UniProtKB - Q8IZL8 (PELP1_HUMAN)
Proline-, glutamic acid- and leucine-rich protein 1
PELP1
Functioni
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- RNA binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
GO - Biological processi
- cellular response to estrogen stimulus Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- rRNA processing Source: Reactome
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Transcription |
Enzyme and pathway databases
PathwayCommonsi | Q8IZL8 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-8849473, PTK6 Expression |
SIGNORi | Q8IZL8 |
Names & Taxonomyi
Protein namesi | Recommended name: Proline-, glutamic acid- and leucine-rich protein 1Alternative name(s): Modulator of non-genomic activity of estrogen receptor Transcription factor HMX3 |
Gene namesi | Name:PELP1 Synonyms:HMX3, MNAR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141456.14 |
HGNCi | HGNC:30134, PELP1 |
MIMi | 609455, gene |
neXtProti | NX_Q8IZL8 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
- nucleoplasm 1 Publication
- Nucleus
Other locations
Note: Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors (PubMed:16140940).By similarity1 Publication
Nucleus
- MLL1 complex Source: UniProtKB
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
- cytoplasm Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- transcriptionally active chromatin Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 826 | K → R: Not sumoylated. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 27043 |
OpenTargetsi | ENSG00000141456 |
PharmGKBi | PA142671186 |
Miscellaneous databases
Pharosi | Q8IZL8, Tbio |
Polymorphism and mutation databases
BioMutai | PELP1 |
DMDMi | 115502553 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000252135 | 2 – 1130 | Proline-, glutamic acid- and leucine-rich protein 1Add BLAST | 1129 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 13 | PhosphoserineBy similarity | 1 | |
Modified residuei | 477 | PhosphoserineCombined sources | 1 | |
Modified residuei | 481 | PhosphoserineCombined sources | 1 | |
Modified residuei | 488 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 745 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 826 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Modified residuei | 1033 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1043 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1629 |
EPDi | Q8IZL8 |
jPOSTi | Q8IZL8 |
MassIVEi | Q8IZL8 |
MaxQBi | Q8IZL8 |
PaxDbi | Q8IZL8 |
PeptideAtlasi | Q8IZL8 |
PRIDEi | Q8IZL8 |
ProteomicsDBi | 71367 |
PTM databases
iPTMneti | Q8IZL8 |
MetOSitei | Q8IZL8 |
PhosphoSitePlusi | Q8IZL8 |
SwissPalmi | Q8IZL8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000141456, Expressed in amniotic fluid and 247 other tissues |
ExpressionAtlasi | Q8IZL8, baseline and differential |
Genevisiblei | Q8IZL8, HS |
Organism-specific databases
HPAi | ENSG00000141456, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3.
Interacts with PI3K, SRC and EGFR in cytoplasm.
Interacts with ESR1 and ESR2 and this interaction is enhanced by 17-beta-estradiol.
Interacts with CREBBP, EP300, AR and NR3C1 in a ligand-dependent manner. Forms two complexes in the presence of 17-beta-estradiol; one with SRC and ESR1 and another with LCK and ESR1.
Interacts with histone H1 and H3 with a greater affinity for H1.
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.
Interacts with NOL9.
Interacts with BCAS3.
Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts (via PELP1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles (PubMed:21326211, PubMed:27814492).
16 PublicationsBinary interactionsi
Hide detailsQ8IZL8
GO - Molecular functioni
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 117973, 85 interactors |
CORUMi | Q8IZL8 |
ELMi | Q8IZL8 |
IntActi | Q8IZL8, 35 interactors |
MINTi | Q8IZL8 |
STRINGi | 9606.ENSP00000301396 |
Miscellaneous databases
RNActi | Q8IZL8, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 33 – 37 | LXXLL motif 1 | 5 | |
Motifi | 69 – 73 | LXXLL motif 2 | 5 | |
Motifi | 111 – 115 | LXXLL motif 3 | 5 | |
Motifi | 155 – 159 | LXXLL motif 4 | 5 | |
Motifi | 177 – 181 | LXXLL motif 5 | 5 | |
Motifi | 264 – 268 | LXXLL motif 6 | 5 | |
Motifi | 271 – 275 | LXXLL motif 7 | 5 | |
Motifi | 364 – 368 | LXXLL motif 8 | 5 | |
Motifi | 459 – 463 | LXXLL motif 9 | 5 | |
Motifi | 579 – 583 | LXXLL motif 10 | 5 | |
Motifi | 584 – 588 | LXXLL motif 11 | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 633 – 872 | Pro-richAdd BLAST | 240 | |
Compositional biasi | 888 – 1101 | Glu-richAdd BLAST | 214 | |
Compositional biasi | 977 – 1083 | Pro-richAdd BLAST | 107 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QQE7, Eukaryota |
GeneTreei | ENSGT00730000111225 |
InParanoidi | Q8IZL8 |
OrthoDBi | 427039at2759 |
PhylomeDBi | Q8IZL8 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR012583, RIX1_N IPR012980, Uncharacterised_NUC202 |
Pfami | View protein in Pfam PF08166, NUC202, 2 hits PF08167, RIX1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAAAVLSGPS AGSAAGVPGG TGGLSAVSSG PRLRLLLLES VSGLLQPRTG
60 70 80 90 100
SAVAPVHPPN RSAPHLPGLM CLLRLHGSVG GAQNLSALGA LVSLSNARLS
110 120 130 140 150
SIKTRFEGLC LLSLLVGESP TELFQQHCVS WLRSIQQVLQ TQDPPATMEL
160 170 180 190 200
AVAVLRDLLR YAAQLPALFR DISMNHLPGL LTSLLGLRPE CEQSALEGMK
210 220 230 240 250
ACMTYFPRAC GSLKGKLASF FLSRVDALSP QLQQLACECY SRLPSLGAGF
260 270 280 290 300
SQGLKHTESW EQELHSLLAS LHTLLGALYE GAETAPVQNE GPGVEMLLSS
310 320 330 340 350
EDGDAHVLLQ LRQRFSGLAR CLGLMLSSEF GAPVSVPVQE ILDFICRTLS
360 370 380 390 400
VSSKNISLHG DGPLRLLLLP SIHLEALDLL SALILACGSR LLRFGILIGR
410 420 430 440 450
LLPQVLNSWS IGRDSLSPGQ ERPYSTVRTK VYAILELWVQ VCGASAGMLQ
460 470 480 490 500
GGASGEALLT HLLSDISPPA DALKLRSPRG SPDGSLQTGK PSAPKKLKLD
510 520 530 540 550
VGEAMAPPSH RKGDSNANSD VCAAALRGLS RTILMCGPLI KEETHRRLHD
560 570 580 590 600
LVLPLVMGVQ QGEVLGSSPY TSSRCRRELY CLLLALLLAP SPRCPPPLAC
610 620 630 640 650
ALQAFSLGQR EDSLEVSSFC SEALVTCAAL THPRVPPLQP MGPTCPTPAP
660 670 680 690 700
VPPPEAPSPF RAPPFHPPGP MPSVGSMPSA GPMPSAGPMP SAGPVPSARP
710 720 730 740 750
GPPTTANHLG LSVPGLVSVP PRLLPGPENH RAGSNEDPIL APSGTPPPTI
760 770 780 790 800
PPDETFGGRV PRPAFVHYDK EEASDVEISL ESDSDDSVVI VPEGLPPLPP
810 820 830 840 850
PPPSGATPPP IAPTGPPTAS PPVPAKEEPE ELPAAPGPLP PPPPPPPPVP
860 870 880 890 900
GPVTLPPPQL VPEGTPGGGG PPALEEDLTV ININSSDEEE EEEEEEEEEE
910 920 930 940 950
EEEEEEEEDF EEEEEDEEEY FEEEEEEEEE FEEEFEEEEG ELEEEEEEED
960 970 980 990 1000
EEEEEELEEV EDLEFGTAGG EVEEGAPPPP TLPPALPPPE SPPKVQPEPE
1010 1020 1030 1040 1050
PEPGLLLEVE EPGTEEERGA DTAPTLAPEA LPSQGEVERE GESPAAGPPP
1060 1070 1080 1090 1100
QELVEEEPSA PPTLLEEETE DGSDKVQPPP ETPAEEEMET ETEAEALQEK
1110 1120 1130
EQDDTAAMLA DFIDCPPDDE KPPPPTEPDS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EV54 | E7EV54_HUMAN | Modulator of non-genomic activity o... | PELP1 | 906 | Annotation score: | ||
C9JFV4 | C9JFV4_HUMAN | Modulator of non-genomic activity o... | PELP1 | 1,180 | Annotation score: | ||
I3L445 | I3L445_HUMAN | Proline-, glutamic acid- and leucin... | PELP1 | 301 | Annotation score: | ||
I3L1P4 | I3L1P4_HUMAN | Proline-, glutamic acid- and leucin... | PELP1 | 148 | Annotation score: | ||
I3L4P1 | I3L4P1_HUMAN | Proline-, glutamic acid- and leucin... | PELP1 | 99 | Annotation score: | ||
I3L4M7 | I3L4M7_HUMAN | Proline-, glutamic acid- and leucin... | PELP1 | 156 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | A → V in AAC17708 (PubMed:11481323).Curated | 1 | |
Sequence conflicti | 896 | E → G in AAN41255 (PubMed:12415108).Curated | 1 | |
Sequence conflicti | 1069 | T → P in AAN41255 (PubMed:12415108).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027766 | 1126 | T → S. Corresponds to variant dbSNP:rs9436Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF547989 mRNA Translation: AAN41255.1 BC002875 mRNA Translation: AAH02875.2 BC010457 mRNA Translation: AAH10457.2 BC069058 mRNA Translation: AAH69058.1 U88153 mRNA Translation: AAC17708.2 Sequence problems. AY882602 mRNA Translation: AAW80659.1 |
CCDSi | CCDS58503.2 |
RefSeqi | NP_001265170.1, NM_001278241.1 NP_055204.3, NM_014389.2 |
Genome annotation databases
Ensembli | ENST00000572293; ENSP00000460300; ENSG00000141456 ENST00000574876; ENSP00000461625; ENSG00000141456 |
GeneIDi | 27043 |
KEGGi | hsa:27043 |
UCSCi | uc059zun.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF547989 mRNA Translation: AAN41255.1 BC002875 mRNA Translation: AAH02875.2 BC010457 mRNA Translation: AAH10457.2 BC069058 mRNA Translation: AAH69058.1 U88153 mRNA Translation: AAC17708.2 Sequence problems. AY882602 mRNA Translation: AAW80659.1 |
CCDSi | CCDS58503.2 |
RefSeqi | NP_001265170.1, NM_001278241.1 NP_055204.3, NM_014389.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 117973, 85 interactors |
CORUMi | Q8IZL8 |
ELMi | Q8IZL8 |
IntActi | Q8IZL8, 35 interactors |
MINTi | Q8IZL8 |
STRINGi | 9606.ENSP00000301396 |
PTM databases
iPTMneti | Q8IZL8 |
MetOSitei | Q8IZL8 |
PhosphoSitePlusi | Q8IZL8 |
SwissPalmi | Q8IZL8 |
Polymorphism and mutation databases
BioMutai | PELP1 |
DMDMi | 115502553 |
Proteomic databases
CPTACi | CPTAC-1629 |
EPDi | Q8IZL8 |
jPOSTi | Q8IZL8 |
MassIVEi | Q8IZL8 |
MaxQBi | Q8IZL8 |
PaxDbi | Q8IZL8 |
PeptideAtlasi | Q8IZL8 |
PRIDEi | Q8IZL8 |
ProteomicsDBi | 71367 |
Protocols and materials databases
Antibodypediai | 23315, 258 antibodies |
Genome annotation databases
Ensembli | ENST00000572293; ENSP00000460300; ENSG00000141456 ENST00000574876; ENSP00000461625; ENSG00000141456 |
GeneIDi | 27043 |
KEGGi | hsa:27043 |
UCSCi | uc059zun.1, human |
Organism-specific databases
CTDi | 27043 |
DisGeNETi | 27043 |
EuPathDBi | HostDB:ENSG00000141456.14 |
GeneCardsi | PELP1 |
HGNCi | HGNC:30134, PELP1 |
HPAi | ENSG00000141456, Low tissue specificity |
MIMi | 609455, gene |
neXtProti | NX_Q8IZL8 |
OpenTargetsi | ENSG00000141456 |
PharmGKBi | PA142671186 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQE7, Eukaryota |
GeneTreei | ENSGT00730000111225 |
InParanoidi | Q8IZL8 |
OrthoDBi | 427039at2759 |
PhylomeDBi | Q8IZL8 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZL8 |
Reactomei | R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-8849473, PTK6 Expression |
SIGNORi | Q8IZL8 |
Miscellaneous databases
BioGRID-ORCSi | 27043, 579 hits in 790 CRISPR screens |
ChiTaRSi | PELP1, human |
GenomeRNAii | 27043 |
Pharosi | Q8IZL8, Tbio |
PROi | PR:Q8IZL8 |
RNActi | Q8IZL8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141456, Expressed in amniotic fluid and 247 other tissues |
ExpressionAtlasi | Q8IZL8, baseline and differential |
Genevisiblei | Q8IZL8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR012583, RIX1_N IPR012980, Uncharacterised_NUC202 |
Pfami | View protein in Pfam PF08166, NUC202, 2 hits PF08167, RIX1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PELP1_HUMAN | |
Accessioni | Q8IZL8Primary (citable) accession number: Q8IZL8 Secondary accession number(s): O15450 Q9BU60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | October 3, 2006 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations