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Entry version 137 (08 May 2019)
Sequence version 2 (22 Sep 2009)
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Protein

Adhesion G-protein coupled receptor G4

Gene

ADGRG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.014

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G41 Publication
Alternative name(s):
G-protein coupled receptor 112
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRG4
Synonyms:GPR112
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18992 ADGRG4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZF6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 2741ExtracellularCuratedAdd BLAST2714
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2742 – 2762Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2763 – 2778CytoplasmicCuratedAdd BLAST16
Transmembranei2779 – 2799Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2800 – 2805ExtracellularCurated6
Transmembranei2806 – 2826Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2827 – 2848CytoplasmicCuratedAdd BLAST22
Transmembranei2849 – 2869Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2870 – 2892ExtracellularCuratedAdd BLAST23
Transmembranei2893 – 2913Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2914 – 2942CytoplasmicCuratedAdd BLAST29
Transmembranei2943 – 2963Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2964 – 2965ExtracellularCurated2
Transmembranei2966 – 2986Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2987 – 3080CytoplasmicCuratedAdd BLAST94

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
139378

Open Targets

More...
OpenTargetsi
ENSG00000156920

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134885132

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADGRG4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
259016241

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000007033528 – 3080Adhesion G-protein coupled receptor G4Add BLAST3053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi58 ↔ 123PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi836N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1020N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2361N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2640N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IZF6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IZF6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZF6

PeptideAtlas

More...
PeptideAtlasi
Q8IZF6

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZF6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71345
71346 [Q8IZF6-2]
71347 [Q8IZF6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZF6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156920 Expressed in 29 organ(s), highest expression level in intestine

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZF6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035324

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126563, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8IZF6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377699

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 228Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST200
Domaini2682 – 2733GPSPROSITE-ProRule annotationAdd BLAST52

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162744

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230882

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZF6

KEGG Orthology (KO)

More...
KOi
K08455

Identification of Orthologs from Complete Genome Data

More...
OMAi
NWLNSIF

Database of Orthologous Groups

More...
OrthoDBi
148879at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZF6

TreeFam database of animal gene trees

More...
TreeFami
TF321769

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IZF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKEHIIYQKL YGLILMSSFI FLSDTLSLKG KKLDFFGRGD TYVSLIDTIP
60 70 80 90 100
ELSRFTACID LVFMDDNSRY WMAFSYITNN ALLGREDIDL GLAGDHQQLI
110 120 130 140 150
LYRLGKTFSI RHHLASFQWH TICLIWDGVK GKLELFLNKE RILEVTDQPH
160 170 180 190 200
NLTPHGTLFL GHFLKNESSE VKSMMRSFPG SLYYFQLWDH ILENEEFMKC
210 220 230 240 250
LDGNIVSWEE DVWLVNKIIP TVDRTLRCFV PENMTIQEKS TTVSQQIDMT
260 270 280 290 300
TPSQITGVKP QNTAHSSTLL SQSIPIFATD YTTISYSNTT SPPLETMTAQ
310 320 330 340 350
KILKTLVDET ATFAVDVLST SSAISLPTQS ISIDNTTNSM KKTKSPSSES
360 370 380 390 400
TKTTKMVEAM ATEIFQPPTP SNFLSTSRFT KNSVVSTTSA IKSQSAVTKT
410 420 430 440 450
TSLFSTIEST SMSTTPCLKQ KSTNTGALPI STAGQEFIES TAAGTVPWFT
460 470 480 490 500
VEKTSPASTH VGTASSFPPE PVLISTAAPV DSVFPRNQTA FPLATTDMKI
510 520 530 540 550
AFTVHSLTLP TRLIETTPAP RTAETELTST NFQDVSLPRV EDAMSTSMSK
560 570 580 590 600
ETSSKTFSFL TSFSFTGTES VQTVIDAEAT RTALTPEITL ASTVAETMLS
610 620 630 640 650
STITGRVYTQ NTPTADGHLL TLMSTRSAST SKAPESGPTS TTDEAAHLFS
660 670 680 690 700
SNETIWTSRP DQALLASMNT TTILTFVPNE NFTSAFHENT TYTEYLSATT
710 720 730 740 750
NITPLKASPE GKGTTANDAT TARYTTAVSK LTSPWFANFS IVSGTTSITN
760 770 780 790 800
MPEFKLTTLL LKTIPMSTKP ANELPLTPRE TVVPSVDIIS TLACIQPNFS
810 820 830 840 850
TEESASETTQ TEINGAIVFG GTTTPVPKSA TTQRLNATVT RKEATSHYLM
860 870 880 890 900
RKSTIAAVAE VSPFSTMLEV TDESAQRVTA SVTVSSFPDI EKLSTPLDNK
910 920 930 940 950
TATTEVRESW LLTKLVKTTP RSSYNEMTEM FNFNHTYVAH WTSETSEGIS
960 970 980 990 1000
AGSPTSGSTH IFGEPLGAST TRISETSFST TPTDRTATSL SDGILPPQPT
1010 1020 1030 1040 1050
AAHSSATPVP VTHMFSLPVN GSSVVAEETE VTMSEPSTLA RAFSTSVLSD
1060 1070 1080 1090 1100
VSNLSSTTMT TALVPPLDQT ASTTIVIVPT HGDLIRTTSE ATVISVRKTS
1110 1120 1130 1140 1150
MAVPSLTETP FHSLRLSTPV TAKAETTLFS TSVDTVTPST HTLVCSKPPP
1160 1170 1180 1190 1200
DNIPPASSTH VISTTSTPEA TQPISQVEET STYALSFPYT FSGGGVVASL
1210 1220 1230 1240 1250
ATGTTETSVV DETTPSHISA NKLTTSVNSH ISSSATYRVH TPVSIQLVTS
1260 1270 1280 1290 1300
TSVLSSDKDQ MTISLGKTPR TMEVTEMSPS KNSFISYSRG TPSLEMTDTG
1310 1320 1330 1340 1350
FPETTKISSH QTHSPSEIPL GTPSDGNLAS SPTSGSTQIT PTLTSSNTVG
1360 1370 1380 1390 1400
VHIPEMSTSL GKTALPSQAL TITTFLCPEK ESTSALPAYT PRTVEMIVNS
1410 1420 1430 1440 1450
TYVTHSVSYG QDTSFVDTTT SSSTRISNPM DINTTFSHLH SLRTQPEVTS
1460 1470 1480 1490 1500
VASFISESTQ TFPESLSLST AGLYNDGFTV LSDRITTAFS VPNVPTMLPR
1510 1520 1530 1540 1550
ESSMATSTPI YQMSSLPVNV TAFTSKKVSD TPPIVITKSS KTMHPGCLKS
1560 1570 1580 1590 1600
PCTATSGPMS EMSSIPVNNS AFTPATVSSD TSTRVGLFST LLSSVTPRTT
1610 1620 1630 1640 1650
MTMQTSTLDV TPVIYAGATS KNKMVSSAFT TEMIEAPSRI TPTTFLSPTE
1660 1670 1680 1690 1700
PTLPFVKTVP TTIMAGIVTP FVGTTAFSPL SSKSTGAISS IPKTTFSPFL
1710 1720 1730 1740 1750
SATQQSSQAD EATTLGILSG ITNRSLSTVN SGTGVALTDT YSRITVPENM
1760 1770 1780 1790 1800
LSPTHADSLH TSFNIQVSPS LTSFKSASGP TKNVKTTTNC FSSNTRKMTS
1810 1820 1830 1840 1850
LLEKTSLTNY ATSLNTPVSY PPWTPSSATL PSLTSFVYSP HSTEAEISTP
1860 1870 1880 1890 1900
KTSPPPTSQM VEFPVLGTRM TSSNTQPLLM TSWNIPTAEG SQFPISTTIN
1910 1920 1930 1940 1950
VPTSNEMETE TLHLVPGPLS TFTASQTGLV SKDVMAMSSI PMSGILPNHG
1960 1970 1980 1990 2000
LSENPSLSTS LRAITSTLAD VKHTFEKMTT SVTPGTTLPS ILSGATSGSV
2010 2020 2030 2040 2050
ISKSPILTWL LSSLPSGSPP ATVSNAPHVM TSSTVEVSKS TFLTSDMISA
2060 2070 2080 2090 2100
HPFTNLTTLP SATMSTILTR TIPTPTLGGI TTGFPTSLPM SINVTDDIVY
2110 2120 2130 2140 2150
ISTHPEASSR TTITANPRTV SHPSSFSRKT MSPSTTDHTL SVGAMPLPSS
2160 2170 2180 2190 2200
TITSSWNRIP TASSPSTLII PKPTLDSLLN IMTTTSTVPG ASFPLISTGV
2210 2220 2230 2240 2250
TYPFTATVSS PISSFFETTW LDSTPSFLST EASTSPTATK STVSFYNVEM
2260 2270 2280 2290 2300
SFSVFVEEPR IPITSVINEF TENSLNSIFQ NSEFSLATLE TQIKSRDISE
2310 2320 2330 2340 2350
EEMVMDRAIL EQREGQEMAT ISYVPYSCVC QVIIKASSSL ASSELMRKIK
2360 2370 2380 2390 2400
SKIHGNFTHG NFTQDQLTLL VNCEHVAVKK LEPGNCKADE TASKYKGTYK
2410 2420 2430 2440 2450
WLLTNPTETA QTRCIKNEDG NATRFCSISI NTGKSQWEKP KFKQCKLLQE
2460 2470 2480 2490 2500
LPDKIVDLAN ITISDENAED VAEHILNLIN ESPALGKEET KIIVSKISDI
2510 2520 2530 2540 2550
SQCDEISMNL THVMLQIINV VLEKQNNSAS DLHEISNEIL RIIERTGHKM
2560 2570 2580 2590 2600
EFSGQIANLT VAGLALAVLR GDHTFDGMAF SIHSYEEGTD PEIFLGNVPV
2610 2620 2630 2640 2650
GGILASIYLP KSLTERIPLS NLQTILFNFF GQTSLFKTKN VTKALTTYVV
2660 2670 2680 2690 2700
SASISDDMFI QNLADPVVIT LQHIGGNQNY GQVHCAFWDF ENNNGLGGWN
2710 2720 2730 2740 2750
SSGCKVKETN VNYTICQCDH LTHFGVLMDL SRSTVDSVNE QILALITYTG
2760 2770 2780 2790 2800
CGISSIFLGV AVVTYIAFHK LRKDYPAKIL INLCTALLML NLVFLINSWL
2810 2820 2830 2840 2850
SSFQKVGVCI TAAVALHYFL LVSFTWMGLE AVHMYLALVK VFNIYIPNYI
2860 2870 2880 2890 2900
LKFCLVGWGI PAIMVAITVS VKKDLYGTLS PTTPFCWIKD DSIFYISVVA
2910 2920 2930 2940 2950
YFCLIFLMNL SMFCTVLVQL NSVKSQIQKT RRKMILHDLK GTMSLTFLLG
2960 2970 2980 2990 3000
LTWGFAFFAW GPMRNFFLYL FAIFNTLQGF FIFVFHCVMK ESVREQWQIH
3010 3020 3030 3040 3050
LCCGWLRLDN SSDGSSRCQI KVGYKQEGLK KIFEHKLLTP SLKSTATSST
3060 3070 3080
FKSLGSAQGT PSEISFPNDD FDKDPYCSSP
Length:3,080
Mass (Da):333,368
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3449BC820B251BD3
GO
Isoform 2 (identifier: Q8IZF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     2243-2381: Missing.
     2593-2637: Missing.
     2979-3012: Missing.
     3069-3080: DDFDKDPYCSSP → APELSALHVVASEPTTG

Show »
Length:2,804
Mass (Da):301,615
Checksum:iB6E45BB089F26D65
GO
Isoform 3 (identifier: Q8IZF6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: D → V
     25-229: Missing.

Note: No experimental confirmation available.
Show »
Length:2,875
Mass (Da):309,429
Checksum:iFC26A9AA34552F93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti229Missing in AAN46668 (PubMed:12435584).Curated1
Sequence conflicti2426Missing in AAN46668 (PubMed:12435584).Curated1
Sequence conflicti2694Missing in AAN46668 (PubMed:12435584).Curated1
Sequence conflicti2769Missing in AAN46668 (PubMed:12435584).Curated1
Sequence conflicti2885Missing in AAN46668 (PubMed:12435584).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055929276I → M1 PublicationCorresponds to variant dbSNP:rs4829829Ensembl.1
Natural variantiVAR_059329368P → H1 PublicationCorresponds to variant dbSNP:rs5930931Ensembl.1
Natural variantiVAR_0593301213T → N. Corresponds to variant dbSNP:rs4829830Ensembl.1
Natural variantiVAR_0593311540S → P. Corresponds to variant dbSNP:rs912002Ensembl.1
Natural variantiVAR_0593321791F → L. Corresponds to variant dbSNP:rs5930932Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0381701 – 63Missing in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_03817124D → V in isoform 3. Curated1
Alternative sequenceiVSP_03817225 – 229Missing in isoform 3. CuratedAdd BLAST205
Alternative sequenceiVSP_0381732243 – 2381Missing in isoform 2. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_0381742593 – 2637Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0381752979 – 3012Missing in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0381763069 – 3080DDFDK…YCSSP → APELSALHVVASEPTTG in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY140954 mRNA Translation: AAN46668.1
AY882585 mRNA Translation: AAW78659.1
AL078638 Genomic DNA No translation available.
AL136167 Genomic DNA No translation available.
AL161778 Genomic DNA No translation available.
AY255581 mRNA Translation: AAO85093.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35409.1 [Q8IZF6-1]

NCBI Reference Sequences

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RefSeqi
NP_722576.3, NM_153834.3 [Q8IZF6-1]
XP_011529571.1, XM_011531269.2 [Q8IZF6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000370652; ENSP00000359686; ENSG00000156920 [Q8IZF6-1]
ENST00000394141; ENSP00000377697; ENSG00000156920 [Q8IZF6-3]
ENST00000394143; ENSP00000377699; ENSG00000156920 [Q8IZF6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
139378

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:139378

UCSC genome browser

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UCSCi
uc004ezu.1 human [Q8IZF6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY140954 mRNA Translation: AAN46668.1
AY882585 mRNA Translation: AAW78659.1
AL078638 Genomic DNA No translation available.
AL136167 Genomic DNA No translation available.
AL161778 Genomic DNA No translation available.
AY255581 mRNA Translation: AAO85093.1
CCDSiCCDS35409.1 [Q8IZF6-1]
RefSeqiNP_722576.3, NM_153834.3 [Q8IZF6-1]
XP_011529571.1, XM_011531269.2 [Q8IZF6-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126563, 1 interactor
IntActiQ8IZF6, 1 interactor
STRINGi9606.ENSP00000377699

Protein family/group databases

MEROPSiP02.014

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiQ8IZF6
PhosphoSitePlusiQ8IZF6

Polymorphism and mutation databases

BioMutaiADGRG4
DMDMi259016241

Proteomic databases

EPDiQ8IZF6
jPOSTiQ8IZF6
PaxDbiQ8IZF6
PeptideAtlasiQ8IZF6
PRIDEiQ8IZF6
ProteomicsDBi71345
71346 [Q8IZF6-2]
71347 [Q8IZF6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370652; ENSP00000359686; ENSG00000156920 [Q8IZF6-1]
ENST00000394141; ENSP00000377697; ENSG00000156920 [Q8IZF6-3]
ENST00000394143; ENSP00000377699; ENSG00000156920 [Q8IZF6-1]
GeneIDi139378
KEGGihsa:139378
UCSCiuc004ezu.1 human [Q8IZF6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
139378
DisGeNETi139378

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADGRG4
HGNCiHGNC:18992 ADGRG4
HPAiHPA035324
neXtProtiNX_Q8IZF6
OpenTargetsiENSG00000156920
PharmGKBiPA134885132

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00940000162744
HOGENOMiHOG000230882
InParanoidiQ8IZF6
KOiK08455
OMAiNWLNSIF
OrthoDBi148879at2759
PhylomeDBiQ8IZF6
TreeFamiTF321769

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADGRG4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GPR112

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
139378

Protein Ontology

More...
PROi
PR:Q8IZF6

Gene expression databases

BgeeiENSG00000156920 Expressed in 29 organ(s), highest expression level in intestine
GenevisibleiQ8IZF6 HS

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRG4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZF6
Secondary accession number(s): A2A2J1
, A2A2J2, Q5EGP2, Q86SM6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: September 22, 2009
Last modified: May 8, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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