UniProtKB - Q8IZE3 (PACE1_HUMAN)

BLAST

>sp|Q8IZE3|PACE1_HUMAN Protein-associating with the carboxyl-terminal domain of ezrin OS=Homo sapiens OX=9606 GN=SCYL3 PE=1 SV=3
MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTL
RHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHL
THNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTT
LPECHGHARDAFSFGTLVESLLTILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLL
SHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVF
AEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSH
IEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKI
FKRTAPSFTKNTDLSLEDSPMCVVCSHHSQISPILENPFSSIFPKCFFSGSTPINSKKHI
QRDYYNTLLQTGDPFSQPIKFPINGLSDVKNTSEDSENFPSSSKKSEEWPDWSEPEEPEN
QTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPVTSGEQK
PIPALLSLTEESMPWKSSLPQKISLVQRGDDADQIEPPKVSSQERPLKVPSELGLGEEFT
IQVKKKPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSSKFAAAE
ITEGEAEGWEEEGELNWEDNNW

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History
Entry version 151 (07 Nov 2018)
Sequence version 3 (23 Jan 2007)
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Protein

Protein-associating with the carboxyl-terminal domain of ezrin

Gene

SCYL3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May play a role in regulating cell adhesion/migration complexes in migrating cells.1 Publication

GO - Molecular functionⁱ

ATP binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration
Source: UniProtKB
Non-traceable author statementⁱ
- 12651155
protein phosphorylation Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkⁱ	Q8IZE3

SignaLinkⁱ

Q8IZE3

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein-associating with the carboxyl-terminal domain of ezrin Alternative name(s): Ezrin-binding protein PACE-1 SCY1-like protein 3
Gene namesⁱ	Name:SCYL3 Synonyms:PACE1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000000457.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19285 SCYL3
MIMⁱ	608192 gene
neXtProtⁱ	NX_Q8IZE3

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Golgi apparatus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	2 – 6	GSENS → M: No Golgi targeting, accumulates in the cytoplasm. 1 Publication		5

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57147
Open Targets More...OpenTargetsⁱ	ENSG00000000457
PharmGKBⁱ	PA142670945

Polymorphism and mutation databases

BioMutaⁱ	SCYL3
DMDMⁱ	61214481

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCurated
ChainⁱPRO_0000058167	2 – 742	Protein-associating with the carboxyl-terminal domain of ezrinAdd BLAST		741

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication	1
Modified residueⁱ	439	PhosphoserineBy similarity	1
Modified residueⁱ	707	PhosphoserineCombined sources	1

Post-translational modificationⁱ

May be myristoylated; myristoylation may target it to Golgi compartment.1 Publication

Phosphorylated.1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDⁱ	Q8IZE3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IZE3
PaxDbⁱ	Q8IZE3
PeptideAtlas More...PeptideAtlasⁱ	Q8IZE3
PRIDEⁱ	Q8IZE3
ProteomicsDBⁱ	71333 71334 [Q8IZE3-2]

PTM databases

iPTMnetⁱ	Q8IZE3
PhosphoSitePlusⁱ	Q8IZE3

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000000457 Expressed in 208 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_SCYL3
ExpressionAtlasⁱ	Q8IZE3 baseline and differential
Genevisibleⁱ	Q8IZE3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA005624

HPAⁱ

HPA005624

Interactionⁱ

Subunit structureⁱ

Interacts with EZR/VIL2 C-terminal domain.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EZR	P15311	4	EBI-1380680,EBI-1056902
GABARAPL1	Q9H0R8	3	EBI-1380680,EBI-746969
LHX8	Q68G74	3	EBI-1380680,EBI-8474075
TXN2	Q99757	3	EBI-1380680,EBI-2932492

Protein-protein interaction databases

BioGridⁱ	121404, 11 interactors
IntActⁱ	Q8IZE3, 15 interactors
STRINGⁱ	9606.ENSP00000356744

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IZE3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	2 – 245	Protein kinasePROSITE-ProRule annotationAdd BLAST	244
Repeatⁱ	199 – 238	HEAT 1Add BLAST	40
Repeatⁱ	285 – 323	HEAT 2Add BLAST	39
Repeatⁱ	333 – 370	HEAT 3Add BLAST	38
Repeatⁱ	372 – 409	HEAT 4Add BLAST	38

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	548 – 742	Interaction with EZR1 PublicationAdd BLAST		195

Domainⁱ

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG1243 Eukaryota ENOG410XQTG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000151043
HOVERGENⁱ	HBG053485
InParanoidⁱ	Q8IZE3
KEGG Orthology (KO) More...KOⁱ	K17542
OMAⁱ	VCKFSEA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B8M
PhylomeDBⁱ	Q8IZE3
TreeFamⁱ	TF313435

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR021133 HEAT_type_2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50077 HEAT_REPEAT, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8IZE3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSENSALKS YTLREPPFTL PSGLAVYPAV LQDGKFASVF VYKRENEDKV 
        60         70         80         90        100
NKAAKHLKTL RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSSAEV 
       110        120        130        140        150
CAGIYDILLA LIFLHDRGHL THNNVCLSSV FVSEDGHWKL GGMETVCKVS 
       160        170        180        190        200
QATPEFLRSI QSIRDPASIP PEEMSPEFTT LPECHGHARD AFSFGTLVES 
       210        220        230        240        250
LLTILNEQVS ADVLSSFQQT LHSTLLNPIP KCRPALCTLL SHDFFRNDFL 
       260        270        280        290        300
EVVNFLKSLT LKSEEEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF 
       310        320        330        340        350
AEPVAVKSFL PYLLGPKKDH AQGETPCLLS PALFQSRVIP VLLQLFEVHE 
       360        370        380        390        400
EHVRMVLLSH IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSD SIVAITLHSL 
       410        420        430        440        450
AVLVSLLGPE VVVGGERTKI FKRTAPSFTK NTDLSLEDSP MCVVCSHHSQ 
       460        470        480        490        500
ISPILENPFS SIFPKCFFSG STPINSKKHI QRDYYNTLLQ TGDPFSQPIK 
       510        520        530        540        550
FPINGLSDVK NTSEDSENFP SSSKKSEEWP DWSEPEEPEN QTVNIQIWPR 
       560        570        580        590        600
EPCDDVKSQC TTLDVEESSW DDCEPSSLDT KVNPGGGITA TKPVTSGEQK 
       610        620        630        640        650
PIPALLSLTE ESMPWKSSLP QKISLVQRGD DADQIEPPKV SSQERPLKVP 
       660        670        680        690        700
SELGLGEEFT IQVKKKPVKD PEMDWFADMI PEIKPSAAFL ILPELRTEMV 
       710        720        730        740 
PKKDDVSPVM QFSSKFAAAE ITEGEAEGWE EEGELNWEDN NW

Length:742

Mass (Da):82,857

Last modified:January 23, 2007 - v3

Checksum:ⁱ2F7D03681A4F641B

Isoform 2 (identifier: Q8IZE3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
438-491: Missing.

« Hide

        10         20         30         40         50
MGSENSALKS YTLREPPFTL PSGLAVYPAV LQDGKFASVF VYKRENEDKV 
        60         70         80         90        100
NKAAKHLKTL RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSSAEV 
       110        120        130        140        150
CAGIYDILLA LIFLHDRGHL THNNVCLSSV FVSEDGHWKL GGMETVCKVS 
       160        170        180        190        200
QATPEFLRSI QSIRDPASIP PEEMSPEFTT LPECHGHARD AFSFGTLVES 
       210        220        230        240        250
LLTILNEQVS ADVLSSFQQT LHSTLLNPIP KCRPALCTLL SHDFFRNDFL 
       260        270        280        290        300
EVVNFLKSLT LKSEEEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF 
       310        320        330        340        350
AEPVAVKSFL PYLLGPKKDH AQGETPCLLS PALFQSRVIP VLLQLFEVHE 
       360        370        380        390        400
EHVRMVLLSH IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSD SIVAITLHSL 
       410        420        430        440        450
AVLVSLLGPE VVVGGERTKI FKRTAPSFTK NTDLSLEGDP FSQPIKFPIN 
       460        470        480        490        500
GLSDVKNTSE DSENFPSSSK KSEEWPDWSE PEEPENQTVN IQIWPREPCD 
       510        520        530        540        550
DVKSQCTTLD VEESSWDDCE PSSLDTKVNP GGGITATKPV TSGEQKPIPA 
       560        570        580        590        600
LLSLTEESMP WKSSLPQKIS LVQRGDDADQ IEPPKVSSQE RPLKVPSELG 
       610        620        630        640        650
LGEEFTIQVK KKPVKDPEMD WFADMIPEIK PSAAFLILPE LRTEMVPKKD 
       660        670        680 
DVSPVMQFSS KFAAAEITEG EAEGWEEEGE LNWEDNNW

Show »

Length:688

Mass (Da):76,731

Checksum:ⁱ96DCB00F38A7F928

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	X6RHX1	X6RHX1_HUMAN		Protein-associating with the carbox... Protein-associating with the carboxyl-terminal domain of ezrin	SCYL3	588	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	613	M → T in AAN23123 (PubMed:12651155).Curated		1
Sequence conflictⁱ	613	M → T in AAN41656 (PubMed:12651155).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051690	597	G → A1 PublicationCorresponds to variant dbSNP:rs12143301Ensembl.		1
Natural variantⁱVAR_051691	621	Q → R3 PublicationsCorresponds to variant dbSNP:rs4656197Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_013125	438 – 491	Missing in isoform 2. 3 PublicationsAdd BLAST		54

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF540957 mRNA Translation: AAN23123.1 AY144493 mRNA Translation: AAN41656.1 AL117233 mRNA Translation: CAB55300.1 AK292507 mRNA Translation: BAF85196.1 AL031297 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90867.1 BC014662 mRNA Translation: AAH14662.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1286.1 [Q8IZE3-2] CCDS1287.1 [Q8IZE3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_065156.5, NM_020423.6 [Q8IZE3-2] NP_851607.2, NM_181093.3 [Q8IZE3-1] XP_006711528.1, XM_006711465.1 [Q8IZE3-1] XP_011508103.1, XM_011509801.1 [Q8IZE3-1] XP_016857351.1, XM_017001862.1 [Q8IZE3-2] XP_016857352.1, XM_017001863.1 [Q8IZE3-2]
UniGeneⁱ	Hs.435560 Hs.443551

Genome annotation databases

Ensemblⁱ	ENST00000367770; ENSP00000356744; ENSG00000000457 [Q8IZE3-1] ENST00000367771; ENSP00000356745; ENSG00000000457 [Q8IZE3-2] ENST00000367772; ENSP00000356746; ENSG00000000457 [Q8IZE3-1]
GeneIDⁱ	57147
KEGGⁱ	hsa:57147
UCSC genome browser More...UCSCⁱ	uc001ggs.5 human [Q8IZE3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IZE3-2	cDNA FLJ51470, highly similar to Homo sapiens SCY1-like 3 (SCYL3), transcript variant 1, mRNA		HUMAN		334	UniRef100_Q8IZE3-2
Protein-associating with the carboxyl-terminal domain of ezrin (Fragment)		HUMAN		588
UPI0003EAF850		HUMAN		546

Protein	Similar proteins		Species	Score	Length	Source
Q8IZE3	Uncharacterized protein		PAPAN		742	UniRef90_Q8IZE3
Uncharacterized protein		CHLSB		742
SCY1 like pseudokinase 3		GORGO		742
Uncharacterized protein		MACFA		742
Uncharacterized protein		CERAT		742
+41
Q8IZE3-2	cDNA FLJ51470, highly similar to Homo sapiens SCY1-like 3 (SCYL3), transcript variant 1, mRNA		HUMAN		334	UniRef90_Q8IZE3-2
Uncharacterized protein		PAPAN		754
Uncharacterized protein		NOMLE		699
Uncharacterized protein		PROCO		689
Protein-associating with the carboxyl-terminal domain of ezrin isoform 1		MACMU		688
+34

Protein	Similar proteins		Species	Score	Length	Source
Q8IZE3	Protein-associating with the carboxyl-terminal domain of ezrin		MOUSE		735	UniRef50_Q8IZE3
SCY1 like pseudokinase 3		MACNE		742
Uncharacterized protein		NOMLE		742
Uncharacterized protein		CERAT		742
Uncharacterized protein		COLAP		742
+461

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF540957 mRNA Translation: AAN23123.1 AY144493 mRNA Translation: AAN41656.1 AL117233 mRNA Translation: CAB55300.1 AK292507 mRNA Translation: BAF85196.1 AL031297 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90867.1 BC014662 mRNA Translation: AAH14662.1
CCDSⁱ	CCDS1286.1 [Q8IZE3-2] CCDS1287.1 [Q8IZE3-1]
RefSeqⁱ	NP_065156.5, NM_020423.6 [Q8IZE3-2] NP_851607.2, NM_181093.3 [Q8IZE3-1] XP_006711528.1, XM_006711465.1 [Q8IZE3-1] XP_011508103.1, XM_011509801.1 [Q8IZE3-1] XP_016857351.1, XM_017001862.1 [Q8IZE3-2] XP_016857352.1, XM_017001863.1 [Q8IZE3-2]
UniGeneⁱ	Hs.435560 Hs.443551

3D structure databases

ProteinModelPortalⁱ	Q8IZE3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121404, 11 interactors
IntActⁱ	Q8IZE3, 15 interactors
STRINGⁱ	9606.ENSP00000356744

PTM databases

iPTMnetⁱ	Q8IZE3
PhosphoSitePlusⁱ	Q8IZE3

Polymorphism and mutation databases

BioMutaⁱ	SCYL3
DMDMⁱ	61214481

Proteomic databases

EPDⁱ	Q8IZE3
MaxQBⁱ	Q8IZE3
PaxDbⁱ	Q8IZE3
PeptideAtlasⁱ	Q8IZE3
PRIDEⁱ	Q8IZE3
ProteomicsDBⁱ	71333 71334 [Q8IZE3-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57147
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367770; ENSP00000356744; ENSG00000000457 [Q8IZE3-1] ENST00000367771; ENSP00000356745; ENSG00000000457 [Q8IZE3-2] ENST00000367772; ENSP00000356746; ENSG00000000457 [Q8IZE3-1]
GeneIDⁱ	57147
KEGGⁱ	hsa:57147
UCSCⁱ	uc001ggs.5 human [Q8IZE3-1]

Organism-specific databases

CTDⁱ	57147
DisGeNETⁱ	57147
EuPathDBⁱ	HostDB:ENSG00000000457.13
GeneCardsⁱ	SCYL3
HGNCⁱ	HGNC:19285 SCYL3
HPAⁱ	HPA005624
MIMⁱ	608192 gene
neXtProtⁱ	NX_Q8IZE3
OpenTargetsⁱ	ENSG00000000457
PharmGKBⁱ	PA142670945
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1243 Eukaryota ENOG410XQTG LUCA
GeneTreeⁱ	ENSGT00930000151043
HOVERGENⁱ	HBG053485
InParanoidⁱ	Q8IZE3
KOⁱ	K17542
OMAⁱ	VCKFSEA
OrthoDBⁱ	EOG091G0B8M
PhylomeDBⁱ	Q8IZE3
TreeFamⁱ	TF313435

Enzyme and pathway databases

SignaLinkⁱ	Q8IZE3

SignaLinkⁱ

Q8IZE3

Miscellaneous databases

ChiTaRSⁱ	SCYL3 human
GeneWikiⁱ	SCYL3
GenomeRNAiⁱ	57147
Protein Ontology More...PROⁱ	PR:Q8IZE3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000000457 Expressed in 208 organ(s), highest expression level in buccal mucosa cell
CleanExⁱ	HS_SCYL3
ExpressionAtlasⁱ	Q8IZE3 baseline and differential
Genevisibleⁱ	Q8IZE3 HS

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR021133 HEAT_type_2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50077 HEAT_REPEAT, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PACE1_HUMAN
Accessionⁱ	Q8IZE3Primary (citable) accession number: Q8IZE3 Secondary accession number(s): A8K8Z2 , Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q8IZE3 (PACE1_HUMAN)

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Protein-associating with the carboxyl-terminal domain of ezrin

SCYL3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Golgi apparatus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ