).13 Publications

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cellular response to estrogen stimulus Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • rRNA processing Source: Reactome
  • transcription, DNA-templated Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-8849473 PTK6 Expression
SIGNORiQ8IZL8

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-, glutamic acid- and leucine-rich protein 1
Alternative name(s):
Modulator of non-genomic activity of estrogen receptor
Transcription factor HMX3
Gene namesi
Name:PELP1
Synonyms:HMX3, MNAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141456.14
HGNCiHGNC:30134 PELP1
MIMi609455 gene
neXtProtiNX_Q8IZL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi826K → R: Not sumoylated. 1 Publication1

Organism-specific databases

DisGeNETi27043
OpenTargetsiENSG00000141456
PharmGKBiPA142671186

Polymorphism and mutation databases

BioMutaiPELP1
DMDMi115502553

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002521352 – 1130Proline-, glutamic acid- and leucine-rich protein 1Add BLAST1129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei13PhosphoserineBy similarity1
Modified residuei477PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei488PhosphothreonineCombined sources1
Modified residuei745PhosphothreonineCombined sources1
Cross-linki826Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei1033PhosphoserineCombined sources1
Modified residuei1043PhosphoserineCombined sources1

Post-translational modificationi

Transiently sumoylated, preferentially conjugated to SUMO2 or SUMO3. Sumoylation causes nucleolar exclusion of PELP1 and promotes the recruitment of MDN1 to pre-60S particles. Desumoylation by SUMO isopeptidase SENP3 is needed to release both PELP1 and MDN1 from pre-ribosomes.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IZL8
MaxQBiQ8IZL8
PaxDbiQ8IZL8
PeptideAtlasiQ8IZL8
PRIDEiQ8IZL8
ProteomicsDBi71367

PTM databases

iPTMnetiQ8IZL8
PhosphoSitePlusiQ8IZL8
SwissPalmiQ8IZL8

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000141456
CleanExiHS_HMX3
HS_PELP1
ExpressionAtlasiQ8IZL8 baseline and differential
GenevisibleiQ8IZL8 HS

Organism-specific databases

HPAiHPA053966
HPA056028
HPA060760

Interactioni

Subunit structurei

Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm. Interacts with ESR1 and ESR2 and this interaction is enhanced by 17-beta-estradiol. Interacts with CREBBP, EP300, AR and NR3C1 in a ligand-dependent manner. Forms two complexes in the presence of 17-beta-estradiol; one with SRC and ESR1 and another with LCK and ESR1. Interacts with histone H1 and H3 with a greater affinity for H1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Interacts with BCAS3. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts (via PELP1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles (PubMed:21326211, PubMed:27814492).16 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi117973, 68 interactors
CORUMiQ8IZL8
ELMiQ8IZL8
IntActiQ8IZL8, 29 interactors
MINTiQ8IZL8
STRINGi9606.ENSP00000301396

Structurei

3D structure databases

ProteinModelPortaliQ8IZL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 37LXXLL motif 15
Motifi69 – 73LXXLL motif 25
Motifi111 – 115LXXLL motif 35
Motifi155 – 159LXXLL motif 45
Motifi177 – 181LXXLL motif 55
Motifi264 – 268LXXLL motif 65
Motifi271 – 275LXXLL motif 75
Motifi364 – 368LXXLL motif 85
Motifi459 – 463LXXLL motif 95
Motifi579 – 583LXXLL motif 105
Motifi584 – 588LXXLL motif 115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi633 – 872Pro-richAdd BLAST240
Compositional biasi888 – 1101Glu-richAdd BLAST214
Compositional biasi977 – 1083Pro-richAdd BLAST107

Domaini

The Glu-rich region mediates histones interaction.
The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.

Sequence similaritiesi

Belongs to the RIX1/PELP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJ4S Eukaryota
ENOG4110K7C LUCA
GeneTreeiENSGT00730000111225
HOVERGENiHBG080634
InParanoidiQ8IZL8
KOiK16913
PhylomeDBiQ8IZL8

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR031193 PELP1
IPR012583 RIX1_N
IPR012980 Uncharacterised_NUC202
PANTHERiPTHR45115 PTHR45115, 1 hit
PfamiView protein in Pfam
PF08166 NUC202, 2 hits
PF08167 RIX1, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG 
        60         70         80         90        100
SAVAPVHPPN RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS 
       110        120        130        140        150
SIKTRFEGLC LLSLLVGESP TELFQQHCVS WLRSIQQVLQ TQDPPATMEL 
       160        170        180        190        200
AVAVLRDLLR YAAQLPALFR DISMNHLPGL LTSLLGLRPE CEQSALEGMK 
       210        220        230        240        250
ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY SRLPSLGAGF 
       260        270        280        290        300
SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS 
       310        320        330        340        350
EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS 
       360        370        380        390        400
VSSKNISLHG DGPLRLLLLP SIHLEALDLL SALILACGSR LLRFGILIGR 
       410        420        430        440        450
LLPQVLNSWS IGRDSLSPGQ ERPYSTVRTK VYAILELWVQ VCGASAGMLQ 
       460        470        480        490        500
GGASGEALLT HLLSDISPPA DALKLRSPRG SPDGSLQTGK PSAPKKLKLD 
       510        520        530        540        550
VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI KEETHRRLHD 
       560        570        580        590        600
LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC 
       610        620        630        640        650
ALQAFSLGQR EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP 
       660        670        680        690        700
VPPPEAPSPF RAPPFHPPGP MPSVGSMPSA GPMPSAGPMP SAGPVPSARP 
       710        720        730        740        750
GPPTTANHLG LSVPGLVSVP PRLLPGPENH RAGSNEDPIL APSGTPPPTI 
       760        770        780        790        800
PPDETFGGRV PRPAFVHYDK EEASDVEISL ESDSDDSVVI VPEGLPPLPP 
       810        820        830        840        850
PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP PPPPPPPPVP 
       860        870        880        890        900
GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE 
       910        920        930        940        950
EEEEEEEEDF EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED 
       960        970        980        990       1000
EEEEEELEEV EDLEFGTAGG EVEEGAPPPP TLPPALPPPE SPPKVQPEPE 
      1010       1020       1030       1040       1050
PEPGLLLEVE EPGTEEERGA DTAPTLAPEA LPSQGEVERE GESPAAGPPP 
      1060       1070       1080       1090       1100
QELVEEEPSA PPTLLEEETE DGSDKVQPPP ETPAEEEMET ETEAEALQEK 
      1110       1120       1130
EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS
Length:1,130
Mass (Da):119,700
Last modified:October 3, 2006 - v2
Checksum:i7B0DEE7A198DA9A6
GO

Sequence cautioni

The sequence AAC17708 differs from that shown. Intron retention.Curated
The sequence AAC17708 differs from that shown. Reason: Frameshift at positions 656 and 672.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → V in AAC17708 (PubMed:11481323).Curated1
Sequence conflicti896E → G in AAN41255 (PubMed:12415108).Curated1
Sequence conflicti1069T → P in AAN41255 (PubMed:12415108).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0277661126T → S. Corresponds to variant dbSNP:rs9436Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF547989 mRNA Translation: AAN41255.1
BC002875 mRNA Translation: AAH02875.2
BC010457 mRNA Translation: AAH10457.2
BC069058 mRNA Translation: AAH69058.1
U88153 mRNA Translation: AAC17708.2 Sequence problems.
AY882602 mRNA Translation: AAW80659.1
RefSeqiNP_001265170.1, NM_001278241.1
NP_055204.3, NM_014389.2
UniGeneiHs.744899

Genome annotation databases

EnsembliENST00000574876; ENSP00000461625; ENSG00000141456
GeneIDi27043
KEGGihsa:27043
UCSCiuc059zun.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPELP1_HUMAN
AccessioniPrimary (citable) accession number: Q8IZL8
Secondary accession number(s): O15450
, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 20, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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