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Protein

Zinc finger protein 101

Gene

ZNF101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 124C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 101
Alternative name(s):
Zinc finger protein HZF12
Gene namesi
Name:ZNF101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000181896.11
HGNCiHGNC:12881 ZNF101
MIMi603983 gene
neXtProtiNX_Q8IZC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181896
PharmGKBiPA37470

Polymorphism and mutation databases

BioMutaiZNF101
DMDMi55976740

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474061 – 436Zinc finger protein 101Add BLAST436

Proteomic databases

EPDiQ8IZC7
MaxQBiQ8IZC7
PaxDbiQ8IZC7
PeptideAtlasiQ8IZC7
PRIDEiQ8IZC7
ProteomicsDBi71319

PTM databases

iPTMnetiQ8IZC7
PhosphoSitePlusiQ8IZC7

Expressioni

Tissue specificityi

Expressed in a variety of adult and fetal tissues.1 Publication

Gene expression databases

BgeeiENSG00000181896
CleanExiHS_ZNF101
ExpressionAtlasiQ8IZC7 baseline and differential
GenevisibleiQ8IZC7 HS

Organism-specific databases

HPAiHPA023449
HPA055486

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125102, 15 interactors
IntActiQ8IZC7, 9 interactors
STRINGi9606.ENSP00000319716

Structurei

3D structure databases

ProteinModelPortaliQ8IZC7
SMRiQ8IZC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 82KRABPROSITE-ProRule annotationAdd BLAST79

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 124C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 276C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri282 – 304C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ8IZC7
KOiK09228
OMAiLFQIHVR
OrthoDBiEOG091G02KC
PhylomeDBiQ8IZC7

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IZC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVAFEDVA VNFTQEEWAL LSPSQKNLYR DVTLETFRNL ASVGIQWKDQ
60 70 80 90 100
DIENLYQNLG IKLRSLVERL CGRKEGNEHR ETFSQIPDCH LNKKSQTGVK
110 120 130 140 150
PCKCSVCGKV FLRHSFLDRH MRAHAGHKRS ECGGEWRETP RKQKQHGKAS
160 170 180 190 200
ISPSSGARRT VTPTRKRPYE CKVCGKAFNS PNLFQIHQRT HTGKRSYKCR
210 220 230 240 250
EIVRAFTVSS FFRKHGKMHT GEKRYECKYC GKPIDYPSLF QIHVRTHTGE
260 270 280 290 300
KPYKCKQCGK AFISAGYLRT HEIRSHALEK SHQCQECGKK LSCSSSLHRH
310 320 330 340 350
ERTHSGGKLY ECQKCAKVFR CPTSLQAHER AHTGERPYEC NKCGKTFNYP
360 370 380 390 400
SCFRRHKKTH SGEKPYECTR CGKAFGWCSS LRRHEMTHTG EKPFDCKQCG
410 420 430
KVFTFSNYLR LHERTHLAGR SQCFGRRQGD HLSPGV
Length:436
Mass (Da):50,339
Last modified:March 1, 2003 - v1
Checksum:i48EEA2EEA86212B3
GO
Isoform 2 (identifier: Q8IZC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):36,473
Checksum:iD09DCD06780FF3A0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024197121M → L. Corresponds to variant dbSNP:rs4808209Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559371 – 120Missing in isoform 2. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY149174 mRNA Translation: AAN46749.1
AC011458 Genomic DNA No translation available.
BC119680 mRNA Translation: AAI19681.1
CCDSiCCDS32971.1 [Q8IZC7-1]
CCDS77271.1 [Q8IZC7-2]
RefSeqiNP_001287878.1, NM_001300949.1 [Q8IZC7-2]
NP_149981.2, NM_033204.3 [Q8IZC7-1]
UniGeneiHs.631642
Hs.63187

Genome annotation databases

EnsembliENST00000318110; ENSP00000319716; ENSG00000181896 [Q8IZC7-1]
ENST00000415784; ENSP00000400952; ENSG00000181896 [Q8IZC7-2]
ENST00000592502; ENSP00000468049; ENSG00000181896 [Q8IZC7-1]
GeneIDi94039
KEGGihsa:94039
UCSCiuc002nni.3 human [Q8IZC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN101_HUMAN
AccessioniPrimary (citable) accession number: Q8IZC7
Secondary accession number(s): C9JU83, Q0VDG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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