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UniProtKB - Q8IZE3 (PACE1_HUMAN)

Entry version 171 (23 Feb 2022)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Protein-associating with the carboxyl-terminal domain of ezrin

Gene

SCYL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in regulating cell adhesion/migration complexes in migrating cells.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IZE3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IZE3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-associating with the carboxyl-terminal domain of ezrin
Alternative name(s):
Ezrin-binding protein PACE-1
SCY1-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCYL3
Synonyms:PACE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19285, SCYL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608192, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IZE3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000000457

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2 – 6GSENS → M: No Golgi targeting, accumulates in the cytoplasm. 1 Publication5

Organism-specific databases

DisGeNET

More...DisGeNETi		57147

Open Targets

More...OpenTargetsi		ENSG00000000457

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670945

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IZE3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SCYL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		61214481

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCurated
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000581672 – 742Protein-associating with the carboxyl-terminal domain of ezrinAdd BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei439PhosphoserineBy similarity1
Modified residuei707PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be myristoylated; myristoylation may target it to Golgi compartment.1 Publication
Phosphorylated.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IZE3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IZE3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IZE3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IZE3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IZE3

PeptideAtlas

More...PeptideAtlasi		Q8IZE3

PRoteomics IDEntifications database

More...PRIDEi		Q8IZE3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71333 [Q8IZE3-1]
71334 [Q8IZE3-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8IZE3, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IZE3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IZE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000000457, Expressed in buccal mucosa cell and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IZE3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IZE3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000000457, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EZR/VIL2 C-terminal domain.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121404, 75 interactors

Protein interaction database and analysis system

More...IntActi		Q8IZE3, 18 interactors

Molecular INTeraction database

More...MINTi		Q8IZE3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356746

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IZE3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IZE3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 245Protein kinasePROSITE-ProRule annotationAdd BLAST244
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati199 – 238HEAT 1Add BLAST40
Repeati285 – 323HEAT 2Add BLAST39
Repeati333 – 370HEAT 3Add BLAST38
Repeati372 – 409HEAT 4Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni506 – 544DisorderedSequence analysisAdd BLAST39
Regioni548 – 742Interaction with EZR1 PublicationAdd BLAST195
Regioni568 – 598DisorderedSequence analysisAdd BLAST31
Regioni629 – 652DisorderedSequence analysisAdd BLAST24
Regioni723 – 742DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi724 – 742Acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1243, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00930000151043

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IZE3

Identification of Orthologs from Complete Genome Data

More...OMAi		WFADMVP

Database of Orthologous Groups

More...OrthoDBi		1074965at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IZE3

TreeFam database of animal gene trees

More...TreeFami		TF313435

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR021133, HEAT_type_2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50077, HEAT_REPEAT, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IZE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSENSALKS YTLREPPFTL PSGLAVYPAV LQDGKFASVF VYKRENEDKV 
        60         70         80         90        100
NKAAKHLKTL RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSSAEV 
       110        120        130        140        150
CAGIYDILLA LIFLHDRGHL THNNVCLSSV FVSEDGHWKL GGMETVCKVS 
       160        170        180        190        200
QATPEFLRSI QSIRDPASIP PEEMSPEFTT LPECHGHARD AFSFGTLVES 
       210        220        230        240        250
LLTILNEQVS ADVLSSFQQT LHSTLLNPIP KCRPALCTLL SHDFFRNDFL 
       260        270        280        290        300
EVVNFLKSLT LKSEEEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF 
       310        320        330        340        350
AEPVAVKSFL PYLLGPKKDH AQGETPCLLS PALFQSRVIP VLLQLFEVHE 
       360        370        380        390        400
EHVRMVLLSH IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSD SIVAITLHSL 
       410        420        430        440        450
AVLVSLLGPE VVVGGERTKI FKRTAPSFTK NTDLSLEDSP MCVVCSHHSQ 
       460        470        480        490        500
ISPILENPFS SIFPKCFFSG STPINSKKHI QRDYYNTLLQ TGDPFSQPIK 
       510        520        530        540        550
FPINGLSDVK NTSEDSENFP SSSKKSEEWP DWSEPEEPEN QTVNIQIWPR 
       560        570        580        590        600
EPCDDVKSQC TTLDVEESSW DDCEPSSLDT KVNPGGGITA TKPVTSGEQK 
       610        620        630        640        650
PIPALLSLTE ESMPWKSSLP QKISLVQRGD DADQIEPPKV SSQERPLKVP 
       660        670        680        690        700
SELGLGEEFT IQVKKKPVKD PEMDWFADMI PEIKPSAAFL ILPELRTEMV 
       710        720        730        740 
PKKDDVSPVM QFSSKFAAAE ITEGEAEGWE EEGELNWEDN NW
Length:742
Mass (Da):82,857
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F7D03681A4F641B
GO
Isoform 2 (identifier: Q8IZE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-491: Missing.

Show »
Length:688
Mass (Da):76,731
Checksum:i96DCB00F38A7F928
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RHX1X6RHX1_HUMAN
Protein-associating with the carbox...
SCYL3
588Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti613M → T in AAN23123 (PubMed:12651155).Curated1
Sequence conflicti613M → T in AAN41656 (PubMed:12651155).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051690597G → A1 PublicationCorresponds to variant dbSNP:rs12143301Ensembl.1
Natural variantiVAR_051691621Q → R3 PublicationsCorresponds to variant dbSNP:rs4656197Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013125438 – 491Missing in isoform 2. 3 PublicationsAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF540957 mRNA Translation: AAN23123.1
AY144493 mRNA Translation: AAN41656.1
AL117233 mRNA Translation: CAB55300.1
AK292507 mRNA Translation: BAF85196.1
AL031297 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90867.1
BC014662 mRNA Translation: AAH14662.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1286.1 [Q8IZE3-2]
CCDS1287.1 [Q8IZE3-1]

NCBI Reference Sequences

More...RefSeqi		NP_065156.5, NM_020423.6 [Q8IZE3-2]
NP_851607.2, NM_181093.3 [Q8IZE3-1]
XP_006711528.1, XM_006711465.1 [Q8IZE3-1]
XP_011508103.1, XM_011509801.1 [Q8IZE3-1]
XP_016857351.1, XM_017001862.1 [Q8IZE3-2]
XP_016857352.1, XM_017001863.1 [Q8IZE3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367770; ENSP00000356744; ENSG00000000457
ENST00000367771; ENSP00000356745; ENSG00000000457 [Q8IZE3-2]
ENST00000367772; ENSP00000356746; ENSG00000000457

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57147

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57147

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000367771.11; ENSP00000356745.5; NM_020423.7; NP_065156.5 [Q8IZE3-2]

UCSC genome browser

More...UCSCi		uc001ggs.5, human [Q8IZE3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540957 mRNA Translation: AAN23123.1
AY144493 mRNA Translation: AAN41656.1
AL117233 mRNA Translation: CAB55300.1
AK292507 mRNA Translation: BAF85196.1
AL031297 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90867.1
BC014662 mRNA Translation: AAH14662.1
CCDSiCCDS1286.1 [Q8IZE3-2]
CCDS1287.1 [Q8IZE3-1]
RefSeqiNP_065156.5, NM_020423.6 [Q8IZE3-2]
NP_851607.2, NM_181093.3 [Q8IZE3-1]
XP_006711528.1, XM_006711465.1 [Q8IZE3-1]
XP_011508103.1, XM_011509801.1 [Q8IZE3-1]
XP_016857351.1, XM_017001862.1 [Q8IZE3-2]
XP_016857352.1, XM_017001863.1 [Q8IZE3-2]

3D structure databases

SMRiQ8IZE3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121404, 75 interactors
IntActiQ8IZE3, 18 interactors
MINTiQ8IZE3
STRINGi9606.ENSP00000356746

PTM databases

GlyGeniQ8IZE3, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ8IZE3
PhosphoSitePlusiQ8IZE3

Genetic variation databases

BioMutaiSCYL3
DMDMi61214481

Proteomic databases

EPDiQ8IZE3
jPOSTiQ8IZE3
MassIVEiQ8IZE3
MaxQBiQ8IZE3
PaxDbiQ8IZE3
PeptideAtlasiQ8IZE3
PRIDEiQ8IZE3
ProteomicsDBi71333 [Q8IZE3-1]
71334 [Q8IZE3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		936, 243 antibodies from 23 providers

The DNASU plasmid repository

More...DNASUi		57147

Genome annotation databases

EnsembliENST00000367770; ENSP00000356744; ENSG00000000457
ENST00000367771; ENSP00000356745; ENSG00000000457 [Q8IZE3-2]
ENST00000367772; ENSP00000356746; ENSG00000000457
GeneIDi57147
KEGGihsa:57147
MANE-SelectiENST00000367771.11; ENSP00000356745.5; NM_020423.7; NP_065156.5 [Q8IZE3-2]
UCSCiuc001ggs.5, human [Q8IZE3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57147
DisGeNETi57147

GeneCards: human genes, protein and diseases

More...GeneCardsi		SCYL3
HGNCiHGNC:19285, SCYL3
HPAiENSG00000000457, Low tissue specificity
MIMi608192, gene
neXtProtiNX_Q8IZE3
OpenTargetsiENSG00000000457
PharmGKBiPA142670945
VEuPathDBiHostDB:ENSG00000000457

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1243, Eukaryota
GeneTreeiENSGT00930000151043
InParanoidiQ8IZE3
OMAiWFADMVP
OrthoDBi1074965at2759
PhylomeDBiQ8IZE3
TreeFamiTF313435

Enzyme and pathway databases

PathwayCommonsiQ8IZE3
SignaLinkiQ8IZE3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57147, 16 hits in 1077 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SCYL3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SCYL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57147
PharosiQ8IZE3, Tbio

Protein Ontology

More...PROi		PR:Q8IZE3
RNActiQ8IZE3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000000457, Expressed in buccal mucosa cell and 222 other tissues
ExpressionAtlasiQ8IZE3, baseline and differential
GenevisibleiQ8IZE3, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR021133, HEAT_type_2
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50077, HEAT_REPEAT, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPACE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IZE3
Secondary accession number(s): A8K8Z2
, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: February 23, 2022
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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