UniProtKB - Q8IZD6 (S22AF_HUMAN)
Protein
Solute carrier family 22 member 15
Gene
SLC22A15
Organism
Homo sapiens (Human)
Status
Functioni
Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.By similarity1 Publication
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8IZD6 |
Reactomei | R-HSA-549127, Organic cation transport |
Protein family/group databases
TCDBi | 2.A.1.19.32, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 22 member 15Alternative name(s): Fly-like putative transporter 1 Short name: Flipt 1 |
Gene namesi | Name:SLC22A15 Synonyms:FLIPT1 ORF Names:UNQ9429/PRO34686 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163393.12 |
HGNCi | HGNC:20301, SLC22A15 |
MIMi | 608275, gene |
neXtProti | NX_Q8IZD6 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 42 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 141 – 161 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 165 – 187 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 226 – 246 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 303 – 323 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 338 – 358 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 368 – 388 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 401 – 420 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 433 – 453 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 462 – 482 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55356 |
OpenTargetsi | ENSG00000163393 |
PharmGKBi | PA134870374 |
Miscellaneous databases
Pharosi | Q8IZD6, Tdark |
Polymorphism and mutation databases
BioMutai | SLC22A15 |
DMDMi | 74750790 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000338619 | 1 – 547 | Solute carrier family 22 member 15Add BLAST | 547 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 58 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 63 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 80 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q8IZD6 |
MassIVEi | Q8IZD6 |
PaxDbi | Q8IZD6 |
PeptideAtlasi | Q8IZD6 |
PRIDEi | Q8IZD6 |
ProteomicsDBi | 71330 [Q8IZD6-1] 71331 [Q8IZD6-2] |
PTM databases
GlyGeni | Q8IZD6, 4 sites |
iPTMneti | Q8IZD6 |
PhosphoSitePlusi | Q8IZD6 |
Expressioni
Tissue specificityi
Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.2 Publications
Developmental stagei
Expressed at low levels at 20-25 weeks of gestation in fetal brain, lung, liver and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000163393, Expressed in corpus callosum and 176 other tissues |
Genevisiblei | Q8IZD6, HS |
Organism-specific databases
HPAi | ENSG00000163393, Tissue enhanced (bone marrow, brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120636, 20 interactors |
STRINGi | 9606.ENSP00000358515 |
Miscellaneous databases
RNActi | Q8IZD6, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 529 – 535 | Poly-Glu | 7 |
Sequence similaritiesi
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0255, Eukaryota |
GeneTreei | ENSGT00940000160364 |
HOGENOMi | CLU_001265_33_7_1 |
InParanoidi | Q8IZD6 |
OMAi | AGQFYPM |
OrthoDBi | 464838at2759 |
PhylomeDBi | Q8IZD6 |
TreeFami | TF315847 |
Family and domain databases
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8IZD6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVEEAFQAV GEMGIYQMYL CFLLAVLLQL YVATEAILIA LVGATPSYHW
60 70 80 90 100
DLAELLPNQS HGNQSAGEDQ AFGDWLLTAN GSEIHKHVHF SSSFTSIASE
110 120 130 140 150
WFLIANRSYK VSAASSFFFS GVFVGVISFG QLSDRFGRKK VYLTGFALDI
160 170 180 190 200
LFAIANGFSP SYEFFAVTRF LVGMMNGGMS LVAFVLLNEC VGTAYWALAG
210 220 230 240 250
SIGGLFFAVG IAQYALLGYF IRSWRTLAIL VNLQGTVVFL LSLFIPESPR
260 270 280 290 300
WLYSQGRLSE AEEALYLIAK RNRKLKCTFS LTHPANRSCR ETGSFLDLFR
310 320 330 340 350
YRVLLGHTLI LMFIWFVCSL VYYGLTLSAG DLGGSIYANL ALSGLIEIPS
360 370 380 390 400
YPLCIYLINQ KWFGRKRTLS AFLCLGGLAC LIVMFLPEKK DTGVFAVVNS
410 420 430 440 450
HSLSLLGKLT ISAAFNIVYI YTSELYPTVI RNVGLGTCSM FSRVGGIIAP
460 470 480 490 500
FIPSLKYVQW SLPFIVFGAT GLTSGLLSLL LPETLNSPLL ETFSDLQVYS
510 520 530 540
YRRLGEEALS LQALDPQQCV DKESSLGSES EEEEEFYDAD EETQMIK
Sequence cautioni
The sequence AAH26358 differs from that shown. Reason: Frameshift.Curated
The sequence AAH26358 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043813 | 349 | P → Q1 PublicationCorresponds to variant dbSNP:rs17852419Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034059 | 244 – 245 | FI → VD in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_034060 | 246 – 547 | Missing in isoform 2. 1 PublicationAdd BLAST | 302 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY145501 mRNA Translation: AAN52927.1 AY358258 mRNA Translation: AAQ88625.1 AL357137 Genomic DNA No translation available. AL365318 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56640.1 BC026358 mRNA Translation: AAH26358.1 Sequence problems. AL353933 mRNA Translation: CAB89246.1 |
CCDSi | CCDS44198.1 [Q8IZD6-1] |
PIRi | T48683 |
RefSeqi | NP_060890.2, NM_018420.2 [Q8IZD6-1] |
Genome annotation databases
Ensembli | ENST00000369502; ENSP00000358514; ENSG00000163393 [Q8IZD6-2] ENST00000369503; ENSP00000358515; ENSG00000163393 [Q8IZD6-1] |
GeneIDi | 55356 |
KEGGi | hsa:55356 |
UCSCi | uc001ega.3, human [Q8IZD6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY145501 mRNA Translation: AAN52927.1 AY358258 mRNA Translation: AAQ88625.1 AL357137 Genomic DNA No translation available. AL365318 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56640.1 BC026358 mRNA Translation: AAH26358.1 Sequence problems. AL353933 mRNA Translation: CAB89246.1 |
CCDSi | CCDS44198.1 [Q8IZD6-1] |
PIRi | T48683 |
RefSeqi | NP_060890.2, NM_018420.2 [Q8IZD6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120636, 20 interactors |
STRINGi | 9606.ENSP00000358515 |
Protein family/group databases
TCDBi | 2.A.1.19.32, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q8IZD6, 4 sites |
iPTMneti | Q8IZD6 |
PhosphoSitePlusi | Q8IZD6 |
Polymorphism and mutation databases
BioMutai | SLC22A15 |
DMDMi | 74750790 |
Proteomic databases
EPDi | Q8IZD6 |
MassIVEi | Q8IZD6 |
PaxDbi | Q8IZD6 |
PeptideAtlasi | Q8IZD6 |
PRIDEi | Q8IZD6 |
ProteomicsDBi | 71330 [Q8IZD6-1] 71331 [Q8IZD6-2] |
Protocols and materials databases
Antibodypediai | 9786, 67 antibodies |
DNASUi | 55356 |
Genome annotation databases
Ensembli | ENST00000369502; ENSP00000358514; ENSG00000163393 [Q8IZD6-2] ENST00000369503; ENSP00000358515; ENSG00000163393 [Q8IZD6-1] |
GeneIDi | 55356 |
KEGGi | hsa:55356 |
UCSCi | uc001ega.3, human [Q8IZD6-1] |
Organism-specific databases
CTDi | 55356 |
DisGeNETi | 55356 |
EuPathDBi | HostDB:ENSG00000163393.12 |
GeneCardsi | SLC22A15 |
HGNCi | HGNC:20301, SLC22A15 |
HPAi | ENSG00000163393, Tissue enhanced (bone marrow, brain) |
MIMi | 608275, gene |
neXtProti | NX_Q8IZD6 |
OpenTargetsi | ENSG00000163393 |
PharmGKBi | PA134870374 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0255, Eukaryota |
GeneTreei | ENSGT00940000160364 |
HOGENOMi | CLU_001265_33_7_1 |
InParanoidi | Q8IZD6 |
OMAi | AGQFYPM |
OrthoDBi | 464838at2759 |
PhylomeDBi | Q8IZD6 |
TreeFami | TF315847 |
Enzyme and pathway databases
PathwayCommonsi | Q8IZD6 |
Reactomei | R-HSA-549127, Organic cation transport |
Miscellaneous databases
BioGRID-ORCSi | 55356, 1 hit in 842 CRISPR screens |
ChiTaRSi | SLC22A15, human |
GenomeRNAii | 55356 |
Pharosi | Q8IZD6, Tdark |
PROi | PR:Q8IZD6 |
RNActi | Q8IZD6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163393, Expressed in corpus callosum and 176 other tissues |
Genevisiblei | Q8IZD6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S22AF_HUMAN | |
Accessioni | Q8IZD6Primary (citable) accession number: Q8IZD6 Secondary accession number(s): A8MUR3 Q9NSH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations