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UniProtKB - Q8IZE3 (PACE1_HUMAN)
Protein
Protein-associating with the carboxyl-terminal domain of ezrin
Gene
SCYL3
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in regulating cell adhesion/migration complexes in migrating cells.
1 PublicationGO - Molecular functioni
- ATP binding Source: InterPro
- identical protein binding Source: Ensembl
GO - Biological processi
- cell migration Source: UniProtKB
- cellular protein localization Source: Ensembl
- inflammatory response Source: Ensembl
- neuron development Source: Ensembl
- protein phosphorylation Source: InterPro
- spinal cord motor neuron differentiation Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q8IZE3 |
SignaLinki | Q8IZE3 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein-associating with the carboxyl-terminal domain of ezrinAlternative name(s): Ezrin-binding protein PACE-1 SCY1-like protein 3 |
Gene namesi | Name:SCYL3 Synonyms:PACE1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19285, SCYL3 |
MIMi | 608192, gene |
neXtProti | NX_Q8IZE3 |
VEuPathDBi | HostDB:ENSG00000000457 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- lamellipodium 1 Publication
Note: Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB
- lamellipodium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cytoplasm, Golgi apparatusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 – 6 | GSENS → M: No Golgi targeting, accumulates in the cytoplasm. 1 Publication | 5 |
Organism-specific databases
DisGeNETi | 57147 |
OpenTargetsi | ENSG00000000457 |
PharmGKBi | PA142670945 |
Miscellaneous databases
Pharosi | Q8IZE3, Tbio |
Genetic variation databases
BioMutai | SCYL3 |
DMDMi | 61214481 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCurated | |||
ChainiPRO_0000058167 | 2 – 742 | Protein-associating with the carboxyl-terminal domain of ezrinAdd BLAST | 741 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 | |
Modified residuei | 707 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
May be myristoylated; myristoylation may target it to Golgi compartment.1 Publication
Phosphorylated.1 Publication
Keywords - PTMi
Lipoprotein, Myristate, PhosphoproteinProteomic databases
EPDi | Q8IZE3 |
jPOSTi | Q8IZE3 |
MassIVEi | Q8IZE3 |
MaxQBi | Q8IZE3 |
PaxDbi | Q8IZE3 |
PeptideAtlasi | Q8IZE3 |
PRIDEi | Q8IZE3 |
ProteomicsDBi | 71333 [Q8IZE3-1] 71334 [Q8IZE3-2] |
PTM databases
GlyGeni | Q8IZE3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8IZE3 |
PhosphoSitePlusi | Q8IZE3 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000000457, Expressed in buccal mucosa cell and 222 other tissues |
ExpressionAtlasi | Q8IZE3, baseline and differential |
Genevisiblei | Q8IZE3, HS |
Organism-specific databases
HPAi | ENSG00000000457, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with EZR/VIL2 C-terminal domain.
1 PublicationBinary interactionsi
Q8IZE3
With | #Exp. | IntAct |
---|---|---|
EZR [P15311] | 4 | EBI-1380680,EBI-1056902 |
GABARAPL1 [Q9H0R8] | 3 | EBI-1380680,EBI-746969 |
LHX8 [Q68G74] | 3 | EBI-1380680,EBI-8474075 |
TXN2 [Q99757] | 4 | EBI-1380680,EBI-2932492 |
Isoform 2 [Q8IZE3-2]
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 121404, 75 interactors |
IntActi | Q8IZE3, 18 interactors |
MINTi | Q8IZE3 |
STRINGi | 9606.ENSP00000356746 |
Miscellaneous databases
RNActi | Q8IZE3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 245 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 244 | |
Repeati | 199 – 238 | HEAT 1Add BLAST | 40 | |
Repeati | 285 – 323 | HEAT 2Add BLAST | 39 | |
Repeati | 333 – 370 | HEAT 3Add BLAST | 38 | |
Repeati | 372 – 409 | HEAT 4Add BLAST | 38 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 506 – 544 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 548 – 742 | Interaction with EZR1 PublicationAdd BLAST | 195 | |
Regioni | 568 – 598 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 629 – 652 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 723 – 742 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 724 – 742 | Acidic residuesSequence analysisAdd BLAST | 19 |
Domaini
The protein kinase domain is predicted to be catalytically inactive.
Sequence similaritiesi
Belongs to the protein kinase superfamily.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1243, Eukaryota |
GeneTreei | ENSGT00930000151043 |
InParanoidi | Q8IZE3 |
OMAi | WFADMVP |
OrthoDBi | 1074965at2759 |
PhylomeDBi | Q8IZE3 |
TreeFami | TF313435 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR021133, HEAT_type_2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IZE3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSENSALKS YTLREPPFTL PSGLAVYPAV LQDGKFASVF VYKRENEDKV
60 70 80 90 100
NKAAKHLKTL RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSSAEV
110 120 130 140 150
CAGIYDILLA LIFLHDRGHL THNNVCLSSV FVSEDGHWKL GGMETVCKVS
160 170 180 190 200
QATPEFLRSI QSIRDPASIP PEEMSPEFTT LPECHGHARD AFSFGTLVES
210 220 230 240 250
LLTILNEQVS ADVLSSFQQT LHSTLLNPIP KCRPALCTLL SHDFFRNDFL
260 270 280 290 300
EVVNFLKSLT LKSEEEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF
310 320 330 340 350
AEPVAVKSFL PYLLGPKKDH AQGETPCLLS PALFQSRVIP VLLQLFEVHE
360 370 380 390 400
EHVRMVLLSH IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSD SIVAITLHSL
410 420 430 440 450
AVLVSLLGPE VVVGGERTKI FKRTAPSFTK NTDLSLEDSP MCVVCSHHSQ
460 470 480 490 500
ISPILENPFS SIFPKCFFSG STPINSKKHI QRDYYNTLLQ TGDPFSQPIK
510 520 530 540 550
FPINGLSDVK NTSEDSENFP SSSKKSEEWP DWSEPEEPEN QTVNIQIWPR
560 570 580 590 600
EPCDDVKSQC TTLDVEESSW DDCEPSSLDT KVNPGGGITA TKPVTSGEQK
610 620 630 640 650
PIPALLSLTE ESMPWKSSLP QKISLVQRGD DADQIEPPKV SSQERPLKVP
660 670 680 690 700
SELGLGEEFT IQVKKKPVKD PEMDWFADMI PEIKPSAAFL ILPELRTEMV
710 720 730 740
PKKDDVSPVM QFSSKFAAAE ITEGEAEGWE EEGELNWEDN NW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX6RHX1 | X6RHX1_HUMAN | Protein-associating with the carbox... | SCYL3 | 588 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 613 | M → T in AAN23123 (PubMed:12651155).Curated | 1 | |
Sequence conflicti | 613 | M → T in AAN41656 (PubMed:12651155).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051690 | 597 | G → A1 PublicationCorresponds to variant dbSNP:rs12143301Ensembl. | 1 | |
Natural variantiVAR_051691 | 621 | Q → R3 PublicationsCorresponds to variant dbSNP:rs4656197Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013125 | 438 – 491 | Missing in isoform 2. 3 PublicationsAdd BLAST | 54 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF540957 mRNA Translation: AAN23123.1 AY144493 mRNA Translation: AAN41656.1 AL117233 mRNA Translation: CAB55300.1 AK292507 mRNA Translation: BAF85196.1 AL031297 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90867.1 BC014662 mRNA Translation: AAH14662.1 |
CCDSi | CCDS1286.1 [Q8IZE3-2] CCDS1287.1 [Q8IZE3-1] |
RefSeqi | NP_065156.5, NM_020423.6 [Q8IZE3-2] NP_851607.2, NM_181093.3 [Q8IZE3-1] XP_006711528.1, XM_006711465.1 [Q8IZE3-1] XP_011508103.1, XM_011509801.1 [Q8IZE3-1] XP_016857351.1, XM_017001862.1 [Q8IZE3-2] XP_016857352.1, XM_017001863.1 [Q8IZE3-2] |
Genome annotation databases
Ensembli | ENST00000367770; ENSP00000356744; ENSG00000000457 ENST00000367771; ENSP00000356745; ENSG00000000457 [Q8IZE3-2] ENST00000367772; ENSP00000356746; ENSG00000000457 |
GeneIDi | 57147 |
KEGGi | hsa:57147 |
MANE-Selecti | ENST00000367771.11; ENSP00000356745.5; NM_020423.7; NP_065156.5 [Q8IZE3-2] |
UCSCi | uc001ggs.5, human [Q8IZE3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF540957 mRNA Translation: AAN23123.1 AY144493 mRNA Translation: AAN41656.1 AL117233 mRNA Translation: CAB55300.1 AK292507 mRNA Translation: BAF85196.1 AL031297 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90867.1 BC014662 mRNA Translation: AAH14662.1 |
CCDSi | CCDS1286.1 [Q8IZE3-2] CCDS1287.1 [Q8IZE3-1] |
RefSeqi | NP_065156.5, NM_020423.6 [Q8IZE3-2] NP_851607.2, NM_181093.3 [Q8IZE3-1] XP_006711528.1, XM_006711465.1 [Q8IZE3-1] XP_011508103.1, XM_011509801.1 [Q8IZE3-1] XP_016857351.1, XM_017001862.1 [Q8IZE3-2] XP_016857352.1, XM_017001863.1 [Q8IZE3-2] |
3D structure databases
SMRi | Q8IZE3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121404, 75 interactors |
IntActi | Q8IZE3, 18 interactors |
MINTi | Q8IZE3 |
STRINGi | 9606.ENSP00000356746 |
PTM databases
GlyGeni | Q8IZE3, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8IZE3 |
PhosphoSitePlusi | Q8IZE3 |
Genetic variation databases
BioMutai | SCYL3 |
DMDMi | 61214481 |
Proteomic databases
EPDi | Q8IZE3 |
jPOSTi | Q8IZE3 |
MassIVEi | Q8IZE3 |
MaxQBi | Q8IZE3 |
PaxDbi | Q8IZE3 |
PeptideAtlasi | Q8IZE3 |
PRIDEi | Q8IZE3 |
ProteomicsDBi | 71333 [Q8IZE3-1] 71334 [Q8IZE3-2] |
Protocols and materials databases
Antibodypediai | 936, 243 antibodies from 23 providers |
DNASUi | 57147 |
Genome annotation databases
Ensembli | ENST00000367770; ENSP00000356744; ENSG00000000457 ENST00000367771; ENSP00000356745; ENSG00000000457 [Q8IZE3-2] ENST00000367772; ENSP00000356746; ENSG00000000457 |
GeneIDi | 57147 |
KEGGi | hsa:57147 |
MANE-Selecti | ENST00000367771.11; ENSP00000356745.5; NM_020423.7; NP_065156.5 [Q8IZE3-2] |
UCSCi | uc001ggs.5, human [Q8IZE3-1] |
Organism-specific databases
CTDi | 57147 |
DisGeNETi | 57147 |
GeneCardsi | SCYL3 |
HGNCi | HGNC:19285, SCYL3 |
HPAi | ENSG00000000457, Low tissue specificity |
MIMi | 608192, gene |
neXtProti | NX_Q8IZE3 |
OpenTargetsi | ENSG00000000457 |
PharmGKBi | PA142670945 |
VEuPathDBi | HostDB:ENSG00000000457 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1243, Eukaryota |
GeneTreei | ENSGT00930000151043 |
InParanoidi | Q8IZE3 |
OMAi | WFADMVP |
OrthoDBi | 1074965at2759 |
PhylomeDBi | Q8IZE3 |
TreeFami | TF313435 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZE3 |
SignaLinki | Q8IZE3 |
Miscellaneous databases
BioGRID-ORCSi | 57147, 16 hits in 1077 CRISPR screens |
ChiTaRSi | SCYL3, human |
GeneWikii | SCYL3 |
GenomeRNAii | 57147 |
Pharosi | Q8IZE3, Tbio |
PROi | PR:Q8IZE3 |
RNActi | Q8IZE3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000000457, Expressed in buccal mucosa cell and 222 other tissues |
ExpressionAtlasi | Q8IZE3, baseline and differential |
Genevisiblei | Q8IZE3, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR021133, HEAT_type_2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PACE1_HUMAN | |
Accessioni | Q8IZE3Primary (citable) accession number: Q8IZE3 Secondary accession number(s): A8K8Z2 Q9UBK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families