UniProtKB - Q8IZF7 (AGRF2_HUMAN)
Protein
Adhesion G-protein coupled receptor F2
Gene
ADGRF2
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
Miscellaneous
Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: GDB
GO - Biological processi
- cell surface receptor signaling pathway Source: InterPro
- G protein-coupled receptor signaling pathway Source: GDB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q8IZF7 |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G-protein coupled receptor F2Alternative name(s): G-protein coupled receptor 111 G-protein coupled receptor PGR20 |
Gene namesi | Name:ADGRF2 Synonyms:GPR111, PGR20 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18991, ADGRF2 |
neXtProti | NX_Q8IZF7 |
VEuPathDBi | HostDB:ENSG00000164393.8 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Other locations
- integral component of membrane Source: GDB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 451 | ExtracellularCuratedAdd BLAST | 451 | |
Transmembranei | 452 – 472 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 473 – 487 | CytoplasmicCuratedAdd BLAST | 15 | |
Transmembranei | 488 – 508 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 509 – 530 | ExtracellularCuratedAdd BLAST | 22 | |
Transmembranei | 531 – 551 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 552 – 557 | CytoplasmicCurated | 6 | |
Transmembranei | 558 – 578 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 579 – 606 | ExtracellularCuratedAdd BLAST | 28 | |
Transmembranei | 607 – 627 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 628 – 650 | CytoplasmicCuratedAdd BLAST | 23 | |
Transmembranei | 651 – 671 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 672 – 674 | ExtracellularCurated | 3 | |
Transmembranei | 675 – 695 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 696 – 708 | CytoplasmicCuratedAdd BLAST | 13 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 222611 |
PharmGKBi | PA134984088 |
Miscellaneous databases
Pharosi | Q8IZF7, Tdark |
Genetic variation databases
BioMutai | ADGRF2 |
DMDMi | 59797952 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070334 | 1 – 708 | Adhesion G-protein coupled receptor F2Add BLAST | 708 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 252 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 260 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 305 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 313 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 358 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q8IZF7 |
PaxDbi | Q8IZF7 |
PeptideAtlasi | Q8IZF7 |
PRIDEi | Q8IZF7 |
ProteomicsDBi | 71348 [Q8IZF7-1] 71349 [Q8IZF7-2] |
PTM databases
GlyGeni | Q8IZF7, 7 sites |
iPTMneti | Q8IZF7 |
PhosphoSitePlusi | Q8IZF7 |
Expressioni
Tissue specificityi
High expression in kidney. Up-regulated in lung adenocarcinomas and prostate cancers.1 Publication
Gene expression databases
Bgeei | ENSG00000164393, Expressed in skin of abdomen and 42 other tissues |
ExpressionAtlasi | Q8IZF7, baseline and differential |
Genevisiblei | Q8IZF7, HS |
Organism-specific databases
HPAi | ENSG00000164393, Tissue enhanced (esophagus, lymphoid tissue, skeletal muscle, skin, tongue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 128806, 1 interactor |
IntActi | Q8IZF7, 1 interactor |
STRINGi | 9606.ENSP00000296862 |
Miscellaneous databases
RNActi | Q8IZF7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 391 – 441 | GPSPROSITE-ProRule annotationAdd BLAST | 51 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000162401 |
HOGENOMi | CLU_002753_3_6_1 |
InParanoidi | Q8IZF7 |
OMAi | HHNGCVA |
OrthoDBi | 611778at2759 |
PhylomeDBi | Q8IZF7 |
TreeFami | TF316380 |
Family and domain databases
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR000203, GPS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
PROSITEi | View protein in PROSITE PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IZF7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLTAYGNRR VQPGELPFGA NLTLIHTRAQ PVICSKLLLT KRVSPISFFL
60 70 80 90 100
SKFQNSWGED GWVQLDQLPS PNAVSSDQVH CSAGCTHRKC GWAASKSKEK
110 120 130 140 150
VPARPHGVCD GVCTDYSQCT QPCPPDTQGN MGFSCRQKTW HKITDTCQTL
160 170 180 190 200
NALNIFEEDS RLVQPFEDNI KISVYTGKSE TITDMLLQKC PTDLSCVIRN
210 220 230 240 250
IQQSPWIPGN IAVIVQLLHN ISTAIWTGVD EAKMQSYSTI ANHILNSKSI
260 270 280 290 300
SNWTFIPDRN SSYILLHSVN SFARRLFIDK HPVDISDVFI HTMGTTISGD
310 320 330 340 350
NIGKNFTFSM RINDTSNEVT GRVLISRDEL RKVPSPSQVI SIAFPTIGAI
360 370 380 390 400
LEASLLENVT VNGLVLSAIL PKELKRISLI FEKISKSEER RTQCVGWHSV
410 420 430 440 450
ENRWDQQACK MIQENSQQAV CKCRPSKLFT SFSILMSPHI LESLILTYIT
460 470 480 490 500
YVGLGISICS LILCLSIEVL VWSQVTKTEI TYLRHVCIVN IAATLLMADV
510 520 530 540 550
WFIVASFLSG PITHHKGCVA ATFFVHFFYL SVFFWMLAKA LLILYGIMIV
560 570 580 590 600
FHTLPKSVLV ASLFSVGYGC PLAIAAITVA ATEPGKGYLR PEICWLNWDM
610 620 630 640 650
TKALLAFVIP ALAIVVVNLI TVTLVIVKTQ RAAIGNSMFQ EVRAIVRISK
660 670 680 690 700
NIAILTPLLG LTWGFGVATV IDDRSLAFHI IFSLLNAFQV SPDASDQVQS
ERIHEDVL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6R9E2 | D6R9E2_HUMAN | Adhesion G-protein-coupled receptor... | ADGRF2 | 640 | Annotation score: |
Sequence cautioni
The sequence BAC05907 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 427 | K → E in ABC41928 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024473 | 148 | Q → R. Corresponds to variant dbSNP:rs6907125Ensembl. | 1 | |
Natural variantiVAR_024474 | 467 | I → V1 PublicationCorresponds to variant dbSNP:rs9381594Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040379 | 1 – 68 | Missing in isoform 2. 1 PublicationAdd BLAST | 68 | |
Alternative sequenceiVSP_040380 | 69 – 92 | PSPNA…RKCGW → MTHILLLYYLVFLLPTESCR TLYQ in isoform 2. 1 PublicationAdd BLAST | 24 | |
Alternative sequenceiVSP_040381 | 690 – 708 | VSPDA…HEDVL → GFFILVFGTILDPKIREALK G in isoform 2. 1 PublicationAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY140953 mRNA Translation: AAN46667.1 AB065684 Genomic DNA Translation: BAC05907.1 Sequence problems. DQ315369 mRNA Translation: ABC41928.1 AL356421 Genomic DNA No translation available. AB083617 Genomic DNA Translation: BAB89330.1 AY255612 mRNA Translation: AAO85124.1 |
RefSeqi | NP_722581.4, NM_153839.6 [Q8IZF7-2] |
Genome annotation databases
Ensembli | ENST00000296862; ENSP00000296862; ENSG00000164393 [Q8IZF7-1] ENST00000398742; ENSP00000381727; ENSG00000164393 [Q8IZF7-2] ENST00000467205; ENSP00000425269; ENSG00000164393 [Q8IZF7-2] |
GeneIDi | 222611 |
KEGGi | hsa:222611 |
UCSCi | uc003oyy.3, human [Q8IZF7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY140953 mRNA Translation: AAN46667.1 AB065684 Genomic DNA Translation: BAC05907.1 Sequence problems. DQ315369 mRNA Translation: ABC41928.1 AL356421 Genomic DNA No translation available. AB083617 Genomic DNA Translation: BAB89330.1 AY255612 mRNA Translation: AAO85124.1 |
RefSeqi | NP_722581.4, NM_153839.6 [Q8IZF7-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 128806, 1 interactor |
IntActi | Q8IZF7, 1 interactor |
STRINGi | 9606.ENSP00000296862 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8IZF7, 7 sites |
iPTMneti | Q8IZF7 |
PhosphoSitePlusi | Q8IZF7 |
Genetic variation databases
BioMutai | ADGRF2 |
DMDMi | 59797952 |
Proteomic databases
MassIVEi | Q8IZF7 |
PaxDbi | Q8IZF7 |
PeptideAtlasi | Q8IZF7 |
PRIDEi | Q8IZF7 |
ProteomicsDBi | 71348 [Q8IZF7-1] 71349 [Q8IZF7-2] |
Protocols and materials databases
Antibodypediai | 30795, 92 antibodies |
DNASUi | 222611 |
Genome annotation databases
Ensembli | ENST00000296862; ENSP00000296862; ENSG00000164393 [Q8IZF7-1] ENST00000398742; ENSP00000381727; ENSG00000164393 [Q8IZF7-2] ENST00000467205; ENSP00000425269; ENSG00000164393 [Q8IZF7-2] |
GeneIDi | 222611 |
KEGGi | hsa:222611 |
UCSCi | uc003oyy.3, human [Q8IZF7-1] |
Organism-specific databases
CTDi | 222611 |
DisGeNETi | 222611 |
GeneCardsi | ADGRF2 |
HGNCi | HGNC:18991, ADGRF2 |
HPAi | ENSG00000164393, Tissue enhanced (esophagus, lymphoid tissue, skeletal muscle, skin, tongue) |
neXtProti | NX_Q8IZF7 |
PharmGKBi | PA134984088 |
VEuPathDBi | HostDB:ENSG00000164393.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000162401 |
HOGENOMi | CLU_002753_3_6_1 |
InParanoidi | Q8IZF7 |
OMAi | HHNGCVA |
OrthoDBi | 611778at2759 |
PhylomeDBi | Q8IZF7 |
TreeFami | TF316380 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZF7 |
Miscellaneous databases
BioGRID-ORCSi | 222611, 2 hits in 102 CRISPR screens |
ChiTaRSi | ADGRF2, human |
GeneWikii | GPR111 |
GenomeRNAii | 222611 |
Pharosi | Q8IZF7, Tdark |
PROi | PR:Q8IZF7 |
RNActi | Q8IZF7, protein |
Gene expression databases
Bgeei | ENSG00000164393, Expressed in skin of abdomen and 42 other tissues |
ExpressionAtlasi | Q8IZF7, baseline and differential |
Genevisiblei | Q8IZF7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR000203, GPS |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF01825, GPS, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
PROSITEi | View protein in PROSITE PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRF2_HUMAN | |
Accessioni | Q8IZF7Primary (citable) accession number: Q8IZF7 Secondary accession number(s): Q2PNZ1 Q8TDT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families