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Protein

Solute carrier family 22 member 15

Gene

SLC22A15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.By similarity1 Publication

GO - Molecular functioni

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-549127 Organic cation transport

Protein family/group databases

TCDBi2.A.1.19.32 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 15
Alternative name(s):
Fly-like putative transporter 1
Short name:
Flipt 1
Gene namesi
Name:SLC22A15
Synonyms:FLIPT1
ORF Names:UNQ9429/PRO34686
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163393.12
HGNCiHGNC:20301 SLC22A15
MIMi608275 gene
neXtProtiNX_Q8IZD6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei165 – 187HelicalSequence analysisAdd BLAST23
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Transmembranei401 – 420HelicalSequence analysisAdd BLAST20
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55356
OpenTargetsiENSG00000163393
PharmGKBiPA134870374

Polymorphism and mutation databases

BioMutaiSLC22A15
DMDMi74750790

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003386191 – 547Solute carrier family 22 member 15Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8IZD6
PaxDbiQ8IZD6
PeptideAtlasiQ8IZD6
PRIDEiQ8IZD6
ProteomicsDBi71330
71331 [Q8IZD6-2]

PTM databases

iPTMnetiQ8IZD6
PhosphoSitePlusiQ8IZD6

Expressioni

Tissue specificityi

Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.2 Publications

Developmental stagei

Expressed at low levels at 20-25 weeks of gestation in fetal brain, lung, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000163393 Expressed in 158 organ(s), highest expression level in corpus callosum
CleanExiHS_SLC22A15
GenevisibleiQ8IZD6 HS

Organism-specific databases

HPAiHPA019785

Interactioni

Protein-protein interaction databases

BioGridi120636, 20 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8IZD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi529 – 535Poly-Glu7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI2 Eukaryota
ENOG4110YHH LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG108435
InParanoidiQ8IZD6
KOiK08211
OMAiDLFRYRI
OrthoDBiEOG091G05DV
PhylomeDBiQ8IZD6
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IZD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVEEAFQAV GEMGIYQMYL CFLLAVLLQL YVATEAILIA LVGATPSYHW
60 70 80 90 100
DLAELLPNQS HGNQSAGEDQ AFGDWLLTAN GSEIHKHVHF SSSFTSIASE
110 120 130 140 150
WFLIANRSYK VSAASSFFFS GVFVGVISFG QLSDRFGRKK VYLTGFALDI
160 170 180 190 200
LFAIANGFSP SYEFFAVTRF LVGMMNGGMS LVAFVLLNEC VGTAYWALAG
210 220 230 240 250
SIGGLFFAVG IAQYALLGYF IRSWRTLAIL VNLQGTVVFL LSLFIPESPR
260 270 280 290 300
WLYSQGRLSE AEEALYLIAK RNRKLKCTFS LTHPANRSCR ETGSFLDLFR
310 320 330 340 350
YRVLLGHTLI LMFIWFVCSL VYYGLTLSAG DLGGSIYANL ALSGLIEIPS
360 370 380 390 400
YPLCIYLINQ KWFGRKRTLS AFLCLGGLAC LIVMFLPEKK DTGVFAVVNS
410 420 430 440 450
HSLSLLGKLT ISAAFNIVYI YTSELYPTVI RNVGLGTCSM FSRVGGIIAP
460 470 480 490 500
FIPSLKYVQW SLPFIVFGAT GLTSGLLSLL LPETLNSPLL ETFSDLQVYS
510 520 530 540
YRRLGEEALS LQALDPQQCV DKESSLGSES EEEEEFYDAD EETQMIK
Length:547
Mass (Da):60,540
Last modified:March 1, 2003 - v1
Checksum:iAFE2EEA64B7FFDBC
GO
Isoform 2 (identifier: Q8IZD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-245: FI → VD
     246-547: Missing.

Show »
Length:245
Mass (Da):26,794
Checksum:i628B254C0C1C95FD
GO

Sequence cautioni

The sequence AAH26358 differs from that shown. Reason: Frameshift at position 7.Curated
The sequence AAH26358 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043813349P → Q1 PublicationCorresponds to variant dbSNP:rs17852419Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034059244 – 245FI → VD in isoform 2. 1 Publication2
Alternative sequenceiVSP_034060246 – 547Missing in isoform 2. 1 PublicationAdd BLAST302

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145501 mRNA Translation: AAN52927.1
AY358258 mRNA Translation: AAQ88625.1
AL357137 Genomic DNA No translation available.
AL365318 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56640.1
BC026358 mRNA Translation: AAH26358.1 Sequence problems.
AL353933 mRNA Translation: CAB89246.1
CCDSiCCDS44198.1 [Q8IZD6-1]
PIRiT48683
RefSeqiNP_060890.2, NM_018420.2 [Q8IZD6-1]
UniGeneiHs.125482

Genome annotation databases

EnsembliENST00000369502; ENSP00000358514; ENSG00000163393 [Q8IZD6-2]
ENST00000369503; ENSP00000358515; ENSG00000163393 [Q8IZD6-1]
GeneIDi55356
KEGGihsa:55356
UCSCiuc001ega.3 human [Q8IZD6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145501 mRNA Translation: AAN52927.1
AY358258 mRNA Translation: AAQ88625.1
AL357137 Genomic DNA No translation available.
AL365318 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56640.1
BC026358 mRNA Translation: AAH26358.1 Sequence problems.
AL353933 mRNA Translation: CAB89246.1
CCDSiCCDS44198.1 [Q8IZD6-1]
PIRiT48683
RefSeqiNP_060890.2, NM_018420.2 [Q8IZD6-1]
UniGeneiHs.125482

3D structure databases

ProteinModelPortaliQ8IZD6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120636, 20 interactors

Protein family/group databases

TCDBi2.A.1.19.32 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ8IZD6
PhosphoSitePlusiQ8IZD6

Polymorphism and mutation databases

BioMutaiSLC22A15
DMDMi74750790

Proteomic databases

EPDiQ8IZD6
PaxDbiQ8IZD6
PeptideAtlasiQ8IZD6
PRIDEiQ8IZD6
ProteomicsDBi71330
71331 [Q8IZD6-2]

Protocols and materials databases

DNASUi55356
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369502; ENSP00000358514; ENSG00000163393 [Q8IZD6-2]
ENST00000369503; ENSP00000358515; ENSG00000163393 [Q8IZD6-1]
GeneIDi55356
KEGGihsa:55356
UCSCiuc001ega.3 human [Q8IZD6-1]

Organism-specific databases

CTDi55356
DisGeNETi55356
EuPathDBiHostDB:ENSG00000163393.12
GeneCardsiSLC22A15
HGNCiHGNC:20301 SLC22A15
HPAiHPA019785
MIMi608275 gene
neXtProtiNX_Q8IZD6
OpenTargetsiENSG00000163393
PharmGKBiPA134870374
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRI2 Eukaryota
ENOG4110YHH LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG108435
InParanoidiQ8IZD6
KOiK08211
OMAiDLFRYRI
OrthoDBiEOG091G05DV
PhylomeDBiQ8IZD6
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-HSA-549127 Organic cation transport

Miscellaneous databases

GenomeRNAii55356
PROiPR:Q8IZD6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163393 Expressed in 158 organ(s), highest expression level in corpus callosum
CleanExiHS_SLC22A15
GenevisibleiQ8IZD6 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS22AF_HUMAN
AccessioniPrimary (citable) accession number: Q8IZD6
Secondary accession number(s): A8MUR3
, Q6UXP5, Q8TAL9, Q9NSH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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