Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8IZI9 (IFNL3_HUMAN)

Entry version 129 (12 Aug 2020)
Sequence version 2 (13 Jul 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Interferon lambda-3

Gene

IFNL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IZI9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8854691, Interleukin-20 family signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IZI9

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8IZI9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon lambda-3
Short name:
IFN-lambda-3
Alternative name(s):
Cytokine Zcyto22
Interleukin-28B
Short name:
IL-28B
Interleukin-28C
Short name:
IL-28C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFNL3
Synonyms:IL28B, IL28C, ZCYTO22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000197110.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:18365, IFNL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607402, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IZI9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi57K → A: 51 fold decrease in antiviral activity. 1 Publication1
Mutagenesisi58D → A: 43 fold decrease in antiviral activity. 1 Publication1
Mutagenesisi118V → A: 68 fold decrease in antiviral activity. 1 Publication1
Mutagenesisi121Q → A: 46 fold decrease in antiviral activity. 1 Publication1
Mutagenesisi176F → A: 40 fold decrease in antiviral activity. 1 Publication1
Mutagenesisi179F → A: 650 fold decrease in antiviral activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		282617

MalaCards human disease database

More...MalaCardsi		IFNL3

Open Targets

More...OpenTargetsi		ENSG00000197110

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		284102, Response to antiviral treatment in hepatitis C

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134952671

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IZI9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IFNL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		300669648

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001551022 – 196Interferon lambda-3Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 1361 Publication
Disulfide bondi71 ↔ 1691 Publication
Disulfide bondi188 ↔ 1951 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IZI9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IZI9

PeptideAtlas

More...PeptideAtlasi		Q8IZI9

PRoteomics IDEntifications database

More...PRIDEi		Q8IZI9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71353

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IZI9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IZI9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By viral infections or double-stranded RNA.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197110, Expressed in temporal lobe and 15 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IZI9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IZI9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197110, Tissue enhanced (brain, salivary gland, skin, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129395, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q8IZI9, 2 interactors

Molecular INTeraction database

More...MINTi		Q8IZI9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000409000

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IZI9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IZI9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8IZI9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SSDC, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014310

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_120266_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IZI9

KEGG Orthology (KO)

More...KOi		K22669

Database of Orthologous Groups

More...OrthoDBi		1429532at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IZI9

TreeFam database of animal gene trees

More...TreeFami		TF336172

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038326, IFN-lambda_sf
IPR029177, INF_lambda

The PANTHER Classification System

More...PANTHERi		PTHR31943, PTHR31943, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15177, IL28A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IZI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGDCMPVLV LMAAVLTVTG AVPVARLRGA LPDARGCHIA QFKSLSPQEL 
        60         70         80         90        100
QAFKRAKDAL EESLLLKDCK CRSRLFPRTW DLRQLQVRER PVALEAELAL 
       110        120        130        140        150
TLKVLEATAD TDPALGDVLD QPLHTLHHIL SQLRACIQPQ PTAGPRTRGR 
       160        170        180        190 
LHHWLHRLQE APKKESPGCL EASVTFNLFR LLTRDLNCVA SGDLCV
Length:196
Mass (Da):21,706
Last modified:July 13, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2322E10C887184B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGW8A0A0C4DGW8_HUMAN
Interferon lambda-3
IFNL3 IL28B, hCG_1997257
200Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN28264 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti108T → S in AAN86127 (PubMed:12483210).Curated1
Sequence conflicti120D → G in AAQ01561 (PubMed:16539846).Curated1
Sequence conflicti155L → P in AAQ01561 (PubMed:16539846).Curated1
Sequence conflicti156H → Y in AAN86127 (PubMed:12483210).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06341928R → H. Corresponds to variant dbSNP:rs629976Ensembl.1
Natural variantiVAR_06342070K → R1 PublicationCorresponds to variant dbSNP:rs8103142EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY129149 mRNA Translation: AAN28264.1 Different initiation.
AY184374 mRNA Translation: AAN86127.1
AY336714 mRNA Translation: AAR24509.1
AY336717 mRNA Translation: AAQ01561.1
AC011445 Genomic DNA No translation available.
BC130314 mRNA Translation: AAI30315.1
BC130316 mRNA Translation: AAI30317.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12530.1

NCBI Reference Sequences

More...RefSeqi		NP_001333866.1, NM_001346937.1
NP_742151.2, NM_172139.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000413851; ENSP00000409000; ENSG00000197110

Database of genes from NCBI RefSeq genomes

More...GeneIDi		282617

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:282617

UCSC genome browser

More...UCSCi		uc010xut.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129149 mRNA Translation: AAN28264.1 Different initiation.
AY184374 mRNA Translation: AAN86127.1
AY336714 mRNA Translation: AAR24509.1
AY336717 mRNA Translation: AAQ01561.1
AC011445 Genomic DNA No translation available.
BC130314 mRNA Translation: AAI30315.1
BC130316 mRNA Translation: AAI30317.1
CCDSiCCDS12530.1
RefSeqiNP_001333866.1, NM_001346937.1
NP_742151.2, NM_172139.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HHCX-ray2.80A/B/C/D1-196[»]
5T5WX-ray2.85C34-195[»]
SMRiQ8IZI9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi129395, 2 interactors
IntActiQ8IZI9, 2 interactors
MINTiQ8IZI9
STRINGi9606.ENSP00000409000

PTM databases

iPTMnetiQ8IZI9
PhosphoSitePlusiQ8IZI9

Polymorphism and mutation databases

BioMutaiIFNL3
DMDMi300669648

Proteomic databases

MassIVEiQ8IZI9
PaxDbiQ8IZI9
PeptideAtlasiQ8IZI9
PRIDEiQ8IZI9
ProteomicsDBi71353

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54997, 349 antibodies

The DNASU plasmid repository

More...DNASUi		282617

Genome annotation databases

EnsembliENST00000413851; ENSP00000409000; ENSG00000197110
GeneIDi282617
KEGGihsa:282617
UCSCiuc010xut.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		282617
DisGeNETi282617
EuPathDBiHostDB:ENSG00000197110.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		IFNL3
HGNCiHGNC:18365, IFNL3
HPAiENSG00000197110, Tissue enhanced (brain, salivary gland, skin, testis)
MalaCardsiIFNL3
MIMi607402, gene
neXtProtiNX_Q8IZI9
OpenTargetsiENSG00000197110
Orphaneti284102, Response to antiviral treatment in hepatitis C
PharmGKBiPA134952671

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SSDC, Eukaryota
GeneTreeiENSGT00390000014310
HOGENOMiCLU_120266_0_0_1
InParanoidiQ8IZI9
KOiK22669
OrthoDBi1429532at2759
PhylomeDBiQ8IZI9
TreeFamiTF336172

Enzyme and pathway databases

PathwayCommonsiQ8IZI9
ReactomeiR-HSA-8854691, Interleukin-20 family signaling
SignaLinkiQ8IZI9
SIGNORiQ8IZI9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		282617, 6 hits in 838 CRISPR screens
EvolutionaryTraceiQ8IZI9

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Interleukin_28B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		282617
PharosiQ8IZI9, Tbio

Protein Ontology

More...PROi		PR:Q8IZI9
RNActiQ8IZI9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197110, Expressed in temporal lobe and 15 other tissues
ExpressionAtlasiQ8IZI9, baseline and differential
GenevisibleiQ8IZI9, HS

Family and domain databases

Gene3Di1.20.1250.60, 1 hit
InterProiView protein in InterPro
IPR038326, IFN-lambda_sf
IPR029177, INF_lambda
PANTHERiPTHR31943, PTHR31943, 1 hit
PfamiView protein in Pfam
PF15177, IL28A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFNL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZI9
Secondary accession number(s): A2BDE1
, Q6VN56, Q7Z4J3, Q8IWL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 13, 2010
Last modified: August 12, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again