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UniProtKB - Q8IZD9 (DOCK3_HUMAN)

Protein

Dedicator of cytokinesis protein 3

Gene

DOCK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-9032759 NTRK2 activates RAC1
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Dedicator of cytokinesis protein 3
Alternative name(s):
Modifier of cell adhesion
Presenilin-binding protein
Short name:
PBP
Gene namesi
Name:DOCK3
Synonyms:KIAA0299, MOCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000088538.12
HGNCiHGNC:2989 DOCK3
MIMi603123 gene
neXtProtiNX_Q8IZD9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9.1 Publication

Organism-specific databases

DisGeNETi1795
OpenTargetsiENSG00000088538
PharmGKBiPA27455

Polymorphism and mutation databases

BioMutaiDOCK3
DMDMi32469734

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001899881 – 2030Dedicator of cytokinesis protein 3Add BLAST2030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1658PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IZD9
PaxDbiQ8IZD9
PeptideAtlasiQ8IZD9
PRIDEiQ8IZD9
ProteomicsDBi71332

PTM databases

iPTMnetiQ8IZD9
PhosphoSitePlusiQ8IZD9

Expressioni

Tissue specificityi

In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.1 Publication

Gene expression databases

BgeeiENSG00000088538 Expressed in 140 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_DOCK3
GenevisibleiQ8IZD9 HS

Organism-specific databases

HPAiHPA037543
HPA037544

Interactioni

Subunit structurei

Interacts with presenilin proteins PSEN1 and PSEN2. Interacts with CRK (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1752361,EBI-389883

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi108130, 6 interactors
IntActiQ8IZD9, 9 interactors
STRINGi9606.ENSP00000266037

Structurei

3D structure databases

ProteinModelPortaliQ8IZD9
SMRiQ8IZD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 67SH3PROSITE-ProRule annotationAdd BLAST62
Domaini421 – 599DHR-1PROSITE-ProRule annotationAdd BLAST179
Domaini1228 – 1635DHR-2PROSITE-ProRule annotationAdd BLAST408

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1970 – 1976SH3-bindingSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1731 – 1768Ser-richAdd BLAST38

Domaini

The DHR-2 domain may mediate some GEF activity.By similarity

Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, SH3-binding

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00610000085806
HOGENOMiHOG000006631
HOVERGENiHBG051389
InParanoidiQ8IZD9
KOiK05727
OMAiXQYETVV
OrthoDBiEOG091G00Q4
PhylomeDBiQ8IZD9
TreeFamiTF300423

Family and domain databases

CDDicd08695 C2_Dock-B, 1 hit
cd12048 SH3_DOCK3_B, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037811 C2_Dock-B
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR026800 DOCK3
IPR035767 DOCK3_SH3
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PTHR23317:SF66 PTHR23317:SF66, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IZD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTPTEEEKY GVVICSFRGS VPQGLVLEIG ETVQILEKCE GWYRGVSTKK 
        60         70         80         90        100
PNVKGIFPAN YIHLKKAIVS NRGQYETVVP LEDSIVTEVT ATLQEWASLW 
       110        120        130        140        150
KQLYVKHKVD LFYKLRHVMN ELIDLRRQLL SGHLTQDQVR EVKRHITVRL 
       160        170        180        190        200
DWGNEHLGLD LVPRKDFEVV DSDQISVSDL YKMHLSSRQS VQQSTSQVDT 
       210        220        230        240        250
MRPRHGETCR MPVPHHFFLS LKSFTYNTIG EDTDVFFSLY DMREGKQISE 
       260        270        280        290        300
RFLVRLNKNG GPRNPEKIER MCALFTDLSS KDMKRDLYIV AHVIRIGRML 
       310        320        330        340        350
LNDSKKGPPH LHYRRPYGCA VLSILDVLQS LTEVKEEKDF VLKVYTCNNE 
       360        370        380        390        400
SEWSQIHENI IRKSSAKYSA PSASHGLIIS LQLLRGDMEQ IRRENPMIFN 
       410        420        430        440        450
RGLAITRKLG FPDVIMPGDI RNDLYLTLEK GDFERGGKSV QKNIEVTMYV 
       460        470        480        490        500
LYADGEILKD CISLGSGEPN RSSYHSFVLY HSNSPRWGEI IKLPIPIDRF 
       510        520        530        540        550
RGSHLRFEFR HCSTKDKGEK KLFGFAFSTL MRDDGTTLSD DIHELYVYKC 
       560        570        580        590        600
DENSTFNNHA LYLGLPCCKE DYNGCPNIPS SLIFQRSTKE SFFISTQLSS 
       610        620        630        640        650
TKLTQNVDLL ALLKWKAFPD RIMDVLGRLR HVSGEEIVKF LQDILDTLFV 
       660        670        680        690        700
ILDDNTEKYG LLVFQSLVFI INLLRDIKYF HFRPVMDTYI QKHFAGALAY 
       710        720        730        740        750
KELIRCLKWY MDCSAELIRQ DHIQEAMRAL EYLFKFIVQS RILYSRATCG 
       760        770        780        790        800
MEEEQFRSSI QELFQSIRFV LSLDSRNSET LLFTQAALLN SFPTIFDELL 
       810        820        830        840        850
QMFTVQEVAE FVRGTLGSMP STVHIGQSMD VVKLQSIART VDSRLFSFSE 
       860        870        880        890        900
SRRILLPVVL HHIHLHLRQQ KELLICSGIL GSIFSIVKTS SLEADVMEEV 
       910        920        930        940        950
EMMVESLLDV LLQTLLTIMS KSHAQEAVRG QRCPQCTAEI TGEYVSCLLS 
       960        970        980        990       1000
LLRQMCDTHF QHLLDNFQSK DELKEFLLKI FCVFRNLMKM SVFPRDWMVM 
      1010       1020       1030       1040       1050
RLLTSNIIVT TVQYLSSALH KNFTETDFDF KVWNSYFSLA VLFINQPSLQ 
      1060       1070       1080       1090       1100
LEIITSAKRK KILDKYGDMR VMMAYELFSM WQNLGEHKIH FIPGMIGPFL 
      1110       1120       1130       1140       1150
GVTLVPQPEV RNIMIPIFHD MMDWEQRKNG NFKQVEAELI DKLDSMVSEG 
      1160       1170       1180       1190       1200
KGDESYRELF SLLTQLFGPY PSLLEKVEQE TWRETGISFV TSVTRLMERL 
      1210       1220       1230       1240       1250
LDYRDCMKGE ETENKKIGCT VNLMNFYKSE INKEEMYIRY IHKLCDMHLQ 
      1260       1270       1280       1290       1300
AENYTEAAFT LLLYCELLQW EDRPLREFLH YPSQTEWQRK EGLCRKIIHY 
      1310       1320       1330       1340       1350
FNKGKSWEFG IPLCRELACQ YESLYDYQSL SWIRKMEASY YDNIMEQQRL 
      1360       1370       1380       1390       1400
EPEFFRVGFY GRKFPFFLRN KEYVCRGHDY ERLEAFQQRM LSEFPQAVAM 
      1410       1420       1430       1440       1450
QHPNHPDDAI LQCDAQYLQI YAVTPIPDYV DVLQMDRVPD RVKSFYRVNN 
      1460       1470       1480       1490       1500
VRKFRYDRPF HKGPKDKENE FKSLWIERTT LTLTHSLPGI SRWFEVERRE 
      1510       1520       1530       1540       1550
LVEVSPLENA IQVVENKNQE LRSLISQYQH KQVHGNINLL SMCLNGVIDA 
      1560       1570       1580       1590       1600
AVNGGIARYQ EAFFDKDYIN KHPGDAEKIT QLKELMQEQV HVLGVGLAVH 
      1610       1620       1630       1640       1650
EKFVHPEMRP LHKKLIDQFQ MMRASLYHEF PGLDKLSPAC SGTSTPRGNV 
      1660       1670       1680       1690       1700
LASHSPMSPE SIKMTHRHSP MNLMGTGRHS SSSLSSHASS EAGNMVMLGD 
      1710       1720       1730       1740       1750
GSMGDAPEDL YHHMQLAYPN PRYQGSVTNV SVLSSSQASP SSSSLSSTHS 
      1760       1770       1780       1790       1800
APSQMITSAP SSARGSPSLP DKYRHAREMM LLLPTYRDRP SSAMYPAAIL 
      1810       1820       1830       1840       1850
ENGQPPNFQR ALFQQVVGAC KPCSDPNLSV AEKGHYSLHF DAFHHPLGDT 
      1860       1870       1880       1890       1900
PPALPARTLR KSPLHPIPAS PTSPQSGLDG SNSTLSGSAS SGVSSLSESN 
      1910       1920       1930       1940       1950
FGHSSEAPPR TDTMDSMPSQ AWNADEDLEP PYLPVHYSLS ESAVLDSIKA 
      1960       1970       1980       1990       2000
QPCRSHSAPG CVIPQDPMDP PALPPKPYHP RLPALEHDEG VLLREETERP 
      2010       2020       2030
RGLHRKAPLP PGSAKEEQAR MAWEHGRGEQ
Length:2,030
Mass (Da):233,103
Last modified:March 1, 2003 - v1
Checksum:iFF87E874B926C1C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145303 mRNA Translation: AAN12301.1
AY254099 mRNA Translation: AAP80572.1
AB002297 mRNA Translation: BAA20759.1
CCDSiCCDS46835.1
RefSeqiNP_004938.1, NM_004947.4
UniGeneiHs.476284

Genome annotation databases

EnsembliENST00000266037; ENSP00000266037; ENSG00000088538
GeneIDi1795
KEGGihsa:1795
UCSCiuc011bds.2 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145303 mRNA Translation: AAN12301.1
AY254099 mRNA Translation: AAP80572.1
AB002297 mRNA Translation: BAA20759.1
CCDSiCCDS46835.1
RefSeqiNP_004938.1, NM_004947.4
UniGeneiHs.476284

3D structure databases

ProteinModelPortaliQ8IZD9
SMRiQ8IZD9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108130, 6 interactors
IntActiQ8IZD9, 9 interactors
STRINGi9606.ENSP00000266037

PTM databases

iPTMnetiQ8IZD9
PhosphoSitePlusiQ8IZD9

Polymorphism and mutation databases

BioMutaiDOCK3
DMDMi32469734

Proteomic databases

MaxQBiQ8IZD9
PaxDbiQ8IZD9
PeptideAtlasiQ8IZD9
PRIDEiQ8IZD9
ProteomicsDBi71332

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266037; ENSP00000266037; ENSG00000088538
GeneIDi1795
KEGGihsa:1795
UCSCiuc011bds.2 human

Organism-specific databases

CTDi1795
DisGeNETi1795
EuPathDBiHostDB:ENSG00000088538.12
GeneCardsiDOCK3
HGNCiHGNC:2989 DOCK3
HPAiHPA037543
HPA037544
MIMi603123 gene
neXtProtiNX_Q8IZD9
OpenTargetsiENSG00000088538
PharmGKBiPA27455
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00610000085806
HOGENOMiHOG000006631
HOVERGENiHBG051389
InParanoidiQ8IZD9
KOiK05727
OMAiXQYETVV
OrthoDBiEOG091G00Q4
PhylomeDBiQ8IZD9
TreeFamiTF300423

Enzyme and pathway databases

ReactomeiR-HSA-9032759 NTRK2 activates RAC1
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRSiDOCK3 human
GeneWikiiDock3
GenomeRNAii1795
PROiPR:Q8IZD9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088538 Expressed in 140 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_DOCK3
GenevisibleiQ8IZD9 HS

Family and domain databases

CDDicd08695 C2_Dock-B, 1 hit
cd12048 SH3_DOCK3_B, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037811 C2_Dock-B
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR026800 DOCK3
IPR035767 DOCK3_SH3
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PTHR23317:SF66 PTHR23317:SF66, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDOCK3_HUMAN
AccessioniPrimary (citable) accession number: Q8IZD9
Secondary accession number(s): O15017
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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