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Entry version 139 (29 Sep 2021)
Sequence version 3 (18 May 2010)
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Protein

Adhesion G protein-coupled receptor F4

Gene

ADGRF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor.

Miscellaneous

Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IZF3

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.042

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor F4
Alternative name(s):
G-protein coupled receptor 115
G-protein coupled receptor PGR18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRF4
Synonyms:GPR115, PGR18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19011, ADGRF4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZF3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000153294

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 406ExtracellularCuratedAdd BLAST385
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei407 – 427Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini428 – 440CytoplasmicCuratedAdd BLAST13
Transmembranei441 – 461Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini462 – 485ExtracellularCuratedAdd BLAST24
Transmembranei486 – 506Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini507 – 515CytoplasmicCurated9
Transmembranei516 – 536Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini537 – 561ExtracellularCuratedAdd BLAST25
Transmembranei562 – 582Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini583 – 606CytoplasmicCuratedAdd BLAST24
Transmembranei607 – 627Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini628 – 634ExtracellularCurated7
Transmembranei635 – 655Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini656 – 695CytoplasmicCuratedAdd BLAST40

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
221393

Open Targets

More...
OpenTargetsi
ENSG00000153294

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134954617

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IZF3, Tdark

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4523889

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADGRF4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439339

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000007033622 – 695Adhesion G protein-coupled receptor F4Add BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IZF3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IZF3

PeptideAtlas

More...
PeptideAtlasi
Q8IZF3

PRoteomics IDEntifications database

More...
PRIDEi
Q8IZF3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71341

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8IZF3, 14 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZF3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IZF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153294, Expressed in zone of skin and 98 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IZF3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IZF3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000153294, Tissue enhanced (esophagus, placenta, skin, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128718, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8IZF3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000283303

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IZF3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini346 – 396GPSPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni674 – 695DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi679 – 695Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4193, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161797

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002753_3_6_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZF3

Identification of Orthologs from Complete Genome Data

More...
OMAi
MICCLMF

Database of Orthologous Groups

More...
OrthoDBi
611778at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IZF3

TreeFam database of animal gene trees

More...
TreeFami
TF316380

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017981, GPCR_2-like
IPR008078, GPCR_2_Ig-hepta-like_rcpt
IPR000832, GPCR_2_secretin-like
IPR000203, GPS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF01825, GPS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249, GPCRSECRETIN
PR01695, IGHEPTARCPTR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IZF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMKSQATMI CCLVFFLSTE CSHYRSKIHL KAGDKLQSPE GKPKTGRIQE
60 70 80 90 100
KCEGPCISSS NCSQPCAKDF HGEIGFTCNQ KKWQKSAETC TSLSVEKLFK
110 120 130 140 150
DSTGASRLSV AAPSIPLHIL DFRAPETIES VAQGIRKNCP FDYACITDMV
160 170 180 190 200
KSSETTSGNI AFIVELLKNI STDLSDNVTR EKMKSYSEVA NHILDTAAIS
210 220 230 240 250
NWAFIPNKNA SSDLLQSVNL FARQLHIHNN SENIVNELFI QTKGFHINHN
260 270 280 290 300
TSEKSLNFSM SMNNTTEDIL GMVQIPRQEL RKLWPNASQA ISIAFPTLGA
310 320 330 340 350
ILREAHLQNV SLPRQVNGLV LSVVLPERLQ EIILTFEKIN KTRNARAQCV
360 370 380 390 400
GWHSKKRRWD EKACQMMLDI RNEVKCRCNY TSVVMSFSIL MSSKSMTDKV
410 420 430 440 450
LDYITCIGLS VSILSLVLCL IIEATVWSRV VVTEISYMRH VCIVNIAVSL
460 470 480 490 500
LTANVWFIIG SHFNIKAQDY NMCVAVTFFS HFFYLSLFFW MLFKALLIIY
510 520 530 540 550
GILVIFRRMM KSRMMVIGFA IGYGCPLIIA VTTVAITEPE KGYMRPEACW
560 570 580 590 600
LNWDNTKALL AFAIPAFVIV AVNLIVVLVV AVNTQRPSIG SSKSQDVVII
610 620 630 640 650
MRISKNVAIL TPLLGLTWGF GIATLIEGTS LTFHIIFALL NAFQGFFILL
660 670 680 690
FGTIMDHKIR DALRMRMSSL KGKSRAAENA SLGPTNGSKL MNRQG
Length:695
Mass (Da):77,719
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB902221DD0804D0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFV3A0A0C4DFV3_HUMAN
Adhesion G protein-coupled receptor...
ADGRF4
752Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN46671 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC45257 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti491M → I in AAO85068 (PubMed:12679517).Curated1
Sequence conflicti538 – 540EPE → GPV in AAO85068 (PubMed:12679517).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055930507R → C. Corresponds to variant dbSNP:rs12110938Ensembl.1
Natural variantiVAR_024476541K → N3 PublicationsCorresponds to variant dbSNP:rs9369738Ensembl.1
Natural variantiVAR_036224674S → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs572583506Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ315370 mRNA Translation: ABC41929.1
AB065474 Genomic DNA Translation: BAC45257.1 Sequence problems.
AK095395 mRNA Translation: BAG53042.1
AL356421 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04321.1
AY255556 mRNA Translation: AAO85068.1
AY140957 mRNA Translation: AAN46671.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4922.2

NCBI Reference Sequences

More...
RefSeqi
NP_001334784.1, NM_001347855.1
NP_722580.3, NM_153838.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000283303; ENSP00000283303; ENSG00000153294
ENST00000327753; ENSP00000328319; ENSG00000153294

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
221393

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:221393

UCSC genome browser

More...
UCSCi
uc003oyz.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ315370 mRNA Translation: ABC41929.1
AB065474 Genomic DNA Translation: BAC45257.1 Sequence problems.
AK095395 mRNA Translation: BAG53042.1
AL356421 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04321.1
AY255556 mRNA Translation: AAO85068.1
AY140957 mRNA Translation: AAN46671.1 Sequence problems.
CCDSiCCDS4922.2
RefSeqiNP_001334784.1, NM_001347855.1
NP_722580.3, NM_153838.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi128718, 1 interactor
IntActiQ8IZF3, 1 interactor
STRINGi9606.ENSP00000283303

Chemistry databases

ChEMBLiCHEMBL4523889

Protein family/group databases

MEROPSiP02.042

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

GlyGeniQ8IZF3, 14 sites, 1 O-linked glycan (1 site)
iPTMnetiQ8IZF3
PhosphoSitePlusiQ8IZF3

Genetic variation databases

BioMutaiADGRF4
DMDMi296439339

Proteomic databases

MassIVEiQ8IZF3
PaxDbiQ8IZF3
PeptideAtlasiQ8IZF3
PRIDEiQ8IZF3
ProteomicsDBi71341

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1934, 219 antibodies

The DNASU plasmid repository

More...
DNASUi
221393

Genome annotation databases

EnsembliENST00000283303; ENSP00000283303; ENSG00000153294
ENST00000327753; ENSP00000328319; ENSG00000153294
GeneIDi221393
KEGGihsa:221393
UCSCiuc003oyz.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221393
DisGeNETi221393

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADGRF4
HGNCiHGNC:19011, ADGRF4
HPAiENSG00000153294, Tissue enhanced (esophagus, placenta, skin, tongue)
neXtProtiNX_Q8IZF3
OpenTargetsiENSG00000153294
PharmGKBiPA134954617
VEuPathDBiHostDB:ENSG00000153294

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4193, Eukaryota
GeneTreeiENSGT00940000161797
HOGENOMiCLU_002753_3_6_1
InParanoidiQ8IZF3
OMAiMICCLMF
OrthoDBi611778at2759
PhylomeDBiQ8IZF3
TreeFamiTF316380

Enzyme and pathway databases

PathwayCommonsiQ8IZF3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
221393, 5 hits in 1007 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADGRF4, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GPR115

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
221393
PharosiQ8IZF3, Tdark

Protein Ontology

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PROi
PR:Q8IZF3
RNActiQ8IZF3, protein

Gene expression databases

BgeeiENSG00000153294, Expressed in zone of skin and 98 other tissues
ExpressionAtlasiQ8IZF3, baseline and differential
GenevisibleiQ8IZF3, HS

Family and domain databases

InterProiView protein in InterPro
IPR017981, GPCR_2-like
IPR008078, GPCR_2_Ig-hepta-like_rcpt
IPR000832, GPCR_2_secretin-like
IPR000203, GPS
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF01825, GPS, 1 hit
PRINTSiPR00249, GPCRSECRETIN
PR01695, IGHEPTARCPTR
PROSITEiView protein in PROSITE
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRF4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZF3
Secondary accession number(s): B3KTD0
, Q2PNZ0, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. SIMILARITY comments
    Index of protein domains and families
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