SLC22A15

Functionⁱ

Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.By similarity1 Publication

GO - Molecular functionⁱ

organic anion transmembrane transporter activity Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ion transport, Transport

Biological process

Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-549127 Organic cation transport

Reactomeⁱ

R-HSA-549127 Organic cation transport

Protein family/group databases

TCDBⁱ	2.A.1.19.32 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.19.32 the major facilitator superfamily (mfs)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 22 member 15 Alternative name(s): Fly-like putative transporter 1 Short name: Flipt 1
Gene namesⁱ	Name:SLC22A15 Synonyms:FLIPT1 ORF Names:UNQ9429/PRO34686
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163393.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20301 SLC22A15
MIMⁱ	608275 gene
neXtProtⁱ	NX_Q8IZD6

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	22 – 42	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	111 – 131	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	141 – 161	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	165 – 187	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	201 – 221	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	226 – 246	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	303 – 323	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	338 – 358	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	368 – 388	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	401 – 420	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	433 – 453	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	462 – 482	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55356
Open Targets More...OpenTargetsⁱ	ENSG00000163393
PharmGKBⁱ	PA134870374

Polymorphism and mutation databases

BioMutaⁱ	SLC22A15
DMDMⁱ	74750790

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000338619	1 – 547	Solute carrier family 22 member 15Add BLAST		547

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	58	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	63	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	80	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q8IZD6
PaxDbⁱ	Q8IZD6
PeptideAtlas More...PeptideAtlasⁱ	Q8IZD6
PRIDEⁱ	Q8IZD6
ProteomicsDBⁱ	71330 71331 [Q8IZD6-2]

PTM databases

iPTMnetⁱ	Q8IZD6
PhosphoSitePlusⁱ	Q8IZD6

Expressionⁱ

Tissue specificityⁱ

Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.2 Publications

Developmental stageⁱ

Expressed at low levels at 20-25 weeks of gestation in fetal brain, lung, liver and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163393 Expressed in 158 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_SLC22A15
Genevisibleⁱ	Q8IZD6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019785

HPAⁱ

HPA019785

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	120636, 20 interactors

BioGridⁱ

120636, 20 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IZD6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	529 – 535	Poly-Glu		7

Sequence similaritiesⁱ

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IRI2 Eukaryota ENOG4110YHH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118852
HOGENOMⁱ	HOG000234568
HOVERGENⁱ	HBG108435
InParanoidⁱ	Q8IZD6
KEGG Orthology (KO) More...KOⁱ	K08211
OMAⁱ	DLFRYRI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05DV
PhylomeDBⁱ	Q8IZD6
TreeFamⁱ	TF315847

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8IZD6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVEEAFQAV GEMGIYQMYL CFLLAVLLQL YVATEAILIA LVGATPSYHW 
        60         70         80         90        100
DLAELLPNQS HGNQSAGEDQ AFGDWLLTAN GSEIHKHVHF SSSFTSIASE 
       110        120        130        140        150
WFLIANRSYK VSAASSFFFS GVFVGVISFG QLSDRFGRKK VYLTGFALDI 
       160        170        180        190        200
LFAIANGFSP SYEFFAVTRF LVGMMNGGMS LVAFVLLNEC VGTAYWALAG 
       210        220        230        240        250
SIGGLFFAVG IAQYALLGYF IRSWRTLAIL VNLQGTVVFL LSLFIPESPR 
       260        270        280        290        300
WLYSQGRLSE AEEALYLIAK RNRKLKCTFS LTHPANRSCR ETGSFLDLFR 
       310        320        330        340        350
YRVLLGHTLI LMFIWFVCSL VYYGLTLSAG DLGGSIYANL ALSGLIEIPS 
       360        370        380        390        400
YPLCIYLINQ KWFGRKRTLS AFLCLGGLAC LIVMFLPEKK DTGVFAVVNS 
       410        420        430        440        450
HSLSLLGKLT ISAAFNIVYI YTSELYPTVI RNVGLGTCSM FSRVGGIIAP 
       460        470        480        490        500
FIPSLKYVQW SLPFIVFGAT GLTSGLLSLL LPETLNSPLL ETFSDLQVYS 
       510        520        530        540 
YRRLGEEALS LQALDPQQCV DKESSLGSES EEEEEFYDAD EETQMIK

Length:547

Mass (Da):60,540

Last modified:March 1, 2003 - v1

Checksum:ⁱAFE2EEA64B7FFDBC

GO

Isoform 2 (identifier: Q8IZD6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
244-245: FI → VD
246-547: Missing.

« Hide

        10         20         30         40         50
MEVEEAFQAV GEMGIYQMYL CFLLAVLLQL YVATEAILIA LVGATPSYHW 
        60         70         80         90        100
DLAELLPNQS HGNQSAGEDQ AFGDWLLTAN GSEIHKHVHF SSSFTSIASE 
       110        120        130        140        150
WFLIANRSYK VSAASSFFFS GVFVGVISFG QLSDRFGRKK VYLTGFALDI 
       160        170        180        190        200
LFAIANGFSP SYEFFAVTRF LVGMMNGGMS LVAFVLLNEC VGTAYWALAG 
       210        220        230        240 
SIGGLFFAVG IAQYALLGYF IRSWRTLAIL VNLQGTVVFL LSLVD

Show »

Length:245

Mass (Da):26,794

Checksum:ⁱ628B254C0C1C95FD

GO

Sequence cautionⁱ

The sequence AAH26358 differs from that shown. Reason: Frameshift at position 7.Curated

The sequence AAH26358 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_043813	349	P → Q1 PublicationCorresponds to variant dbSNP:rs17852419Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034059	244 – 245	FI → VD in isoform 2. 1 Publication		2
Alternative sequenceⁱVSP_034060	246 – 547	Missing in isoform 2. 1 PublicationAdd BLAST		302

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY145501 mRNA Translation: AAN52927.1 AY358258 mRNA Translation: AAQ88625.1 AL357137 Genomic DNA No translation available. AL365318 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56640.1 BC026358 mRNA Translation: AAH26358.1 Sequence problems. AL353933 mRNA Translation: CAB89246.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44198.1 [Q8IZD6-1]
PIRⁱ	T48683
NCBI Reference Sequences More...RefSeqⁱ	NP_060890.2, NM_018420.2 [Q8IZD6-1]
UniGeneⁱ	Hs.125482

Genome annotation databases

Ensemblⁱ	ENST00000369502; ENSP00000358514; ENSG00000163393 [Q8IZD6-2] ENST00000369503; ENSP00000358515; ENSG00000163393 [Q8IZD6-1]
GeneIDⁱ	55356
KEGGⁱ	hsa:55356
UCSC genome browser More...UCSCⁱ	uc001ega.3 human [Q8IZD6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IZD6	Solute carrier family 22 member 15 isoform 1 (Fragment)		HUMAN		535	UniRef100_Q8IZD6
cDNA FLJ43082 fis, clone BRTHA3017848, highly similar to Homo sapiens solute carrier family 22 (organic cation transporter), member 15 (SLC22A15), mRNA		HUMAN		374
Q8IZD6-2	SLC22A15 isoform 3		PANTR		245	UniRef100_A0A2J8JRY7

Protein	Similar proteins		Species	Score	Length	Source
Q8IZD6	Solute carrier family 22 member 15		MOUSE		544	UniRef90_Q8IZD6
Solute carrier family 22 member 15 isoform 1 (Fragment)		HUMAN		535
Solute carrier family 22 member 15-like protein		CRIGR		561
Uncharacterized protein		PAPAN		556
Uncharacterized protein		PIG		549
+87
Q8IZD6-2	Solute carrier family 22 member 15		MOUSE		245	UniRef90_S4R1S9
SLC22A15 isoform 3		PONAB		245
SLC22A15 isoform 3		PANTR		245
Solute carrier family 22 member 15		LOXAF		223

Protein	Similar proteins		Species	Score	Length	Source
Q8IZD6	Solute carrier family 22 member 15		MOUSE		544	UniRef50_Q8IZD6
Solute carrier family 22 member 15 isoform 1 (Fragment)		HUMAN		535
Solute carrier family 22 member 15-like protein		CRIGR		561
Uncharacterized protein		PAPAN		556
Solute carrier family 22 member 15		CANLF		549
+282
Q8IZD6-2	Solute carrier family 22 member 15		MOUSE		245	UniRef50_S4R1S9
SLC22A15 isoform 3		PANTR		245
SLC22A15 isoform 3		PONAB		245
Solute carrier family 22 member 15		LOXAF		223
Uncharacterized protein		ORNAN		210
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY145501 mRNA Translation: AAN52927.1 AY358258 mRNA Translation: AAQ88625.1 AL357137 Genomic DNA No translation available. AL365318 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56640.1 BC026358 mRNA Translation: AAH26358.1 Sequence problems. AL353933 mRNA Translation: CAB89246.1
CCDSⁱ	CCDS44198.1 [Q8IZD6-1]
PIRⁱ	T48683
RefSeqⁱ	NP_060890.2, NM_018420.2 [Q8IZD6-1]
UniGeneⁱ	Hs.125482

3D structure databases

ProteinModelPortalⁱ	Q8IZD6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120636, 20 interactors

BioGridⁱ

120636, 20 interactors

Protein family/group databases

TCDBⁱ	2.A.1.19.32 the major facilitator superfamily (mfs)

TCDBⁱ

2.A.1.19.32 the major facilitator superfamily (mfs)

PTM databases

iPTMnetⁱ	Q8IZD6
PhosphoSitePlusⁱ	Q8IZD6

Polymorphism and mutation databases

BioMutaⁱ	SLC22A15
DMDMⁱ	74750790

Proteomic databases

EPDⁱ	Q8IZD6
PaxDbⁱ	Q8IZD6
PeptideAtlasⁱ	Q8IZD6
PRIDEⁱ	Q8IZD6
ProteomicsDBⁱ	71330 71331 [Q8IZD6-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55356
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369502; ENSP00000358514; ENSG00000163393 [Q8IZD6-2] ENST00000369503; ENSP00000358515; ENSG00000163393 [Q8IZD6-1]
GeneIDⁱ	55356
KEGGⁱ	hsa:55356
UCSCⁱ	uc001ega.3 human [Q8IZD6-1]

Organism-specific databases

CTDⁱ	55356
DisGeNETⁱ	55356
EuPathDBⁱ	HostDB:ENSG00000163393.12
GeneCardsⁱ	SLC22A15
HGNCⁱ	HGNC:20301 SLC22A15
HPAⁱ	HPA019785
MIMⁱ	608275 gene
neXtProtⁱ	NX_Q8IZD6
OpenTargetsⁱ	ENSG00000163393
PharmGKBⁱ	PA134870374
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IRI2 Eukaryota ENOG4110YHH LUCA
GeneTreeⁱ	ENSGT00760000118852
HOGENOMⁱ	HOG000234568
HOVERGENⁱ	HBG108435
InParanoidⁱ	Q8IZD6
KOⁱ	K08211
OMAⁱ	DLFRYRI
OrthoDBⁱ	EOG091G05DV
PhylomeDBⁱ	Q8IZD6
TreeFamⁱ	TF315847

Enzyme and pathway databases

Reactomeⁱ	R-HSA-549127 Organic cation transport

Reactomeⁱ

R-HSA-549127 Organic cation transport

Miscellaneous databases

GenomeRNAiⁱ	55356
Protein Ontology More...PROⁱ	PR:Q8IZD6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163393 Expressed in 158 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_SLC22A15
Genevisibleⁱ	Q8IZD6 HS

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf
Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S22AF_HUMAN
Accessionⁱ	Q8IZD6Primary (citable) accession number: Q8IZD6 Secondary accession number(s): A8MUR3 , Q6UXP5, Q8TAL9, Q9NSH5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniRef

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Supporting data

UniProtKB - Q8IZD6 (S22AF_HUMAN)

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Solute carrier family 22 member 15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ