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Protein

Adhesion G protein-coupled receptor F5

Gene

ADGRF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GDB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5683826 Surfactant metabolism

Protein family/group databases

MEROPS protease database

More...
MEROPSi
P02.019

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor F51 Publication
Alternative name(s):
G-protein coupled receptor 116
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRF5Imported
Synonyms:GPR116, KIAA0758
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000069122.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19030 ADGRF5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IZF2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 1006ExtracellularCuratedAdd BLAST985
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1007 – 1027Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini1028 – 1053CytoplasmicCuratedAdd BLAST26
Transmembranei1054 – 1074Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini1075 – 1090ExtracellularCuratedAdd BLAST16
Transmembranei1091 – 1111Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini1112 – 1128CytoplasmicCuratedAdd BLAST17
Transmembranei1129 – 1149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini1150 – 1173ExtracellularCuratedAdd BLAST24
Transmembranei1174 – 1194Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1195 – 1220CytoplasmicCuratedAdd BLAST26
Transmembranei1221 – 1241Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1242 – 1244ExtracellularCurated3
Transmembranei1245 – 1265Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1266 – 1346CytoplasmicCuratedAdd BLAST81

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
221395

Open Targets

More...
OpenTargetsi
ENSG00000069122

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134886165

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADGRF5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462973

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001289622 – 1346Adhesion G protein-coupled receptor F5Add BLAST1325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi293 ↔ 350PROSITE-ProRule annotation
Glycosylationi301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi391 ↔ 449PROSITE-ProRule annotation
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi472N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi492 ↔ 545PROSITE-ProRule annotation
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi649N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi666N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi820N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi963N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi982N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1300PhosphothreonineBy similarity1
Modified residuei1307PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved at multiple sites: one in the GPS domain (S1 site) and the other in the SEA domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. The proteolytic cleavage at S2 site generates a fragment that undergoes proteolytic cleavage by the processing enzyme furin.By similarity
Highly glycosylated.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei51 – 52Cleavage; by furinBy similarity2
Sitei226 – 227CleavageBy similarity2
Sitei990 – 991Cleavage; by autolysisBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IZF2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IZF2

PeptideAtlas

More...
PeptideAtlasi
Q8IZF2

PRoteomics IDEntifications database

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PRIDEi
Q8IZF2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71338
71339 [Q8IZF2-2]
71340 [Q8IZF2-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1914

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IZF2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8IZF2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000069122 Expressed in 228 organ(s), highest expression level in metanephric glomerulus

CleanEx database of gene expression profiles

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CleanExi
HS_GPR116

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IZF2 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Fragment generates by the processing enzyme furin remains attached to the extracellular N-terminal fragment. Interacts (via N-terminal extracellular domain) with SFTPD.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8IZF2, 3 interactors

Molecular INTeraction database

More...
MINTi
Q8IZF2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265417

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IZF2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IZF2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini166 – 273SEAPROSITE-ProRule annotationAdd BLAST108
Domaini267 – 368Ig-like 1Add BLAST102
Domaini369 – 466Ig-like 2Add BLAST98
Domaini471 – 561Ig-like 3Add BLAST91
Domaini951 – 1002GPSPROSITE-ProRule annotationAdd BLAST52

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4193 Eukaryota
ENOG410XSD2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154603

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112764

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051772

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IZF2

KEGG Orthology (KO)

More...
KOi
K08458

Identification of Orthologs from Complete Genome Data

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OMAi
HTGGWDS

Database of Orthologous Groups

More...
OrthoDBi
611778at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IZF2

TreeFam database of animal gene trees

More...
TreeFami
TF316380

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017981 GPCR_2-like
IPR008078 GPCR_2_Ig-hepta-like_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR000082 SEA_dom
IPR036364 SEA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PF01390 SEA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249 GPCRSECRETIN
PR01695 IGHEPTARCPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303 GPS, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits
SSF82671 SSF82671, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 3 hits
PS50024 SEA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IZF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSPRRTTLC LMFIVIYSSK AALNWNYEST IHPLSLHEHE PAGEEALRQK
60 70 80 90 100
RAVATKSPTA EEYTVNIEIS FENASFLDPI KAYLNSLSFP IHGNNTDQIT
110 120 130 140 150
DILSINVTTV CRPAGNEIWC SCETGYGWPR ERCLHNLICQ ERDVFLPGHH
160 170 180 190 200
CSCLKELPPN GPFCLLQEDV TLNMRVRLNV GFQEDLMNTS SALYRSYKTD
210 220 230 240 250
LETAFRKGYG ILPGFKGVTV TGFKSGSVVV TYEVKTTPPS LELIHKANEQ
260 270 280 290 300
VVQSLNQTYK MDYNSFQAVT INESNFFVTP EIIFEGDTVS LVCEKEVLSS
310 320 330 340 350
NVSWRYEEQQ LEIQNSSRFS IYTALFNNMT SVSKLTIHNI TPGDAGEYVC
360 370 380 390 400
KLILDIFEYE CKKKIDVMPI QILANEEMKV MCDNNPVSLN CCSQGNVNWS
410 420 430 440 450
KVEWKQEGKI NIPGTPETDI DSSCSRYTLK ADGTQCPSGS SGTTVIYTCE
460 470 480 490 500
FISAYGARGS ANIKVTFISV ANLTITPDPI SVSEGQNFSI KCISDVSNYD
510 520 530 540 550
EVYWNTSAGI KIYQRFYTTR RYLDGAESVL TVKTSTREWN GTYHCIFRYK
560 570 580 590 600
NSYSIATKDV IVHPLPLKLN IMVDPLEATV SCSGSHHIKC CIEEDGDYKV
610 620 630 640 650
TFHTGSSSLP AAKEVNKKQV CYKHNFNASS VSWCSKTVDV CCHFTNAANN
660 670 680 690 700
SVWSPSMKLN LVPGENITCQ DPVIGVGEPG KVIQKLCRFS NVPSSPESPI
710 720 730 740 750
GGTITYKCVG SQWEEKRNDC ISAPINSLLQ MAKALIKSPS QDEMLPTYLK
760 770 780 790 800
DLSISIDKAE HEISSSPGSL GAIINILDLL STVPTQVNSE MMTHVLSTVN
810 820 830 840 850
VILGKPVLNT WKVLQQQWTN QSSQLLHSVE RFSQALQSGD SPPLSFSQTN
860 870 880 890 900
VQMSSMVIKS SHPETYQQRF VFPYFDLWGN VVIDKSYLEN LQSDSSIVTM
910 920 930 940 950
AFPTLQAILA QDIQENNFAE SLVMTTTVSH NTTMPFRISM TFKNNSPSGG
960 970 980 990 1000
ETKCVFWNFR LANNTGGWDS SGCYVEEGDG DNVTCICDHL TSFSILMSPD
1010 1020 1030 1040 1050
SPDPSSLLGI LLDIISYVGV GFSILSLAAC LVVEAVVWKS VTKNRTSYMR
1060 1070 1080 1090 1100
HTCIVNIAAS LLVANTWFIV VAAIQDNRYI LCKTACVAAT FFIHFFYLSV
1110 1120 1130 1140 1150
FFWMLTLGLM LFYRLVFILH ETSRSTQKAI AFCLGYGCPL AISVITLGAT
1160 1170 1180 1190 1200
QPREVYTRKN VCWLNWEDTK ALLAFAIPAL IIVVVNITIT IVVITKILRP
1210 1220 1230 1240 1250
SIGDKPCKQE KSSLFQISKS IGVLTPLLGL TWGFGLTTVF PGTNLVFHII
1260 1270 1280 1290 1300
FAILNVFQGL FILLFGCLWD LKVQEALLNK FSLSRWSSQH SKSTSLGSST
1310 1320 1330 1340
PVFSMSSPIS RRFNNLFGKT GTYNVSTPEA TSSSLENSSS ASSLLN
Length:1,346
Mass (Da):149,457
Last modified:May 5, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72A9D02B08218A60
GO
Isoform 2 (identifier: Q8IZF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1273-1292: Missing.
     1322-1346: Missing.

Show »
Length:1,301
Mass (Da):144,601
Checksum:i9DEB380A0BEDA44B
GO
Isoform 3 (identifier: Q8IZF2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     272-414: NESNFFVTPE...KQEGKINIPG → R

Note: No experimental confirmation available.
Show »
Length:1,204
Mass (Da):133,307
Checksum:i0106B9A59C2D5B0E
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB43394 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti272Missing in AAN46672 (PubMed:12435584).Curated1
Sequence conflicti573V → I in CAB43394 (PubMed:15489334).Curated1
Sequence conflicti1075Q → R in AL832125 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025326604T → M4 PublicationsCorresponds to variant dbSNP:rs586024Ensembl.1
Natural variantiVAR_055291801V → I1 PublicationCorresponds to variant dbSNP:rs9395218Ensembl.1
Natural variantiVAR_024477856M → T2 PublicationsCorresponds to variant dbSNP:rs547499Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039130272 – 414NESNF…INIPG → R in isoform 3. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_0108371273 – 1292Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0108381322 – 1346Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY140958 mRNA Translation: AAN46672.1
AY498875 mRNA Translation: AAS21061.1
AB018301 mRNA Translation: BAA34478.2 Different initiation.
AL050295 mRNA Translation: CAB43394.1 Sequence problems.
AL832125 mRNA No translation available.
AL096772 Genomic DNA No translation available.
BC066121 mRNA Translation: AAH66121.1
AY255552 mRNA Translation: AAO85064.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4919.1 [Q8IZF2-1]

Protein sequence database of the Protein Information Resource

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PIRi
T08685

NCBI Reference Sequences

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RefSeqi
NP_001091988.1, NM_001098518.1 [Q8IZF2-1]
NP_056049.4, NM_015234.4 [Q8IZF2-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.362806

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265417; ENSP00000265417; ENSG00000069122 [Q8IZF2-1]
ENST00000283296; ENSP00000283296; ENSG00000069122 [Q8IZF2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
221395

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:221395

UCSC genome browser

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UCSCi
uc003oyo.5 human [Q8IZF2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY140958 mRNA Translation: AAN46672.1
AY498875 mRNA Translation: AAS21061.1
AB018301 mRNA Translation: BAA34478.2 Different initiation.
AL050295 mRNA Translation: CAB43394.1 Sequence problems.
AL832125 mRNA No translation available.
AL096772 Genomic DNA No translation available.
BC066121 mRNA Translation: AAH66121.1
AY255552 mRNA Translation: AAO85064.1
CCDSiCCDS4919.1 [Q8IZF2-1]
PIRiT08685
RefSeqiNP_001091988.1, NM_001098518.1 [Q8IZF2-1]
NP_056049.4, NM_015234.4 [Q8IZF2-1]
UniGeneiHs.362806

3D structure databases

ProteinModelPortaliQ8IZF2
SMRiQ8IZF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IZF2, 3 interactors
MINTiQ8IZF2
STRINGi9606.ENSP00000265417

Protein family/group databases

MEROPSiP02.019

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

GlyConnecti1914
iPTMnetiQ8IZF2
PhosphoSitePlusiQ8IZF2

Polymorphism and mutation databases

BioMutaiADGRF5
DMDMi229462973

Proteomic databases

jPOSTiQ8IZF2
PaxDbiQ8IZF2
PeptideAtlasiQ8IZF2
PRIDEiQ8IZF2
ProteomicsDBi71338
71339 [Q8IZF2-2]
71340 [Q8IZF2-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
221395
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265417; ENSP00000265417; ENSG00000069122 [Q8IZF2-1]
ENST00000283296; ENSP00000283296; ENSG00000069122 [Q8IZF2-1]
GeneIDi221395
KEGGihsa:221395
UCSCiuc003oyo.5 human [Q8IZF2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
221395
DisGeNETi221395
EuPathDBiHostDB:ENSG00000069122.18

GeneCards: human genes, protein and diseases

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GeneCardsi
ADGRF5
HGNCiHGNC:19030 ADGRF5
neXtProtiNX_Q8IZF2
OpenTargetsiENSG00000069122
PharmGKBiPA134886165

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00940000154603
HOGENOMiHOG000112764
HOVERGENiHBG051772
InParanoidiQ8IZF2
KOiK08458
OMAiHTGGWDS
OrthoDBi611778at2759
PhylomeDBiQ8IZF2
TreeFamiTF316380

Enzyme and pathway databases

ReactomeiR-HSA-5683826 Surfactant metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ADGRF5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GPR116

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
221395

Protein Ontology

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PROi
PR:Q8IZF2

Gene expression databases

BgeeiENSG00000069122 Expressed in 228 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_GPR116
GenevisibleiQ8IZF2 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR008078 GPCR_2_Ig-hepta-like_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PF01390 SEA, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01695 IGHEPTARCPTR
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 3 hits
PS50024 SEA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRF5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZF2
Secondary accession number(s): O94858
, Q5TF06, Q6RGN2, Q86SP0, Q9Y3Z2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 5, 2009
Last modified: January 16, 2019
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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