UniProtKB - Q8IZI9 (IFNL3_HUMAN)
Interferon lambda-3
IFNL3
Functioni
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
2 PublicationsGO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- signaling receptor binding Source: GO_Central
GO - Biological processi
- defense response to virus Source: UniProtKB
- innate immune response Source: GO_Central
- negative regulation of viral genome replication Source: UniProtKB
- positive regulation of immune response Source: InterPro
- receptor signaling pathway via JAK-STAT Source: InterPro
Keywordsi
Molecular function | Cytokine |
Biological process | Antiviral defense |
Enzyme and pathway databases
PathwayCommonsi | Q8IZI9 |
Reactomei | R-HSA-8854691, Interleukin-20 family signaling |
SignaLinki | Q8IZI9 |
SIGNORi | Q8IZI9 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon lambda-3Short name: IFN-lambda-3 Alternative name(s): Cytokine Zcyto22 Interleukin-28B Short name: IL-28B Interleukin-28C Short name: IL-28C |
Gene namesi | Name:IFNL3 Synonyms:IL28B, IL28C, ZCYTO22 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18365, IFNL3 |
MIMi | 607402, gene |
neXtProti | NX_Q8IZI9 |
VEuPathDBi | HostDB:ENSG00000197110 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 57 | K → A: 51 fold decrease in antiviral activity. 1 Publication | 1 | |
Mutagenesisi | 58 | D → A: 43 fold decrease in antiviral activity. 1 Publication | 1 | |
Mutagenesisi | 118 | V → A: 68 fold decrease in antiviral activity. 1 Publication | 1 | |
Mutagenesisi | 121 | Q → A: 46 fold decrease in antiviral activity. 1 Publication | 1 | |
Mutagenesisi | 176 | F → A: 40 fold decrease in antiviral activity. 1 Publication | 1 | |
Mutagenesisi | 179 | F → A: 650 fold decrease in antiviral activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 282617 |
MalaCardsi | IFNL3 |
OpenTargetsi | ENSG00000197110 |
Orphaneti | 284102, Response to antiviral treatment in hepatitis C |
PharmGKBi | PA134952671 |
Miscellaneous databases
Pharosi | Q8IZI9, Tbio |
Genetic variation databases
BioMutai | IFNL3 |
DMDMi | 300669648 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000015510 | 22 – 196 | Interferon lambda-3Add BLAST | 175 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 37 ↔ 136 | 1 Publication | ||
Disulfide bondi | 71 ↔ 169 | 1 Publication | ||
Disulfide bondi | 188 ↔ 195 | 1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | Q8IZI9 |
PaxDbi | Q8IZI9 |
PeptideAtlasi | Q8IZI9 |
PRIDEi | Q8IZI9 |
PTM databases
iPTMneti | Q8IZI9 |
PhosphoSitePlusi | Q8IZI9 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000197110, Expressed in temporal lobe and 15 other tissues |
ExpressionAtlasi | Q8IZI9, baseline and differential |
Genevisiblei | Q8IZI9, HS |
Organism-specific databases
HPAi | ENSG00000197110, Not detected |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 129395, 9 interactors |
ComplexPortali | CPX-6013, Interferon lambda receptor-ligand complex, IFNL3 variant |
IntActi | Q8IZI9, 2 interactors |
MINTi | Q8IZI9 |
STRINGi | 9606.ENSP00000409000 |
Miscellaneous databases
RNActi | Q8IZI9, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8IZI9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8IZI9 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SSDC, Eukaryota |
GeneTreei | ENSGT00390000014310 |
HOGENOMi | CLU_120266_0_0_1 |
InParanoidi | Q8IZI9 |
OMAi | KAWSCRP |
OrthoDBi | 1429532at2759 |
PhylomeDBi | Q8IZI9 |
TreeFami | TF336172 |
Family and domain databases
Gene3Di | 1.20.1250.60, 1 hit |
InterProi | View protein in InterPro IPR038326, IFN-lambda_sf IPR029177, INF_lambda |
PANTHERi | PTHR31943, PTHR31943, 1 hit |
Pfami | View protein in Pfam PF15177, IL28A, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MTGDCMPVLV LMAAVLTVTG AVPVARLRGA LPDARGCHIA QFKSLSPQEL
60 70 80 90 100
QAFKRAKDAL EESLLLKDCK CRSRLFPRTW DLRQLQVRER PVALEAELAL
110 120 130 140 150
TLKVLEATAD TDPALGDVLD QPLHTLHHIL SQLRACIQPQ PTAGPRTRGR
160 170 180 190
LHHWLHRLQE APKKESPGCL EASVTFNLFR LLTRDLNCVA SGDLCV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGW8 | A0A0C4DGW8_HUMAN | Interferon lambda-3 | IFNL3 IL28B, hCG_1997257 | 200 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 108 | T → S in AAN86127 (PubMed:12483210).Curated | 1 | |
Sequence conflicti | 120 | D → G in AAQ01561 (PubMed:16539846).Curated | 1 | |
Sequence conflicti | 155 | L → P in AAQ01561 (PubMed:16539846).Curated | 1 | |
Sequence conflicti | 156 | H → Y in AAN86127 (PubMed:12483210).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063419 | 28 | R → H. Corresponds to variant dbSNP:rs629976Ensembl. | 1 | |
Natural variantiVAR_063420 | 70 | K → R1 PublicationCorresponds to variant dbSNP:rs8103142EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY129149 mRNA Translation: AAN28264.1 Different initiation. AY184374 mRNA Translation: AAN86127.1 AY336714 mRNA Translation: AAR24509.1 AY336717 mRNA Translation: AAQ01561.1 AC011445 Genomic DNA No translation available. BC130314 mRNA Translation: AAI30315.1 BC130316 mRNA Translation: AAI30317.1 |
CCDSi | CCDS12530.1 |
RefSeqi | NP_001333866.1, NM_001346937.1 NP_742151.2, NM_172139.3 |
Genome annotation databases
Ensembli | ENST00000413851; ENSP00000409000; ENSG00000197110 |
GeneIDi | 282617 |
KEGGi | hsa:282617 |
MANE-Selecti | ENST00000413851.3; ENSP00000409000.2; NM_172139.4; NP_742151.2 |
UCSCi | uc010xut.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY129149 mRNA Translation: AAN28264.1 Different initiation. AY184374 mRNA Translation: AAN86127.1 AY336714 mRNA Translation: AAR24509.1 AY336717 mRNA Translation: AAQ01561.1 AC011445 Genomic DNA No translation available. BC130314 mRNA Translation: AAI30315.1 BC130316 mRNA Translation: AAI30317.1 |
CCDSi | CCDS12530.1 |
RefSeqi | NP_001333866.1, NM_001346937.1 NP_742151.2, NM_172139.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3HHC | X-ray | 2.80 | A/B/C/D | 1-196 | [»] | |
5T5W | X-ray | 2.85 | C | 34-195 | [»] | |
SMRi | Q8IZI9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 129395, 9 interactors |
ComplexPortali | CPX-6013, Interferon lambda receptor-ligand complex, IFNL3 variant |
IntActi | Q8IZI9, 2 interactors |
MINTi | Q8IZI9 |
STRINGi | 9606.ENSP00000409000 |
PTM databases
iPTMneti | Q8IZI9 |
PhosphoSitePlusi | Q8IZI9 |
Genetic variation databases
BioMutai | IFNL3 |
DMDMi | 300669648 |
Proteomic databases
MassIVEi | Q8IZI9 |
PaxDbi | Q8IZI9 |
PeptideAtlasi | Q8IZI9 |
PRIDEi | Q8IZI9 |
Protocols and materials databases
Antibodypediai | 54997, 379 antibodies from 30 providers |
DNASUi | 282617 |
Genome annotation databases
Ensembli | ENST00000413851; ENSP00000409000; ENSG00000197110 |
GeneIDi | 282617 |
KEGGi | hsa:282617 |
MANE-Selecti | ENST00000413851.3; ENSP00000409000.2; NM_172139.4; NP_742151.2 |
UCSCi | uc010xut.3, human |
Organism-specific databases
CTDi | 282617 |
DisGeNETi | 282617 |
GeneCardsi | IFNL3 |
HGNCi | HGNC:18365, IFNL3 |
HPAi | ENSG00000197110, Not detected |
MalaCardsi | IFNL3 |
MIMi | 607402, gene |
neXtProti | NX_Q8IZI9 |
OpenTargetsi | ENSG00000197110 |
Orphaneti | 284102, Response to antiviral treatment in hepatitis C |
PharmGKBi | PA134952671 |
VEuPathDBi | HostDB:ENSG00000197110 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SSDC, Eukaryota |
GeneTreei | ENSGT00390000014310 |
HOGENOMi | CLU_120266_0_0_1 |
InParanoidi | Q8IZI9 |
OMAi | KAWSCRP |
OrthoDBi | 1429532at2759 |
PhylomeDBi | Q8IZI9 |
TreeFami | TF336172 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZI9 |
Reactomei | R-HSA-8854691, Interleukin-20 family signaling |
SignaLinki | Q8IZI9 |
SIGNORi | Q8IZI9 |
Miscellaneous databases
BioGRID-ORCSi | 282617, 8 hits in 958 CRISPR screens |
EvolutionaryTracei | Q8IZI9 |
GeneWikii | Interleukin_28B |
GenomeRNAii | 282617 |
Pharosi | Q8IZI9, Tbio |
PROi | PR:Q8IZI9 |
RNActi | Q8IZI9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197110, Expressed in temporal lobe and 15 other tissues |
ExpressionAtlasi | Q8IZI9, baseline and differential |
Genevisiblei | Q8IZI9, HS |
Family and domain databases
Gene3Di | 1.20.1250.60, 1 hit |
InterProi | View protein in InterPro IPR038326, IFN-lambda_sf IPR029177, INF_lambda |
PANTHERi | PTHR31943, PTHR31943, 1 hit |
Pfami | View protein in Pfam PF15177, IL28A, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IFNL3_HUMAN | |
Accessioni | Q8IZI9Primary (citable) accession number: Q8IZI9 Secondary accession number(s): A2BDE1 Q8IWL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | July 13, 2010 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families