UniProtKB - Q8IZL8 (PELP1_HUMAN)

BLAST

>sp|Q8IZL8|PELP1_HUMAN Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2
MAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRLLLLESVSGLLQPRTGSAVAPVHPPN
RSAPHLPGLMCLLRLHGSVGGAQNLSALGALVSLSNARLSSIKTRFEGLCLLSLLVGESP
TELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGL
LTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLACECY
SRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSS
EDGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHG
DGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGILIGRLLPQVLNSWSIGRDSLSPGQ
ERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRG
SPDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLI
KEETHRRLHDLVLPLVMGVQQGEVLGSSPYTSSRCRRELYCLLLALLLAPSPRCPPPLAC
ALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPF
RAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVP
PRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISL
ESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLP
PPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEE
EEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEV
EDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGA
DTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPP
ETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPPPPTEPDS

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History
Entry version 140 (12 Sep 2018)
Sequence version 2 (03 Oct 2006)
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Protein

Proline-, glutamic acid- and leucine-rich protein 1

Gene

PELP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211).13 Publications

GO - Molecular functionⁱ

chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17505058
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17505058

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to estrogen stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 17505058
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 17505058
rRNA processing Source: Reactome
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Repressor
Biological process	Transcription

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-8849473 PTK6 Expression
SIGNORⁱ	Q8IZL8

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proline-, glutamic acid- and leucine-rich protein 1 Alternative name(s): Modulator of non-genomic activity of estrogen receptor Transcription factor HMX3
Gene namesⁱ	Name:PELP1 Synonyms:HMX3, MNAR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000141456.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30134 PELP1
MIMⁱ	609455 gene
neXtProtⁱ	NX_Q8IZL8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	826	K → R: Not sumoylated. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27043
Open Targets More...OpenTargetsⁱ	ENSG00000141456
PharmGKBⁱ	PA142671186

Polymorphism and mutation databases

BioMutaⁱ	PELP1
DMDMⁱ	115502553

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000252135	2 – 1130	Proline-, glutamic acid- and leucine-rich protein 1Add BLAST		1129

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	13	PhosphoserineBy similarity	1
Modified residueⁱ	477	PhosphoserineCombined sources	1
Modified residueⁱ	481	PhosphoserineCombined sources	1
Modified residueⁱ	488	PhosphothreonineCombined sources	1
Modified residueⁱ	745	PhosphothreonineCombined sources	1
Cross-linkⁱ	826	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residueⁱ	1033	PhosphoserineCombined sources	1
Modified residueⁱ	1043	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Transiently sumoylated, preferentially conjugated to SUMO2 or SUMO3. Sumoylation causes nucleolar exclusion of PELP1 and promotes the recruitment of MDN1 to pre-60S particles. Desumoylation by SUMO isopeptidase SENP3 is needed to release both PELP1 and MDN1 from pre-ribosomes.2 Publications

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q8IZL8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IZL8
PaxDbⁱ	Q8IZL8
PeptideAtlas More...PeptideAtlasⁱ	Q8IZL8
PRIDEⁱ	Q8IZL8
ProteomicsDBⁱ	71367

PTM databases

iPTMnetⁱ	Q8IZL8
PhosphoSitePlusⁱ	Q8IZL8
SwissPalmⁱ	Q8IZL8

Expressionⁱ

Tissue specificityⁱ

Widely expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000141456 Expressed in 237 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_HMX3 HS_PELP1
ExpressionAtlasⁱ	Q8IZL8 baseline and differential
Genevisibleⁱ	Q8IZL8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA053966 HPA056028 HPA060760

HPAⁱ

HPA053966
HPA056028
HPA060760

Interactionⁱ

Subunit structureⁱ

Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3. Interacts with PI3K, SRC and EGFR in cytoplasm. Interacts with ESR1 and ESR2 and this interaction is enhanced by 17-beta-estradiol. Interacts with CREBBP, EP300, AR and NR3C1 in a ligand-dependent manner. Forms two complexes in the presence of 17-beta-estradiol; one with SRC and ESR1 and another with LCK and ESR1. Interacts with histone H1 and H3 with a greater affinity for H1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9. Interacts with BCAS3. Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts (via PELP1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles (PubMed:21326211, PubMed:27814492).16 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
H3F3B	P84243	11	EBI-716449,EBI-120658
KDM1A	O60341	6	EBI-716449,EBI-710124
MDN1	Q9NU22	3	EBI-716449,EBI-1050480
NFKB1	P19838	2	EBI-716449,EBI-300010
NPM1	P06748	3	EBI-716449,EBI-78579
SENP3	Q9H4L4	5	EBI-716449,EBI-2880236
SUMO2	P61956	4	EBI-716449,EBI-473220
WDR18	Q9BV38	3	EBI-716449,EBI-727429

GO - Molecular functionⁱ

transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17505058

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117973, 68 interactors
CORUMⁱ	Q8IZL8
ELMⁱ	Q8IZL8
IntActⁱ	Q8IZL8, 29 interactors
Molecular INTeraction database More...MINTⁱ	Q8IZL8
STRINGⁱ	9606.ENSP00000301396

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IZL8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	33 – 37	LXXLL motif 1	5
Motifⁱ	69 – 73	LXXLL motif 2	5
Motifⁱ	111 – 115	LXXLL motif 3	5
Motifⁱ	155 – 159	LXXLL motif 4	5
Motifⁱ	177 – 181	LXXLL motif 5	5
Motifⁱ	264 – 268	LXXLL motif 6	5
Motifⁱ	271 – 275	LXXLL motif 7	5
Motifⁱ	364 – 368	LXXLL motif 8	5
Motifⁱ	459 – 463	LXXLL motif 9	5
Motifⁱ	579 – 583	LXXLL motif 10	5
Motifⁱ	584 – 588	LXXLL motif 11	5

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	633 – 872	Pro-richAdd BLAST	240
Compositional biasⁱ	888 – 1101	Glu-richAdd BLAST	214
Compositional biasⁱ	977 – 1083	Pro-richAdd BLAST	107

Domainⁱ

The Glu-rich region mediates histones interaction.

The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1.

Sequence similaritiesⁱ

Belongs to the RIX1/PELP1 family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IJ4S Eukaryota ENOG4110K7C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111225
HOVERGENⁱ	HBG080634
InParanoidⁱ	Q8IZL8
KEGG Orthology (KO) More...KOⁱ	K16913
PhylomeDBⁱ	Q8IZL8

Family and domain databases

InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR031193 PELP1 IPR012583 RIX1_N IPR012980 Uncharacterised_NUC202
PANTHERⁱ	PTHR45115 PTHR45115, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08166 NUC202, 2 hits PF08167 RIX1, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.ⁱShow all

Q8IZL8-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG 
        60         70         80         90        100
SAVAPVHPPN RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS 
       110        120        130        140        150
SIKTRFEGLC LLSLLVGESP TELFQQHCVS WLRSIQQVLQ TQDPPATMEL 
       160        170        180        190        200
AVAVLRDLLR YAAQLPALFR DISMNHLPGL LTSLLGLRPE CEQSALEGMK 
       210        220        230        240        250
ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY SRLPSLGAGF 
       260        270        280        290        300
SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS 
       310        320        330        340        350
EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS 
       360        370        380        390        400
VSSKNISLHG DGPLRLLLLP SIHLEALDLL SALILACGSR LLRFGILIGR 
       410        420        430        440        450
LLPQVLNSWS IGRDSLSPGQ ERPYSTVRTK VYAILELWVQ VCGASAGMLQ 
       460        470        480        490        500
GGASGEALLT HLLSDISPPA DALKLRSPRG SPDGSLQTGK PSAPKKLKLD 
       510        520        530        540        550
VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI KEETHRRLHD 
       560        570        580        590        600
LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC 
       610        620        630        640        650
ALQAFSLGQR EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP 
       660        670        680        690        700
VPPPEAPSPF RAPPFHPPGP MPSVGSMPSA GPMPSAGPMP SAGPVPSARP 
       710        720        730        740        750
GPPTTANHLG LSVPGLVSVP PRLLPGPENH RAGSNEDPIL APSGTPPPTI 
       760        770        780        790        800
PPDETFGGRV PRPAFVHYDK EEASDVEISL ESDSDDSVVI VPEGLPPLPP 
       810        820        830        840        850
PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP PPPPPPPPVP 
       860        870        880        890        900
GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE 
       910        920        930        940        950
EEEEEEEEDF EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED 
       960        970        980        990       1000
EEEEEELEEV EDLEFGTAGG EVEEGAPPPP TLPPALPPPE SPPKVQPEPE 
      1010       1020       1030       1040       1050
PEPGLLLEVE EPGTEEERGA DTAPTLAPEA LPSQGEVERE GESPAAGPPP 
      1060       1070       1080       1090       1100
QELVEEEPSA PPTLLEEETE DGSDKVQPPP ETPAEEEMET ETEAEALQEK 
      1110       1120       1130
EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS

Length:1,130

Mass (Da):119,700

Last modified:October 3, 2006 - v2

Checksum:ⁱ7B0DEE7A198DA9A6

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
C9JFV4	C9JFV4_HUMAN	Proline-, glutamic acid- and leucin... Proline-, glutamic acid- and leucine-rich protein 1	PELP1	1,180	Annotation score:
E7EV54	E7EV54_HUMAN	Proline-, glutamic acid- and leucin... Proline-, glutamic acid- and leucine-rich protein 1	PELP1	906	Annotation score:
I3L1P4	I3L1P4_HUMAN	Proline-, glutamic acid- and leucin... Proline-, glutamic acid- and leucine-rich protein 1	PELP1	148	Annotation score:
I3L445	I3L445_HUMAN	Proline-, glutamic acid- and leucin... Proline-, glutamic acid- and leucine-rich protein 1	PELP1	301	Annotation score:
I3L4P1	I3L4P1_HUMAN	Proline-, glutamic acid- and leucin... Proline-, glutamic acid- and leucine-rich protein 1	PELP1	99	Annotation score:
I3L4M7	I3L4M7_HUMAN	Proline-, glutamic acid- and leucin... Proline-, glutamic acid- and leucine-rich protein 1	PELP1	156	Annotation score:

Sequence cautionⁱ

The sequence AAC17708 differs from that shown. Intron retention.Curated

The sequence AAC17708 differs from that shown. Reason: Frameshift at positions 656 and 672.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	2	A → V in AAC17708 (PubMed:11481323).Curated	1
Sequence conflictⁱ	896	E → G in AAN41255 (PubMed:12415108).Curated	1
Sequence conflictⁱ	1069	T → P in AAN41255 (PubMed:12415108).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_027766	1126	T → S. Corresponds to variant dbSNP:rs9436Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF547989 mRNA Translation: AAN41255.1 BC002875 mRNA Translation: AAH02875.2 BC010457 mRNA Translation: AAH10457.2 BC069058 mRNA Translation: AAH69058.1 U88153 mRNA Translation: AAC17708.2 Sequence problems. AY882602 mRNA Translation: AAW80659.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001265170.1, NM_001278241.1 NP_055204.3, NM_014389.2
UniGeneⁱ	Hs.744899

Genome annotation databases

Ensemblⁱ	ENST00000574876; ENSP00000461625; ENSG00000141456
GeneIDⁱ	27043
KEGGⁱ	hsa:27043
UCSC genome browser More...UCSCⁱ	uc059zun.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IZL8	Proline-, glutamic acid- and leucine-rich protein 1		MACMU		1130	UniRef90_Q8IZL8
Proline-, glutamic acid- and leucine-rich protein 1		HUMAN		1180
Proline, glutamate and leucine rich protein 1		CERAT		1243
Proline, glutamate and leucine rich protein 1		CHLSB		1222
Proline, glutamate and leucine rich protein 1		SAIBB		1192
+54

Protein	Similar proteins		Species	Score	Length	Source
Q8IZL8	Proline-, glutamic acid- and leucine-rich protein 1		MACMU		1130	UniRef50_Q8IZL8
Proline-, glutamic acid- and leucine-rich protein 1		HUMAN		1180
Proline, glutamate and leucine rich protein 1		CERAT		1243
Proline, glutamate and leucine rich protein 1		CHLSB		1222
Proline, glutamate and leucine rich protein 1		SAIBB		1192
+54

Entry informationⁱ

Entry nameⁱ	PELP1_HUMAN
Accessionⁱ	Q8IZL8Primary (citable) accession number: Q8IZL8 Secondary accession number(s): O15450 , Q5EGN3, Q6NTE6, Q96FT1, Q9BU60
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	October 3, 2006
	Last modified:	September 12, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IZL8 (PELP1_HUMAN)

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Proline-, glutamic acid- and leucine-rich protein 1

PELP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ