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Protein

Dedicator of cytokinesis protein 3

Gene

DOCK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-9032759 NTRK2 activates RAC1
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 3
Alternative name(s):
Modifier of cell adhesion
Presenilin-binding protein
Short name:
PBP
Gene namesi
Name:DOCK3
Synonyms:KIAA0299, MOCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000088538.12
HGNCiHGNC:2989 DOCK3
MIMi603123 gene
neXtProtiNX_Q8IZD9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9.1 Publication

Organism-specific databases

DisGeNETi1795
OpenTargetsiENSG00000088538
PharmGKBiPA27455

Polymorphism and mutation databases

BioMutaiDOCK3
DMDMi32469734

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001899881 – 2030Dedicator of cytokinesis protein 3Add BLAST2030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1658PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IZD9
PaxDbiQ8IZD9
PeptideAtlasiQ8IZD9
PRIDEiQ8IZD9
ProteomicsDBi71332

PTM databases

iPTMnetiQ8IZD9
PhosphoSitePlusiQ8IZD9

Expressioni

Tissue specificityi

In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.1 Publication

Gene expression databases

BgeeiENSG00000088538 Expressed in 140 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_DOCK3
GenevisibleiQ8IZD9 HS

Organism-specific databases

HPAiHPA037543
HPA037544

Interactioni

Subunit structurei

Interacts with presenilin proteins PSEN1 and PSEN2. Interacts with CRK (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1752361,EBI-389883

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108130, 6 interactors
IntActiQ8IZD9, 9 interactors
STRINGi9606.ENSP00000266037

Structurei

3D structure databases

ProteinModelPortaliQ8IZD9
SMRiQ8IZD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 67SH3PROSITE-ProRule annotationAdd BLAST62
Domaini421 – 599DHR-1PROSITE-ProRule annotationAdd BLAST179
Domaini1228 – 1635DHR-2PROSITE-ProRule annotationAdd BLAST408

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1970 – 1976SH3-bindingSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1731 – 1768Ser-richAdd BLAST38

Domaini

The DHR-2 domain may mediate some GEF activity.By similarity

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00610000085806
HOGENOMiHOG000006631
HOVERGENiHBG051389
InParanoidiQ8IZD9
KOiK05727
OMAiXQYETVV
OrthoDBiEOG091G00Q4
PhylomeDBiQ8IZD9
TreeFamiTF300423

Family and domain databases

CDDicd08695 C2_Dock-B, 1 hit
cd12048 SH3_DOCK3_B, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037811 C2_Dock-B
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR026800 DOCK3
IPR035767 DOCK3_SH3
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PTHR23317:SF66 PTHR23317:SF66, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IZD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTPTEEEKY GVVICSFRGS VPQGLVLEIG ETVQILEKCE GWYRGVSTKK
60 70 80 90 100
PNVKGIFPAN YIHLKKAIVS NRGQYETVVP LEDSIVTEVT ATLQEWASLW
110 120 130 140 150
KQLYVKHKVD LFYKLRHVMN ELIDLRRQLL SGHLTQDQVR EVKRHITVRL
160 170 180 190 200
DWGNEHLGLD LVPRKDFEVV DSDQISVSDL YKMHLSSRQS VQQSTSQVDT
210 220 230 240 250
MRPRHGETCR MPVPHHFFLS LKSFTYNTIG EDTDVFFSLY DMREGKQISE
260 270 280 290 300
RFLVRLNKNG GPRNPEKIER MCALFTDLSS KDMKRDLYIV AHVIRIGRML
310 320 330 340 350
LNDSKKGPPH LHYRRPYGCA VLSILDVLQS LTEVKEEKDF VLKVYTCNNE
360 370 380 390 400
SEWSQIHENI IRKSSAKYSA PSASHGLIIS LQLLRGDMEQ IRRENPMIFN
410 420 430 440 450
RGLAITRKLG FPDVIMPGDI RNDLYLTLEK GDFERGGKSV QKNIEVTMYV
460 470 480 490 500
LYADGEILKD CISLGSGEPN RSSYHSFVLY HSNSPRWGEI IKLPIPIDRF
510 520 530 540 550
RGSHLRFEFR HCSTKDKGEK KLFGFAFSTL MRDDGTTLSD DIHELYVYKC
560 570 580 590 600
DENSTFNNHA LYLGLPCCKE DYNGCPNIPS SLIFQRSTKE SFFISTQLSS
610 620 630 640 650
TKLTQNVDLL ALLKWKAFPD RIMDVLGRLR HVSGEEIVKF LQDILDTLFV
660 670 680 690 700
ILDDNTEKYG LLVFQSLVFI INLLRDIKYF HFRPVMDTYI QKHFAGALAY
710 720 730 740 750
KELIRCLKWY MDCSAELIRQ DHIQEAMRAL EYLFKFIVQS RILYSRATCG
760 770 780 790 800
MEEEQFRSSI QELFQSIRFV LSLDSRNSET LLFTQAALLN SFPTIFDELL
810 820 830 840 850
QMFTVQEVAE FVRGTLGSMP STVHIGQSMD VVKLQSIART VDSRLFSFSE
860 870 880 890 900
SRRILLPVVL HHIHLHLRQQ KELLICSGIL GSIFSIVKTS SLEADVMEEV
910 920 930 940 950
EMMVESLLDV LLQTLLTIMS KSHAQEAVRG QRCPQCTAEI TGEYVSCLLS
960 970 980 990 1000
LLRQMCDTHF QHLLDNFQSK DELKEFLLKI FCVFRNLMKM SVFPRDWMVM
1010 1020 1030 1040 1050
RLLTSNIIVT TVQYLSSALH KNFTETDFDF KVWNSYFSLA VLFINQPSLQ
1060 1070 1080 1090 1100
LEIITSAKRK KILDKYGDMR VMMAYELFSM WQNLGEHKIH FIPGMIGPFL
1110 1120 1130 1140 1150
GVTLVPQPEV RNIMIPIFHD MMDWEQRKNG NFKQVEAELI DKLDSMVSEG
1160 1170 1180 1190 1200
KGDESYRELF SLLTQLFGPY PSLLEKVEQE TWRETGISFV TSVTRLMERL
1210 1220 1230 1240 1250
LDYRDCMKGE ETENKKIGCT VNLMNFYKSE INKEEMYIRY IHKLCDMHLQ
1260 1270 1280 1290 1300
AENYTEAAFT LLLYCELLQW EDRPLREFLH YPSQTEWQRK EGLCRKIIHY
1310 1320 1330 1340 1350
FNKGKSWEFG IPLCRELACQ YESLYDYQSL SWIRKMEASY YDNIMEQQRL
1360 1370 1380 1390 1400
EPEFFRVGFY GRKFPFFLRN KEYVCRGHDY ERLEAFQQRM LSEFPQAVAM
1410 1420 1430 1440 1450
QHPNHPDDAI LQCDAQYLQI YAVTPIPDYV DVLQMDRVPD RVKSFYRVNN
1460 1470 1480 1490 1500
VRKFRYDRPF HKGPKDKENE FKSLWIERTT LTLTHSLPGI SRWFEVERRE
1510 1520 1530 1540 1550
LVEVSPLENA IQVVENKNQE LRSLISQYQH KQVHGNINLL SMCLNGVIDA
1560 1570 1580 1590 1600
AVNGGIARYQ EAFFDKDYIN KHPGDAEKIT QLKELMQEQV HVLGVGLAVH
1610 1620 1630 1640 1650
EKFVHPEMRP LHKKLIDQFQ MMRASLYHEF PGLDKLSPAC SGTSTPRGNV
1660 1670 1680 1690 1700
LASHSPMSPE SIKMTHRHSP MNLMGTGRHS SSSLSSHASS EAGNMVMLGD
1710 1720 1730 1740 1750
GSMGDAPEDL YHHMQLAYPN PRYQGSVTNV SVLSSSQASP SSSSLSSTHS
1760 1770 1780 1790 1800
APSQMITSAP SSARGSPSLP DKYRHAREMM LLLPTYRDRP SSAMYPAAIL
1810 1820 1830 1840 1850
ENGQPPNFQR ALFQQVVGAC KPCSDPNLSV AEKGHYSLHF DAFHHPLGDT
1860 1870 1880 1890 1900
PPALPARTLR KSPLHPIPAS PTSPQSGLDG SNSTLSGSAS SGVSSLSESN
1910 1920 1930 1940 1950
FGHSSEAPPR TDTMDSMPSQ AWNADEDLEP PYLPVHYSLS ESAVLDSIKA
1960 1970 1980 1990 2000
QPCRSHSAPG CVIPQDPMDP PALPPKPYHP RLPALEHDEG VLLREETERP
2010 2020 2030
RGLHRKAPLP PGSAKEEQAR MAWEHGRGEQ
Length:2,030
Mass (Da):233,103
Last modified:March 1, 2003 - v1
Checksum:iFF87E874B926C1C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145303 mRNA Translation: AAN12301.1
AY254099 mRNA Translation: AAP80572.1
AB002297 mRNA Translation: BAA20759.1
CCDSiCCDS46835.1
RefSeqiNP_004938.1, NM_004947.4
UniGeneiHs.476284

Genome annotation databases

EnsembliENST00000266037; ENSP00000266037; ENSG00000088538
GeneIDi1795
KEGGihsa:1795
UCSCiuc011bds.2 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145303 mRNA Translation: AAN12301.1
AY254099 mRNA Translation: AAP80572.1
AB002297 mRNA Translation: BAA20759.1
CCDSiCCDS46835.1
RefSeqiNP_004938.1, NM_004947.4
UniGeneiHs.476284

3D structure databases

ProteinModelPortaliQ8IZD9
SMRiQ8IZD9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108130, 6 interactors
IntActiQ8IZD9, 9 interactors
STRINGi9606.ENSP00000266037

PTM databases

iPTMnetiQ8IZD9
PhosphoSitePlusiQ8IZD9

Polymorphism and mutation databases

BioMutaiDOCK3
DMDMi32469734

Proteomic databases

MaxQBiQ8IZD9
PaxDbiQ8IZD9
PeptideAtlasiQ8IZD9
PRIDEiQ8IZD9
ProteomicsDBi71332

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266037; ENSP00000266037; ENSG00000088538
GeneIDi1795
KEGGihsa:1795
UCSCiuc011bds.2 human

Organism-specific databases

CTDi1795
DisGeNETi1795
EuPathDBiHostDB:ENSG00000088538.12
GeneCardsiDOCK3
HGNCiHGNC:2989 DOCK3
HPAiHPA037543
HPA037544
MIMi603123 gene
neXtProtiNX_Q8IZD9
OpenTargetsiENSG00000088538
PharmGKBiPA27455
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00610000085806
HOGENOMiHOG000006631
HOVERGENiHBG051389
InParanoidiQ8IZD9
KOiK05727
OMAiXQYETVV
OrthoDBiEOG091G00Q4
PhylomeDBiQ8IZD9
TreeFamiTF300423

Enzyme and pathway databases

ReactomeiR-HSA-9032759 NTRK2 activates RAC1
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRSiDOCK3 human
GeneWikiiDock3
GenomeRNAii1795
PROiPR:Q8IZD9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088538 Expressed in 140 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_DOCK3
GenevisibleiQ8IZD9 HS

Family and domain databases

CDDicd08695 C2_Dock-B, 1 hit
cd12048 SH3_DOCK3_B, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037811 C2_Dock-B
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR026800 DOCK3
IPR035767 DOCK3_SH3
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PTHR23317:SF66 PTHR23317:SF66, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDOCK3_HUMAN
AccessioniPrimary (citable) accession number: Q8IZD9
Secondary accession number(s): O15017
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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