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Protein

Interferon lambda-2

Gene

IFNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.3 Publications

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ8IZJ0
SIGNORiQ8IZJ0

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-2
Short name:
IFN-lambda-2
Alternative name(s):
Cytokine Zcyto20
Interleukin-28A
Short name:
IL-28A
Gene namesi
Name:IFNL2
Synonyms:IL28A, ZCYTO20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000183709.7
HGNCiHGNC:18364 IFNL2
MIMi607401 gene
neXtProtiNX_Q8IZJ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi282616
OpenTargetsiENSG00000183709
PharmGKBiPA134934396

Polymorphism and mutation databases

BioMutaiIFNL2
DMDMi55976531

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001550926 – 200Interferon lambda-2Add BLAST175

Proteomic databases

PaxDbiQ8IZJ0
PeptideAtlasiQ8IZJ0
PRIDEiQ8IZJ0
ProteomicsDBi71354

PTM databases

iPTMnetiQ8IZJ0
PhosphoSitePlusiQ8IZJ0

Expressioni

Inductioni

By viral infections or double-stranded RNA.2 Publications

Gene expression databases

BgeeiENSG00000183709 Expressed in 12 organ(s), highest expression level in epithelium of nasopharynx
CleanExiHS_IL28A
GenevisibleiQ8IZJ0 HS

Organism-specific databases

HPAiCAB025489

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129394, 1 interactor
STRINGi9606.ENSP00000333639

Structurei

3D structure databases

ProteinModelPortaliQ8IZJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0IH Eukaryota
ENOG410ZDRD LUCA
GeneTreeiENSGT00390000014310
HOGENOMiHOG000232074
HOVERGENiHBG052108
InParanoidiQ8IZJ0
KOiK22669
OMAiKESLGCL
OrthoDBiEOG091G0RUH
PhylomeDBiQ8IZJ0
TreeFamiTF336172

Family and domain databases

Gene3Di1.20.1250.60, 1 hit
InterProiView protein in InterPro
IPR038326 IFN-lambda_sf
IPR029177 INF_lambda
PANTHERiPTHR31943 PTHR31943, 1 hit
PfamiView protein in Pfam
PF15177 IL28A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IZJ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLDMTGDCT PVLVLMAAVL TVTGAVPVAR LHGALPDARG CHIAQFKSLS
60 70 80 90 100
PQELQAFKRA KDALEESLLL KDCRCHSRLF PRTWDLRQLQ VRERPMALEA
110 120 130 140 150
ELALTLKVLE ATADTDPALV DVLDQPLHTL HHILSQFRAC IQPQPTAGPR
160 170 180 190 200
TRGRLHHWLY RLQEAPKKES PGCLEASVTF NLFRLLTRDL NCVASGDLCV
Length:200
Mass (Da):22,288
Last modified:March 1, 2003 - v1
Checksum:iDFC7B49F31BF488E
GO

Sequence cautioni

The sequence AAR24510 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151T → A in AAN86126 (PubMed:12483210).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05338410T → M. Corresponds to variant dbSNP:rs554971Ensembl.1
Natural variantiVAR_053385112T → A. Corresponds to variant dbSNP:rs8103362Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129148 mRNA Translation: AAN28263.1
DQ126336 Genomic DNA Translation: AAZ38827.1
DQ126337 mRNA Translation: AAZ38828.1
BC113581 mRNA Translation: AAI13582.1
BC113583 mRNA Translation: AAI13584.1
AY184373 mRNA Translation: AAN86126.1
AY336715 mRNA Translation: AAR24510.1 Different initiation.
CCDSiCCDS42567.1
RefSeqiNP_742150.1, NM_172138.1
UniGeneiHs.567792

Genome annotation databases

EnsembliENST00000331982; ENSP00000333639; ENSG00000183709
GeneIDi282616
KEGGihsa:282616
UCSCiuc002oku.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-28 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129148 mRNA Translation: AAN28263.1
DQ126336 Genomic DNA Translation: AAZ38827.1
DQ126337 mRNA Translation: AAZ38828.1
BC113581 mRNA Translation: AAI13582.1
BC113583 mRNA Translation: AAI13584.1
AY184373 mRNA Translation: AAN86126.1
AY336715 mRNA Translation: AAR24510.1 Different initiation.
CCDSiCCDS42567.1
RefSeqiNP_742150.1, NM_172138.1
UniGeneiHs.567792

3D structure databases

ProteinModelPortaliQ8IZJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129394, 1 interactor
STRINGi9606.ENSP00000333639

PTM databases

iPTMnetiQ8IZJ0
PhosphoSitePlusiQ8IZJ0

Polymorphism and mutation databases

BioMutaiIFNL2
DMDMi55976531

Proteomic databases

PaxDbiQ8IZJ0
PeptideAtlasiQ8IZJ0
PRIDEiQ8IZJ0
ProteomicsDBi71354

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331982; ENSP00000333639; ENSG00000183709
GeneIDi282616
KEGGihsa:282616
UCSCiuc002oku.2 human

Organism-specific databases

CTDi282616
DisGeNETi282616
EuPathDBiHostDB:ENSG00000183709.7
GeneCardsiIFNL2
HGNCiHGNC:18364 IFNL2
HPAiCAB025489
MIMi607401 gene
neXtProtiNX_Q8IZJ0
OpenTargetsiENSG00000183709
PharmGKBiPA134934396
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0IH Eukaryota
ENOG410ZDRD LUCA
GeneTreeiENSGT00390000014310
HOGENOMiHOG000232074
HOVERGENiHBG052108
InParanoidiQ8IZJ0
KOiK22669
OMAiKESLGCL
OrthoDBiEOG091G0RUH
PhylomeDBiQ8IZJ0
TreeFamiTF336172

Enzyme and pathway databases

ReactomeiR-HSA-8854691 Interleukin-20 family signaling
SignaLinkiQ8IZJ0
SIGNORiQ8IZJ0

Miscellaneous databases

GenomeRNAii282616
PROiPR:Q8IZJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183709 Expressed in 12 organ(s), highest expression level in epithelium of nasopharynx
CleanExiHS_IL28A
GenevisibleiQ8IZJ0 HS

Family and domain databases

Gene3Di1.20.1250.60, 1 hit
InterProiView protein in InterPro
IPR038326 IFN-lambda_sf
IPR029177 INF_lambda
PANTHERiPTHR31943 PTHR31943, 1 hit
PfamiView protein in Pfam
PF15177 IL28A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNL2_HUMAN
AccessioniPrimary (citable) accession number: Q8IZJ0
Secondary accession number(s): Q45KQ8, Q6VN55, Q8IWL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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