Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q8IZF6 (AGRG4_HUMAN)

Entry version 149 (10 Feb 2021)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Adhesion G-protein coupled receptor G4

Gene

ADGRG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IZF6

Protein family/group databases

MEROPS protease database

More...MEROPSi		P02.014

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G41 Publication
Alternative name(s):
G-protein coupled receptor 112
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRG4
Synonyms:GPR112
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18992, ADGRG4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IZF6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000156920.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 2741ExtracellularCuratedAdd BLAST2714
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2742 – 2762Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini2763 – 2778CytoplasmicCuratedAdd BLAST16
Transmembranei2779 – 2799Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini2800 – 2805ExtracellularCurated6
Transmembranei2806 – 2826Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini2827 – 2848CytoplasmicCuratedAdd BLAST22
Transmembranei2849 – 2869Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini2870 – 2892ExtracellularCuratedAdd BLAST23
Transmembranei2893 – 2913Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini2914 – 2942CytoplasmicCuratedAdd BLAST29
Transmembranei2943 – 2963Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini2964 – 2965ExtracellularCurated2
Transmembranei2966 – 2986Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini2987 – 3080CytoplasmicCuratedAdd BLAST94

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000156920

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134885132

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IZF6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADGRG4

Domain mapping of disease mutations (DMDM)

More...DMDMi		259016241

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000007033528 – 3080Adhesion G-protein coupled receptor G4Add BLAST3053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi58 ↔ 123PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi836N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi899N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1020N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2361N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2640N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IZF6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IZF6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IZF6

PeptideAtlas

More...PeptideAtlasi		Q8IZF6

PRoteomics IDEntifications database

More...PRIDEi		Q8IZF6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71345 [Q8IZF6-1]
71346 [Q8IZF6-2]
71347 [Q8IZF6-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8IZF6, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IZF6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IZF6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in fetal retina. Highly expressed in normal enterochromaffin cells and in neuroendocrine carcinoma. Detected in normal liver; highly expressed in primary liver carcinoma.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000156920, Expressed in duodenum and 35 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IZF6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000156920, Tissue enriched (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126563, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q8IZF6, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377699

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IZF6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 228Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST200
Domaini2682 – 2733GPSPROSITE-ProRule annotationAdd BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4193, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162744

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000643_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IZF6

Identification of Orthologs from Complete Genome Data

More...OMAi		NFTTLPF

Database of Orthologous Groups

More...OrthoDBi		148879at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IZF6

TreeFam database of animal gene trees

More...TreeFami		TF321769

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR001759, Pentraxin-related

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF01825, GPS, 1 hit
PF00354, Pentaxin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00303, GPS, 1 hit
SM00159, PTX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS51828, PTX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IZF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKEHIIYQKL YGLILMSSFI FLSDTLSLKG KKLDFFGRGD TYVSLIDTIP 
        60         70         80         90        100
ELSRFTACID LVFMDDNSRY WMAFSYITNN ALLGREDIDL GLAGDHQQLI 
       110        120        130        140        150
LYRLGKTFSI RHHLASFQWH TICLIWDGVK GKLELFLNKE RILEVTDQPH 
       160        170        180        190        200
NLTPHGTLFL GHFLKNESSE VKSMMRSFPG SLYYFQLWDH ILENEEFMKC 
       210        220        230        240        250
LDGNIVSWEE DVWLVNKIIP TVDRTLRCFV PENMTIQEKS TTVSQQIDMT 
       260        270        280        290        300
TPSQITGVKP QNTAHSSTLL SQSIPIFATD YTTISYSNTT SPPLETMTAQ 
       310        320        330        340        350
KILKTLVDET ATFAVDVLST SSAISLPTQS ISIDNTTNSM KKTKSPSSES 
       360        370        380        390        400
TKTTKMVEAM ATEIFQPPTP SNFLSTSRFT KNSVVSTTSA IKSQSAVTKT 
       410        420        430        440        450
TSLFSTIEST SMSTTPCLKQ KSTNTGALPI STAGQEFIES TAAGTVPWFT 
       460        470        480        490        500
VEKTSPASTH VGTASSFPPE PVLISTAAPV DSVFPRNQTA FPLATTDMKI 
       510        520        530        540        550
AFTVHSLTLP TRLIETTPAP RTAETELTST NFQDVSLPRV EDAMSTSMSK 
       560        570        580        590        600
ETSSKTFSFL TSFSFTGTES VQTVIDAEAT RTALTPEITL ASTVAETMLS 
       610        620        630        640        650
STITGRVYTQ NTPTADGHLL TLMSTRSAST SKAPESGPTS TTDEAAHLFS 
       660        670        680        690        700
SNETIWTSRP DQALLASMNT TTILTFVPNE NFTSAFHENT TYTEYLSATT 
       710        720        730        740        750
NITPLKASPE GKGTTANDAT TARYTTAVSK LTSPWFANFS IVSGTTSITN 
       760        770        780        790        800
MPEFKLTTLL LKTIPMSTKP ANELPLTPRE TVVPSVDIIS TLACIQPNFS 
       810        820        830        840        850
TEESASETTQ TEINGAIVFG GTTTPVPKSA TTQRLNATVT RKEATSHYLM 
       860        870        880        890        900
RKSTIAAVAE VSPFSTMLEV TDESAQRVTA SVTVSSFPDI EKLSTPLDNK 
       910        920        930        940        950
TATTEVRESW LLTKLVKTTP RSSYNEMTEM FNFNHTYVAH WTSETSEGIS 
       960        970        980        990       1000
AGSPTSGSTH IFGEPLGAST TRISETSFST TPTDRTATSL SDGILPPQPT 
      1010       1020       1030       1040       1050
AAHSSATPVP VTHMFSLPVN GSSVVAEETE VTMSEPSTLA RAFSTSVLSD 
      1060       1070       1080       1090       1100
VSNLSSTTMT TALVPPLDQT ASTTIVIVPT HGDLIRTTSE ATVISVRKTS 
      1110       1120       1130       1140       1150
MAVPSLTETP FHSLRLSTPV TAKAETTLFS TSVDTVTPST HTLVCSKPPP 
      1160       1170       1180       1190       1200
DNIPPASSTH VISTTSTPEA TQPISQVEET STYALSFPYT FSGGGVVASL 
      1210       1220       1230       1240       1250
ATGTTETSVV DETTPSHISA NKLTTSVNSH ISSSATYRVH TPVSIQLVTS 
      1260       1270       1280       1290       1300
TSVLSSDKDQ MTISLGKTPR TMEVTEMSPS KNSFISYSRG TPSLEMTDTG 
      1310       1320       1330       1340       1350
FPETTKISSH QTHSPSEIPL GTPSDGNLAS SPTSGSTQIT PTLTSSNTVG 
      1360       1370       1380       1390       1400
VHIPEMSTSL GKTALPSQAL TITTFLCPEK ESTSALPAYT PRTVEMIVNS 
      1410       1420       1430       1440       1450
TYVTHSVSYG QDTSFVDTTT SSSTRISNPM DINTTFSHLH SLRTQPEVTS 
      1460       1470       1480       1490       1500
VASFISESTQ TFPESLSLST AGLYNDGFTV LSDRITTAFS VPNVPTMLPR 
      1510       1520       1530       1540       1550
ESSMATSTPI YQMSSLPVNV TAFTSKKVSD TPPIVITKSS KTMHPGCLKS 
      1560       1570       1580       1590       1600
PCTATSGPMS EMSSIPVNNS AFTPATVSSD TSTRVGLFST LLSSVTPRTT 
      1610       1620       1630       1640       1650
MTMQTSTLDV TPVIYAGATS KNKMVSSAFT TEMIEAPSRI TPTTFLSPTE 
      1660       1670       1680       1690       1700
PTLPFVKTVP TTIMAGIVTP FVGTTAFSPL SSKSTGAISS IPKTTFSPFL 
      1710       1720       1730       1740       1750
SATQQSSQAD EATTLGILSG ITNRSLSTVN SGTGVALTDT YSRITVPENM 
      1760       1770       1780       1790       1800
LSPTHADSLH TSFNIQVSPS LTSFKSASGP TKNVKTTTNC FSSNTRKMTS 
      1810       1820       1830       1840       1850
LLEKTSLTNY ATSLNTPVSY PPWTPSSATL PSLTSFVYSP HSTEAEISTP 
      1860       1870       1880       1890       1900
KTSPPPTSQM VEFPVLGTRM TSSNTQPLLM TSWNIPTAEG SQFPISTTIN 
      1910       1920       1930       1940       1950
VPTSNEMETE TLHLVPGPLS TFTASQTGLV SKDVMAMSSI PMSGILPNHG 
      1960       1970       1980       1990       2000
LSENPSLSTS LRAITSTLAD VKHTFEKMTT SVTPGTTLPS ILSGATSGSV 
      2010       2020       2030       2040       2050
ISKSPILTWL LSSLPSGSPP ATVSNAPHVM TSSTVEVSKS TFLTSDMISA 
      2060       2070       2080       2090       2100
HPFTNLTTLP SATMSTILTR TIPTPTLGGI TTGFPTSLPM SINVTDDIVY 
      2110       2120       2130       2140       2150
ISTHPEASSR TTITANPRTV SHPSSFSRKT MSPSTTDHTL SVGAMPLPSS 
      2160       2170       2180       2190       2200
TITSSWNRIP TASSPSTLII PKPTLDSLLN IMTTTSTVPG ASFPLISTGV 
      2210       2220       2230       2240       2250
TYPFTATVSS PISSFFETTW LDSTPSFLST EASTSPTATK STVSFYNVEM 
      2260       2270       2280       2290       2300
SFSVFVEEPR IPITSVINEF TENSLNSIFQ NSEFSLATLE TQIKSRDISE 
      2310       2320       2330       2340       2350
EEMVMDRAIL EQREGQEMAT ISYVPYSCVC QVIIKASSSL ASSELMRKIK 
      2360       2370       2380       2390       2400
SKIHGNFTHG NFTQDQLTLL VNCEHVAVKK LEPGNCKADE TASKYKGTYK 
      2410       2420       2430       2440       2450
WLLTNPTETA QTRCIKNEDG NATRFCSISI NTGKSQWEKP KFKQCKLLQE 
      2460       2470       2480       2490       2500
LPDKIVDLAN ITISDENAED VAEHILNLIN ESPALGKEET KIIVSKISDI 
      2510       2520       2530       2540       2550
SQCDEISMNL THVMLQIINV VLEKQNNSAS DLHEISNEIL RIIERTGHKM 
      2560       2570       2580       2590       2600
EFSGQIANLT VAGLALAVLR GDHTFDGMAF SIHSYEEGTD PEIFLGNVPV 
      2610       2620       2630       2640       2650
GGILASIYLP KSLTERIPLS NLQTILFNFF GQTSLFKTKN VTKALTTYVV 
      2660       2670       2680       2690       2700
SASISDDMFI QNLADPVVIT LQHIGGNQNY GQVHCAFWDF ENNNGLGGWN 
      2710       2720       2730       2740       2750
SSGCKVKETN VNYTICQCDH LTHFGVLMDL SRSTVDSVNE QILALITYTG 
      2760       2770       2780       2790       2800
CGISSIFLGV AVVTYIAFHK LRKDYPAKIL INLCTALLML NLVFLINSWL 
      2810       2820       2830       2840       2850
SSFQKVGVCI TAAVALHYFL LVSFTWMGLE AVHMYLALVK VFNIYIPNYI 
      2860       2870       2880       2890       2900
LKFCLVGWGI PAIMVAITVS VKKDLYGTLS PTTPFCWIKD DSIFYISVVA 
      2910       2920       2930       2940       2950
YFCLIFLMNL SMFCTVLVQL NSVKSQIQKT RRKMILHDLK GTMSLTFLLG 
      2960       2970       2980       2990       3000
LTWGFAFFAW GPMRNFFLYL FAIFNTLQGF FIFVFHCVMK ESVREQWQIH 
      3010       3020       3030       3040       3050
LCCGWLRLDN SSDGSSRCQI KVGYKQEGLK KIFEHKLLTP SLKSTATSST 
      3060       3070       3080
FKSLGSAQGT PSEISFPNDD FDKDPYCSSP
Length:3,080
Mass (Da):333,368
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3449BC820B251BD3
GO
Isoform 2 (identifier: Q8IZF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     2243-2381: Missing.
     2593-2637: Missing.
     2979-3012: Missing.
     3069-3080: DDFDKDPYCSSP → APELSALHVVASEPTTG

Show »
Length:2,804
Mass (Da):301,615
Checksum:iB6E45BB089F26D65
GO
Isoform 3 (identifier: Q8IZF6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: D → V
     25-229: Missing.

Show »
Length:2,875
Mass (Da):309,429
Checksum:iFC26A9AA34552F93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti229Missing in AAN46668 (PubMed:12435584).Curated1
Sequence conflicti2426Missing in AAN46668 (PubMed:12435584).Curated1
Sequence conflicti2694Missing in AAN46668 (PubMed:12435584).Curated1
Sequence conflicti2769Missing in AAN46668 (PubMed:12435584).Curated1
Sequence conflicti2885Missing in AAN46668 (PubMed:12435584).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055929276I → M1 PublicationCorresponds to variant dbSNP:rs4829829Ensembl.1
Natural variantiVAR_059329368P → H1 PublicationCorresponds to variant dbSNP:rs5930931Ensembl.1
Natural variantiVAR_0593301213T → N. Corresponds to variant dbSNP:rs4829830Ensembl.1
Natural variantiVAR_0593311540S → P. Corresponds to variant dbSNP:rs912002Ensembl.1
Natural variantiVAR_0593321791F → L. Corresponds to variant dbSNP:rs5930932Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0381701 – 63Missing in isoform 2. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_03817124D → V in isoform 3. Curated1
Alternative sequenceiVSP_03817225 – 229Missing in isoform 3. CuratedAdd BLAST205
Alternative sequenceiVSP_0381732243 – 2381Missing in isoform 2. 1 PublicationAdd BLAST139
Alternative sequenceiVSP_0381742593 – 2637Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_0381752979 – 3012Missing in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0381763069 – 3080DDFDK…YCSSP → APELSALHVVASEPTTG in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY140954 mRNA Translation: AAN46668.1
AY882585 mRNA Translation: AAW78659.1
AL078638 Genomic DNA No translation available.
AL136167 Genomic DNA No translation available.
AL161778 Genomic DNA No translation available.
AY255581 mRNA Translation: AAO85093.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35409.1 [Q8IZF6-1]

NCBI Reference Sequences

More...RefSeqi		NP_722576.3, NM_153834.3 [Q8IZF6-1]
XP_011529571.1, XM_011531269.2 [Q8IZF6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370652; ENSP00000359686; ENSG00000156920 [Q8IZF6-1]
ENST00000394141; ENSP00000377697; ENSG00000156920 [Q8IZF6-3]
ENST00000394143; ENSP00000377699; ENSG00000156920 [Q8IZF6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		139378

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:139378

UCSC genome browser

More...UCSCi		uc004ezu.1, human [Q8IZF6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY140954 mRNA Translation: AAN46668.1
AY882585 mRNA Translation: AAW78659.1
AL078638 Genomic DNA No translation available.
AL136167 Genomic DNA No translation available.
AL161778 Genomic DNA No translation available.
AY255581 mRNA Translation: AAO85093.1
CCDSiCCDS35409.1 [Q8IZF6-1]
RefSeqiNP_722576.3, NM_153834.3 [Q8IZF6-1]
XP_011529571.1, XM_011531269.2 [Q8IZF6-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126563, 2 interactors
IntActiQ8IZF6, 1 interactor
STRINGi9606.ENSP00000377699

Protein family/group databases

MEROPSiP02.014

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ8IZF6, 8 sites
iPTMnetiQ8IZF6
PhosphoSitePlusiQ8IZF6

Genetic variation databases

BioMutaiADGRG4
DMDMi259016241

Proteomic databases

EPDiQ8IZF6
jPOSTiQ8IZF6
PaxDbiQ8IZF6
PeptideAtlasiQ8IZF6
PRIDEiQ8IZF6
ProteomicsDBi71345 [Q8IZF6-1]
71346 [Q8IZF6-2]
71347 [Q8IZF6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51733, 40 antibodies

Genome annotation databases

EnsembliENST00000370652; ENSP00000359686; ENSG00000156920 [Q8IZF6-1]
ENST00000394141; ENSP00000377697; ENSG00000156920 [Q8IZF6-3]
ENST00000394143; ENSP00000377699; ENSG00000156920 [Q8IZF6-1]
GeneIDi139378
KEGGihsa:139378
UCSCiuc004ezu.1, human [Q8IZF6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		139378

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADGRG4
HGNCiHGNC:18992, ADGRG4
HPAiENSG00000156920, Tissue enriched (intestine)
neXtProtiNX_Q8IZF6
OpenTargetsiENSG00000156920
PharmGKBiPA134885132
VEuPathDBiHostDB:ENSG00000156920.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4193, Eukaryota
GeneTreeiENSGT00940000162744
HOGENOMiCLU_000643_0_0_1
InParanoidiQ8IZF6
OMAiNFTTLPF
OrthoDBi148879at2759
PhylomeDBiQ8IZF6
TreeFamiTF321769

Enzyme and pathway databases

PathwayCommonsiQ8IZF6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		139378, 14 hits in 500 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADGRG4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPR112

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		139378
PharosiQ8IZF6, Tdark

Protein Ontology

More...PROi		PR:Q8IZF6
RNActiQ8IZF6, protein

Gene expression databases

BgeeiENSG00000156920, Expressed in duodenum and 35 other tissues
GenevisibleiQ8IZF6, HS

Family and domain databases

InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR001759, Pentraxin-related
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF01825, GPS, 1 hit
PF00354, Pentaxin, 1 hit
PRINTSiPR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00159, PTX, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS51828, PTX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRG4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZF6
Secondary accession number(s): A2A2J1
, A2A2J2, Q5EGP2, Q86SM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: September 22, 2009
Last modified: February 10, 2021
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again